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Soshi Seike et al.
Biochimica et biophysica acta, 1858(12), 3150-3156 (2016-11-05)
Beta-toxin produced by Clostridium perfringens is a key virulence factor of fatal hemorrhagic enterocolitis and enterotoxemia. This toxin belongs to a family of β-pore-forming toxins (PFTs). We reported recently that the ATP-gated P2X We examined the effect of Panx1 in
Pawan Kumar Raghav et al.
Life sciences, 214, 84-97 (2018-10-12)
The biological mechanisms underlying the effects of stem cell factor (SCF) and an inhibitor, NSC87877 (N) of the c-Kit negative regulator (SHP-1 and SHP-2) on cell proliferation are different. Therefore, we compared the cell's response to these two either alone
Miao Yu et al.
Scientific reports, 7(1), 3350-3350 (2017-06-15)
Fibroblastic reticular cells (FRCs) in the T cell zone of lymph nodes (LNs) are pivotal for T cell survival, mobility, and peripheral tolerance. Here, we demonstrate that during homeostasis, FRCs also suppress T cell activation via producing high level of
Pablo Fernández-Rubio et al.
The journal of gene medicine, 17(10-12), 219-228 (2015-08-01)
Targeted lentiviral vectors may contribute to circumventing genotoxicity associated with uncontrolled transcription of therapeutic genes. Some vectors replacing strong viral sequences for gene promoters such as β-globin, CD4, CD19 or Igκ were able to drive tissue-specific expression of the transgene.
Rossella Cannarella et al.
Journal of clinical medicine, 8(6) (2019-06-09)
There is ongoing debate as to whether the decline of sperm production in recent times may be related to a parallel increase in the rate of obesity and diabetes. Lower anti-Müllerian hormone (AMH) and inhibin B secretion have been observed
Jacob O Brunkard et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(32), 10044-10049 (2015-07-08)
A fundamental mystery of plant cell biology is the occurrence of "stromules," stroma-filled tubular extensions from plastids (such as chloroplasts) that are universally observed in plants but whose functions are, in effect, completely unknown. One prevalent hypothesis is that stromules
Soshi Seike et al.
PloS one, 11(1), e0147957-e0147957 (2016-01-26)
Clostridium perfringens delta-toxin is a β-pore-forming toxin and a putative pathogenic agent of C. perfringens types B and C. However, the mechanism of cytotoxicity of delta-toxin remains unclear. Here, we investigated the mechanisms of cell death induced by delta-toxin in
Luís Gustavo Romani Fernandes et al.
Toxins, 12(6) (2020-06-12)
Insect venom can cause systemic allergic reactions, including anaphylaxis. Improvements in diagnosis and venom immunotherapy (VIT) are based on a better understanding of an immunological response triggered by venom allergens. Previously, we demonstrated that the recombinant phospholipase A1 (rPoly p
Rossella Cannarella et al.
Journal of clinical medicine, 8(6) (2019-06-09)
Several lines of evidence suggest that insulin-like growth factor 1 (IGF1) is involved in Sertoli cell (SC) proliferation and that its receptor (IGF1R) could mediate follicle-stimulating hormone (FSH) effects. To examine the role of the growth hormone (GH)-IGF1 axis on
Yu-Feng Liu et al.
Arthritis research & therapy, 20(1), 168-168 (2018-08-05)
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease. The dysregulated immune system plays an important role in the pathogenesis of AS. Myeloid-derived suppressor cells (MDSCs) play a key immunoregulatory role in autoimmune arthritis. The aim of this study was
Masamichi Watanabe et al.
Journal of lipid research, 58(6), 1143-1152 (2017-04-14)
In addition to functioning as detergents that aid digestion of dietary lipids in the intestine, some bile acids have been shown to exhibit antimicrobial activity. However, detailed information on the bactericidal activities of the diverse molecular species of bile acid
Muhammad Muhammad et al.
Biomolecules, 10(8) (2020-08-23)
Polysaccharides are widely used as building blocks of scaffolds and hydrogels in tissue engineering, which may require their chemical modification to permit crosslinking. The goal of this study was to generate a library of oxidized alginate (oALG) and oxidized hyaluronic
Huahui Yu et al.
Experimental cell research, 390(1), 111953-111953 (2020-03-12)
MUC1 is a tumor-associated antigen (TAA) overexpressed in many tumor types, which makes it an attractive target for cancer immunotherapy. However, this marker is a non-mutated antigen without high immunogenicity. In this study, we designed several new altered peptides by
Miao Yu et al.
Nature communications, 11(1), 515-515 (2020-01-26)
CD73, an ecto-5'-nucleotidase (NT5E), serves as an immune checkpoint by generating adenosine (ADO), which suppresses immune activation through the A2A receptor. Elevated CD73 levels in tumor tissues correlate with poor clinical outcomes. However, the crucial source of CD73 activity within
José Misael Vicente Hernández-Vázquez et al.
European journal of pharmacology, 871, 172942-172942 (2020-01-24)
(25R)-spirost-5-en-3β-ol, also known as diosgenin (DSG), exerts antiproliferative activity on diverse cell lines, induces apoptosis, and acts as a chemopreventative agent. However, the relationship between DSG glycosides and apoptotic, necrotic, and antiproliferative activity remains unclear. It is in this regard
J E Geddings et al.
