21529

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Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers--a powerful strategy for breast cancer diagnosis.

Catarina L Silva et al.

Talanta, 89, 360-368 (2012-01-31)

A sensitive assay to identify volatile organic metabolites (VOMs) as biomarkers that can accurately diagnose the onset of breast cancer using non-invasively collected clinical specimens is ideal for early detection. Therefore the aim of this study was to establish the

Statistical approach to study the interactive effects of process parameters for enhanced xylitol production by Candida tropicalis and its potential for the synthesis of xylitol monoesters.

Swati Misra et al.

Food science and technology international = Ciencia y tecnologia de los alimentos internacional, 19(6), 535-548 (2013-06-05)

Previous results showed that an indigenously isolated yeast strain of Candida tropicalis was found to produce 12.11 g/L of xylitol under unoptimized conditions in presence of 50 g/L of xylose. In the present study, optimizing the process using one-variable at-a-time resulted in

Molecular self assembly of mixed comb-like dextran surfactant polymers for SPR virus detection.

Katanchalee Mai-Ngam et al.

Carbohydrate polymers, 112, 440-447 (2014-08-19)

The synthesis of two comb-like dextran surfactant polymers, that are different in their dextran molecular weight (MW) distribution and the presence of carboxylic groups, and their characterization are reported. A bimodal carboxylic dextran surfactant polymer consists of poly(vinyl amine) (PVAm)

Lesch-Nyhan syndrome: reduced amino acid concentrations in CSF and brain.

R A Harkness

Advances in experimental medicine and biology, 253A, 159-163 (1989-01-01)

Systemic protection through remote ischemic preconditioning is spread by platelet-dependent signaling in mice.

Christian E Oberkofler et al.

Hepatology (Baltimore, Md.), 60(4), 1409-1417 (2014-04-05)

Remote ischemic preconditioning (RIPC), the repetitive transient mechanical obstruction of vessels at a limb remote to the operative site, is a novel strategy to mitigate distant organ injury associated with surgery. In the clinic, RIPC has demonstrated efficacy in protecting

Protic ionic liquids (PILs) nanostructure and physicochemical properties: development of high-throughput methodology for PIL creation and property screens.

Tamar L Greaves et al.

Physical chemistry chemical physics : PCCP, 17(4), 2357-2365 (2014-12-06)

A high-throughput approach was developed in order to prepare and dry a series of protic ionic liquids (PILs) from 48 Brønsted acid-base combinations. Many combinations comprised an alkyl carboxylic acid paired with an alkyl amine. Visual screens were developed to

Comparison of cell attachment and caseinolytic activities of five tumour cell types.

J Varani et al.

Journal of cell science, 34, 133-144 (1978-12-01)

We have examined the ability of 5 tumour cell types to attach to plastic flasks in medium containing either 10% foetal calf serum or 10% normal human serum and compared this ability with cell-associated caseinolytic activity. The cell types used

Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.

Anna Maria Ferrari et al.

Bioorganic & medicinal chemistry, 15(24), 7865-7877 (2007-09-18)

Among the available methods for predicting free energies of binding of ligands to a protein, the molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) and molecular mechanics generalized Born surface area (MM-GBSA) approaches have been validated for a relatively limited number of

Displacement of hexanol by the hexanoic acid overoxidation product in alcohol oxidation on a model supported palladium nanoparticle catalyst.

Avram M Buchbinder et al.

Journal of the American Chemical Society, 133(44), 17816-17823 (2011-09-17)

This work characterizes the adsorption, structure, and binding mechanism of oxygenated organic species from cyclohexane solution at the liquid/solid interface of optically flat alumina-supported palladium nanoparticle surfaces prepared by atomic layer deposition (ALD). The surface-specific nonlinear optical vibrational spectroscopy, sum-frequency

Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation.

Pierre Daumar et al.

