229857

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Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium.

Yuki Ohta et al.

Toxicology and applied pharmacology, 226(2), 169-177 (2007-11-09)

All nutritional selenium sources are transformed into the assumed common intermediate selenide for the syntheses of selenoproteins for utilization and/or of selenosugar for excretion. Methylselenol [monomethylselenide, MMSe] is the assumed intermediate leading to other methylated metabolites, dimethylselenide (DMSe) and trimethylselenonium

GFP labelling and epigenetic enzyme expression of bone marrow-derived mesenchymal stem cells from bovine foetuses.

P Díaz et al.

Research in veterinary science, 99, 120-128 (2015-02-01)

Mesenchymal stem cells (MSC) are multipotent progenitor cells defined by their ability to self-renew and give rise to differentiated progeny. Since MSC from adult tissues represent a promising source of cells for a wide range of cellular therapies, there is

Insulin, ascorbate, and glucose have a much greater influence than transferrin and selenous acid on the in vitro growth of engineered cartilage in chondrogenic media.

Alexander D Cigan et al.

Tissue engineering. Part A, 19(17-18), 1941-1948 (2013-04-03)

The primary goal of this study was to characterize the response of chondrocyte-seeded agarose constructs to varying concentrations of several key nutrients in a chondrogenic medium, within the overall context of optimizing the key nutrients and the placement of nutrient

Meniscus is more susceptible than cartilage to catabolic and anti-anabolic effects of adipokines.

J F Nishimuta et al.

Osteoarthritis and cartilage, 23(9), 1551-1562 (2015-04-29)

This study compared the effects on cartilage and meniscus matrix catabolism and biosynthesis of several adipokines implicated in osteoarthritis (OA). Bovine cartilage and meniscus explants were cultured for 1 or 9 days in serum-free medium alone or with 0.02, 0.2

Stromal-epithelial interaction study: The effect of corneal epithelial cells on growth factor expression in stromal cells using organotypic culture model.

Takeshi Kobayashi et al.

Experimental eye research, 135, 109-117 (2015-02-17)

Interactions between stromal and epithelial cells play important roles in the development, homeostasis, and pathological conditions of the cornea. Soluble cytokines are critical factors in stromal-epithelial interactions, and growth factors secreted from corneal stromal cells contribute to the regulation of

Influence of combined use of selenious acid and SH compounds in parenteral preparations.

A Terada et al.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 11(2), 105-109 (1997-06-01)

The influence of the combined use of selenious acid and SH compounds (glutathione (GSH) and cysteine (Cys), or ascorbic acid (Asc)) on cultured venous vascular cells was investigated experimentally. When cultured human umbilical venous vascular endothelial cells were exposed to

Aromatic derivatives and tellurium analogues of cyclic seleninate esters and spirodioxyselenuranes that act as glutathione peroxidase mimetics.

Thomas G Back et al.

The Journal of organic chemistry, 70(23), 9230-9236 (2005-11-05)

[Reaction: see text]. Several novel organoselenium and tellurium compounds were prepared and evaluated as mimetics of the selenoenzyme glutathione peroxidase, which protects cells from oxidative stress by reducing harmful peroxides with the thiol glutathione. The compounds were tested for catalytic

Evaluation of the toxicity of Salmonella selective media for shortening the enrichment period.

H Chen et al.

International journal of food microbiology, 18(2), 151-159 (1993-04-01)

Five Salmonella serotypes recovering from heat injury exhibited different kinetics of resuscitation and growth. Exponential growth was reached before full resuscitation. Fully resuscitated cells and uninjured cells at low cell densities exhibited sensitivity when transferred from non-selective media to selective

Isolation and characterization of meniscus derived stem cells from rabbit as a possible treatment for damaged meniscus.

Jianchao Gui et al.

Current stem cell research & therapy, 10(4), 353-363 (2015-05-20)

The successful surgical restoration of damaged meniscus has been a challenge, largely owing to a lack of characterization of meniscus cells and their precursors. Numerous strategies to repair or replace meniscus have achieved only limited success. Several recent studies have

N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias.

Antonio G Soto et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(27), E3600-E3608 (2015-06-24)

Protease-activated receptor-1 (PAR1) is a G-protein-coupled receptor (GPCR) for the coagulant protease thrombin. Similar to other GPCRs, PAR1 is promiscuous and couples to multiple heterotrimeric G-protein subtypes in the same cell and promotes diverse cellular responses. The molecular mechanism by

Are biological agents toxic to human chondrocytes and osteocytes?

