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关键词:'230162'
显示 1-30 共 213 条结果 关于 "230162" 范围 论文
Ryszard Jasztold-Howorko et al.
Acta poloniae pharmaceutica, 70(5), 823-832 (2013-10-24)
In this paper, we describe our results of the synthesis and biological testing of analogues of the natural alkaloids olivacine and ellipticine. We have synthesized fourteen new 1-substituted pyrido[4,3-b]carbazole derivatives. All of them were tested in vitro for their anticancer
Fang Liu et al.
Neoplasia (New York, N.Y.), 10(11), 1275-1284 (2008-10-28)
Accumulating evidence suggests that multiple complex mechanisms may be involved, simultaneously or complementarily, in the emergence and development of multidrug resistance (MDR) in various cancers. Cell adhesion-mediated MDR is one such mechanism. In the present study, we initially observed increased
Ijeoma Adaku Umelo et al.
Oncotarget, 6(24), 20132-20144 (2015-05-21)
KRAS is a frequently mutated oncogene in lung cancer and among the most refractory to EGFR targeted therapy. Recently, preclinical evidence in pancreatic cancer has demonstrated that mutant KRAS can be regulated by EGFR. However, the distinct correlation between the
Lin Hou et al.
International journal of nanomedicine, 10, 4507-4520 (2015-07-28)
A tumor-targeting carrier, hyaluronic acid (HA)-functionalized single-walled carbon nanotubes (SWCNTs), was explored to deliver magnetic resonance imaging (MRI) contrast agents (CAs) targeting to the tumor cells specifically. In this system, HA surface modification for SWCNTs was simply accomplished by amidation
Aline I Riechardt et al.
The British journal of ophthalmology, 99(12), 1739-1745 (2015-09-09)
Mutations in the gene coding for the kinase B-Raf are associated with tumour growth in conjunctival melanoma. The purpose of this study is to explore effects of pharmacological B-Raf inhibition in conjunctival melanoma cell lines. The B-Raf genotypes were assessed
Xinhong Guo et al.
Journal of pharmaceutical sciences, 103(10), 3225-3234 (2014-09-02)
Derivatives of fullerene (C60) as photosensitizers have rarely been studied as delivery carrier materials. The focus of this study was to explore the potential advantages of diadduct malonic acid-fullerene (DMA-C60) as delivery carrier materials and combination of chemo-phototherapy of some
Kwan Kim et al.
ACS applied materials & interfaces, 4(10), 5498-5504 (2012-10-10)
Many drugs are charged molecules and are weak bases or acids having counterions. Their binding to biological surfaces is generally difficult to assess by vibrational spectroscopy. In this work, we demonstrated the potential of surface-enhanced Raman scattering (SERS) conducted using
Leandro C Cerchietti et al.
Cancer research, 68(9), 3361-3369 (2008-05-03)
Transcription factors play a central role in malignant transformation by activating or repressing waves of downstream target genes. Therapeutic targeting of transcription factors can reprogram cancer cells to lose their advantages in growth and survival. The BCL6 transcriptional repressor plays
Subash Dhakal et al.
Communications biology, 4(1), 1281-1281 (2021-11-14)
Ammonia and its amine-containing derivatives are widely found in natural decomposition byproducts. Here, we conducted biased chemoreceptor screening to investigate the mechanisms by which different concentrations of ammonium salt, urea, and putrescine in rotten fruits affect feeding and oviposition behavior.
M Li et al.
European review for medical and pharmacological sciences, 19(11), 1945-1950 (2015-07-01)
The study was aimed at evaluating the in vitro cytotoxicity of some commonly used drugs in ophthalmology. Hydrocortisone sodium succinate, Dexamethasone sodium phosphate, 5-Fluorouracil, Tobramycin and Pilocarpine nitrate are frequently used in various indications involving eye care, and the aim
Hong Zhu et al.
Free radical biology & medicine, 71, 121-132 (2014-04-01)
Dihydroartemisinin (DHA), one of the main metabolites of artemisinin and its derivatives, presents anti-cancer potential in vitro and in vivo. To explore the mechanisms of resistance toward DHA, a DHA-resistant cell line, HeLa/DHA, was established with a resistance factor of
Chao-Hua Yan et al.
International journal of clinical and experimental medicine, 8(8), 14432-14439 (2015-11-10)
Plumbagin, a naphthoquinone constituent of Plumbago zeylanica L. (Plumbaginaceae), has been extensively studied for its pharmacological activities and reported to show a good anti-cancer activity in different human cancer cell lines. It is known to exhibit proapoptotic, antiangiogenic and antimetastatic
Ningning Li et al.
Oncogenesis, 8(3), 13-13 (2019-02-21)
Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the survival of stem cell-like cells referred to as cancer stem-like cells (CSCs). The origin of CSCs is linked to the epithelial-mesenchymal transition (EMT) process. Currently, it remains poorly understood
Pengcheng Yu et al.
Acta biomaterialia, 14, 115-124 (2014-12-17)
Chemotherapy is an important approach for clinical cancer treatment. However, the success of chemotherapy is usually hindered by the occurrence of intrinsic or acquired multidrug resistance of cancer cells. Herein, we reported an effective approach to overcome doxorubicin (DOX) resistance
Ivan Sieveking et al.
Bioorganic & medicinal chemistry, 22(17), 4609-4620 (2014-08-16)
A series of new 2-aminonaphthoquinones and related compounds were synthesized and evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited epimastigote growth and trypomastigote viability. Several compounds showed similar or higher activity and selectivity as compared with
Deirdre A Costello et al.