Bioconjugate chemistry, 23(8), 1557-1566 (2012-07-13)

Solid tumors often develop an acidic microenvironment, which plays a critical role in tumor progression and is associated with increased level of invasion and metastasis. The 37-residue pH (low) insertion peptide (pHLIP) is under study as an imaging platform because

Vine-shoot waste aqueous extracts for re-use in agriculture obtained by different extraction techniques: phenolic, volatile, and mineral compounds.

Rosario Sánchez-Gómez et al.

Journal of agricultural and food chemistry, 62(45), 10861-10872 (2014-10-23)

Vine-shoots are an important waste in all viticulture areas that should be re-used with innovative applications. The aim of this work was to produce Airén waste vine-shoot aqueous extracts by four solid-liquid extraction techniques such as conventional solid-liquid extraction (CSLE)

Determination of volatile, phenolic, organic acid and sugar components in a Turkish cv. Dortyol (Citrus sinensis L. Osbeck) orange juice.

Kelebek H and Selli S

Journal of the Science of Food and Agriculture, 91(10), 1855-1862 (2011)

Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer.

Candide Hounsou et al.

ACS chemical biology, 10(2), 466-474 (2014-10-29)

G protein-coupled receptors (GPCRs) have been described to form hetero-oligomers. The importance of these complexes in physiology and pathology is considered crucial, and heterodimers represent promising new targets to discover innovative therapeutics. However, there is a lack of binding assays

Upregulated IL-32 Expression And Reduced Gut Short Chain Fatty Acid Caproic Acid in People Living With HIV With Subclinical Atherosclerosis.

Mohamed El-Far et al.

Frontiers in immunology, 12, 664371-664371 (2021-05-04)

Despite the success of antiretroviral therapy (ART), people living with HIV (PLWH) are still at higher risk for cardiovascular diseases (CVDs) that are mediated by chronic inflammation. Identification of novel inflammatory mediators with the inherent potential to be used as

Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid.

C Jakobs et al.

Clinica chimica acta; international journal of clinical chemistry, 140(2), 157-166 (1984-07-16)

A method is described in which ammonia chemical ionization gas chromatography-mass spectrometry was utilized in the selected ion monitoring mode to provide an accurate, selective approach to the quantification in amniotic fluid of a number of hydroxylated organic acids derived

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.

Christine Greiner et al.

Bioorganic & medicinal chemistry, 19(11), 3394-3401 (2011-05-17)

5-Lipoxygenase (5-LO) and microsomal prostaglandin E₂ synthase (mPGES)-1 are key enzymes in the biosynthesis of leukotrienes and prostaglandin (PG)E₂, respectively, and are considered as valuable targets for the treatment of inflammatory diseases. Here, we present the identification of 2-mercaptohexanoic acid

A biosynthetic pathway for hexanoic acid production in Kluyveromyces marxianus.

Cheon Y, et al.

Journal of Biotechnology, 182, 30-36 (2014)

Cell-associated proteases affect tumour cell migration in vitro.

J Varani et al.

Journal of cell science, 36, 241-252 (1979-04-01)

The in vitro migratory activity of mouse fibrosarcoma cells in medium containing either foetal calf serum or normal human serum was studied. These 2 sera were studied because foetal calf serum contains high levels of protease inhibitor activity while human

Short chain fatty acids (propionic and hexanoic) decrease Staphylococcus aureus internalization into bovine mammary epithelial cells and modulate antimicrobial peptide expression.

Nayeli Alva-Murillo et al.

Veterinary microbiology, 155(2-4), 324-331 (2011-09-21)

Short chain fatty acids (SCFAs) are critical nutrients for ruminants and are mainly obtained from bacterial fermentation of carbohydrates. In addition to their nutrimental function, SCFAs have antimicrobial and anti-inflammatory properties, as well as immunomodulatory roles. It has been reported

Review of the toxicologic properties of medium-chain triglycerides.

K A Traul et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 38(1), 79-98 (2000-02-24)

Medium chain triglycerides (MCTs) are a family of triglycerides, containing predominantly, caprylic (C(8)) and capric (C(10)) fatty acids with lesser amounts of caproic (C(6)) and lauric (C(12)) fatty acids. MCTs are widely used for parenteral nutrition in individuals requiring supplemental

IgA-mediated clearance and tissue deposition of dinitrophenylated human serum albumin at various DNP:HSA ratios.

