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D Nuttall et al.
The bone & joint journal, 96-B(8), 1077-1081 (2014-08-03)
Resurfacing of the humeral head is commonly used within the UK to treat osteoarthritis (OA) of the shoulder. We present the results of a small prospective randomised study of this procedure using the Global CAP prosthesis with two different coatings
Kestutis Valancius et al.
Acta orthopaedica, 84(6), 544-548 (2013-11-01)
Hydroxyapatite (HA) coating is believed to improve bone-implant ingrowth and long-term survival of prostheses. Recent studies, however, have challenged this view. Furthermore, HA particles may produce third-body wear and initiate aseptic loosening of implants. We report the performance of HA-
F Munarin et al.
International journal of biological macromolecules, 72, 199-209 (2014-08-12)
Pectin-based biocomposite hydrogels were produced by internal gelation, using different hydroxyapatite (HA) powders from commercial source or synthesized by the wet chemical method. HA possesses the double functionality of cross-linking agent and inorganic reinforcement. The mineralogical composition, grain size, specific
Muriel Babey et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(6), 1064-1076 (2014-12-17)
The primary goal of this study was to determine whether the IGF1R in mature osteoblasts and osteocytes was required for the catabolic actions of continuous parathyroid hormone (cPTH). Igf1r was deleted from male and female FVN/B mice by breeding with
Weihong Qu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 990, 15-22 (2015-04-05)
Column chromatography has been widely used as a scalable purification strategy for recombinant adeno-associated virus (rAAV) vectors. The rAAV1, 2, 4, 5, 6, 8 and 9 serotypes could be separated using affinity resins, ion exchange resins or other types of
Janeyuth Chaisakul et al.
Toxicon : official journal of the International Society on Toxinology, 102, 48-54 (2015-05-12)
Brown snake (Pseudonaja spp.)-induced early cardiovascular collapse is a life-threatening medical emergency in Australia. We have previously shown that this effect can be mimicked in animals and is mediated via the release of endogenous mediators. In the present study, we
Chemical characterization of silicon-substituted hydroxyapatite
Gibson I, et al.
Journal of Biomedical Materials Research, 44(4), 422-428 (1999)
Gregor Buehrer et al.
Tissue engineering. Part A, 21(1-2), 96-105 (2014-08-20)
In this study the induction of bone formation in an axially vascularized bone matrix using mesenchymal stem cells (MSCs) and application of bone morphogenetic protein 2 (BMP2) was analyzed in the arteriovenous loop (AVL) model. An AVL was created in
Petra Korlević et al.
BioTechniques, 59(2), 87-93 (2014-01-01)
Although great progress has been made in improving methods for generating DNA sequences from ancient biological samples, many, if not most, samples are still not amenable for analyses due to overwhelming contamination with microbial or modern human DNA. Here we
Minsung Park et al.
Colloids and surfaces. B, Biointerfaces, 130, 222-228 (2015-04-26)
Nanofibrous 2,2,6,6-tetramethylpiperidine-1-oxyl(TEMPO)-oxidized bacterial cellulose (TOBC) was used as a dispersant of hydroxyapatite (HA) nanoparticles in aqueous solution. The surfaces of TOBC nanofibers were negatively charged after the reaction with the TEMPO/NaBr/NaClO system at pH 10 and room temperature. HA nanoparticles
Taichi Inui et al.
Applied and environmental microbiology, 81(16), 5471-5476 (2015-06-07)
Carbohydrate availability shifts when bacteria attach to a surface and form biofilm. When salivary planktonic bacteria form an oral biofilm, a variety of polysaccharides and glycoproteins are the primary carbon sources; however, simple sugar availabilities are limited due to low
Y Lei et al.
Journal of dental research, 93(12), 1264-1269 (2014-09-25)
Dental professionals are seeing a growing population of patients with visible signs of dental erosion. The approach currently being used to address the problem typically leverages the enamel protection benefits of fluoride. In this report, an alternative new block copolymer
Fangfang Sun et al.
Journal of biomedical nanotechnology, 9(11), 1914-1920 (2013-09-26)
Guided bone regeneration (GBR) is a new method of promoting new bone formation by blocking the proliferation of regenerated connective tissue or providing additional interventions such as direct drug delivery and mechanical support. This in vivo study of bone regeneration
Lin Lu et al.
Journal of applied biomaterials & functional materials, 12(3), 145-154 (2014-01-16)
Polycaprolactone (PCL) and polycaprolactone-hydroxyapatite (PCL-HA) scaffolds with 600-µm pore size were fabricated by drop-on-demand printing (DDP) structured porogen method followed with injection molding. Specimens with special dimensions of 4.2×4.2×5.4 mm3 and 6.6×6.6×13.8 mm3 were designed and fabricated for compression and
Radosław Olkowski et al.
Journal of materials science. Materials in medicine, 26(12), 270-270 (2015-10-30)
Calcium phosphate cements (CPC) are valuable bone fillers. Recently they have been also considered as the basis for drug-, growth factors- or cells-delivery systems. Broad possibilities to manipulate CPC composition provide a unique opportunity to obtain materials with a wide
E Buraka et al.
