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Izumi Ujihara et al.
Neuropharmacology, 99, 589-599 (2015-08-25)
The sensation of thirst experienced after heavy alcohol drinking is widely regarded as a consequence of ethanol (EtOH)-induced diuresis, but EtOH in high doses actually induces anti-diuresis. The present study was designed to investigate the introduction mechanism of water and
When is it appropriate to treat ethylene glycol intoxication with fomepizole alone without hemodialysis?
Gregory K Buller et al.
Seminars in dialysis, 24(4), 441-442 (2011-08-02)
Amanda M Barkley-Levenson et al.
Brain sciences, 11(1) (2021-01-23)
Central nervous system (CNS) hyperexcitability is a clinically significant feature of acute ethanol withdrawal. There is evidence for a genetic contribution to withdrawal severity, but specific genetic risk factors have not been identified. The gene glyoxalase 1 (Glo1) has been
María Elena Quintanilla et al.
Alcohol (Fayetteville, N.Y.), 45(8), 751-762 (2011-08-06)
The main goal of this study was to investigate the ability of an ethanol dose (1g/kg) administered intraperitoneally to induce conditioned place preference (CPP) and/or conditioned place aversion (CPA) in two lines of rats selectively bred for their high (UChB)
Raido Paasma et al.
Clinical toxicology (Philadelphia, Pa.), 50(9), 823-831 (2012-09-21)
INTRODUCTION. Thorough prognostic and metabolic studies of methanol poisonings are scarce. Our aims were to evaluate the factors associated with sequelae and death from methanol poisoning, to develop a simple risk-assessment chart to evaluate factors associated with sequelae and death
Jessica H Hartman et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(10), 1976-1983 (2012-07-19)
We are the first to report allosterism during styrene oxidation by recombinant CYP2E1 and human liver microsomes. At low styrene concentrations, oxidation is inefficient because of weak binding to CYP2E1 (K(s) = 830 μM). A second styrene molecule then binds
Jeffrey Brent
Clinical toxicology (Philadelphia, Pa.), 48(5), 401-406 (2010-07-01)
The use and clinical efficacy of the alcohol dehydrogenase inhibitor fomepizole is well established for the treatment of ethylene glycol and methanol poisonings in adults. A computerized search of the U.S. National Academy of medicine and EMBase databases was undertaken
Rebeca Gracia et al.
Clinical toxicology (Philadelphia, Pa.), 50(8), 743-748 (2012-08-16)
Fomepizole has been utilized with remarkable success for ethylene glycol and methanol poisonings in children and adults. However, very little information is available regarding the safe and effective use of fomepizole in pregnancy. The goal of this research was to
Katariina Nurmi et al.
PloS one, 8(11), e78537-e78537 (2013-11-19)
In the pathogenesis of coronary atherosclerosis, local macrophage-driven inflammation and secretion of proinflammatory cytokines, interleukin-1β (IL-1β) in particular, are recognized as key factors. Moderate alcohol consumption is associated with a reduced risk of coronary artery disease mortality. Here we examined
Courtney R Plumlee et al.
Virology journal, 2, 89-89 (2005-12-06)
Alcohol abuse reduces response rates to IFN therapy in patients with chronic hepatitis C. To model the molecular mechanisms behind this phenotype, we characterized the effects of ethanol on Jak-Stat and MAPK pathways in Huh7 human hepatoma cells, in HCV
Yehuda Shabtai et al.
Scientific reports, 8(1), 347-347 (2018-01-13)
Alcohol consumption during pregnancy induces Fetal Alcohol Spectrum Disorder (FASD), which has been proposed to arise from competitive inhibition of retinoic acid (RA) biosynthesis. We provide biochemical and developmental evidence identifying acetaldehyde as responsible for this inhibition. In the embryo
Ariel R Topletz et al.
Molecular pharmacology, 87(3), 430-441 (2014-12-11)
All-trans-retinoic acid (atRA), the active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). The primary hydroxylated metabolites formed from atRA by CYP26A1, and the subsequent metabolite 4-oxo-atRA, bind to RARs and potentially have
Jennifer L Goldman et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1372-1380 (2015-07-04)
Trimethoprim (TMP) has been widely used since the 1960s, both alone and in combination with sulfamethoxazole. Unfortunately, information regarding the role that cytochrome P450 enzymes (P450s) play in the formation of TMP primary metabolites is scarce. Hence, we undertook in
Abhinav Parashar et al.
Dose-response : a publication of International Hormesis Society, 16(2), 1559325818774421-1559325818774421 (2018-05-18)
Recently, electron transfers and catalyses in a bevy of redox reactions mediated by hemeproteins were explained by murburn concept. The term "murburn" is abstracted from "muredburning" or "mildunrestrictedburning" and connotes a novel "molecule-unbound ion-radical" interaction paradigm. Quite unlike the genetic
Nathalie De Brabander et al.
European journal of pediatrics, 164(3), 158-161 (2004-12-04)
Methanol poisoning is not frequently observed in children; however, without treatment, serious intoxication can be complicated by visual impairment, coma, metabolic acidosis, respiratory and circulatory insufficiency and death. Treatment in a paediatric intensive care is therefore compulsory. Methanol is metabolised
Ying Wang et al.
