202-163-5

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Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter.

Astrid Murumägi et al.

The Journal of biological chemistry, 278(22), 19784-19790 (2003-03-26)

Defects in the AIRE gene cause a monogenic autoimmune syndrome APECED (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy), which is characterized by loss of self-tolerance to multiple organs. In concordance with its role in immune tolerance, AIRE is most strongly expressed in

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