Chemico-biological interactions, 220, 200-207 (2014-07-13)
The ability to intercalate between DNA strands determines the cytotoxic activity of numerous anticancer drugs. Strikingly, intercalating activity was also reported for some compounds considered to be antimutagenic. The aim of this study was to determine the mode of interaction
Amun Makani et al.
The Journal of arthroplasty, 29(4), 827-830 (2013-09-28)
The purpose of this study was to evaluate the outcome of femoral component revisions using a long tapered HA coated femoral revision stem. Between 2001 and 2008, 55 femoral component revisions were performed using this stem. Forty-one patients were available
Ioan A Lina et al.
Spine, 39(5), 347-355 (2013-12-25)
A posterolateral rabbit spinal fusion model was used to evaluate the effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) and teriparatide (PTH [1-34]) used individually and in combination on spinal fusion outcomes. To test the efficacy of parathyroid hormone on
A Cipitria et al.
Acta biomaterialia, 23, 282-294 (2015-05-26)
Scaffold architecture guides bone formation. However, in critical-sized long bone defects additional BMP-mediated osteogenic stimulation is needed to form clinically relevant volumes of new bone. The hierarchical structure of bone determines its mechanical properties. Yet, the micro- and nanostructure of
Salwa M Maria et al.
Acta biomaterialia, 20, 140-146 (2015-04-02)
Bone resorbing osteoclasts represent an important therapeutic target for diseases associated with bone and joint destruction, such as rheumatoid arthritis, periodontitis, and osteoporosis. The quantification of osteoclast resorptive activity in vitro is widely used for screening new anti-resorptive medications. The
Haydar Çelik et al.
Molecular cancer therapeutics, 14(11), 2497-2507 (2015-09-12)
Ezrin is a member of the ERM (ezrin, radixin, moesin) family of proteins and functions as a linker between the plasma membrane and the actin cytoskeleton. Ezrin is a key driver of tumor progression and metastatic spread of osteosarcoma. We
Bio-Emulation: biomimetically emulating nature utilizing a histoanatomic approach; visual synthesis.
Panaghiotis Bazos et al.
The international journal of esthetic dentistry, 9(3), 330-352 (2014-08-16)
A thorough understanding of the spatial distribution pertaining to the histo-anatomic coronal structures and dynamic light interaction of the natural dentition provides the dental team with the ultimate strategic advantage with regards to optical integration of the final restoration. The
Sien Lin et al.
Calcified tissue international, 96(6), 541-551 (2015-03-31)
Previous studies reported that statins showed positive effects on bone in both human and animal models. This study aimed to investigate the effects of atorvastatin on the prevention of osteoporosis and dyslipidemia in ovariectomized rats fed with high-fat emulsion. The
Sayed Modinur Rahaman et al.
Indian journal of biochemistry & biophysics, 52(2), 119-124 (2015-06-30)
The role of angiotensin II in regulating Na+/K(+)-ATPase activity has been investigated in bovine pulmonary artery smooth muscle cells (BPASMCs). Our study reveals that angiotensin II inhibits the Na+/K+ATPase activity via glutathionylation of the pump with the involvement of an
Kushagra Saran et al.
Advanced healthcare materials, 4(3), 432-445 (2014-10-10)
During minimally invasive orthopedic surgeries, surgical intervention is required at two stages; to attain hemostasis and subsequently to implant the bone graft or its substitute. There is an apparent need for a material which can simultaneously control bone bleeding and
H S Alghamdi et al.
Journal of dental research, 92(11), 982-988 (2013-09-24)
Osteoporotic conditions are anticipated to affect the osseointegration of dental implants. This study aimed to evaluate the effect of a radiofrequent magnetron-sputtered calcium phosphate (CaP) coating on dental implant integration upon installment in the femoral condyles of both healthy and
Ariba Farooq et al.
Materials science & engineering. C, Materials for biological applications, 56, 104-113 (2015-08-08)
Development of biodegradable composites having the ability to suppress or eliminate the pathogenic micro-biota or modulate the inflammatory response has attracted great interest in order to limit/repair periodontal tissue destruction. The present report includes the development of non-steroidal anti-inflammatory drug
Bor-Shiunn Lee et al.
Scientific reports, 5, 13352-13352 (2015-08-22)
There is no topically applicable low concentration fluoride delivery device available for caries prevention. This study was aimed to assess the use of a low concentration (1450 ppm) fluoride strip as an effective fluoride delivery system against enamel demineralization. The enamel
Alberto Nilo et al.
ACS chemical biology, 10(7), 1737-1746 (2015-04-24)
Gram-positive Streptococcus agalactiae or group B Streptococcus (GBS) is a leading cause of invasive infections in pregnant women, newborns, and elderly people. Vaccination of pregnant women represents the best strategy for prevention of neonatal disease, and GBS polysaccharide-based conjugate vaccines
Ya-Ling Wang et al.
Neural regeneration research, 10(10), 1635-1642 (2015-12-23)
We have designed a novel nerve guidance conduit (NGC) made from silk fibroin and poly(lactic-co-glycolic acid) through electrospinning and weaving (ESP-NGCs). Several physical and biological properties of the ESP-NGCs were assessed in order to evaluate their biocompatibility. The physical properties
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