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显示 31-60 共 374 条结果 关于 "184861" 范围 论文
Megan P Caputo et al.
Brain, behavior, and immunity, 81, 455-469 (2019-07-05)
Neonatal brain development can be disrupted by infection that results in microglial cell activation and neuroinflammation. Studies indicate that polyunsaturated fatty acids (PUFAs) and their metabolites can resolve inflammation. It is not known if dietary PUFA increases lipid metabolites in
Sebastian Andris et al.
Journal of biotechnology, 317, 48-58 (2020-05-04)
Antibody-drug conjugates (ADCs) are hybrid molecules based on monoclonal antibodies (mAbs) with covalently attached cytotoxic small-molecule drugs. Due to their potential for targeted cancer therapy, they form part of the diversifying pipeline of various biopharmaceutical companies, in addition to currently
Jeffrey L Barr et al.
Neuroscience letters, 735, 135196-135196 (2020-06-26)
Docosahexaenoic acid (DHA) an omega-3 polyunsaturated fatty acid, is an agonist of FFA1 receptor. DHA administration reduces the heart rate via unclear mechanisms. We examined the effect of DHA on neurons of nucleus ambiguus that provide the parasympathetic control of
Amanda Lo Van et al.
Molecular neurobiology, 56(2), 986-999 (2018-06-03)
Docosahexaenoic acid (DHA, 22:6n-3) is an essential omega-3 polyunsaturated fatty acid (PUFA) that is required for proper brain development and cerebral functions. While DHA deficiency in the brain was shown to be linked to the emergence of cerebral diseases, a
Xiaoli Zhu et al.
Scientific reports, 10(1), 6448-6448 (2020-04-17)
Neonatal necrotizing enterocolitis (NEC) is a serious gastrointestinal disease with high death rate in premature infants. Fish oil (FO) and its constituents have been shown to ameliorate intestinal inflammation and mucosal damage. However, the underlying mechanism of action is not
Yusuke Yamamoto et al.
Analytical and bioanalytical chemistry, 413(1), 245-254 (2020-10-23)
Lysophosphatidylethanolamines (LysoPEs) are the partial hydrolysis products of phosphatidylethanolamine. Despite the unique in vitro bioactivities of LysoPEs, there are limited reports on the pathophysiological role of LysoPEs in the serum, due to the lack of sensitive analytical methods for determination
Roman Jaramillo et al.
Journal of chromatography. A, 1612, 460696-460696 (2020-01-02)
Thermodynamic modeling of GC × GC separations provides a tool for rapid method evaluation and optimization. Separations of 95 hydrocarbons on two cryogenically modulated GC × GC systems (atmospheric outlet and vacuum outlet) are modeled, displaying average second dimension retention time modeling absolute errors
Heitor O Santos et al.
Nutrients, 12(10) (2020-10-22)
Cardiovascular diseases remain a global challenge, and lipid-associated biomarkers can predict cardiovascular events. Extensive research on cardiovascular benefits of omega-3 polyunsaturated fatty acids (n3-PUFAs) is geared towards fish oil supplementation and fish-rich diets. Nevertheless, vegetarianism and veganism are becoming more
Mutay Aslan et al.
Toxicology in vitro : an international journal published in association with BIBRA, 66, 104836-104836 (2020-03-30)
This study evaluated polyunsaturated fatty acids (PUFAs) in human kidney epithelial cells exposed to diclofenac (DCL) toxicity. Kidney cells were treated with DCL to induce cytotoxicity and thymoquinone (TQ) was administered to decrease cytotoxic effects. Levels of arachidonic acid (AA
Einar Vargas-Bello-Pérez et al.
Veterinary sciences, 6(2) (2019-06-20)
A prior study in bovine mammary (MACT) cells indicated that long-chain fatty acids (LCFA) C16:0 and C18:0, but not unsaturated LCFA, control transcription of milk fat-related genes partly via the activation of peroxisome proliferator-activated receptor gamma (PPARγ). However, in that
Shuli Yang et al.
Journal of diabetes research, 2019, 7074042-7074042 (2020-01-21)
To investigate the effects of cod-liver oil on metabolic status and high-sensitivity C-reactive protein (hs-CRP) in patients with gestational diabetes mellitus (GDM). This study was a randomized, double-blinded, placebo-controlled trial with the allocation ratio of 1 : 1. The contents of EPA
Kento Sawane et al.
Nutrients, 11(12) (2019-11-27)
The metabolism and generation of bioactive lipid mediators are key events in the exertion of the beneficial effects of dietary omega-3 fatty acids in the regulation of allergic inflammation. Here, we found that dietary linseed oil, which contains high amounts
Bo Yang et al.
Psychotherapy and psychosomatics, 88(4), 215-224 (2019-07-04)
Endocannabinoids (ECs) are one type of bioactive endogenous neuroinflammatory mediator derived from polyunsaturated fatty acids (PUFAs), which may regulate the emotional processes. Here, we assessed the effect of ω-3 PUFAs on EC levels, which may be the novel targets for
Minal Jaggar et al.
Frontiers in neuroendocrinology, 56, 100815-100815 (2019-12-06)
Sex is a critical factor in the diagnosis and development of a number of mental health disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease, multiple sclerosis, anorexia nervosa and others; likely due to differences in sex steroid hormones and genetics.
Ahmed A Elmarakby et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1864(11), 1669-1680 (2019-07-28)
Recent studies suggest a potential role of bioactive lipids in acute kidney injury induced by lipopolysaccharide (LPS). The current study was designed to determine the profiling activities of various polyunsaturated fatty acid (PUFA) metabolizing enzymes, including lipoxygenases (LO), cyclooxygenase, and
Yvoni Kyriakidou et al.
