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Katsuya Dezaki et al.
Apoptosis : an international journal on programmed cell death, 17(8), 821-831 (2012-03-31)
Sustained rise in cytosolic Ca(2+) and cell shrinkage mainly caused by K(+) and Cl(-) efflux are known to be prerequisites to apoptotic cell death. Here, we investigated how the efflux of K(+) and Cl(-) as well as the rise in
Nishant Chetwani et al.
Analytical chemistry, 83(8), 3017-3023 (2011-03-23)
The novel effects resulting from the entrainment of low mobility ions during alternating current (ac) electrospray ionization are examined through mass spectrometry and voltage/current measurements. Curious phenomena such as pH modulation at high frequencies (>150 kHz) of an applied ac
Rebecca S Lam et al.
Biochimica et biophysica acta, 1667(2), 241-248 (2004-12-08)
Changes in the level of membrane cholesterol regulate a variety of signaling processes including those mediated by acylated signaling molecules that localize to lipid rafts. Recently several types of ion channels have been shown to have cholesterol-dependent activity and to
A S Ghatpande et al.
British journal of pharmacology, 132(8), 1755-1760 (2001-04-20)
Tetrapentylammonium (TPeA) block of rat brain type IIA sodium channel alpha subunit was studied using whole cell patch clamp. Results indicate that TPeA blocks the inactivating brain sodium channel in a potential and use-dependent manner similar to that of the
Chemical modification of polymers via phase transfer catalysis
Nishikubo T.
Handbook of Phase Transfer Catalysis, 480-509 (1997)
Quaternary Ammonium Salts as Alkylating Reagents in C-H Activation Chemistry.
Spettel M, et al.
Organic Letters, 19(16), 4287-4290 (2017)
Roger C Lo et al.
Bioanalysis, 4(6), 693-701 (2012-03-29)
Different markers have been used to label DNA for sample detection in gel electrophoresis. Intercalating dyes, (e.g., YOYO) have been widely used to label DNA for sample detection, because they do not require the use of radioisotopes, covalent attachment or
Quaternary ammonium salts as highly efficient and green alkylating agents for N-alkylation of azaheterocycles under microwave irradiation.
Khalafi-Nezhad A, et al.
Journal of the Iranian Chemical Society, 5(1), S40-S46 (2008)
Quantitative analysis of tetrapentylammonium-induced blockade of open N-methyl-D-aspartate channels.
A I Sobolevsky
Biophysical journal, 79(3), 1324-1335 (2000-09-02)
The blockade of open N-methyl-d-aspartate (NMDA) channels by tetrapentylammonium (TPentA) in acutely isolated rat hippocampal neurons was studied using whole-cell patch-clamp techniques. TPentA prevented the closure of the NMDA channel following what is known as the foot-in-the-door mechanism. Hooked tail
B Hennig et al.
British journal of pharmacology, 158(5), 1263-1275 (2009-09-30)
The aim of this study was to identify the actions of H(2)S on ion transport across rat distal colon. Changes in short-circuit current (Isc) induced by the H(2)S-donor, NaHS, were measured in Ussing chambers. Cytosolic Ca(2+) concentration was evaluated using
T L Constantopoulos et al.
Journal of the American Society for Mass Spectrometry, 10(7), 625-634 (1999-06-29)
The effect of salt concentration on analyte response using electrospray ionization mass spectrometry (ESI-MS) was measured and compared to that predicted by Enke's equilibrium partitioning model. The model predicts that analyte response will be proportional to concentration and that the
Novel catalyst based on Co-complex to prepare MWCNT.
Alonso-Nu?ez G, et al.
Materials Letters, 109, 163-166 (2013)
B Unsöld et al.
Pflugers Archiv : European journal of physiology, 441(2-3), 368-378 (2001-02-24)
Previous studies have shown that heteromultimeric KCNQ1/KCNE1 (KvLQT1/minK) channels and homomultimeric KCNQ1 (KvLQT1) channels exhibit different current properties, e.g. distinct kinetics and different sensitivities to drugs. In this study we report on the divergent responses to internal pH changes and
Shinghua Ding et al.
The Journal of general physiology, 126(3), 213-226 (2005-08-17)
The crystal structure of an open potassium channel reveals a kink in the inner helix that lines the pore (Jiang, Y.X., A. Lee, J.Y. Chen, M. Cadene, B.T. Chait, and R. MacKinnon. 2002. Nature 417:523-526). The putative hinge point is
Weng Zhanping et al.
Gynecologic oncology, 104(2), 455-460 (2006-10-04)
To study the role of Voltage-gated potassium ion channels (Kv) in cell proliferation and cell cycle of ovarian cancer cell. The effects of voltage-gate K+ channels on human ovarian cancer cell line (A2780 cell) proliferation and cell cycle were observed
Andrés Jara-Oseguera et al.
