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Susanne M Krug et al.
Biomaterials, 34(1), 275-282 (2012-10-17)
Sodium caprate is a promising candidate for inducing drug absorption enhancement. The mechanism of that uptake-enhancing effect is not fully understood so far. We investigated how caprate acts in an established human intestinal cell line, HT-29/B6, on the transient opening
Catarina L Silva et al.
Talanta, 89, 360-368 (2012-01-31)
A sensitive assay to identify volatile organic metabolites (VOMs) as biomarkers that can accurately diagnose the onset of breast cancer using non-invasively collected clinical specimens is ideal for early detection. Therefore the aim of this study was to establish the
Liang Li et al.
Journal of dairy science, 96(4), 2003-2010 (2013-03-07)
The influence of fatty acids on the β-oxidation system and thioesterase of Lactococcus lactis was investigated in this study. The results showed that fatty acids (C8:0-C16:0) significantly inhibited the growth of Lactococcus lactis, and laurate (C12:0) had the highest bactericidal
M Duran et al.
The Journal of pediatrics, 107(3), 397-404 (1985-09-01)
Five patients aged 7 to 21 months are described who developed attacks of coma after a short prodromal illness with diarrhea or vomiting or both. Four had concomitant hypoglycemia, and all had hypoketonemia, with excessive urinary excretion of medium-chain dicarboxylic
Yunbao Liu et al.
Journal of natural products, 73(7), 1193-1195 (2010-06-23)
Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple formazan by mitochondrial enzymes. NADPH is the basis of established in vitro cell viability assays. An antioxidant assay
Yong Yu et al.
Die Pharmazie, 68(9), 732-743 (2013-10-24)
Raltitrexed (RTX) has shown clinical activity in a variety of advanced solid tumours. Its oral bioavailability is low and its intestinal absorption mechanism is not clear. In the present study, the absorption mechanism of RTX in the small intestine was
David J Brayden et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 830-839 (2014-12-03)
There is debate over the narrow safety margin of many oral permeation enhancers. The sodium salts of medium chain fatty acids (MCFAs) are components of selected oral peptide formulations being assessed in advanced clinical studies. The aim of the study
Jürgen Zentek et al.
Archives of animal nutrition, 66(1), 14-26 (2012-03-09)
The influence of low dietary levels of free and encapsulated medium-chain fatty acids on their concentrations in the digesta, the gastric microbial ecology and bacterial metabolic products in the gastrointestinal tract (GIT) in weaned piglets was studied. Starting after weaning
Makiko Washiyama et al.
Biological & pharmaceutical bulletin, 36(3), 384-389 (2013-03-02)
The control of permeability through the paracellular route has been paid great attention to for enhanced bioavailability of macromolecular and hydrophilic drugs. The paracellular permeability is controlled by tight junctions (TJ), and claudins are the major constituents of TJ. Despite
Dongjiao Fan et al.
Drug development and industrial pharmacy, 39(9), 1447-1456 (2012-10-02)
The aim of the investigation was to compare the effectiveness of two absorption enhancers, sodium caprate (C10) and sodium deoxycholate (SDC), in increasing the bioavailability of a poorly absorbed paracellar flux drug, berberine chloride, across the intestinal mucosae of rats
Guojian Liao et al.
Microbial cell factories, 12, 19-19 (2013-02-26)
Daptomycin is an important antibiotic against infections caused by drug-resistant pathogens. Its production critically depends on the addition of decanoic acid during fermentation. Unfortunately, decanoic acid (>2.5 mM) is toxic to daptomycin producer, Streptomyces roseosporus. To understand the mechanism underlying
Rosario Sánchez-Gómez et al.
Journal of agricultural and food chemistry, 62(45), 10861-10872 (2014-10-23)
Vine-shoots are an important waste in all viticulture areas that should be re-used with innovative applications. The aim of this work was to produce Airén waste vine-shoot aqueous extracts by four solid-liquid extraction techniques such as conventional solid-liquid extraction (CSLE)
Marco A M Da Silva et al.
Applied biochemistry and biotechnology, 105 -108, 757-767 (2003-05-02)
The production of monoglyceride emulsifiers commonly employed in the food, cosmetic, and pharmaceutical industries can be catalyzed by lipases, biocatalysts that are becoming increasingly attractive in the enzyme market. The aim of this study was to produce monocaprin utilizing a
Yanpeng Dong et al.
Microbiological research, 167(10), 602-607 (2012-06-15)
The functions of two long-chain fatty acid CoA ligase genes (facl) in crude oil-degrading Geobacillus thermodenitrificans NG80-2 were characterized. Facl1 and Facl2 encoded by GTNG_0892 and GTNG_1447 were expressed in Escherichia coli and purified as His-tagged fusion proteins. Both enzymes
S Tanaka et al.
Journal of gastroenterology and hepatology, 16(7), 748-754 (2001-07-12)
It has been suggested that dietary fat exacerbates intestinal inflammation. We investigated the effect of fatty acids on interleukin (IL)-8 production in a human intestinal epithelial cell line (Caco-2). The cells were cultured as monolayers on microporous membranes in culture
Daniel S Liu et al.
