235-985-8

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Vasodilator-stimulated phosphoprotein regulates inside-out signaling of beta2 integrins in neutrophils.

Ravi K Deevi et al.

Journal of immunology (Baltimore, Md. : 1950), 184(12), 6575-6584 (2010-05-21)

The monomeric GTPase Rap1 controls functional activation of beta2 integrins in leukocytes. In this article, we describe a novel mechanism by which the chemoattractant fMLP activates Rap1 and inside-out signaling of beta2 integrins. We found that fMLP-induced activation of Rap1

Elemental mass spectrometry to study metallo-transcriptomic changes during the in vitro degeneration of the retinal pigment epithelium.

Ana Álvarez-Barrios et al.

Analytical and bioanalytical chemistry (2023-07-29)

Trace elements play crucial roles in cellular biology. Their improper homeostasis may contribute to the progress of eye diseases, exacerbated during ageing. The retinal pigment epithelium (RPE) is progressively deteriorated during age-related neurodegeneration and metal homeostasis may be compromised. In

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