DNA synthesis
and cell division: antagonism by cell-permeable
ceramides. Mol. Pharmacol., 47, 833-839 (1995).
3. Sharma, K., The yins and yangs of ceramide. Cell
Res., 1-10 (1999).
4. Salinas
release in macrophages and monocytes (IC50 = 40 nM for IL-1ß and IL-1a, 80 nM for IL-6,
110 nM for PGE2, and 210 nM for IL-8 and TNF-a), as well as LPS-induced NF-kB activation
(IC50 = 270 nM) and NO
Cdk9, respectively). Also inhibits Cdk4/D1, Cdk6/D3,
and GSK-3b at higher concentrations (IC50 = 839 nM, 282 nM,
and 754 nM, respectively). Purity: ≥95% by HPLC. M.W. 473.4
HN
N N
N
Cl
Cl
CASP4 NP_150649.1 M y n/d n/d
117 Caspase 5 C6979 838 CASP5 NP_004338.1 M y n/d n/d
118 Caspase 6 C7599 839 CASP6 NP_116787.1 P y n/d n/d
119 Caspase 7 C7724 840 CASP7 NP_203126.1 P y n/d n/d
120 Anti
CASP4 NP_150649.1 M y n/d n/d
117 Caspase 5 C6979 838 CASP5 NP_004338.1 M y n/d n/d
118 Caspase 6 C7599 839 CASP6 NP_116787.1 P y n/d n/d
119 Caspase 7 C7724 840 CASP7 NP_203126.1 P y n/d n/d
120 Anti
M WB APur Rb IgG 100 µL 07-838
Anti-phospho-IR/IGF1R (Tyr1158) H WB IC IH APur Rb IgG 100 µL 07-839
Anti-phospho-IR/IGF1R (TyrpY1162/1163) H WB IC IH APur Rb IgG 100 µL 07-840
Anti-phospho-IR/IGF1R