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Masahide Harada et al.
Journal of the American College of Cardiology, 66(1), 47-58 (2015-07-04)
Atrial fibrillation (AF) is associated with metabolic stress, which activates adenosine monophosphate-regulated protein kinase (AMPK). This study sought to examine AMPK response to AF and associated metabolic stress, along with consequences for atrial cardiomyocyte Ca(2+) handling. Calcium ion (Ca(2+)) transients
M-E Willemin et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(4), 803-812 (2015-03-15)
In vitro metabolism of permethrin, a pyrethroid insecticide, was assessed in primary human hepatocytes. In vitro kinetic experiments were performed to estimate the Michaelis-Menten parameters and the clearances or formation rates of the permethrin isomers (cis- and trans-) and three
Irina I Popadyuk et al.
Bioorganic & medicinal chemistry, 23(15), 5022-5034 (2015-06-04)
We report the synthesis and biological activity of new semi-synthetic derivatives of naturally occurring deoxycholic acid (DCA) bearing 2-cyano-3-oxo-1-ene, 3-oxo-1(2)-ene or 3-oxo-4(5)-ene moieties in ring A and 12-oxo or 12-oxo-9(11)-ene moieties in ring C. Bioassays using murine macrophage-like cells and
Francesca Cargnin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16650-16661 (2014-12-17)
The RE1 Silencing Transcription Factor (REST) acts as a governor of the mature neuronal phenotype by repressing a large consortium of neuronal genes in non-neuronal cells. In the developing nervous system, REST is present in progenitors and downregulated at terminal
Maren Lindner et al.
Brain : a journal of neurology, 138(Pt 7), 1875-1893 (2015-04-25)
Remyelination failure plays an important role in the pathophysiology of multiple sclerosis, but the underlying cellular and molecular mechanisms remain poorly understood. We now report actively demyelinating lesions in patients with multiple sclerosis are associated with increased glial expression of
Takeshi Imai et al.
Bioscience, biotechnology, and biochemistry, 78(8), 1376-1380 (2014-08-19)
Selenite is a selenium source for selenoprotein biosynthesis in mammalian cells. Although previous studies have suggested the involvement of glutathione (GSH) and/or thioredoxin reductase in selenite metabolism, intracellular selenite metabolism remains largely unknown. Here, we report that GSH depletion did
Juliana Medeiros et al.
Analytical and quantitative cytopathology and histopathology, 35(5), 278-282 (2013-11-29)
To analyze the morphology of the oviduct of commercial egg-laying hens supplemented with organic minerals. A total of 2,400 Dekalb hens at 42 weeks of age were included in the study. Throughout the period of the experiment (10 months, divided
Mi Lan Kang et al.
Biomaterials, 35(37), 9984-9994 (2014-09-23)
We developed an intra-articular (IA) drug delivery system to treat osteoarthritis (OA) that consisted of kartogenin conjugated chitosan (CHI-KGN). Kartogenin, which promotes the selective differentiation of mesenchymal stem cells (MSCs) into chondrocytes, was conjugated with low-molecular-weight chitosan (LMWCS) and medium-molecular-weight
Jose L Luque-Garcia et al.
Analytica chimica acta, 801, 1-13 (2013-10-22)
Mercury is a well-known risk to ecosystems and human health. Considering that no effective treatment is available to counteract mercury toxicity, the effectiveness of different trace elements, agents and nutrients with antioxidant properties to protect or reverse mercury toxicity is
Ekaterina A Ivanova et al.
PloS one, 10(3), e0120998-e0120998 (2015-03-27)
Nephropathic cystinosis is a lysosomal storage disorder caused by mutations in the CTNS gene encoding cystine transporter cystinosin that results in accumulation of amino acid cystine in the lysosomes throughout the body and especially affects kidneys. Early manifestations of the
Petter Angell Olsen et al.
PloS one, 9(12), e115496-e115496 (2014-12-24)
Pancreatic adenocarcinoma (PA) is among the most aggressive human tumors with an overall 5-year survival rate of <5% and available treatments are only minimal effective. WNT/β-catenin signaling has been identified as one of 12 core signaling pathways that are commonly
BoBae Lee et al.
Journal of biomechanics, 48(1), 171-175 (2014-12-04)
Dynamic nanomechanical properties of bovine bone marrow stromal cells (BMSCs) and their newly synthesized cartilage-like matrices were studied at nanometer scale deformation amplitudes. The increase in their dynamic modulus, |E(*)| (e.g., 2.4±0.4 kPa at 1 Hz to 9.7±0.2 kPa at
Ke-Wei Zhao et al.
Journal of cellular biochemistry, 116(11), 2563-2576 (2015-04-23)
Changes in plasma protein levels in synovial fluid (SF) have been implicated in osteoarthritis and rheumatoid arthritis. It was previously thought that the presence of plasma proteins in SF reflected ultrafiltration or extravasation from the vasculature, possibly due to retraction
Gerrit Erdmann et al.
Genome medicine, 7(1), 46-46 (2015-06-30)
Mesenchymal stem cells (MSCs) are promising candidates for cellular therapies ranging from tissue repair in regenerative medicine to immunomodulation in graft versus host disease after allogeneic transplantation or in autoimmune diseases. Nonetheless, progress has been hampered by their enormous phenotypic
Naveen Kaushal et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3683-3692 (2014-09-05)
Inflammation is a hallmark of inflammatory bowel disease (IBD) that involves macrophages. Given the inverse link between selenium (Se) status and IBD-induced inflammation, our objective was to demonstrate that selenoproteins in macrophages were essential to suppress proinflammatory mediators, in part
Robin M Skory et al.
