240176

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A thermostable Salmonella phage endolysin, Lys68, with broad bactericidal properties against gram-negative pathogens in presence of weak acids.

Hugo Oliveira et al.

PloS one, 9(10), e108376-e108376 (2014-10-08)

Resistance rates are increasing among several problematic Gram-negative pathogens, a fact that has encouraged the development of new antimicrobial agents. This paper characterizes a Salmonella phage endolysin (Lys68) and demonstrates its potential antimicrobial effectiveness when combined with organic acids towards

Mitochondrial metabolism and stress response of yeast: Applications in fermentation technologies.

Hiroshi Kitagaki et al.

Journal of bioscience and bioengineering, 117(4), 383-393 (2013-11-12)

Mitochondria are sites of oxidative respiration. During sake brewing, sake yeasts are exposed to long periods of hypoxia; the structure, role, and metabolism of mitochondria of sake yeasts have not been studied in detail. It was first elucidated that the

The secretion of organic acids is also regulated by factors other than aluminum.

Haiyan Ding et al.

Environmental monitoring and assessment, 186(2), 1123-1131 (2013-10-08)

As a result of natural processes and human activities, aluminum (Al) toxicity is recognized as a major limiting factor for plant productivity, and the secretion of organic acids facilitated by channel proteins is one of the most important Al resistance

Pre-alcoholic fermentation acidification of red grape must using Lactobacillus plantarum.

Cristóbal A Onetto et al.

Antonie van Leeuwenhoek, 108(6), 1469-1475 (2015-10-07)

Red grape musts from overripe grapes are characterised by high pH and sugar concentration. Corrections with organic acids are commonly used to secure the alcoholic fermentation and improve the organoleptic characteristics of the wine. In this study we test an

Conversion of solid dispersion prepared by acid-base interaction into free-flowing and tabletable powder by using Neusilin® US2.

Ankita Shah et al.

International journal of pharmaceutics, 484(1-2), 172-180 (2015-03-01)

A novel method of greatly increasing solubility and dissolution rate of a model basic drug, haloperidol, by interacting it with water-soluble weak organic acids in aqueous media was previously reported in the literature. Amorphous solid dispersion (SD) was formed when

Fungal biotransformation of crude glycerol into malic acid.

Thomas P West

Zeitschrift fur Naturforschung. C, Journal of biosciences, 70(5-6), 165-167 (2015-06-26)

Malic acid production from the biodiesel coproduct crude glycerol by Aspergillus niger ATCC 9142, ATCC 10577 and ATCC 12846 was observed to occur with the highest malic acid level acid being produced by A. niger ATCC 12846. Fungal biomass production

Phytochemical Characterization of Chinese Bayberry (Myrica rubra Sieb. et Zucc.) of 17 Cultivars and Their Antioxidant Properties.

Xianan Zhang et al.

International journal of molecular sciences, 16(6), 12467-12481 (2015-06-05)

In order to fully understand the variations of fruit quality-related phytochemical composition in Chinese bayberry (Myrica rubra Sieb. et Zucc.), mature fruit of 17 cultivars from Zhejiang and Jiangsu provinces was used for the investigation of fruit quality attributes, including

Physico-chemical properties, antioxidant activity and mineral contents of pineapple genotypes grown in china.

Xin-Hua Lu et al.

Molecules (Basel, Switzerland), 19(6), 8518-8532 (2014-06-25)

The fruit physico-chemical properties, antioxidant activity and mineral contents of 26 pineapple [Ananas comosus (L.) Merr.] genotypes grown in China were measured. The results showed great quantitative differences in the composition of these pineapple genotypes. Sucrose was the dominant sugar

GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy.

Mengjie Li et al.

American journal of physiology. Renal physiology, 304(11), F1317-F1324 (2013-03-08)

Early diagnosis of diabetic nephropathy (DN) is difficult although it is of crucial importance to prevent its development. To probe potential markers and the underlying mechanism of DN, an animal model of DN, the db/db mice, was used and serum

Metabolic responses to iron deficiency in roots of Carrizo citrange [Citrus sinensis (L.) Osbeck. x Poncirus trifoliata (L.) Raf].

Mary-Rus Martínez-Cuenca et al.

Tree physiology, 33(3), 320-329 (2013-03-07)

The effects of iron (Fe) deficiency on the low-molecular-weight organic acid (LMWOA) metabolism have been investigated in Carrizo citrange (CC) [Citrus sinensis (L.) Osb. × Poncirus trifoliata (L.) Raf.] roots. Major LMWOAs found in roots, xylem sap and root exudates were citrate

Acetate Dissimilation and Assimilation in Mycobacterium tuberculosis Depend on Carbon Availability.

