221-382-7

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Site-directed mutagenesis of alanine-382 of human antithrombin III.

R C Austin et al.

FEBS letters, 280(2), 254-258 (1991-03-25)

Antithrombin III Hamilton is a structural variant of antithrombin III (AT-III) with normal heparin affinity but impaired serine protease inhibitory activity. The molecular defect of AT-III-Hamilton is a substitution of threonine for alanine at amino acid residue 382. Recently it

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