200-228-2

应用筛选条件

关键词:'200-228-2'

显示 1-10 共 10 条结果关于 "200-228-2" 范围论文

Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine.

R T Pickard et al.

The Journal of biological chemistry, 271(32), 19225-19231 (1996-08-09)

Cytosolic phospholipase A2 (cPLA2) hydrolyzes the sn-2-acyl ester bond of phospholipids and shows a preference for arachidonic acid-containing substrates. We found previously that Ser-228 is essential for enzyme activity and is likely to function as a nucleophile in the catalytic

NMR solution structure of the human prion protein.

R Zahn et al.

Proceedings of the National Academy of Sciences of the United States of America, 97(1), 145-150 (2000-01-05)

The NMR structures of the recombinant human prion protein, hPrP(23-230), and two C-terminal fragments, hPrP(90-230) and hPrP(121-230), include a globular domain extending from residues 125-228, for which a detailed structure was obtained, and an N-terminal flexibly disordered "tail." The globular

Toward the molecular basis of inherited prion diseases: NMR structure of the human prion protein with V210I mutation.

Ivana Biljan et al.

Journal of molecular biology, 412(4), 660-673 (2011-08-16)

The development of transmissible spongiform encephalopathies (TSEs) is associated with the conversion of the cellular prion protein (PrP(C)) into a misfolded, pathogenic isoform (PrP(Sc)). Spontaneous generation of PrP(Sc) in inherited forms of disease is caused by mutations in gene coding

[Superoxide dismutase gene polymorphisms and functional activity in chronic obstructive pulmonary disease].

Feng Guo et al.

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 34(6), 424-428 (2011-07-26)

To explore the association of genetic polymorphism of superoxide dismutase (SOD) and superoxide dismutase activity in chronic obstructive pulmonary disease. A total of 114 patients with COPD (the COPD group) and 80 healthy volunteers (the control group) were enrolled in

Pilot clinical trial and phenotypic analysis in chemotherapy-pretreated, metastatic triple-negative breast cancer patients treated with oral TAK-228 and TAK-117 (PIKTOR) to increase DNA damage repair deficiency followed by cisplatin and nab paclitaxel.

Jessica D Lang et al.

Biomarker research, 11(1), 73-73 (2023-07-26)

A subset of triple-negative breast cancers (TNBCs) have homologous recombination deficiency with upregulation of compensatory DNA repair pathways. PIKTOR, a combination of TAK-228 (TORC1/2 inhibitor) and TAK-117 (PI3Kα inhibitor), is hypothesized to increase genomic instability and increase DNA damage repair

NMR structure of the bovine prion protein.

F López Garcia et al.

Proceedings of the National Academy of Sciences of the United States of America, 97(15), 8334-8339 (2000-07-19)

The NMR structures of the recombinant 217-residue polypeptide chain of the mature bovine prion protein, bPrP(23-230), and a C-terminal fragment, bPrP(121-230), include a globular domain extending from residue 125 to residue 227, a short flexible chain end of residues 228-230

Efficient HPLC method for the determination of nicarbazin, as dinitrocarbanilide in broiler liver.

Emiliana Capurro et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 822(1-2), 154-159 (2005-07-12)

A simple, fast and reliable HPLC-UV method has been developed for the determination of dinitrocarbanilide residues in broiler liver. Liver samples (2 g) were extracted with two portions of acetonitrile (10 and 5 ml), defatted with hexane and evaporated to

Methoxychlor and estradiol induce oxidative stress DNA damage in the mouse ovarian surface epithelium.

Daniel A Symonds et al.

Toxicological sciences : an official journal of the Society of Toxicology, 105(1), 182-187 (2008-05-27)

Estrogenic compounds such as 17beta-estradiol (E(2)) and methoxychlor (MXC) induce oxidative stress damage in breast cells and mouse ovarian follicles, respectively. However, little is known about whether estrogenic compounds cause oxidative stress in the ovarian surface epithelium (OSE). Thus, this

Urine Tenofovir Concentrations Correlate With Plasma and Relate to Tenofovir Disoproxil Fumarate Adherence: A Randomized, Directly Observed Pharmacokinetic Trial (TARGET Study).

Paul K Drain et al.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 70(10), 2143-2151 (2019-07-18)

Direct measurement of tenofovir (TFV) in urine could be an objective measure to monitor adherence to preexposure prophylaxis (PrEP) or TFV-based antiretroviral therapy (ART). We conducted a 3-arm randomized, pharmacokinetic study of tenofovir disoproxil fumarate (TDF) 300 mg/emtricitabine (FTC) 200

Multi-unit dosage formulations of theophylline for controlled release applications.

Michael U Uhumwangho et al.

Acta poloniae pharmaceutica, 64(6), 553-559 (2008-03-08)

The study was carried out to investigate the drug release profiles of multi-unit dosage formulations of theophylline consisting of both the fast and slow release components in a unit dose. The fast release component consisted of conventional granules of theophylline

1/1