Nadine Rücker et al.

Journal of bacteriology, 197(19), 3182-3190 (2015-07-29)

Mycobacterium tuberculosis persists inside granulomas in the human lung. Analysis of the metabolic composition of granulomas from guinea pigs revealed that one of the organic acids accumulating in the course of infection is acetate (B. S. Somashekar, A. G. Amin

Chemical synthesis of lithium niobate powders (LiNbO3) prepared from water-soluble DL-malic acid complexes

Camargo ER and Kakihana M

Chemistry of Materials, 13(5), 1905-1909 (2001)

Krill Oil Ameliorates Mitochondrial Dysfunctions in Rats Treated with High-Fat Diet.

Alessandra Ferramosca et al.

BioMed research international, 2015, 645984-645984 (2015-08-25)

In recent years, several studies focused their attention on the role of dietary fats in the pathogenesis of hepatic steatosis. It has been demonstrated that a high-fat diet is able to induce hyperglycemia, hyperinsulinemia, obesity, and nonalcoholic fatty liver disease.

Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside.

Duoduo Chen et al.

Molecular microbiology, 87(6), 1237-1244 (2013-01-26)

Nicotine is an environmental toxicant in tobacco waste, imposing a serious hazard for human health. Some bacteria including Pseudomonas spp. strains are able to metabolize nicotine to non-toxic compounds. The pyrrolidine pathway of nicotine degradation in Pseudomonas putida S16 has

Activation of glycerol metabolic pathway by evolutionary engineering of Rhizopus oryzae to strengthen the fumaric acid biosynthesis from crude glycerol.

Di Huang et al.

Bioresource technology, 196, 263-272 (2015-08-09)

Rhizopus oryzae is strictly inhibited by biodiesel-based by-product crude glycerol, which results in low fumaric acid production. In this study, evolutionary engineering was employed to activate the glycerol utilization pathway for fumaric acid production. An evolved strain G80 was selected

Comparative proteome analysis reveals differential regulation of glycolytic and antioxidant enzymes in cortex and hippocampus exposed to short-term hypobaric hypoxia.

Narendra Kumar Sharma et al.

Journal of proteomics, 79, 277-298 (2013-01-15)

Hypoxia is one of the major stressors at high altitude. Exposure to hypobaric hypoxia induces several adverse consequences to the structural and functional integrity of brain. In an attempt to understand the proteome modulation, we used 2-DE coupled with MALDI-TOF/TOF

Development of a continuous bioconversion system using a thermophilic whole-cell biocatalyst.

Pham Huynh Ninh et al.

Applied and environmental microbiology, 79(6), 1996-2001 (2013-01-22)

The heat treatment of recombinant mesophilic cells having heterologous thermophilic enzymes results in the denaturation of indigenous mesophilic enzymes and the elimination of undesired side reactions; therefore, highly selective whole-cell catalysts comparable to purified enzymes can be readily prepared. However

Effect of saliva stimulants (Hybrin and malic acid) on cervical root surfaces in vitro.

G Anneroth et al.

Scandinavian journal of dental research, 88(3), 214-218 (1980-06-01)

Two saliva stimulating drugs, solutions of Hybrin and malic acid were in an in vitro study found to have a heavy demineralizing effect on the root surface of the dental hard tissue. Consequently the drugs cannot be recommended to patients

Final report on the safety assessment of Malic Acid and Sodium Malate.

Z Fiume

International journal of toxicology, 20 Suppl 1, 47-55 (2001-05-19)

Malic Acid functions in cosmetic formulations as a pH adjuster, and Sodium Malate functions as a skin conditioning agent-humectant. Malic Acid is reportedly used in almost 50 cosmetic formulations across a range of product types at low concentrations, whereas Sodium

Loss of sulfur dioxide and changes in some chemical properties of Malatya apricots (Prunus armeniaca L.) during sulfuring and drying.

Meltem Türkyılmaz et al.

Journal of the science of food and agriculture, 94(12), 2488-2496 (2014-01-22)

This study was conducted to determine the differences in some analytical properties of four apricot cultivars and to determine the changes in these analytical properties during sulfuring and sun-drying. There were significant differences in the contents of polyphenols, carotenoids and

Immobilization of malate dehydrogenase on carbon nanotubes for development of malate biosensor.

A Ruhal et al.