The Journal of general physiology, 132(5), 547-562 (2008-10-29)
The transient receptor potential vanilloid 1 (TRPV1) nonselective cationic channel is a polymodal receptor that activates in response to a wide variety of stimuli. To date, little structural information about this channel is available. Here, we used quaternary ammonium ions
A I Sobolevsky et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(24), 10611-10626 (1999-12-14)
Using whole-cell patch-clamp techniques, we studied the interaction of open NMDA channels with tetraalkylammonium compounds: tetraethylammonium (TEA), tetrapropylammonium (TPA), tetrabutylammonium (TBA), and tetrapentylammonium (TPentA). Analysis of the blocking kinetics, concentration, and agonist dependencies using a set of kinetic models allowed
B McNamara et al.
British journal of pharmacology, 131(7), 1373-1378 (2000-11-23)
1. We investigated the effect of oestradiol on basolateral potassium channels in human colonic epithelium. 2. Ion transport was quantified using short circuit current (I:(sc)) measurements of samples mounted in Ussing chambers. Serosal K transport was studied using nystatin permeabilization
Toru Takahashi et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 26(11), 1151-1156 (2010-11-17)
The effect of urea as an electrophoretic buffer solution modifier on the ion-association (IA) capillary electrophoresis (CE) separation of four anionic metal complexes of Al(III), Co(III), Cr(III), and Fe(III) with 2,2'-dihydroxyazobenezene-5,5'-disulfonate (DHABS) using a hydrophobic ion-association agent, tetrapentylammonium bromide, was
Markus Rapedius et al.
Channels (Austin, Tex.), 6(6), 473-478 (2012-09-20)
We previously reported that TREK-1 gating by internal pH and pressure occurs close to or within the selectivity filter. These conclusions were based upon kinetic measurements of high-affinity block by quaternary ammonium (QA) ions that appeared to exhibit state-independent accessibility
Joel G Davis et al.
The journal of physical chemistry. B, 119(29), 9417-9422 (2014-11-22)
Raman multivariate curve resolution (Raman-MCR), as well as quantum and classical calculations, are used to probe water structural changes in the hydration shells of carboxylic acids and tetraalkyl ammonium ions with various aliphatic chain lengths. The results reveal that water
J Su et al.
Pflugers Archiv : European journal of physiology, 442(1), 49-56 (2001-05-26)
The aim of the present study was to characterize depolarization-activated outward currents in insulin-secreting INS-1 cells and to investigate the role of K+ channels other than the KATP channels in the regulation of insulin release. Outward currents were inhibited by
Hassan Musa et al.
The Journal of physiology, 557(Pt 3), 863-878 (2004-04-27)
Connexin40 (Cx40) contains a specific binding site for spermine (affinity approximately 100 microm) whereas connexin43 (Cx43) is unaffected by identical concentrations of intracellular spermine. Replacement of two unique glutamate residues, E9 and E13, from the cytoplasmic amino terminal domain of
X Wang et al.
The Journal of pharmacology and experimental therapeutics, 295(2), 524-530 (2000-10-25)
Tetraethylammonium (TEA), the quaternary ammonium ion and nonselective K(+) channel blocker, is protective against neuronal apoptosis. We now tested two TEA analogs, tetrapentylammonium (TPeA) and tetrahexylammonium (THA), for their effects on apoptotic neuronal death and for their pharmacological profiles on
D Kumar et al.
Parasitology, 129(Pt 6), 779-793 (2005-01-15)
Fibres isolated from the ventral sucker of Fasciola hepatica were identified as muscle on the basis of their contractility, and their actin and myosin staining. They were voltage-clamped at a holding potential of -40 mV and depolarization-activated outward currents were
X Yao et al.
Life sciences, 65(1), 55-62 (1999-07-14)
Cell proliferation of carcinoma cells DLD-1 derived from colon cancer as measured by [3H] thymidine incorporation was drastically reduced in the presence of 4-aminopyridine, an inhibitors of voltage-gated K channel. A number of nonspecific K+ channel inhibitors including TPeA, TEA
Stefan Verlohren et al.
Hypertension (Dallas, Tex. : 1979), 44(3), 271-276 (2004-08-11)
Periadventitial adipose tissue produces vasoactive substances that influence vascular contraction. Earlier studies addressed this issue in aorta, a vessel that does not contribute to peripheral vascular resistance. We tested the hypothesis that periadventitial adipose tissue modulates contraction of smaller arteries
Simple Quaternary Ammonium Ions R 4 N+(R= nPr, nBu, nPen) as Versatile Structure Directors for the Synthesis of Zeolite-Like, Heterobimetallic Cyanide Frameworks.
Poll EM, et al.
Journal of Solid State Chemistry, 152(1), 286-301 (2000)
Maria G Signorello et al.
European journal of biochemistry, 270(9), 2005-2012 (2003-04-24)
The results of the present study show that human platelets take up l-arginine by two transport systems which are compatible with the systems y+ and y+L. These Na+independent transporters have been distinguished by treating platelets with N-ethylmaleimide that blocks selectively
The electrochemical synthesis of the graphite intercalation compounds containing tetra-n-alkylammonium cations.
Sirisaksoontorn W and Lerner MM.
Journal of Sol-Gel Science and Technology, 2(9), M28-M32 (2013)
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