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Amanda L A Mohr et al.
Journal of analytical toxicology, 38(7), 427-431 (2014-06-09)
Ongoing changes in the synthetic cannabinoid drug market create the need for relevant targeted immunoassays for rapid screening of biological samples. We describe the validation and performance characteristics of an enzyme-linked immunosorbent assay designed to detect use of one of
M Lotti et al.
Chemico-biological interactions, 119-120, 519-524 (1999-07-27)
Certain esterase inhibitors elicit or intensify the clinical expression of various insults to axons. This phenomenon was called promotion of axonopathies because these chemicals are not additive neurotoxicants nor do they interfere with the pharmacokinetics. Characterization of promotion was carried
Tamar L Greaves et al.
Physical chemistry chemical physics : PCCP, 17(4), 2357-2365 (2014-12-06)
A high-throughput approach was developed in order to prepare and dry a series of protic ionic liquids (PILs) from 48 Brønsted acid-base combinations. Many combinations comprised an alkyl carboxylic acid paired with an alkyl amine. Visual screens were developed to
D D Kuznetsov et al.
Expert opinion on pharmacotherapy, 2(6), 1009-1013 (2001-10-05)
The propensity of patients with carcinoma in situ (CIS) of the bladder to progress to invasive and metastatic disease is clearly established. Today, the standard therapy in treating patients with CIS of the bladder is intravesical bacillus Calmette-Guerin (BCG). Nevertheless
N B Gross et al.
Neuroscience, 199, 272-283 (2011-09-29)
Binge administration of the psychostimulant drug, methamphetamine (mAMPH), produces long-lasting structural and functional abnormalities in the striatum. mAMPH binges produce nonexocytotic release of dopamine (DA), and mAMPH-induced activation of excitatory afferent inputs to cortex and striatum is evidenced by elevated
Ramadan A Abuknesha et al.
The Analyst, 130(6), 956-963 (2005-05-25)
Previously unreported paraquat derivatives were prepared and used to develop enzyme-immunoassay methods for paraquat in serum and urine matrices. The study involved comparison of the effects of novel paraquat derivatives made of methyl and ethyl-4,4'-bipyridinium and cyanuric chloride (heterologous bridges)
Elisa Brasili et al.
The Journal of nutrition, 143(10), 1549-1557 (2013-08-16)
Age-related dysbioses of intestinal microbiota and decline in the overall metabolic homeostasis are frequently found in the elderly. Probiotic supplementation may represent a way to prevent or reduce the senescence-associated metabolic disorders. The present study evaluated the metabolic impact of
Le Xin et al.
ChemSusChem, 6(4), 674-686 (2013-03-05)
Herein, we report an effective approach to electricity storage in biofuels by selective electrocatalytic reduction of levulinic acid (LA) to high-energy-density valeric acid (VA) or γ-valerolactone (gVL) on a non-precious Pb electrode in a single-polymer electrolyte membrane electrocatalytic (flow) cell
Jan H Lui et al.
Cell, 184(2), 489-506 (2020-12-19)
Single-cell transcriptomics has been widely applied to classify neurons in the mammalian brain, while systems neuroscience has historically analyzed the encoding properties of cortical neurons without considering cell types. Here we examine how specific transcriptomic types of mouse prefrontal cortex
V U Täuber et al.
Arzneimittel-Forschung, 26(7b), 1492-1495 (1976-01-01)
Percutaneous absorption of 6alpha,9-difluor-11beta-hydroxy-16alpha-methyl-21-valeryloxy-1,4-pregnadience-3,20-dione (diflucortolone valerate, DFV, Nerisona), betamethasone 17-valerate (BV), beclomethasone dipropionate (BDP) and fluocinolone acetonide (FA) by damaged skin was examined on the backs of 4 healthy males from whom the stratum corneum had been removed by "stripping".
Daniel Girma Mulat et al.
Talanta, 143, 56-63 (2015-06-17)
In anaerobic digestion of organic matter, several metabolic pathways are involved during the simultaneous production and consumption of short-chain fatty acids (SCFA) in general and acetate in particular. Understanding the role of each pathway requires both the determination of the
S G Vhile et al.
Animal : an international journal of animal bioscience, 6(5), 807-814 (2012-05-09)
Different levels of dried Jerusalem artichoke were fed to entire male pigs 1 week before slaughter. The objective was to investigate the effect on skatole level in the hindgut and in adipose tissue, as well as the effect on microflora
Tim J C Jacob et al.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 48(1), 67-80 (2003-04-16)
A psychophysical detection test was used to measure the response of human subjects to 'good' and 'bad' smells. Different intensities and frequencies of odour stimulation were delivered by an olfactometer and the responses to a group of malodours (valeric acid
Mahesh Chemudupati et al.
Journal of virology, 94(16) (2020-05-29)
Butyrate is an abundant metabolite produced by gut microbiota. While butyrate is a known histone deacetylase inhibitor that activates expression of many genes involved in immune system pathways, its effects on virus infections and on the antiviral type I interferon
A Gysler et al.
Pharmaceutical research, 16(9), 1386-1391 (1999-09-25)
To investigate pharmacokinetic differences between the nonhalogenated double ester prednicarbate (PC) and the fluorinated monoester betamethasone 17-valerate (BM17V) their metabolism in human keratinocytes and fibroblasts as well as their permeation and biotransformation in reconstructed epidermis and excised human skin was
R Punnonen et al.
