186260

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Nutritional values and bioactive components of under-utilised vegetables consumed by indigenous people in Malaysia.

Norsuhaila Abdul Wahab et al.

Journal of the science of food and agriculture, 95(13), 2704-2711 (2014-11-21)

Diverse plants species in the forest remain under-utilised and they are mainly consumed only by local people. However, increasing issues in food security prompted the present study, which explores the nutritional and antioxidant aspects of Malaysian under-utilised vegetables. The studied

Validation of a high performance liquid chromatography method for the stabilization of epigallocatechin gallate.

Joana F Fangueiro et al.

International journal of pharmaceutics, 475(1-2), 181-190 (2014-09-02)

Epigallocatechin gallate (EGCG) is a green tea catechin with potential health benefits, such as anti-oxidant, anti-carcinogenic and anti-inflammatory effects. In general, EGCG is highly susceptible to degradation, therefore presenting stability problems. The present paper was focused on the study of

Validation of a New Recombinant Antibody Fragment (rFab)-Based Homogeneous Enzyme Immunoassay for the Highly Specific Detection of 6-Acetylmorphine in Urine.

Guohong Wang et al.

Journal of analytical toxicology, 39(9), 726-733 (2015-08-28)

The detection of 6-acetylmorphine (6-AM) in urine by immunoassay methods is challenging due to its short half-life and its similarity in structure to many commonly abused opiates that are often present at very high concentrations in urine. Current 6-AM homogeneous

Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells.

Yong-Hui Ding et al.

Drug design, development and therapy, 9, 425-464 (2015-01-28)

Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown potent anticancer effects, and is under clinical investigation for the treatment of

Determination of drugs of abuse in bovine dentin using liquid chromatography-electrospray ionization tandem mass spectrometry.

J Spinner et al.

Journal of mass spectrometry : JMS, 49(12), 1306-1313 (2014-12-06)

Drugs deposited in human teeth are well preserved; the spectrum of toxicological investigations may therefore be supplemented by an analysis method for drugs in teeth. A liquid chromatography-electrospray ionization tandem mass spectrometry assay for the detection and quantification of basic

In vitro and in vivo evaluation of heparin mediated growth factor release from tissue-engineered constructs for anterior cruciate ligament reconstruction.

Natalie L Leong et al.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(2), 229-236 (2014-11-05)

Anterior cruciate ligament (ACL) rupture is a common injury often necessitating surgical treatment with graft reconstruction. Due to limitations associated with current graft options, there is interest in a tissue-engineered substitute for use in ACL regeneration. While they represent an

Controlling osteogenic stem cell differentiation via soft bioinspired hydrogels.

Amit K Jha et al.

PloS one, 9(6), e98640-e98640 (2014-06-18)

Osteogenic differentiation of human mesenchymal stem cells (hMSCs) is guided by various physical and biochemical factors. Among these factors, modulus (i.e., rigidiy) of the ECM has gained significant attention as a physical osteoinductive signal that can contribute to endochondral ossification

Dissimilation of the C2 sulfonates.

Alasdair M Cook et al.

Archives of microbiology, 179(1), 1-6 (2002-12-10)

Organosulfonates are widespread in the environment, both as natural products and as xenobiotics; and they generally share the property of chemical stability. A wide range of phenomena has evolved in microorganisms able to utilize the sulfur or the carbon moiety

CMVpp65 Vaccine Enhances the Antitumor Efficacy of Adoptively Transferred CD19-Redirected CMV-Specific T Cells.

Xiuli Wang et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 21(13), 2993-3002 (2015-04-04)

T cells engineered with chimeric antigen receptors (CAR) recognizing CD19 can induce complete remission of B-cell malignancies in clinical trials; however, in some disease settings, CAR therapy confers only modest clinical benefit due to attenuated persistence of CAR T cells.

Characterizing the structure of lipodisq nanoparticles for membrane protein spectroscopic studies.

Rongfu Zhang et al.

Biochimica et biophysica acta, 1848(1 Pt B), 329-333 (2014-05-24)

Membrane protein spectroscopic studies are challenging due to the difficulty introduced in preparing homogenous and functional hydrophobic proteins incorporated into a lipid bilayer system. Traditional membrane mimics such as micelles or liposomes have proved to be powerful in solubilizing membrane

Shade avoidance components and pathways in adult plants revealed by phenotypic profiling.

Kazunari Nozue et al.