J M Epps et al.

Molecular immunology, 25(8), 731-738 (1988-08-01)

Dinitrophenylated human serum albumin (DNP-HSA) with various DNP:HSA ratios was prepared by direct conjugation with dinitrobenzene sulfate or with a caproic acid spacer group (DNP-cap-HSA) using DNP-epsilon-amino-caproic acid N-hydroxy-succinimide ester. The substitution ratio and chemical linkage (presence of a spacer

HPLC-APCI-MS determination of free fatty acids in Tibet folk medicine lomatogonium rotatum with fluorescence detection and mass spectrometric identification.

Li Y, et al.

Journal of Liquid Chromatography and Related Technologies, 29(18), 2741-2751 (2006)

Impact of peroxydisulfate in the presence of zero valent iron on the oxidation of cyclohexanoic acid and naphthenic acids from oil sands process-affected water.

Przemysław Drzewicz et al.

Environmental science & technology, 46(16), 8984-8991 (2012-07-18)

Large volumes of oil sands process-affected water (OSPW) are produced during the extraction of bitumen from oil sands in Alberta, Canada. The degradation of a model naphthenic acid, cyclohexanoic acid (CHA), and real naphthenic acids (NAs) from OSPW were investigated

Allergic contact cheilitis caused by ditrimethylolpropane triethylhexanoate in a lipstick.

Maiko Miura et al.

Contact dermatitis, 64(5), 301-302 (2011-04-13)

The effect of aliphatic carboxylic acids on olfaction-based host-seeking of the malaria mosquito Anopheles gambiae sensu stricto.

Renate C Smallegange et al.

Journal of chemical ecology, 35(8), 933-943 (2009-07-25)

The role of aliphatic carboxylic acids in host-seeking response of the malaria mosquito Anopheles gambiae sensu stricto was examined both in a dual-choice olfactometer and with indoor traps. A basic attractive blend of ammonia + lactic acid served as internal

Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.

J D Shoemaker et al.

Journal of chromatography, 562(1-2), 125-138 (1991-01-02)

Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio

Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members.

Gregory Kaler et al.

The Journal of biological chemistry, 282(33), 23841-23853 (2007-06-08)

Organic anion transporters (OATs, SLC22) interact with a remarkably diverse array of endogenous and exogenous organic anions. However, little is known about the structural features that determine their substrate selectivity. We examined the substrate binding preferences and transport function of

The hexanoyl-CoA precursor for cannabinoid biosynthesis is formed by an acyl-activating enzyme in Cannabis sativa trichomes.

Jake M Stout et al.

The Plant journal : for cell and molecular biology, 71(3), 353-365 (2012-02-23)

The psychoactive and analgesic cannabinoids (e.g. Δ(9) -tetrahydrocannabinol (THC)) in Cannabis sativa are formed from the short-chain fatty acyl-coenzyme A (CoA) precursor hexanoyl-CoA. Cannabinoids are synthesized in glandular trichomes present mainly on female flowers. We quantified hexanoyl-CoA using LC-MS/MS and

Inhibition of insulin and T3-induced fatty acid synthase by hexanoate.

Murielle M Akpa et al.

Lipids, 45(11), 997-1009 (2010-09-03)

Fatty acid synthase (FAS) is responsible for the de novo synthesis of palmitate and stearate. This enzyme is activated by insulin and T(3), and inhibited by fatty acids. In this study, we show that insulin and T(3) have an inducing

New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes.

Fátima Camões et al.

Biochimica et biophysica acta, 1853(1), 111-125 (2014-10-14)

Peroxisomes are ubiquitous organelles which participate in a variety of essential biochemical pathways. An intimate interrelationship between peroxisomes and mitochondria is emerging in mammals, where both organelles cooperate in fatty acid β-oxidation and cellular lipid homeostasis. As mitochondrial fatty acid

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