Human reproduction (Oxford, England), 30(6), 1386-1395 (2015-03-19)
Can cultured follicles model the ovarian cycle, including follicular- and luteal-phase hormone synthesis patterns and ovulation? Under gonadotrophin stimulation, murine follicles grown in an encapsulated three-dimensional system ovulate in vitro and murine and human follicle hormone synthesis mimics follicular and
S Matsumura et al.
Oral diseases, 21(3), 361-372 (2014-09-03)
The characteristics of cell populations extracted from oral mucosal non-epithelial tissues and their ability to differentiate were evaluated in vitro as a potential source of cells for mandibular and corneal regeneration. Oral mucosal non-epithelial cells (OMNECs) were extracted from tissue
Raed Felimban et al.
Tissue engineering. Part A, 20(15-16), 2213-2223 (2014-03-25)
Hyaline cartilage repair is a significant challenge in orthopedics and current techniques result in formation of fibrocartilage. Human infrapatellar fat pad (hIPFP)-derived mesenchymal stem cells (MSCs) are capable of differentiation into multiple tissue lineages, including cartilage and bone. Chondrogenesis is
Sotirios Christodoulou et al.
Nature communications, 6, 7905-7905 (2015-07-30)
Strain in colloidal heteronanocrystals with non-centrosymmetric lattices presents a unique opportunity for controlling optoelectronic properties and adds a new degree of freedom to existing wavefunction engineering and doping paradigms. We synthesized wurtzite CdSe nanorods embedded in a thick CdS shell
Elisa Corritore et al.
Cellular reprogramming, 16(6), 456-466 (2014-12-02)
β-Cell replacement therapy is a promising field of research that is currently evaluating new sources of cells for clinical use. Pancreatic epithelial cells are potent candidates for β-cell engineering, but their large-scale expansion has not been evidenced yet. Here we
Doug Van Hoewyk
Annals of botany, 112(6), 965-972 (2013-08-02)
Despite selenium's toxicity in plants at higher levels, crops supply most of the essential dietary selenium in humans. In plants, inorganic selenium can be assimilated into selenocysteine, which can replace cysteine in proteins. Selenium toxicity in plants has been attributed
Asha K Patel et al.
Biomaterials, 61, 257-265 (2015-05-26)
Cardiomyocytes from human stem cells have applications in regenerative medicine and can provide models for heart disease and toxicity screening. Soluble components of the culture system such as growth factors within serum and insoluble components such as the substrate on
Liezl Rae Balaoing et al.
PloS one, 10(6), e0130749-e0130749 (2015-06-20)
Valve endothelial cells (VEC) have unique phenotypic responses relative to other types of vascular endothelial cells and have highly sensitive hemostatic functions affected by changes in valve tissues. Furthermore, effects of environmental factors on VEC hemostatic function has not been
Corin Williams et al.
Acta biomaterialia, 14, 84-95 (2014-12-03)
Solubilized cardiac extracellular matrix (ECM) is being developed as an injectable therapeutic that offers promise for promoting cardiac repair. However, the ECM alone forms a hydrogel that is very soft compared to the native myocardium. As both the stiffness and
Ayano Oi et al.
The Journal of reproduction and development, 61(3), 191-197 (2015-03-06)
In this study, we examined the effects of reconstructed oocyte-granulosa cell complexes (OGCs) on the development of porcine oocytes derived from early antral follicles (EAFs; 0.5-0.7 mm in diameter). When denuded oocytes were cocultured with granulosa cells derived from other
Beibei Chen et al.
Journal of chromatography. A, 1363, 62-70 (2014-08-19)
In this paper, the "state of the art" of chiral speciation of selenoamino acids (SeAAs) in biological samples is critically reviewed. The significance and the features of such studies are highlighted. A special focus lies on chiral speciation of SeAAs
Ken Ye et al.
PloS one, 9(6), e99410-e99410 (2014-06-12)
Infrapatellar fat pad adipose stem cells (IPFP-ASCs) have been shown to harbor chondrogenic potential. When combined with 3D polymeric structures, the stem cells provide a source of stem cells to engineer 3D tissues for cartilage repair. In this study, we
John Austin Milner, PhD (1947-2013).
Cindy D Davis et al.
The Journal of nutrition, 144(4), 411-413 (2014-02-07)
Sandra A Jacobs et al.
Cell transplantation, 23(9), 1099-1110 (2013-04-09)
Human multipotent adult progenitor cells (hMAPCs) are isolated from bone marrow with a more extensive expansion capacity compared to human mesenchymal stem cells (hMSCs) and with the ability to differentiate into endothelium. Like hMSCs, hMAPCs inhibit T-cell proliferation induced by
Dillip Kumar Bishi et al.
Journal of materials science. Materials in medicine, 25(11), 2579-2589 (2014-07-12)
Liver tissue engineering using polymeric nanofibrous scaffold and stem cells holds great promises for treating end-stage liver failures. The aim of this study was to evaluate hepatic trans-differentiation potential of human mesenchymal stem cells (hMSCs) on a biomagnetic electrospun nanofibrous
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