Mehmet Isyar et al.

Journal of orthopaedic surgery and research, 10, 118-118 (2015-08-01)

The aim of the present study is to investigate the effects of biological agents (BAs) on human chondrocytes and osteocytes in vitro. Primary cell cultures obtained from gonarthrosis patients were divided into four groups, two of which were designated as

Reduction of selenite by Azospirillum brasilense with the formation of selenium nanoparticles.

Anna V Tugarova et al.

Microbial ecology, 68(3), 495-503 (2014-05-28)

The ability to reduce selenite (SeO(3)(2-)) ions with the formation of selenium nanoparticles was demonstrated in Azospirillum brasilense for the first time. The influence of selenite ions on the growth of A. brasilense Sp7 and Sp245, two widely studied wild-type

A fatal case of gun blue ingestion in a toddler.

D A Quadrani et al.

Veterinary and human toxicology, 42(2), 96-98 (2000-04-06)

Acute selenium poisoning occurs infrequently. The form of selenium encountered plays a great role in toxicity. Several fatalities have been reported and all but I involved ingestion of selenious acid or selenium dioxide. A healthy 22-mo-old male ingested up to

Dangerous in small amounts: ten nondrug substances that cause harm.

Dana Bartlett

Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association, 29(4), 377-379 (2003-07-23)

Physical Stimuli-Induced Chondrogenic Differentiation of Mesenchymal Stem Cells Using Magnetic Nanoparticles.

Boram Son et al.

Advanced healthcare materials, 4(9), 1339-1347 (2015-04-08)

Chondrogenic commitments of mesenchymal stem cells (MSCs) require 3D cellular organization. Furthermore, recent progresses in bioreactor technology have contributed to the development of various biophysical stimulation platforms for efficient cartilage tissue formation. Here, an approach is reported to drive 3D

sb203580 preconditioning recharges matrix-expanded human adult stem cells for chondrogenesis in an inflammatory environment - A feasible approach for autologous stem cell based osteoarthritic cartilage repair.

Ying Zhang et al.

Biomaterials, 64, 88-97 (2015-07-01)

Autologous stem cells are a promising cell source for cartilage regeneration; however, cell replicative senescence and joint posttraumatic inflammation provide challenges in bringing this treatment modality to fruition. In this study, we hypothesized that preconditioning with p38 MAPK inhibitor (sb203580)

Wiberg E and Wiberg N

Inorganic Chemistry null

Thyroid hormones enhance the biomechanical functionality of scaffold-free neocartilage.

Jennifer K Lee et al.

Arthritis research & therapy, 17, 28-28 (2015-04-18)

The aim of this study was to investigate the effects of thyroid hormones tri-iodothyronine (T3), thyroxine (T4), and parathyroid hormone (PTH) from the parathyroid glands, known to regulate the developing limb and growth plate, on articular cartilage tissue regeneration using

Useful properties of undifferentiated mesenchymal stromal cells and adipose tissue as the source in liver-regenerative therapy studied in an animal model of severe acute fulminant hepatitis.

Bruna Maria Manzini et al.

Cytotherapy, 17(8), 1052-1065 (2015-07-04)

End-stage liver diseases frequently require liver transplantation. Cell therapy could be an alternative. This study aimed to analyze whether undifferentiated mesenchymal stromal cells (U-MSCs) or MSC-derived hepatocyte-like cells (DHLCs) from adipose tissue (AT), umbilical cord blood (UCB) and bone marrow

Synthesis, vibrational and quantum chemical investigations of hydrogen bonded complex betaine dihydrogen selenite.

V Arjunan et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 744-758 (2012-08-14)

The molecular complex of betaine with selenious acid namely, betaine dihydrogen selenite (C(5)H(13)NO(5)Se, BDHSe) was synthesised by the reaction of betaine and SeO(2) in a 1:1:1 solution of isopropanol, methanol and water. Crystals were grown from this solution by cooling

Fibrous Scaffolds with Varied Fiber Chemistry and Growth Factor Delivery Promote Repair in a Porcine Cartilage Defect Model.

Iris L Kim et al.