Journal of the International Society of Sports Nutrition, 18(1), 9-9 (2021-01-15)
Exercise-induced muscle damage (EIMD) results in transient muscle inflammation, strength loss, muscle soreness and may cause subsequent exercise avoidance. Omega-3 (n-3) supplementation may minimise EIMD via its anti-inflammatory properties, however, its efficacy remains unclear. Healthy males (n = 14, 25.07 ± 4.05 years) were randomised
Chukwudi O Onwosi et al.
Environmental technology, 41(24), 3178-3190 (2019-04-16)
We investigated a number of microbiological activities in the soil to serve as biomonitoring tools in assessing the ecotoxicity of diesel-contaminated soil samples during the different periods of bioremediation. Sawdust was used as the biostimulant for the biodegradation of artificial
Zhengping Wu et al.
Die Pharmazie, 74(11), 675-679 (2019-11-20)
Docosahexaenoic acid (DHA) is rich in fish oil with many pharmacological impacts such as anti-inflammation and anti-cancer activities. In the present study, we aimed to investigate the inhibitory effects of DHA on the invasion and inflammation in prostate cancer cells.
Daniel Hilger et al.
Science (New York, N.Y.), 369(6503) (2020-08-01)
Family B heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) play important roles in carbohydrate metabolism. Recent structures of family B GPCR-Gs protein complexes reveal a disruption in the α-helix of transmembrane segment 6 (TM6) not observed in family A
Daniel González-Hedström et al.
Nutrients, 13(1) (2020-12-31)
Aging is associated with a progressive decline in skeletal muscle mass, strength and function (sarcopenia). We have investigated whether a mixture of algae oil (25%) and extra virgin olive oil (75%) could exert beneficial effects on sarcopenia. Young (3 months)
Steven C Perry et al.
Journal of lipid research, 61(7), 1087-1103 (2020-05-15)
The two oxylipins 7S,14S-dihydroxydocosahexaenoic acid (diHDHA) and 7S,17S-diHDHA [resolvin D5 (RvD5)] have been found in macrophages and infectious inflammatory exudates and are believed to function as specialized pro-resolving mediators (SPMs). Their biosynthesis is thought to proceed through sequential oxidations of
Monise Helen Masuchi Buscato et al.
Food chemistry, 327, 127087-127087 (2020-05-27)
This study investigated the lipid oxidation reactions of furan fatty acids, long-chain ω-3 polyunsaturated fatty acids, and tocopherols in an enriched ω-3 fish oil to better understand their degradation kinetics. Furthermore, the influence of an added monomethyl furan fatty acid
Guanglin Zhang et al.
Molecular nutrition & food research, e2000788-e2000788 (2020-10-17)
The influence of docosahexaenoic acid (DHA) on cardiometabolic and cognitive phenotypes, and multi-omic alterations in the brain under two metabolic conditions is explored to understand context-specific nutritional effects. Rats are randomly assigned to a DHA-rich or a control chow diet
Zhuo-Hao Liu et al.
International journal of molecular sciences, 21(19) (2020-09-30)
Spinal cord injury (SCI) is associated with disability and a drastic decrease in quality of life for affected individuals. Previous studies support the idea that docosahexaenoic acid (DHA)-based pharmacological approach is a promising therapeutic strategy for the management of acute
Lichchavi D Rajasinghe et al.
Frontiers in immunology, 11, 2179-2179 (2020-10-31)
Airway exposure of lupus-prone NZBWF1 mice to crystalline silica (cSiO2), a known trigger of human autoimmune disease, elicits sterile inflammation and alveolar macrophage death in the lung that, in turn, induces early autoimmune onset and accelerates lupus progression to fatal
Hiroki Suganuma et al.
Prostaglandins, leukotrienes, and essential fatty acids, 164, 102217-102217 (2020-12-09)
Oxylipins synthesized by oxidation of long-chain polyunsaturated fatty acids (LCPUFAs) are bioactive downstream lipid mediators. The aim of this study was to describe oxylipin levels in preterm infants born 30 to 33 weeks' gestation who were enrolled in a randomized
Cuiping Shi et al.
Food chemistry, 298, 125029-125029 (2019-07-02)
Thermal processing methods have important effects on food lipids. In this work, ultra-high-performance liquid chromatography-Q-Extractive Orbitrap mass spectrometry and lipidsearch software were applied to analyze effect of three types of thermal processing methods on the lipidomics profile of tilapia fillets.
Thomas R Lane et al.
Antiviral research, 182, 104908-104908 (2020-08-18)
We have recently identified three molecules (tilorone, quinacrine and pyronaridine tetraphosphate) which all demonstrated efficacy in the mouse model of infection with mouse-adapted Ebola virus (EBOV) model of disease and had similar in vitro inhibition of an Ebola pseudovirus (VSV-EBOV-GP)
Laís Ferraz Brito et al.
Journal of the science of food and agriculture, 99(13), 5870-5880 (2019-06-18)
Sepsis is a set of serious organic manifestations caused by an infection, whose progression culminates in exacerbated inflammation and oxidative stress, poor prognosis, and high hospital costs. Antioxidants used against sepsis have been evaluated, including essential oils such as β-caryophyllene
Xingran Chen et al.
IUBMB life, 71(11), 1740-1750 (2019-07-03)
Alcoholic liver disease (ALD) is generated from excessive alcohol consumption, characterized by hepatic steatosis. Mechanistically, excessive hepatic lipid accumulation was attributed to the aberrant lipin-1 signaling during the development of alcoholic steatosis in rodent species and human. Dihydroartemisinin (DHA) has
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