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显示 1-30 #N/A 213 条结果 关于 "230162" 范围 论文
Wei-Lan Yeh et al.
PloS one, 9(6), e98805-e98805 (2014-06-03)
Tamoxifen has long been used and still is the most commonly used endocrine therapy for treatment of both early and advanced estrogen receptor-positive breast cancer in pre- and post-menopause women. Tamoxifen exerts its cytotoxic effect primarily through cytostasis which is
Minerva Nájera-Martínez et al.
Inhalation toxicology, 24(11), 762-773 (2012-09-08)
Halomethanes (HMs) can be formed during the chlorination process to obtain drinking water. In liver cells, HMs had been shown to be mutagenic and carcinogenic; however, their bioactivation by CYP 2E1 and GSTT1 is required. Although inhalation is the most
Elena Geromichalou et al.
European journal of medicinal chemistry, 96, 47-57 (2015-04-16)
Recent science evidenced the interlinkage of oxidative stress and cancer. Due to the inherent complexity of cancer and its accompanying effect of oxidative stress, novel molecules, containing combinatorial functionalities should be targeted. Herein, we synthesized gemcitabine-5'-O-lipoate derived from a regioselective
Oluwaseun Adebayo Bamodu et al.
Cancer letters, 364(2), 125-134 (2015-05-16)
Triple-negative breast cancer (TNBC) is chemotherapy-refractory and associated with poor clinical prognosis. Doxorubicin (Doxo), a class I anthracycline and first-line anticancer agent, effective against a wide spectrum of neoplasms including breast carcinoma, is associated with several cumulative dose-dependent adverse effects
E E Gurdal et al.
Drug research, 63(3), 121-128 (2013-03-01)
This study presents the synthesis of nineteen 1-(substitutedbenzoyl)-4-benzhydrylpiperazine and 1-[(substitutedphenyl)sulfonyl]-4-benzhydrylpiperazine derivatives. In vitro cytotoxic activities of the compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Among the test compounds, benzamide
J Correa-Betanzo et al.
Food chemistry, 165, 522-531 (2014-07-21)
Wild blueberries are rich in polyphenols and have several potential health benefits. Understanding the factors that affect the bioaccessibility and bioavailability of polyphenols is important for evaluating their biological significance and efficacy as functional food ingredients. Since the bioavailability of
Marijke C C Sachweh et al.
Oncotarget, 6(18), 16488-16506 (2015-06-02)
Malignant melanoma is the most dangerous type of skin cancer. Although recent progress in treatment has been achieved, lack of response, drug resistance and relapse remain major problems. The tumor suppressor p53 is rarely mutated in melanoma, yet it is
Francis W Hunter et al.
Molecular cancer therapeutics, 13(11), 2501-2514 (2014-09-07)
Triple-negative breast cancer (TNBC) is an aggressive malignancy with poor clinical outcome and few validated drug targets. Two prevalent features of TNBC, tumor hypoxia and derangement of homologous recombination (HR) repair, are potentially exploitable for therapy. This study investigated whether
Leslie Walling et al.
Assay and drug development technologies, 10(6), 507-513 (2012-03-01)
A solute aspirated into a prefilled tube of diluent undergoes a dilution effect known as dispersion. Traditionally the effects of dispersion have been considered a negative consequence of using liquid-filled fixed-tip liquid handlers. We present a novel device and technique
M Maltz et al.
Journal of dentistry, 40(9), 776-782 (2012-06-06)
The aim of this study was to compare microbiological infection after conventional carious dentine removal with incomplete carious dentine removal and sealing. Eighty-seven patients (12-50 years of age) under treatment at the Dental Clinics of the Federal University of Rio
Michael Krumpel et al.
Experimental cell research, 339(1), 154-162 (2015-10-03)
Tartrate-resistant acid phosphatase (TRAP/ACP5/uteroferrin/purple acid phosphatase/PP5) has received considerable attention as a newly discovered proinvasion metastasis driver associated with different malignancies. This renders TRAP an interesting target for novel anti-cancer therapy approaches. TRAP exists as two isoforms, 5a and 5b
Yuwei Chen et al.
Bioscience reports, 40(5) (2020-05-05)
The liver is a vital organ and the hepatic lobule serves as the most basic structural and functional unit which is mainly assembled with parenchymal cells including hepatocytes and biliary epithelial cells. The continuous tubular arrangement of biliary cells which
Jurairat Jongthawin et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(8), 8051-8064 (2014-05-20)
Prostaglandin E2 (PGE2) involves in progression of various chronic inflammation-related cancers including cholangiocarcinoma (CCA). This study aimed to determine the role of PGE2 signaling, its biosynthesis-related enzymes in a clinical prognosis, and their targeted inhibition in CCA progression. The immunohistochemical
Dual receptor-specific peptides modified liposomes as VEGF siRNA vector for tumor-targeting therapy.
Zhenzhen Yang et al.
Current gene therapy, 14(4), 289-299 (2014-07-22)
Tumor angiogenesis involves multiple signaling pathways that provide potential therapeutic targets to inhibit tumor growth and metastasis. Regarding the significant role of vascular endothelial growth factor (VEGF) in angiogenesis and tumor progression, VEGF sequence-specific small interfering RNA (siRNA) for anti-angiogenic
He Wang et al.