Toxicology letters, 236(2), 82-89 (2015-05-10)
Resveratrol (RES) has been shown to possess many pharmacological activities including protective effect against liver damage induced by hepatotoxins. In the present study, the hepato-protective effect of RES against acetaminophen (APAP)-induced liver injury in mice and the involved mechanisms was
Xiaomei Fan et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(12), 1982-1990 (2014-09-14)
Schisandra sphenanthera is widely used as a tonic and restorative in many countries to enhance the function of liver and other organs. Wuzhi tablet (WZ) is a preparation of an ethanol extract of Schisandra sphenanthera. Our previous study demonstrated that
Anand Joshi et al.
Cancer chemotherapy and pharmacology, 86(5), 633-640 (2020-09-30)
To investigate the metabolic pathways of triapine in primary cultures of human hepatocytes and human hepatic subcellular fractions; to investigate interactions of triapine with tenofovir and emtricitabine; and to evaluate triapine as a perpetrator of drug interactions. The results will
Paul G Thomes et al.
Biochemical pharmacology, 96(1), 30-38 (2015-05-02)
Alcoholic liver disease (ALD) is a major healthcare challenge worldwide. Emerging evidence reveals that ethanol administration disrupts the intestinal epithelial tight junction (TJ) complex; this defect allows for the paracellular translocation of gut-derived pathogenic molecules to reach the liver to
Gayle Hann et al.
BMJ case reports, 2012, doi:10-doi:10 (2012-05-19)
This case report describes the presentation and management of a 2-year-old child who ingested a potentially fatal amount of ethylene glycol (EG). There are few published cases worldwide of EG poisoning in children managed with fomepizole. All cases described in
Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis.
Huang W, Booth DM, Cane MC, et al.
Gut, 63(8), 1313-1324 (2014)
Kelly M Tart et al.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 21(3), 268-272 (2011-06-03)
To describe the clinical experience and therapeutic use of fomepizole (4-methylpyrazole [4-MP]) in 3 cats with naturally occurring ethylene glycol (EG) toxicity. All cats were documented to be EG positive by an ethylene glycol test kit. This report describes the
Karolina Orywal et al.
Anticancer research, 40(7), 3857-3863 (2020-07-06)
The aim of this study was to define the alterations in the activity of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) in normal and cancerous lung cells. Lung tissues were taken from 36 patients during surgical resection of cancer.
Kaori Matsumoto et al.
Xenobiotica; the fate of foreign compounds in biological systems, 50(7), 783-792 (2019-12-20)
The pathway for the transformation of the prodrug nabumetone, 4-(6-methoxynaphthalen-2-yl)butan-2-one, to the active metabolite 6-methoxy-2-naphthylacetic acid (6-MNA), a potent cyclooxygenase-2 inhibitor, has not yet been clarified in humans.To confirm the activation pathway, authentic standards of the nabumetone intermediates, 2-(6-methoxynaphthalen-2-yl)ethyl acetate
Hang Pong Ng et al.
Frontiers in immunology, 11, 53-53 (2020-03-03)
Alcohol differentially affects human health, depending on the pattern of exposure. Moderate intake provides beneficial mood modulation and an anti-inflammatory effect, while excessive consumption leads to immunosuppression and various alcohol use disorders. The mechanism underlying this bi-phasic action mode of
Kenneth E McMartin et al.
Clinical toxicology (Philadelphia, Pa.), 50(5), 375-383 (2012-05-05)
Fomepizole, a potent inhibitor of alcohol dehydrogenase, has replaced ethanol as antidote for methanol and ethylene glycol intoxications because of a longer duration of action and fewer adverse effects. Prior human studies have indicated that single doses of fomepizole are
Paul G Thomes et al.
Autophagy, 9(1), 63-73 (2012-10-24)
Acute and chronic ethanol administration increase autophagic vacuole (i.e., autophagosome; AV) content in liver cells. This enhancement depends on ethanol oxidation. Here, we used parental (nonmetabolizing) and recombinant (ethanol-metabolizing) Hep G2 cells to identify the ethanol metabolite that causes AV
J G Schier et al.
Clinical toxicology (Philadelphia, Pa.), 51(10), 923-929 (2013-11-26)
Diethylene glycol (DEG) mass poisoning is a persistent public health problem. Unfortunately, there are no human biological data on DEG and its suspected metabolites in poisoning. If present and associated with poisoning, the evidence for use of traditional therapies such
Cost of hemodialysis versus fomepizole-only for treatment of ethylene glycol intoxication.
Michael A Darracq et al.
Clinical toxicology (Philadelphia, Pa.), 51(3), 188-188 (2013-01-30)
Alcohol-induced microtubule acetylation leads to the accumulation of large, immobile lipid droplets.
Jennifer L Groebner et al.
American journal of physiology. Gastrointestinal and liver physiology, 317(4), G373-G386 (2019-08-03)
Although steatosis (fatty liver) is a clinically well-described early stage of alcoholic liver disease, surprisingly little is known about how it promotes hepatotoxicity. We have shown that ethanol consumption leads to microtubule hyperacetylation that can explain ethanol-induced defects in protein
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