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Min Li et al.
Journal of inorganic biochemistry, 107(1), 40-46 (2011-12-17)
Multifunctional phosphonium-lanthanide compounds that simultaneously possess paramagnetism, luminescence, and tumor mitochondrial targeting properties were prepared by use of a facile method. These compounds were fully characterized by use of (1)H, (13)C, (31)P NMR, FT-IR, and elemental analyses. The thermal properties
Denice C Bay et al.
Biochimica et biophysica acta, 1798(3), 526-535 (2009-12-29)
Escherichia coli multidrug resistance protein E (EmrE) is a four transmembrane alpha-helix protein, and a member of the small multidrug resistance protein family that confers resistance to a broad range of quaternary cation compounds (QCC) via proton motive force. The
Myocardial imaging for mitochondrial membrane potential.
H William Strauss et al.
JACC. Cardiovascular imaging, 5(3), 293-296 (2012-03-17)
Yang Zhou et al.
Bioconjugate chemistry, 22(8), 1459-1472 (2011-06-24)
Alteration in mitochondrial transmembrane potential (ΔΨ(m)) is an important characteristic of cancer. The observation that the enhanced negative mitochondrial potential is prevalent in tumor cell phenotype provides a conceptual basis for development of mitochondrion-targeting therapeutic drugs and molecular imaging probes.
Liliana Rodrigues et al.
Antimicrobial agents and chemotherapy, 57(2), 751-757 (2012-11-21)
Efflux pumps are membrane proteins capable of actively transporting a broad range of substrates from the cytoplasm to the exterior of the cell. Increased efflux activity in response to drug treatment may be the first step in the development of
Jürgen A Bohnert et al.
Antimicrobial agents and chemotherapy, 54(9), 3770-3775 (2010-07-08)
AcrAB-TolC is the major constitutively expressed efflux pump system that provides resistance to a variety of antimicrobial agents and dyes in Escherichia coli. However, no systematically optimized real-time dye efflux assay has been published for the measurement of its activity
Do Kyun Kim et al.
Journal of microbiology and biotechnology, 23(3), 430-435 (2013-03-07)
Multidrug resistance, especially multidrug efflux mechanisms that extrude structurally unrelated cytotoxic compounds from the cell by multidrug transporters, is a serious problem and one of the main reasons for the failure of therapeutic treatment of infections by pathogenic microorganisms as
M S El-Shahawi et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 27(7), 757-757 (2011-07-13)
Fast and selective sorptions of Cr(VI) species from aqueous media onto tetraphenylphosphonium bromide (TPP(+) · Br(-)) physically immobilized polyurethane foams (PUFs) sorbent were achieved. Based on the Scatchard model of binding sites of the PUFs and Langmuir and Dubinin-Radushkevich (D-R)
Jody L Floyd et al.
Antimicrobial agents and chemotherapy, 54(12), 5406-5412 (2010-09-22)
A multidrug efflux pump designated LmrS (lincomycin resistance protein of Staphylococcus aureus), belonging to the major facilitator superfamily (MFS) of transporters, was cloned, and the role of LmrS in antimicrobial efflux was evaluated. The highest relative increase in MIC, 16-fold
Yael Elbaz et al.
The Journal of biological chemistry, 283(18), 12276-12283 (2008-03-07)
Glycine residues may play functional and structural roles in membrane proteins. In this work we studied the role of glycine residues in EmrE, a small multidrug transporter from Escherichia coli. EmrE extrudes various drugs across the plasma membrane in exchange
Keiko Komagoe et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 10(7), 1181-1188 (2011-04-08)
We analysed the porphyrin-induced photodynamic inactivation of the membrane functions of bacteria through the in situ monitoring of changes in respiration rates, membrane permeability and membrane potential, using electrochemical sensors, such as oxygen, K(+) and tetraphenylphosphonium (TPP(+)) electrodes. We used
Jae Sung Lee et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(32), 7945-7953 (2008-08-08)
At the immature calyx of Held, the fast decay phase of a Ca(2+) transient induced by tetanic stimulation (TS) was followed by a period of elevated [Ca(2+)](i) for tens of seconds, referred to as posttetanic residual calcium (Ca(res)). We investigated
Gagandeep S Gurm et al.
JACC. Cardiovascular imaging, 5(3), 285-292 (2012-03-17)
This study tested the hypothesis that 4-[(18)F]fluorophenyltriphenylphosphonium ((18)F-TPP) is useful for in vivo positron emission tomography (PET) measurement of mitochondrial membrane potential (ΔΨm). Its utility as a blood flow tracer also was evaluated. Tetraphenylphosphonium is useful for in vitro measurement
Avi Swed et al.
Molecular pharmaceutics, 6(6), 1883-1890 (2009-09-03)
Tetraphenylphosphonium (TPP), a phosphonium cation, is a promising means for tumor imaging. A major contributor to the pharmacokinetics of phosphonium cations is the efflux transporter P-glycoprotein (P-gp). For this application it is important to ascertain the influence of the multidrug
L A Vasil'ev et al.
