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Kamen P Simeonov et al.
PloS one, 9(6), e100134-e100134 (2014-06-26)
Direct reprogramming by overexpression of defined transcription factors is a promising new method of deriving useful but rare cell types from readily available ones. While the method presents numerous advantages over induced pluripotent stem (iPS) cell approaches, a focus on
Alessandro R Zorzi et al.
International journal of molecular sciences, 16(11), 26813-26831 (2015-11-17)
Cell therapy is a promising approach to improve cartilage healing. Adipose tissue is an abundant and readily accessible cell source. Previous studies have demonstrated good cartilage repair results with adipose tissue mesenchymal stem cells in small animal experiments. This study
Qingnian Goh et al.
Experimental cell research, 331(2), 292-308 (2014-10-05)
We previously demonstrated that the expression of intercellular adhesion molecule-1 (ICAM-1) by skeletal muscle cells after muscle overload contributes to ensuing regenerative and hypertrophic processes in skeletal muscle. The objective of the present study is to reveal mechanisms through which
Sachie K Ogawa et al.
General physiology and biophysics, 32(1), 47-54 (2013-03-28)
Selenoprotein P (SeP) not only represents the major selenoprotein in plasma, but also provides more than 50% of the total plasma selenium. However, there is no report concerning the direct action of selenium or selenium-containing compounds on the contraction and
Sara Chiappalupi et al.
Biomaterials, 75, 313-326 (2015-11-03)
Duchenne muscular dystrophy (DMD) is a genetic disease characterized by progressive muscle degeneration leading to impaired locomotion, respiratory failure and premature death. In DMD patients, inflammatory events secondary to dystrophin mutation play a major role in the progression of the
Cornelia M Hooper et al.
PloS one, 9(11), e112909-e112909 (2014-11-21)
Medulloblastoma is the most common form of malignant paediatric brain tumour and is the leading cause of childhood cancer related mortality. The four molecular subgroups of medulloblastoma that have been identified - WNT, SHH, Group 3 and Group 4 -
Seigo Hatada et al.
Stem cells translational medicine, 4(9), 998-1010 (2015-07-18)
Human pluripotent stem cells (hPSCs) are now being used for both disease modeling and cell therapy; however, efficient homologous recombination (HR) is often crucial to develop isogenic control or reporter lines. We showed that limited low-dose irradiation (LDI) using either
Xue-Ling Wei et al.
Clinica chimica acta; international journal of clinical chemistry, 438, 80-85 (2014-08-26)
Previous experimental studies have shown an antagonistic interaction between cadmium and selenium. We explored the interaction between cadmium and selenium on human breast cancer risk. A case-control study, enrolled 240 incident invasive breast cancer patients and 246 age-matched controls from
Junko Nio-Kobayashi et al.
Molecular human reproduction, 21(8), 645-654 (2015-05-25)
Intense macrophage infiltration is observed during luteolysis in various animals including women; however, we still do not know how macrophage infiltration into the human corpus luteum (CL) during luteolysis is regulated. In this study, we examined the expression, localization and
Yuvabharath Kondaveeti et al.
Cancer letters, 364(1), 44-58 (2015-04-29)
Epithelial-mesenchymal transition (EMT) induces invasive properties in epithelial tumors and promotes metastasis. Although EMT-mediated cellular and molecular changes are well understood, very little is known about EMT-induced metabolic changes. HER2-positive BT-474 breast cancer cells were induced to undergo a stable
S M Cheng et al.
British journal of pharmacology, 172(1), 214-234 (2014-09-16)
The aim of this study was to determine the potency and molecular mechanism of action of YM155, a first-in-class survivin inhibitor that is currently under phase I/II clinical investigations, in various drug-resistant breast cancers including the oestrogen receptor positive (ER(+)
Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage.
Eleftherios A Makris et al.
Tissue engineering. Part A, 21(5-6), 884-894 (2014-12-05)
Toward developing engineered cartilage for the treatment of cartilage defects, achieving relevant functional properties before implantation remains a significant challenge. Various chemical and mechanical stimuli have been used to enhance the functional properties of engineered musculoskeletal tissues. Recently, Ca(2+)-modulating agents
Amlan Kanti Ghosh et al.
Cytokine, 73(1), 44-52 (2015-02-24)
Nonconventional innate memory CD8(+) T cells characteristically expressing CD44, CD122, eomesodermin (Eomes) and promyelocytic leukemia zinc finger (PLZF) were derived in culture from CD4(+)CD8(+) double positive (DP) thymocytes of normal BALB/c and C57BL/6 mice. These culture-differentiated cells constitutively express toll-like
Lei Yang et al.
Asian Pacific journal of cancer prevention : APJCP, 14(4), 2181-2184 (2013-06-04)
Prostate cancer is the most common malignancy in men in the United States. Surgery or radiation are sometimes unsatisfactory treatments because of the complications such as incontinence or erectile dysfunction. Selenium was found to be effective to prevent prostate cancer
A Dennis Lemly
Ecotoxicology and environmental safety, 104, 160-167 (2014-03-29)
Selenium pollution from coal ash wastewater was investigated in Lake Sutton, NC. This lake has been continuously used as a cooling pond for a coal-fired power plant since 1972. Historic and recent levels of contamination in fish tissues (14-105µg Se/g
Jing-Jing Xu et al.
