230-135-2

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Pralatrexate with vitamin supplementation in patients with previously treated, advanced non-small cell lung cancer: safety and efficacy in a phase 1 trial.

Christopher G Azzoli et al.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 6(11), 1915-1922 (2011-08-16)

Pralatrexate is an antifolate designed for preferential tumor cell uptake and accumulation and received accelerated Food and Drug Administration approval in relapsed/refractory peripheral T-cell lymphoma. Pralatrexate 135 to 150 mg/m(2) every 2 weeks without vitamin supplementation was active in non-small

Photochemical cross-linking between rabbit skeletal troponin subunits. Troponin I-troponin T interactions.

P C Chong et al.

The Journal of biological chemistry, 257(19), 11667-11672 (1982-10-10)

The heterobifunctional photoaffinity probe, AGTC (N-(4-azidobenzoyl-[2-3H]glycyl)-S-(2-thiopyridyl) cysteine), was attached to cysteines 48 and 64 of troponin I to determine which component of rabbit skeletal troponin was in close proximity to these cysteines. The reconstituted troponin complex (AGC labeled CM-TnI, TnT

Combined administration of a 5-hydroxytryptamine (5-HT)1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo.

H Rollema et al.

Journal of neurochemistry, 67(5), 2204-2207 (1996-11-01)

In vivo microdialysis in guinea pig hypothalamus was used to study the effect of serotonin [5-hydroxytryptamine (5-HT)] subtype 1D autoreceptor blockade on the increase in extracellular 5-HT levels produced by a selective 5-HT reuptake inhibitor (SSRI). Administration of the selective

Characterization of alpha-2 adrenergic receptors in the OK cell, an opossum kidney cell line.

T J Murphy et al.

The Journal of pharmacology and experimental therapeutics, 244(2), 571-578 (1988-02-01)

We have characterized alpha-2 adrenergic receptors in OK cells, an opossum kidney-derived cell line. In membrane saturation binding experiments, [3H]rauwolscine (Kd = 74 pM) was 3-fold more potent than [3H]yohimbine (Kd = 230 pM). Each labeled a single class of

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