Cellular and molecular biology (Noisy-le-Grand, France), 58(1), 15-20 (2013-01-01)

An amperometric malic acid biosensor was developed by immobilizing malate dehydrogenase on multi-walled carbon nanotubes (MWCNT) coated on screen printed carbon electrode. The screen printed carbon electrode is made up of three electrodes viz., carbon as working, platinum as counter

The control of brain mitochondrial energization by cytosolic calcium: the mitochondrial gas pedal.

Frank Norbert Gellerich et al.

IUBMB life, 65(3), 180-190 (2013-02-13)

This review focuses on problems of the intracellular regulation of mitochondrial function in the brain via the (i) supply of mitochondria with ADP by means of ADP shuttles and channels and (ii) the Ca(2+) control of mitochondrial substrate supply. The

[Occurrence of alpha-alkyl-substituted malic acids, and beta-hydroxy-beta-alkyl-substituted dicarboxylic and tricarboxylic acid derivatives in normal urine (author's transl)].

M Spiteller et al.

Journal of chromatography, 164(3), 319-329 (1979-11-11)

Urine contains a number of alpha-hydroxy acids so far unknown to occur in biological liquids. Besides the already as urine constituent known methylmalic acid, also the ethyl, isopropyl and butyl derivatives of malic acid were found. Further metabolites in urine

Interactions between cranberries and fungi: the proposed function of organic acids in virulence suppression of fruit rot fungi.

Mariusz Tadych et al.

Frontiers in microbiology, 6, 835-835 (2015-09-01)

Cranberry fruit are a rich source of bioactive compounds that may function as constitutive or inducible barriers against rot-inducing fungi. The content and composition of these compounds change as the season progresses. Several necrotrophic fungi cause cranberry fruit rot disease

Reassessment of the transhydrogenase/malate shunt pathway in Clostridium thermocellum ATCC 27405 through kinetic characterization of malic enzyme and malate dehydrogenase.

M Taillefer et al.

Applied and environmental microbiology, 81(7), 2423-2432 (2015-01-27)

Clostridium thermocellum produces ethanol as one of its major end products from direct fermentation of cellulosic biomass. Therefore, it is viewed as an attractive model for the production of biofuels via consolidated bioprocessing. However, a better understanding of the metabolic

C-phycocyanin prevents cisplatin-induced mitochondrial dysfunction and oxidative stress.

Berenice Fernández-Rojas et al.

Molecular and cellular biochemistry, 406(1-2), 183-197 (2015-05-15)

The potential of C-phycocyanin (C-PC) to prevent cisplatin (CP)-induced kidney mitochondrial dysfunction was determined in CD-1 male mice. The CP-induced mitochondrial dysfunction was characterized by ultrastructural abnormalities and by decrease in the following parameters in isolated kidney mitochondria: adenosine diphosphate

Gas Chromatography-Quadrupole Time-of-Flight Mass Spectrometry-Based Determination of Isotopologue and Tandem Mass Isotopomer Fractions of Primary Metabolites for (13)C-Metabolic Flux Analysis.

Teresa Mairinger et al.

Analytical chemistry, 87(23), 11792-11802 (2015-10-30)

For the first time an analytical work flow based on accurate mass gas chromatography-quadrupole time-of-flight mass spectrometry (GC-QTOFMS) with chemical ionization for analysis providing a comprehensive picture of (13)C distribution along the primary metabolism is elaborated. The method provides a

Genetic and phytochemical analysis of the in vitro regenerated Pilosocereus robinii by ISSR, SDS-PAGE and HPLC.

Salah Khattab et al.

Gene, 533(1), 313-321 (2013-09-21)

Pilosocereus robinii is a rare species which is experiencing sudden population collapse. Identifying and developing effective conservation and management strategies to halt the forestall extinction of this species is crucial. The present study was conducted to assess the best conditions

Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis.

Jordan M Wilkins et al.

Aging, 12(14), 15134-15156 (2020-07-09)

Multiple sclerosis (MS) is a central nervous system inflammatory demyelinating disease and the most common cause of non-traumatic disability in young adults. Despite progress in the treatment of the active relapsing disease, therapeutic options targeting irreversible progressive decline remain limited.

Effect of organic acids on calcium phosphate nucleation and osteogenic differentiation of human mesenchymal stem cells on peptide functionalized nanofibers.

Danial Barati et al.

Langmuir : the ACS journal of surfaces and colloids, 31(18), 5130-5140 (2015-04-17)

Carboxylate-rich organic acids play an important role in controlling the growth of apatite crystals and the extent of mineralization in the natural bone. The objective of this work was to investigate the effect of organic acids on calcium phosphate (CaP)

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