Journal of endocrinological investigation, 3(3), 217-221 (1980-07-01)
The occurence of high affinity and limited capacity estrogen receptors in skin specimens was investigated and the concentrations of cytoplasmic and nuclear receptors were studied in 14 normal and 22 castrated women. The skin estrogen receptor levels were low in
Bo Tjellström et al.
Scandinavian journal of gastroenterology, 47(12), 1454-1459 (2012-09-29)
Exclusive enteral nutrition (EEN) is a first-line treatment in children with active Crohn's disease (CD) but is seldom used in adults with active disease. The mode of action of EEN in suppressing mucosal inflammation is not fully understood, but modulation
Wolfram Gronwald et al.
Kidney international, 79(11), 1244-1253 (2011-03-11)
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (NMR) spectroscopy with support vector machine-based
S Kakishima et al.
Plant biology (Stuttgart, Germany), 13(3), 502-507 (2011-04-15)
During the second blooming of a cultivated Amorphophallus gigas Teijsm and Binnend in the Botanical Gardens of the University of Tokyo, the surface temperature of the inflorescence was measured using an infrared camera. Contrary to studies of other species in
Gamze Bora-Tatar et al.
Bioorganic & medicinal chemistry, 17(14), 5219-5228 (2009-06-13)
In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop the structure-activity relationships of carboxylic acid HDAC inhibitors. HDAC inhibition activities were
F H Nielsen et al.
Acta obstetricia et gynecologica Scandinavica, 56(4), 367-370 (1977-01-01)
The serum concentrations of triglycerides, cholesterol, and free glycerol were determined in 23 climacteric women, before and after the administration of three different steroid drugs. Each drug was given within a period of 12 weeks (3 cycles). Period I: Norgestrel
Joel G Davis et al.
The journal of physical chemistry. B, 119(29), 9417-9422 (2014-11-22)
Raman multivariate curve resolution (Raman-MCR), as well as quantum and classical calculations, are used to probe water structural changes in the hydration shells of carboxylic acids and tetraalkyl ammonium ions with various aliphatic chain lengths. The results reveal that water
Jelena M Vujić et al.
European journal of medicinal chemistry, 46(9), 4559-4565 (2011-08-16)
Platinum(II) complexes (1-4) with bidentate N,N'-ligands, O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid were synthesized and characterized by IR, (1)H NMR and (13)C NMR spectroscopy and elemental analysis. DFT calculations were performed for the complexes
F J Martínez Casado et al.
The journal of physical chemistry. B, 113(39), 12896-12902 (2009-09-10)
Lithium propanoate and pentanoate were characterized by DSC, single crystal and powder XRD and FTIR and impedance spectroscopies. Lithium propanoate presents a solid-to-solid transition (SII-SI) at T(ss) = (549.1 +/- 0.7) K on first heating that varies on the second
O Siddiqui et al.
Journal of pharmacokinetics and biopharmaceutics, 17(4), 405-424 (1989-08-01)
The permeation of triamcinolone, hydrocortisone, prednisolone, corticosterone, triamcinolone acetonide, testosterone, and betamethasone-17-valerate through excised human stratum corneum was quantified. The time course of permeation could be adequately described by a simple diffusion model suggesting that shunt transport may not be
Michael Sarlea et al.
ChemSusChem, 3(1), 85-90 (2009-11-20)
Nitriles act as important intermediates for the chemical industry and are accessible on a large scale through hydrocyanation or ammonoxidation. Nitrile hydrolysis yields amides and acids used in various applications. The conventional nitrile hydrolysis process relies on stoichiometric amounts of
Martin Koller et al.
Macromolecular bioscience, 7(2), 218-226 (2007-02-14)
Three different microbial wild-type strains are compared with respect to their potential as industrial scale polyhydroxyalkanoate (PHA) producers from the feed stock whey lactose. The halophilic archaeon Haloferax mediterranei as well as two eubacterial strains (Pseudomonas hydrogenovora and Hydrogenophaga pseudoflava)
May Lee Low et al.
Bioconjugate chemistry, 25(12), 2269-2284 (2014-11-11)
A new series of six Schiff bases derived from S-methyldithiocarbazate (SMDTC) and S-benzyldithiocarbazate (SBDTC) with methyl levulinate (SMML, SBML), levulinic acid (SMLA, SBLA), and 4-carboxybenzaldehyde (SM4CB, SB4CB) were reacted with copper(II), producing complexes of general formula ML2 (M = Cu(II)
C J L Silwood et al.
Journal of dental research, 81(6), 422-427 (2002-07-05)
We have explored the ability of high-resolution NMR techniques to (1) index salivary biomolecules and (2) provide valuable data regarding intra- and inter-subject variability in the concentrations of a series of components readily determinable by this technique (organic acids and
Adelene S M Wong et al.
Soft matter, 11(15), 2993-3002 (2015-03-04)
This study reports a novel nanoparticle system with simple and modular one-step assembly, which can respond intelligently to biologically relevant variations in pH. Importantly, these particles also show the ability to induce escape from the endosomal/lysosomal compartments of the cell
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