Oncotarget, 6(5), 2827-2842 (2015-01-22)
Resistance to treatment with anticancer drugs is a signiï¬cant obstacle and a fundamental cause of therapeutic failure in cancer therapy. Functional doxorubicin (DOX) nanoparticles for targeted delivery of the classical cytotoxic anticancer drug DOX to tumor cells, using folate-terminated polyrotaxanes
Tomomi Ichinose et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(26), 8761-8771 (2014-06-27)
In the visual system, diverse image processing starts with bipolar cells, which are the second-order neurons of the retina. Thirteen subtypes of bipolar cells have been identified, which are thought to encode different features of image signaling and to initiate
Oluwaseun Adebayo Bamodu et al.
Cells, 9(3) (2020-03-22)
Resistance to radiotherapy (IR), with consequent disease recurrence, continues to limit the efficacy of contemporary anticancer treatment for patients with hepatocellular carcinoma (HCC), especially in late stage. Despite accruing evidence implicating the PI3K/AKT signaling pathway in cancer-promoting hypoxia, cancerous cell
Yasaman KalantarMotamedi et al.
iScience, 24(9), 103080-103080 (2021-09-30)
Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound combinations based on transcriptomic profiles from both the disease
Daniela E Oprea-Lager et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(3), 319-327 (2014-11-20)
The objective of the present study is to determine whether uptake of [(18)F]fluoromethylcholine ([(18)F]FCH) in comparison with 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) accurately reflects chemotherapy efficacy at the tumor cell level in prostate cancer (PC). The effects of docetaxel and cabazitaxel on viable
Scott A Longwell et al.
Lab on a chip, 20(1), 93-106 (2019-11-09)
Microfluidic devices are an enabling technology for many labs, facilitating a wide range of applications spanning high-throughput encapsulation, molecular separations, and long-term cell culture. In many cases, however, their utility is limited by a 'world-to-chip' barrier that makes it difficult
Hsien-Yi Wang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 69, 347-356 (2014-04-23)
Momordica charantia Linn. (Cucurbitaceae), also called bitter melon, has traditionally been used as a natural anti-diabetic agent for anti-hyperglycemic activity in several animal models and clinical trials. We investigated the differences in the anti-diabetic properties and mechanism of action of
Mariana Ilha et al.
Journal of cellular biochemistry, 120(11), 19031-19043 (2019-07-02)
Caveolin-1 (Cav-1) expression is increased in hepatic stellate cells (HSC) upon liver cirrhosis and it functions as an integral membrane protein of lipid rafts and caveolae that regulates and integrates multiple signals as a platform. This study aimed to evaluate
James C Liao et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(48), 12982-12992 (2008-11-28)
The neuronal networks in spinal cord can produce a diverse array of motor behaviors. In aquatic vertebrates such as fishes and tadpoles, these include escape behaviors, swimming across a range of speeds, and struggling. We addressed the question of whether
Szabolcs Gergely et al.
Oxidative medicine and cellular longevity, 2015, 178513-178513 (2015-07-03)
Antracyclines are effective antitumor agents. One of the most commonly used antracyclines is doxorubicin, which can be successfully used to treat a diverse spectrum of tumors. Application of these drugs is limited by their cardiotoxic effect, which is determined by
Chen Xia et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(2), 816-824 (2015-09-12)
To explore whether Nrf2 was associated with drug-resistance in cisplatin resistant A549 (A549/DDP) cells, and if cryptotanshinone (CTS), one of the bioactive compounds isolated from the roots of Salvia miltiorrhiza Bunge (Danshen), could enhance the sensitivity in A549/DDP cells towards
Guo-An Liu et al.
Die Pharmazie, 70(4), 263-268 (2015-05-28)
The ent-kaurane diterpenoid weisinensis B shows significant cytotoxicity to human chronic myeloid leukemia K562 cells. It inhibits cell growth at low concentration and kills cells at high concentration. The compound induced cell apoptosis and necrosis mainly associated with G2/M phase
José-Manuel Molina-Molina et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 74, 233-239 (2014-12-03)
Zearalenone (ZEN) is a well-known mycotoxin present in numerous agricultural products. Humans and animals are therefore at a risk of exposure to zearalenone through consumption of contaminated food. After intake, ZEN is reduced to α- and β-zearalenol (α-ZEL and β-ZEL)
Mesenchymal stem cell-induced doxorubicin resistance in triple negative breast cancer.
Chen DR, Lu DY, Lin HY, et al.
BioMed Research International, 2014, 532161-532161 (2014)
Sang-Gu Yeo et al.
Archives of pharmacal research, 38(2), 193-202 (2014-04-23)
Human enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) are major causative agents of hand, foot, and mouth disease (HFMD) especially in infants and children under 5 years of age. Despite recent outbreaks of HFMD, there are no approved therapeutics against
Kaushalkumar Dave et al.
PloS one, 9(12), e115712-e115712 (2014-12-30)
The study was aimed at investigating localized topical drug delivery to the breast via mammary papilla (nipple). 5-fluorouracil (5-FU) and estradiol (EST) were used as model hydrophilic and hydrophobic compounds respectively. Porcine and human nipple were used for in-vitro penetration
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