Tissue engineering. Part A, 21(21-22), 2680-2690 (2015-09-25)

Current clinically approved methods for cartilage repair are generally based on either endogenous cell recruitment (e.g., microfracture) or chondrocyte delivery (e.g., autologous chondrocyte implantation). However, both methods culminate in repair tissue with inferior mechanical properties and the addition of biomaterials

Fluocinolone Acetonide Is a Potent Synergistic Factor of TGF-β3-Associated Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells for Articular Surface Regeneration.

Emilio Satoshi Hara et al.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(9), 1585-1596 (2015-03-11)

Articular cartilage repair remains a challenging problem. Based on a high-throughput screening and functional analysis, we found that fluocinolone acetonide (FA) in combination with transforming growth factor beta 3 (TGF-β3) strongly potentiated chondrogenic differentiation of human bone marrow-derived mesenchymal stem

Three-dimensional polycaprolactone-hydroxyapatite scaffolds combined with bone marrow cells for cartilage tissue engineering.

Bo Wei et al.

Journal of biomaterials applications, 30(2), 160-170 (2015-03-15)

The goal of this study was to investigate the chondrogenic potential of three-dimensional polycaprolactone-hydroxyapatite (PCL-HA) scaffolds loaded with bone marrow cells in vitro and the effect of PCL-HA scaffolds on osteochondral repair in vivo. Here, bone marrow was added to

Effects of selenium on development, survival, and accumulation in the honeybee (Apis mellifera L.).

Kristen R Hladun et al.

Environmental toxicology and chemistry, 32(11), 2584-2592 (2013-10-12)

Apis mellifera L. (Hymenoptera: Apidae) is an important agricultural pollinator in the United States and throughout the world. In areas of selenium (Se) contamination, honeybees may be at risk because of the biotransfer of Se from plant products such as

Bone regeneration in a massive rat femur defect through endochondral ossification achieved with chondrogenically differentiated MSCs in a degradable scaffold.

Noriko Harada et al.

Biomaterials, 35(27), 7800-7810 (2014-06-24)

Mesenchymal stem cells (MSCs) are multipotent cells capable of proliferating and differentiating into several lineages. In regenerative medicine, their potential as a resource for tissue-replacement therapy is receiving much attention. However, transplanting MSCs to repair larger bone defects in animal

Image-based evaluations of distribution and cytotoxicity of Irinotecan (CPT-11) in a multi-compartment micro-cell coculture device.

Hidenari Nakayama et al.

Journal of bioscience and bioengineering, 117(6), 756-762 (2014-01-01)

We recently developed a polydimethylsiloxane (PDMS)-based three-compartment microfluidic cocultivation device enabling real-time interactions of different cell populations as an advanced physiologically-relevant cell-based assay. This device had valves and small magnetic stirrer-based internal pumps for easy and flexible perfusion operations. In

Immunomodulatory of selenium nano-particles decorated by sulfated Ganoderma lucidum polysaccharides.

Jianguo Wang et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 183-189 (2014-03-15)

In this study, we employed a one-step method to prepare selenium nanoparticles (SeNPs) decorated by the water-soluble derivative of Ganoderma lucidum polysaccharides (SPS). The SeNPs-SPS complexes were stable, and the diameter of the SeNPs was homogeneous at around 25 nm.

Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes.

Loqman A Mohamed et al.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(3), 427-438 (2014-09-17)

PURPOSE. The knowledge of hepatic disposition kinetics of tacrine, a first cholinesterase inhibitor was approved by FDA for the treatment of Alzheimer's disease (AD), would help to understand its hepatotoxicity, its therapeutic effect, and improve the management of patients with

Using a decellularized splenic matrix as a 3D scaffold for hepatocyte cultivation in vitro: a preliminary trial.

Xing-Long Zheng et al.

Biomedical materials (Bristol, England), 10(4), 045023-045023 (2015-08-21)

Using a decellularized liver matrix (DLM) to reengineer liver tissue is a promising therapy for end-stage liver disease. However, the limited supply of donor organs still hampers its potential clinical application, while a xenogenic decellularized matrix may bring a risk

Thiol-mediated multiple mechanisms centered on selenodiglutathione determine selenium cytotoxicity against MCF-7 cancer cells.

Takao Tobe et al.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(4), 687-694 (2015-03-19)

Selenium (Se) is an essential antioxidative micronutrient but can exert cancer-selective cytotoxicity if the nutritional levels are too high. Selenodiglutathione (GSSeSG) is a primary Se metabolite conjugated with two glutathione (GSH) moieties. GSSeSG has been suggested to be an important

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