Journal of thrombosis and haemostasis : JTH, 14(1), 153-166 (2015-10-31)
ESSENTIALS: Cancer patients have a high rate of venous thrombosis (VT) but the underlying mechanisms are unknown. Tumor-derived, tissue factor-positive microvesicles in platelet activation in vitro and in vivo were studied. Tumor-derived, tissue factor-positive microvesicles enhanced VT in mice. Platelets
R E Petroski et al.
Journal of neuroscience methods, 52(1), 23-32 (1994-04-01)
A method for selectively labeling cultured neurons using the vital dye, 5(6)-carboxyfluorescein diacetate (CFDA), is described. This non-fluorescent membrane-permeant dye is cleaved by cytosolic esterases into the fluorescent anion, 5(6)-carboxyfluorescein (CF). Both astrocytes and neurons exhibit brilliant fluorochromasia within minutes
Cholpajsorn Junhom et al.
Experimental cell research, 340(1), 71-80 (2015-12-29)
Characterization and identification of cancer cell, chemotherapy, resistance is important for both routine cancer therapy and trouble-shooting the medication treatment regimen. Present techniques for characterizing cancer cell resistance require multiple methods and steps, which are time-consuming and expensive. We present
Zhiyuan Zhang et al.
The Plant cell, 29(8), 2027-2046 (2017-07-28)
Plasmodesmata (PDs) play vital roles in cell-to-cell communication and plant development. Emerging evidence suggests that sterols are involved in PD activity during cytokinesis. However, whether sterols contribute to PD gating between established cells remains unknown. Here, we isolated
Xinggen Fang et al.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 19(9), 1283-1286 (2012-07-14)
Endothelial progenitor cells (EPC) are believed to be involved in aneurysmal repair and remodeling. The aim of this study was to test this hypothesis and, if true, explore how EPC contribute to aneurysm repair in a rabbit model of elastase-induced
Dan Yan et al.
Investigative ophthalmology & visual science, 61(14), 22-22 (2020-12-17)
This study aimed to investigate the therapeutic effects and underlying mechanisms of locally delivered regulatory T cells (Tregs) on acute corneal wound healing after alkali burn. After corneal alkali burn, the mice were injected subconjunctivally with regulatory T cells (Tregs)
Makoto Kubo et al.
International journal of molecular sciences, 21(5) (2020-03-14)
Leucine-rich repeat kinase 2 (LRRK2) is the causal molecule of familial Parkinson's disease. Although the characteristics of LRRK2 have gradually been revealed, its true physiological functions remain unknown. LRRK2 is highly expressed in immune cells such as B2 cells and
Zhuo Chen et al.
Journal of controlled release : official journal of the Controlled Release Society, 320, 469-483 (2020-01-29)
Astrocytes are key stromal components in glioblastoma (GBM) and have complex interactions with the GBM cells (GBC) promoting the survival, progression and therapy resistance of GBM. In this study, we first demonstrated the existence of a reciprocal activation loop mediated
Ting Yang et al.
Immunobiology, 218(4), 548-553 (2012-08-14)
Donor lymphocyte transfusion (DLT) may induce the graft-versus-leukemia (GVL) effect for patients with AML relapsed after transplant. However, AML is a highly diverse disease and the limited overall efficacy of DLT in clinical practice emphasizes the importance of identifying a
Celia Guilini et al.
Analytical chemistry, 87(17), 8858-8866 (2015-08-12)
Swiftness, reliability, and sensitivity of live bacteria detection in drinking water are key issues for human safety. The most widespread used indicator of live bacteria is a caged form of carboxyfluorescein in which 3' and 6' hydroxyl groups are masked
Stuart D Card et al.
Mycologia, 105(1), 221-229 (2012-07-18)
Fluorescent dyes were assessed for their ability to stain viable hyphae of the fungi Neotyphodium lolii and N. coenophialum, symbiotic endophytes of the Pooideae grasses Lolium perenne and Festuca arundinacea, respectively. The fluorescein-based fluorophores; fluorescein diacetate (FDA), 5(6)-carboxy-fluorescein diacetate (CFDA)
Giacomo Braschi et al.
Frontiers in microbiology, 9, 2783-2783 (2018-11-30)
Essential oils (EOs) or their components represent one of the most promising natural, safe, and feasible alternatives to prevent the growth of food-borne pathogens like Listeria monocytogenes and Escherichia coli in food matrices. Although antimicrobial properties of EOs and their
Kun Li et al.
Water research, 182, 115953-115953 (2020-06-20)
Most of the current studies on the toxicology of pristine nanoparticles (NPs) are environmentally irrelevant, because their ''aging'' process accompanied by the physicochemical transformation is inevitable in the environment. Considering aging phenomenon will gain a better understanding of the toxicity
L C J Ellis et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(6), 1165-1175 (2014-06-08)
Hepatic efflux of drug candidates is an important issue in pre-clinical drug development. Here we utilise a method which quantifies and distinguishes efflux of drugs at the canalicular and sinusoidal membranes in rat hepatocyte cultures. Bi-phasic kinetics of transport of
Yaichi Kawakatsu et al.
Plant biotechnology (Tokyo, Japan), 37(4), 451-458 (2021-04-15)
Grafting is an indispensable agricultural technology for propagating useful tree varieties and obtaining beneficial traits of two varieties/species-as stock and scion-at the same time. Recent studies of molecular events during grafting have revealed dynamic physiological and transcriptomic changes. Strategies focused
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