International journal of clinical and experimental medicine, 8(1), 916-921 (2015-03-19)
Systemic lupus erythematosus (SLE) involves multiple factors, which result in the breakdown of self-tolerance and development of autoimmunity with organ damage. Bone marrow mesenchymal stem cells (BMMSCs) from the patients with SLE showed an impaired proliferative capacity compared with that
Diana L Moughon et al.
Cancer research, 75(22), 4742-4752 (2015-10-17)
Malignant ascites is a common complication in the late stages of epithelial ovarian cancer (EOC) that greatly diminishes the quality of life of patients. Malignant ascites is a known consequence of vascular dysfunction, but current approved treatments are not effective
Rupak Shivakoti et al.
Nutrients, 6(11), 5061-5078 (2014-11-18)
A case-cohort study, within a multi-country trial of antiretroviral therapy (ART) efficacy (Prospective Evaluation of Antiretrovirals in Resource Limited Settings (PEARLS)), was conducted to determine if pre-ART serum selenium deficiency is independently associated with human immunodeficiency virus (HIV) disease progression
Anjum Khanam et al.
Food chemistry, 194, 1293-1299 (2015-10-17)
Selenium (Se) is an essential nutrient with diverse physiological functions. The selenium content of commonly consumed cereals, pulses and green leafy vegetables (GLV) was determined. Bioaccessibility of Se, and its organic forms selenomethionine (SeMet), and selenocysteine (SeCys2) was also examined
C C Ude et al.
Osteoarthritis and cartilage, 23(8), 1294-1306 (2015-04-19)
Our previous studies on osteoarthritis (OA) revealed positive outcome after chondrogenically induced cells treatment. Presently, the functional improvements of these treated OA knee joints were quantified followed by evaluation of the mechanical properties of the engineered cartilages. Baseline electromyogram (EMGs)
Fang Wang et al.
Systems biology in reproductive medicine, 60(3), 136-142 (2014-02-13)
We explored the molecular mechanisms of obesity and insulin resistance in patients with polycystic ovary syndrome (PCOS) using a human embryonic stem cell model (hESCs). Three PCOS-derived and one non-PCOS-derived hESC lines were induced into adipocytes, and then total RNA
Jun-Hwan Kim et al.
Ecotoxicology and environmental safety, 104, 96-102 (2014-03-19)
Juvenile Pagrus major (mean length 15.8±1.6cm, and mean weight 90.4±4.7g) were exposed for 4 weeks with waterborne selenium concentration (0, 50, 100, 200, and 400µg/L). The profile of Se accumulation among tissue in P. major is dependent on the exposure
Ana Antonic et al.
International journal of stroke : official journal of the International Stroke Society, 9(5), 544-552 (2014-01-08)
Hypothermia provides neuroprotection after cardiac arrest, hypoxic-ischemic encephalopathy, and in animal models of ischemic stroke. However, as drug development for stroke has been beset by translational failure, we sought additional evidence that hypothermia protects human neurons against ischemic injury. Human
Akiko Kawamura et al.
Nagoya journal of medical science, 77(3), 425-437 (2015-09-29)
This retrospective study assessed the effects of menopausal status and menstrual cycle on background parenchymal enhancement (BPE) of breast magnetic resonance imaging (MRI), and investigated whether the degree of BPE can be predicted by findings of mammography, ultrasonography (US), and
J Zellner et al.
Journal of biomechanics, 48(8), 1479-1484 (2015-02-24)
This study analyses the influence of dynamic hydrostatic pressure on chondrogenesis of human meniscus-derived fibrochondrocytes and explores the differences in chondrogenic differentiation under loading conditions between cells derived from the avascular inner zone and vascularized outer region of the meniscus.
Alejandro A Arriagada et al.
Endocrinology, 156(4), 1540-1551 (2015-01-17)
Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated by TSH and by the
Selenium for sepsis: what have we learned so far?
Ting-Shuo Huang et al.
Critical care medicine, 41(11), e396-e396 (2013-10-29)
Learning from history in micronutrient research.
Theodore M Brasky et al.
Journal of the National Cancer Institute, 107(1), 375-375 (2014-12-17)
Fatai Adigun Aborode et al.
Metallomics : integrated biometal science, 7(7), 1056-1066 (2015-03-10)
Three month old Thunbergia alata were exposed for 13 days to 10 μM selenite to determine the biotransformation of selenite in their roots. Selenium in formic acid extracts (80 ± 3%) was present as selenopeptides with Se-S bonds and selenium-PC
Christopher Pekor et al.
Tissue engineering. Part C, Methods, 21(7), 705-715 (2015-01-07)
The development of functional engineered tissue constructs depends on high cell densities and appropriate vascularization. In this study we implemented a four-compartment three-dimensional perfusion bioreactor culture model for studying the effects of medium perfusion on endothelial, hepatic, and hematopoietic cell
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