PLoS genetics, 11(4), e1004953-e1004953 (2015-04-16)

Shade from neighboring plants limits light for photosynthesis; as a consequence, plants have a variety of strategies to avoid canopy shade and compete with their neighbors for light. Collectively the response to foliar shade is called the shade avoidance syndrome

Characterization of polymeric nanomaterials using analytical ultracentrifugation.

Leosveys Diaz et al.

Environmental science & technology, 49(12), 7302-7309 (2015-05-20)

The characterization of nanomaterials represents a complex analytical challenge due to their dynamic nature (small size, high reactivity, and instability) and the low concentrations in the environment, often below typical analytical detection limits. Analytical ultracentrifugation (AUC) is especially useful for

Alendronate-Eluting Biphasic Calcium Phosphate (BCP) Scaffolds Stimulate Osteogenic Differentiation.

Sung Eun Kim et al.

BioMed research international, 2015, 320713-320713 (2015-07-30)

Biphasic calcium phosphate (BCP) scaffolds have been widely used in orthopedic and dental fields as osteoconductive bone substitutes. However, BCP scaffolds are not satisfactory for the stimulation of osteogenic differentiation and maturation. To enhance osteogenic differentiation, we prepared alendronate- (ALN-)

Chiral separation of amines in subcritical fluid chromatography using polysaccharide stationary phases and acidic additives.

Rodger W Stringham

Journal of chromatography. A, 1070(1-2), 163-170 (2005-05-03)

The chiral separation of basic compounds by subcritical fluid chromatography (SFC) is often unsuccessful, due possibly to multiple interactions of the analyte with the mobile and stationary phase. Incorporation of a strong acid, ethanesulfonic acid (ESA), into the sample diluent

Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.

Adam L Green et al.

Neuro-oncology, 17(5), 697-707 (2014-11-05)

Glioblastoma (GBM) is poorly responsive to current chemotherapy. The nuclear transporter exportin 1 (XPO1, CRM1) is often highly expressed in GBM, which may portend a poor prognosis. Here, we determine the efficacy of novel selective inhibitors of nuclear export (SINE)

Direct aqueous injection LC-ESI/MS/MS analysis of water for 11 chloro- and thiomethyltriazines and metolachlor and its ethanesulfonic and oxanilic acid degradates.

Sung-Ben Huang et al.

Journal of agricultural and food chemistry, 56(8), 2595-2602 (2008-04-01)

A multianalyte method is reported for the determination of atrazine, simazine, propazine, and their respective dealkylated chlorotriazine metabolites; ametryn and prometryn and their respective dealkylated thiomethyltriazine metabolites; and S-metolachlor and its ethanesulfonic and oxanilic acid degradates in deionized, ground, surface

Cytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate is cooperative and shear enhanced.

Harden Rieger et al.

Blood, 125(2), 383-391 (2014-10-30)

Infections with the human malaria parasite Plasmodium falciparum during pregnancy can lead to severe complications for both mother and child, resulting from the cytoadhesion of parasitized erythrocytes in the intervillous space of the placenta. Cytoadherence is conferred by the specific

PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System.

Kujaany Kana et al.

Tissue engineering. Part A, 21(17-18), 2379-2389 (2015-06-30)

Myocardial infarction, a prevalent cardiovascular disease, is associated with cardiomyocyte cell death, and eventually heart failure. Cardiac tissue engineering has provided hopes for alternative treatment options, and high-fidelity tissue models for drug discovery. The signal transduction mechanisms relayed in response

The role of nanostructures and hydrophilicity in osseointegration: In-vitro protein-adsorption and blood-interaction studies.

Brigitte S Kopf et al.

Journal of biomedical materials research. Part A, 103(8), 2661-2672 (2015-01-30)

Protein adsorption and blood coagulation play important roles in the early stages of osseointegration and are strongly influenced by surface properties. We present a systematic investigation of the influence of different surface properties on the adsorption of the blood proteins

G-CSF mobilizes CD34+ regulatory monocytes that inhibit graft-versus-host disease.

Maud D'Aveni et al.

Science translational medicine, 7(281), 281ra42-281ra42 (2015-04-04)

Granulocyte colony-stimulating factor (G-CSF) is routinely used to collect peripheral blood stem cells (PBSCs) from healthy donors for allogeneic hematopoietic stem cell transplantation (allo-HSCT). We show that, in both humans and mice, G-CSF mobilizes a subset of CD34(+) cells with

Improved Insulin Secretion by Autologous Islet Transplantation, Compared to Oral Antidiabetic Agents, After Distal Pancreatectomy.

Ji Won Yoon et al.