Journal of virology, 89(1), 350-360 (2014-10-17)
Influenza A virus strains adapt to achieve successful entry into host species. Entry is mediated by the viral membrane protein hemagglutinin (HA), which triggers membrane fusion and genome release under acidic conditions in the endosome. In addition to changes in
Maria J Ramalho et al.
Beilstein journal of nanotechnology, 6, 1306-1318 (2015-07-23)
Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were studied as drug delivery vehicles for calcitriol, the active form of vitamin D3. In vitro effects of calcitriol encapsulated in PLGA nanoparticles were evaluated with respect to free calcitriol on human pancreatic cell lines, S2-013
Monika Litwin et al.
Molecular and cellular biochemistry, 410(1-2), 131-142 (2015-09-01)
In recent years, special attention has been paid to finding new pro-angiogenic factors which could be used in gene therapy of vascular diseases such as critical limb ischaemia (CLI). Angiogenesis, the formation of new blood vessels, is a complex process
Zhi Li et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 14(6), 1197-1206 (2015-05-23)
Recently, porous carbons have showed great potential in many areas. In this study, TiO2-doped mesoporous carbonaceous (TiO2@C) nanoparticles were obtained by a simple one-pot hydrothermal treatment, folic acid (FA) was conjugated to TiO2@C through an amide bond, then Mitoxantrone HCl
Elisa Pfeiffer et al.
Experimental biology and medicine (Maywood, N.J.), 240(5), 645-656 (2014-11-15)
Primary human hepatocytes (PHH) are considered to be the gold standard for in vitro testing of xenobiotic metabolism and hepatotoxicity. However, PHH cultivation in 2D mono-cultures leads to dedifferentiation and a loss of function. It is well known that hepatic
Aranya Manosroi et al.
Journal of ethnopharmacology, 161, 11-17 (2014-12-08)
Thai/Lanna region has its own folklore wisdoms including the traditional medicinal plant recipes. Thai/Lanna medicinal plant recipe database "MANOSROI III" has been developed by Prof. Dr. Jiradej Manosroi. It consists of over 200,000 recipes for all diseases including cancer. To
Linlin Sun et al.
PloS one, 10(4), e0122830-e0122830 (2015-04-09)
Atherosclerosis is a common cardiovascular disease that involves the build-up of plaque on the inner walls of the arteries. Intraplaque neovacularization has been shown to be essential in the pathogenesis of atherosclerosis. Previous studies showed that small-molecule compounds targeting farnesyl
Yang Gao et al.
Experimental and therapeutic medicine, 19(3), 2202-2210 (2020-02-28)
The NOD-like receptor protein 3/caspase-1 inflammasome can be activated in human dental pulp tissue and fibroblasts; however, the underlying mechanisms are poorly understood. In the present study, lipopolysaccharide (LPS) was used to treat dental pulp cells to establish an inflammation
Huiping Sun et al.
Molecular pharmaceutics, 12(9), 3323-3331 (2015-07-30)
Metastasis is the primary cause resulting in the high mortality of breast cancer. The inherent antimetastasis bioactivity of Pluronic copolymers with a wide range of hydrophilic-lipophilic balance (HLB) including Pluronic L61, P85, P123, F127, F68, and F108 was first explored
Hiroshi Jikihara et al.
Oncology reports, 33(3), 1131-1140 (2015-01-13)
Garlic and its constituents are reported to have a preventive effect against colorectal cancer in animal models. Aged garlic extract (AGE), which is produced by natural extraction from fresh garlic for more than 10 months in aqueous ethanol, also has
Morgane Sanzey et al.
PloS one, 10(5), e0123544-e0123544 (2015-05-02)
Major efforts have been put in anti-angiogenic treatment for glioblastoma (GBM), an aggressive and highly vascularized brain tumor with dismal prognosis. However clinical outcome with anti-angiogenic agents has been disappointing and tumors quickly develop escape mechanisms. In preclinical GBM models
Zhaoming Guo et al.
International journal of pharmaceutics, 493(1-2), 380-389 (2015-05-26)
EphA2 is a transmembrane receptor tyrosine kinase that is highly expressed on both tumor neovasculature and some kinds of tumor cells. Here, a homing peptide with a sequence of YSAYPDSVPMMSK (YSA) that binds specifically with EphA2 was utilized to modify
Annika M Bourgonje et al.
Oncotarget, 5(18), 8690-8702 (2014-09-23)
Gliomas are primary brain tumors for which surgical resection and radiotherapy is difficult because of the diffuse infiltrative growth of the tumor into the brain parenchyma. For development of alternative, drug-based, therapies more insight in the molecular processes that steer
Yung-Ting Kuo et al.
PloS one, 10(5), e0125343-e0125343 (2015-05-08)
Neuroblastoma (NB) is a common neural crest-derived extracranial solid cancer in children. Among all childhood cancers, NB causes devastating loss of young lives as it accounts for 15% of childhood cancer mortality. Neuroblastoma, especially high-risk stage 4 NB with MYCN
Anna Schueth et al.
The Journal of urology, 192(3), 973-980 (2014-04-08)
We developed 2-photon laser scanning microscopy analysis of the native murine bladder. Bladder tissue from wild-type mice was imaged by 2-photon laser scanning microscopy autofluorescence and second harmonic generation microscopy. Bladder wall layers and structures were analyzed using differences in
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