Biochemistry. Biokhimiia, 77(4), 354-361 (2012-07-20)
Tetraphenylphosphonium (TPP(+)) and tetramethylrhodamine ethyl ester (TMRE(+)) cations used as transmembrane carriers of ubiquinone (MitoQ) and plastoquinone (SkQ, SkQR) in mitochondria prevented at nanomolar concentrations the chitosan- or H(2)O(2)-induced destruction of the nucleus in epidermal cells of epidermis isolated from
The Journal of Physical Chemistry, 96, 7137-7137 (1992)
Rimantas Daugelavicius et al.
International journal of antimicrobial agents, 36(3), 234-238 (2010-05-22)
Multidrug resistance (MDR) pumps are one of the major causes of antibiotic resistance in Pseudomonas aeruginosa. Thus, fast and reliable methods are needed to assay the efficiency of MDR pumps in these bacteria. In this study, it was demonstrated that
M S Muntyan et al.
Biochemistry. Biokhimiia, 77(8), 917-924 (2012-08-07)
The electrical potential on the membrane was measured in cells of strains AL2 and ALJ15 of the extremely alkaliphilic bacterium Thioalkalivibrio versutus using the penetrating cation tetraphenylphosphonium (TPP(+)) and a TPP(+)-selective electrode. The potentials were -228 ± 5 and -224
Hisato Kato et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 26(10), 1019-1021 (2010-10-19)
The photodynamic inactivation of the membrane functions of bacteria was analyzed in situ, using K(+) and tetraphenylphosphonium (TPP(+)) electrodes, as well as an oxygen electrode. Tetrakis(4-N-trimethylaminophenyl)porphine (TTMAPP) and rose bengal were used, since both dyes act strongly on bacteria, such
Jae Sung Lee et al.
Journal of neurophysiology, 109(7), 1724-1734 (2013-01-04)
The sensitivity of posttetanic potentiation (PTP) to high-frequency stimulation (HFS) steeply decays during the first 2 postnatal weeks. We investigated the underlying mechanisms for the developmental change of PTP induced by HFS (100 Hz, 2 s) at postnatal days 4-6
Sepan T Amadi et al.
The Journal of biological chemistry, 285(34), 26710-26718 (2010-06-17)
EmrE, a member of the small multidrug transporters superfamily, extrudes positively charged hydrophobic compounds out of Escherichia coli cytoplasm in exchange for inward movement of protons down their electrochemical gradient. Although its transport mechanism has been thoroughly characterized, the structural
Carmen E DeMarco et al.
Antimicrobial agents and chemotherapy, 51(9), 3235-3239 (2007-06-20)
Efflux is an important resistance mechanism in Staphylococcus aureus, but its frequency in patients with bacteremia is unknown. Nonreplicate bloodstream isolates were collected over an 8-month period, and MICs of four common efflux pump substrates, with and without the broad-spectrum
Faiza Waheed et al.
American journal of physiology. Cell physiology, 298(6), C1376-C1387 (2010-03-20)
Plasma membrane depolarization activates the Rho/Rho kinase (ROK) pathway and thereby enhances myosin light chain (MLC) phosphorylation, which in turn is thought to be a key regulator of paracellular permeability. However, the upstream mechanisms that couple depolarization to Rho activation
Effects of dietary polyunsaturated fatty acids on mitochondrial metabolism in mammalian hibernation.
Alexander R Gerson et al.
The Journal of experimental biology, 211(Pt 16), 2689-2699 (2008-08-12)
Thirteen-lined ground squirrels (Spermophilus tridecemlineatus) were fed one of four isocaloric, isolipemic diets containing 16, 22, 35 or 55 mg linoleic acid (18:2n-6) per gram. Mitochondrial properties were compared between hibernating and summer active states, and between diet groups. As
Nir Fluman et al.
Molecular cell, 47(5), 777-787 (2012-07-31)
Multidrug transporters are ubiquitous efflux pumps that provide cells with defense against various toxic compounds. In bacteria, which typically harbor numerous multidrug transporter genes, the majority function as secondary multidrug/proton antiporters. Proton-coupled secondary transport is a fundamental process that is
Fedor F Severin et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(2), 663-668 (2010-01-19)
A unique phenomenon of mitochondria-targeted protonophores is described. It consists in a transmembrane H(+)-conducting fatty acid cycling mediated by penetrating cations such as 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) or dodecyltriphenylphosphonium (C(12)TPP). The phenomenon has been modeled by molecular dynamics and directly proved by
Denice C Bay et al.
Biochimica et biophysica acta, 1818(5), 1318-1331 (2012-02-14)
Escherichia coli EmrE protein is the archetypical member of the small multidrug resistance protein family in bacteria and confers host resistance to a wide assortment of toxic quaternary cation compounds by secondary active efflux. This protein can form a variety
Toshiaki Hattori et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(3-4), 477-480 (2009-12-17)
Five chitosan oligosaccharides were separated in acidic aqueous solution by capillary electrophoresis (CE) with indirect photometric detection using a positively coated capillary. Electrophoretic mobility of the chitooligosaccharides (COSs) depended on the number of monomer units in acidic aqueous solution, similar
Carlos M Palmeira et al.
Methods in molecular biology (Clifton, N.J.), 810, 89-101 (2011-11-08)
The study of the mitochondrial membrane potential (ΔΨ) is essential for an integrated appraisal of mitochondrial function, since it reflects differences in electrical potential and represents the main component of the proton electrochemical gradient accounting for more than 90% of
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