218-206-6

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Screening for mutations in exon 4 of the LDL receptor gene in a German population with severe hypercholesterolemia.

J Giesel et al.

Human genetics, 96(3), 301-304 (1995-09-01)

A group of 218 patients with severe hypercholesterolemia (LDL cholesterol > 260 mg/dl) living in the Cologne area were screened for mutations in the 3 half of exon 4 of the low density lipoprotein (LDL) receptor gene by the single-strand

Hydrogen sulphide as a novel therapy to ameliorate cyclosporine nephrotoxicity.

Gwyn Lee et al.

The Journal of surgical research, 197(2), 419-426 (2015-05-21)

Calcineurin inhibitors have significant nephrotoxic side effects, which can exacerbate ischemia-reperfusion injury in renal transplantation. Novel therapeutic agents such as hydrogen sulphide (H₂S) may reduce these harmful effects. This study investigated the effects of H₂S on cyclosporine (CsA) induced nephrotoxicity.

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