Cell transplantation, 24(8), 1615-1626 (2014-07-01)

In this study, the effects of autologous islet transplantation (ITx) were compared to those of oral antidiabetic drugs (OAD) after distal pancreatectomy (NCT01922492). We enrolled nondiabetic patients who underwent distal pancreatectomy for benign tumors. In the ITx group, islets were

ATPase inhibitor based luciferase assay for prolonged and enhanced ATP pool measurement as an efficient fish freshness indicator.

Rajeev Ranjan et al.

Analytical and bioanalytical chemistry, 406(18), 4541-4549 (2014-05-20)

The nucleotide degradation pathway in somatic cells leads to the accumulation of products such as hypoxanthine and inosine, which are commonly used as fish and meat freshness indicators. Assays based on these molecules cannot differentiate the postmortem time over a

Covalent binding of nanoliposomes to the surface of magnetotactic bacteria for the synthesis of self-propelled therapeutic agents.

Samira Taherkhani et al.

ACS nano, 8(5), 5049-5060 (2014-04-02)

The targeted and effective delivery of therapeutic agents remains an unmet goal in the field of controlled release systems. Magnetococcus marinus MC-1 magnetotactic bacteria (MTB) are investigated as potential therapeutic carriers. By combining directional magnetotaxis-microaerophilic control of these self-propelled agents

Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population.

Sheryl S L Tan et al.

Clinical and translational gastroenterology, 5, e51-e51 (2014-02-28)

Sphingosine kinase 1 (SphK1) phosphorylates the membrane sphingolipid, sphingosine, to sphingosine-1-phosphate (S1P), an oncogenic mediator, which drives tumor cell growth and survival. Although SphK1 has gained increasing prominence as an oncogenic determinant in several cancers, its potential as a therapeutic

Inhibition of human efflux transporter ABCC2 (MRP2) by self-emulsifying drug delivery system: influences of concentration and combination of excipients.

Liang Li et al.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(4), 447-460 (2015-01-13)

This study investigated influences of concentration and combination of excipients, commonly used in self-emulsifying drug delivery systems (SEDDS), on inhibition of human efflux transporter ABCC2 (MRP2). Ten commonly used excipients of SEDDS with inhibitory effect on MRP2 including Cremophor® EL

Synthesis and In Vitro Evaluation of Thiolated Carrageenan.

Wongsakorn Suchaoin et al.

Journal of pharmaceutical sciences, 104(8), 2523-2530 (2015-06-04)

The aim of this study was to generate and characterize a thiolated carrageenan. Thiolated carrageenan (carrageenan-SH) was synthesized from kappa (κ)- and iota (ι)-carrageenan by bromine replacement of the hydroxyl moieties followed by substitution to thiol groups using thiourea. Thiolated

A test to determine the nature and presence of the memory effect columns packed with the amylose tris(3,5-dimethylphenylcarbamate) stationary phase.

Joel Putnam et al.

Journal of chromatography. A, 1218(37), 6302-6307 (2011-07-30)

Acid/base mobile phase modifiers affect enantioseparations in ways that are not fully understood yet, for the lack of systematic studies. This makes chiral analysis of some pharmaceuticals difficult to reproduce. Once a column has been exposed to a modifier, the

Lupeol derivative mitigates Echis carinatus venom-induced tissue destruction by neutralizing venom toxins and protecting collagen and angiogenic receptors on inflammatory cells.

G D Katkar et al.

Biochimica et biophysica acta, 1850(12), 2393-2409 (2015-09-24)

Echis carinatus bite is a serious threat in South-Asian countries including India, as it causes highest number of deaths and terrifying long-term tissue destruction at the bitten site. Although venom metalloproteinases and hyaluronidases are the suggested key players, studies on

Dechlorination of chloroacetanilide herbicides by plant growth regulator sodium bisulfite.

Haitao Bian et al.

Water research, 43(14), 3566-3574 (2009-06-13)

Chloroacetanilide herbicides are frequently detected in groundwater and surface waters, and pose high risks to aquatic biota. In this study, sodium bisulfite (NaHSO(3)), a plant growth regulator used in China, was used to remove three chloroacetanilide herbicides including alachlor, acetochlor

The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity.

Avanti Gokhale et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(19), 7643-7653 (2015-05-15)

Dysbindin is a schizophrenia susceptibility factor and subunit of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) required for lysosome-related organelle biogenesis, and in neurons, synaptic vesicle assembly, neurotransmission, and plasticity. Protein networks, or interactomes, downstream of dysbindin/BLOC-1 remain partially

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