200-184-4

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Desvenlafaxine compared with placebo for treatment of menopausal vasomotor symptoms: a 12-week, multicenter, parallel-group, randomized, double-blind, placebo-controlled efficacy trial.

JoAnn V Pinkerton et al.

Menopause (New York, N.Y.), 20(1), 28-37 (2012-09-27)

The aim of this study was to assess the 12-week efficacy of desvenlafaxine in treating moderate to severe vasomotor symptoms and the clinical relevance of improvements in postmenopausal women experiencing 50 or more moderate to severe hot flashes per week.

D-dimer and D-dimer/fibrinogen ratio in predicting pulmonary embolism in patients evaluated in a hospital emergency department.

H Kara et al.

Acta clinica Belgica, 69(4), 240-245 (2014-07-12)

The D-dimer level, fibrinogen level, and D-dimer/fibrinogen ratio are used in the diagnosis of pulmonary embolism, but results vary. We evaluated these parameters in the diagnosis of pulmonary embolism in emergency clinic patients. In this prospective study, 200 patients (pulmonary

Bioequivalence and pharmacokinetic comparison of a single 200-mg dose of meclofenoxate hydrochloride capsule and tablet formulations in healthy Chinese adult male volunteers: a randomized sequence, open-label, two-period crossover study.

Jian-Jun Zou et al.

Clinical therapeutics, 30(9), 1651-1657 (2008-10-09)

Meclofenoxate hydrochloride is a psychostimulant in the nootropic agent group available in capsule and tablet formulations approved for traumatic cataphora, alcoholic poisoning, anoxia neonatorum, and children's enuresis in China. Although these 2 generic formulations are marketed in China, information regarding

Probing the instabilities in the dynamics of helical fragments from mouse PrPC.

Ruxandra I Dima et al.

Proceedings of the National Academy of Sciences of the United States of America, 101(43), 15335-15340 (2004-10-21)

The first step in the formation of the protease resistant form (PrPSc) of prion proteins involves a conformational transition of the monomeric cellular form of PrPC to a more stable aggregation prone state PrPC*. A search of PDBselect and Escherichia

Medical complications during inpatient rehabilitation among patients with traumatic disorders of consciousness.

John Whyte et al.

Archives of physical medicine and rehabilitation, 94(10), 1877-1883 (2013-06-06)

To assess the incidence of medical complications in patients with recent traumatic disorders of consciousness (DOCs). Data on adverse events in a placebo controlled trial of amantadine hydrochloride revealed no group difference, which allowed these events to be reanalyzed descriptively

[Studies on pharmacokinetics of evodiamine and rutaecarpine in rats plasma after oral administration extracts of euodiae fructus].

Tiandong Bao et al.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(24), 3519-3522 (2012-03-01)

Develop an LC-MS method to determine evodiamine and rutaecarpine in rats plasma simultaneously. The method was employed to investigate pharmacokinetics of evodiamine and rutaecarpine. Blood samples were collected in different time after oral administrated with the extracts of Euodiae Fructus

Dexamethasone measurement during low-dose suppression test for suspected hypercortisolism: threshold development with and validation.

F Ceccato et al.

Journal of endocrinological investigation, 43(8), 1105-1113 (2020-02-16)

Dexamethasone Suppression Test (DST), recommended for Cushing's Syndrome (CS) diagnosis, explores the pituitary feedback to glucocorticoids. Its diagnostic accuracy could be affected by dexamethasone bioavailability, and therefore, we have developed and validated a dexamethasone threshold after 1-mg DST. We studied

The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes.

Maria Luiza Caramori et al.

Diabetes, 52(12), 3010-3013 (2003-11-25)

The peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism has been associated with a decreased risk of type 2 diabetes and a lower albumin excretion rate (AER) in patients with established diabetes. We performed a case-control study aiming to evaluate the

Urine concentrations of fentanyl and norfentanyl during application of Duragesic transdermal patches.

Alphonse Poklis et al.

Journal of analytical toxicology, 28(6), 422-425 (2004-11-02)

A study of the urinary concentration of fentanyl (F) and its major metabolite norfentanyl (NF) in chronic pain patients treated with the Duragesic continuous release transdermal patches is presented. These patches are available in 10, 20, 30, and 40 cm(2)

Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a randomised non-inferiority trial.

Maryline Bonnet et al.

The Lancet. Infectious diseases, 13(4), 303-312 (2013-02-26)

In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-based antiretroviral therapy (started at

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