ACS nano, 6(12), 11080-11087 (2012-11-28)
We present a methodology for targeting quantum dots to specific proteins on living cells in two steps. In the first step, Escherichia coli lipoic acid ligase (LplA) site-specifically attaches 10-bromodecanoic acid onto a 13 amino acid recognition sequence that is
T M Lima et al.
Toxicology in vitro : an international journal published in association with BIBRA, 16(6), 741-747 (2002-11-09)
The fatty acids have an important role in the control of leukocyte metabolism and function. Higher concentrations of certain fatty acids, particularly polyunsaturated fatty acids (PUFAs) and volatile fatty acids, can cause cell death via apoptosis or, when concentrations are
Xiaoling Zang et al.
Journal of proteome research, 13(7), 3444-3454 (2014-06-13)
Prostate cancer (PCa) is the second leading cause of cancer-related mortality in men. The prevalent diagnosis method is based on the serum prostate-specific antigen (PSA) screening test, which suffers from low specificity, overdiagnosis, and overtreatment. In this work, untargeted metabolomic
Lianying Zhang et al.
Toxicology and applied pharmacology, 279(3), 275-283 (2014-07-08)
Perfluorinated compounds (PFCs) have been shown to disrupt lipid metabolism and even induce cancer in rodents through activation of peroxisome proliferator-activated receptors (PPARs). Lines of evidence showed that PPARα was activated by PFCs. However, the information on the binding interactions
Moazameh Peyrovi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 41-47 (2015-01-13)
Optimization of supramolecular solvent-based microextraction (SSME) of Loratadine and its determination with high-performance liquid chromatography (HPLC) with ultra violet (UV) detection were investigated. A factorial design (FD) and a central composite face-centered (CCF) were applied to evaluate the SSME procedure.
F Van Immerseel et al.
Applied and environmental microbiology, 70(6), 3582-3587 (2004-06-09)
The most common source of Salmonella infections in humans is food of poultry origin. Salmonella enterica serovar Enteritidis has a particular affinity for the contamination of the egg supply. In this study, the medium-chain fatty acids (MCFA), caproic, caprylic, and
Sean David Hughes et al.
Journal of neurochemistry, 129(3), 426-433 (2014-01-05)
The Ketogenic diet (KD) is an effective treatment with regards to treating pharmaco-resistant epilepsy. However, there are difficulties around compliance and tolerability. Consequently, there is a need for refined/simpler formulations that could replicate the efficacy of the KD. One of
Hiroyuki Kaiya et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 135(3), 421-429 (2003-07-02)
We have identified ghrelin and cDNA encoding precursor protein from the stomach of a euryhaline tilapia, Oreochromis mossambicus. The sequence of 20-amino acid tilapia ghrelin is GSSFLSPSQKPQNKVKSSRI. The third serine residue was modified by n-decanoic acid. The carboxyl-terminal end of
Mengshu Wang et al.
Biological & pharmaceutical bulletin, 35(5), 745-752 (2012-06-13)
The purpose of this study was to investigate the transport mechanism of exendin-4 using Madin Darby canine kidney (MDCK) cell monolayer as an in vitro model of the human intestinal barrier. The roles of active and passive mechanisms of exendin-4
Continuous solid-phase extraction and gas chromatography-mass spectrometry determination of pharmaceuticals and hormones in water samples.
Azzouz A, et al.
Journal of Chromatography A, 1217(17), 2956-2963 (2010)
G Del Vecchio et al.
Molecular pharmaceutics, 9(9), 2523-2533 (2012-07-26)
Claudin-5 is a tight junction (TJ) protein which limits the diffusion of small hydrophilic molecules. Thus, it represents a potential pharmacological target to improve drug delivery to the tissues protected by claudin-5-dependent barriers. Sodium caprate is known as an absorption
Renate C Smallegange et al.
Journal of chemical ecology, 35(8), 933-943 (2009-07-25)
The role of aliphatic carboxylic acids in host-seeking response of the malaria mosquito Anopheles gambiae sensu stricto was examined both in a dual-choice olfactometer and with indoor traps. A basic attractive blend of ammonia + lactic acid served as internal
Wei Zhang et al.
Journal of peptide science : an official publication of the European Peptide Society, 18(3), 163-169 (2012-01-18)
The stereocontrolled synthesis of fully protected (2S,4S,6S)-2-amino-6-hydroxy-4-methyl-8-oxodecanoic acid was accomplished using a glutamate derivative as starting material. The key steps of this stereochemical synthetic pathway involved an Evans asymmetric alkylation, a Sharpless asymmetric epoxidation, and a Grignard reaction.
Richard V Hymas et al.
Journal of pharmaceutical sciences, 101(7), 2340-2352 (2012-05-01)
The present study describes a physical model approach applicable to understanding the transport of highly lipophilic, ionizable drugs across a lipophilic membrane between two aqueous compartments in the presence of a cyclodextrin in the aqueous phase. Model predictions were compared
G J A Wanten et al.
European journal of clinical investigation, 32(4), 285-289 (2002-04-16)
Unsaturated fatty acids are known as neutrophil activators. In the present study we investigated whether saturated triglycerides and fatty acids may also contribute to the previously observed activation of neutrophils by nutritional lipid emulsions. Furthermore we tested the hypothesis that
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