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Dongxia Hou et al.
PloS one, 10(11), e0142442-e0142442 (2015-11-12)
Trophoblasts (TR) are specialized cells of the placenta and play an important role in embryo implantation. The in vitro culture of trophoblasts provided an important tool to investigate the mechanisms of implantation. In the present study, porcine trophoblast cells were
Radha Karki et al.
European journal of medicinal chemistry, 84, 555-565 (2014-07-26)
A series of eighteen trihydroxylated 2,4,6-triphenyl pyridines were designed and synthesized which contain hydroxyl groups at ortho, meta or para position of each phenyl rings attached to the central pyridine. They were evaluated for topoisomerase I and II inhibitory activity
Cheng-Feng Zhang et al.
The Journal of investigative dermatology, 135(5), 1348-1357 (2014-10-08)
Autophagy is the central cellular mechanism for delivering organelles and cytoplasm to lysosomes for degradation and recycling of their molecular components. To determine the contribution of autophagy to melanocyte (MC) biology, we inactivated the essential autophagy gene Atg7 specifically in
Manish M Khandagale et al.
Journal of chromatography. A, 1356, 180-187 (2014-07-09)
The solvent dependency of the detection response is a major limitation of corona-charged aerosol detection (C-CAD). The present study empirically investigates the utility of temperature and flow-rate gradients to overcome solvent gradient limitations of C-CAD. In preliminary flow-injection investigations, it
Y Lei et al.
Oncogene, 34(4), 485-495 (2014-02-18)
High expression of Ankyrin Repeat Domain 1 (ANKRD1) in ovarian carcinoma is associated with poor survival, and in ovarian cancer cell lines is associated with platinum resistance. Importantly, decreasing ANKRD1 expression using siRNA increases cisplatin sensitivity. In this study, we
Bin Dai et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 54-61 (2014-12-23)
A simple, rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for simultaneous determination of six components including apigenin, quercetin, apigenin-7-O-β-D-glucoside, quercetin-3-O-β-D-glucoside, 3'-methoxyluteolin-7-O-β-D-glucoside, and tricin-7-O-β-D-glucopyranoside in rat plasma using formononetin as the internal standard (IS). The
Qing Shen et al.
Food chemistry, 194, 508-515 (2015-10-17)
A micro-scale matrix solid-phase dispersion (MSPD) technique, using hydrophilic-lipophilic balance (HLB) material as sorbent and a pipette tip (PT) as the cartridge, was developed for the extraction and purification of sulfonamides in fish tissue. Eluates from PT-MSPD were analyzed using
Olumuyiwa N Adedeji et al.
Antimicrobial agents and chemotherapy, 59(9), 5114-5122 (2015-04-22)
Artemisinin-based combination therapies (ACTs) have been adopted by most African countries, including Nigeria, as first-line treatments for uncomplicated falciparum malaria. Fixed-dose combinations of these ACTs, amodiaquine-artesunate (FDC AQAS) and artemether-lumefantrine (AL), were introduced in Nigeria to improve compliance and achieve
Han Lin et al.
Biology of reproduction, 92(3), 77-77 (2015-01-23)
Cyclin-dependent kinase inhibitors p21(Cip1) (CDKN1A) and p27(Kip1) (CDKN1B) are expressed in Leydig cells. Previously, we reported that Cdkn1b knockout in the mouse led to increased Leydig cell proliferative capacity and lower steroidogenesis. However, the relative importance of CDKN1A and CDKN1B
Ai-Li Sun
The Analyst, 140(23), 7948-7954 (2015-10-27)
A new electrochemical immunosensor with signal enhancement was designed for sensitive detection of disease-related protein (human carbohydrate antigen 19-9, CA 19-9 used in this case). The assay was carried out on a capture antibody-modified screen-printed carbon electrode with a sandwich-type
Siddharth Jambhrunkar et al.
Molecular pharmaceutics, 11(10), 3642-3655 (2014-08-29)
Mesoporous silica nanoparticles (MCM-41) with different surface chemistry were used as carrier system to study its influence on drug delivery and anticancer activity of curcumin (CUR). CUR was encapsulated in pristine MCM-41 (hydrophilic and negatively charged), amino functionalized MCM-41 (MCM-41-NH2
Remco A Koster et al.
Therapeutic drug monitoring, 36(1), 35-45 (2013-09-28)
To facilitate the monitoring of drug abuse by patients, a method was developed and validated for fast and highly selective screening for amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine, methylenedioxyamphetamine, methylenedioxyethylamphetamine, methylphenidate, cocaine, benzoylecgonine, morphine, codeine, heroin, 6-monoacteylmorphine, methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, nicotine, and cotinine in
Anthony Tomlinson et al.
Molecular pharmaceutics, 12(11), 3805-3815 (2015-10-01)
Polysorbate 20 (PS20), a commonly used surfactant in biopharmaceuticals, showed degradation upon long-term (∼18-36 months) storage of two monoclonal antibody (mAb, mAb-A, and mAb-B) drug products at 2-8 °C. The PS20 degradation resulted in the accumulation of free fatty acids
Walter Hundt et al.
European radiology, 25(4), 1107-1118 (2014-11-30)
We investigated the effect of targeted gene therapy to melanoma tumours (M21) by MR-imaging. M21 and M21-L tumours were grown to a size of 850 mm(3). M21 and M21-L tumours were intravenously treated with an αvβ3-integrin-ligand-coupled nanoparticle (RGDNP)/RAF(-) complex five
S Orlandini et al.
Journal of chromatography. A, 1380, 177-185 (2015-01-15)
Quality by design (QbD) concepts, in accordance with International Conference on Harmonisation Pharmaceutical Development guideline Q8(R2), represent an innovative strategy for the development of analytical methods. In this paper QbD principles have been comprehensively applied in the set-up of a
Song Hee Choi et al.
BMB reports, 48(10), 565-570 (2015-03-06)
In several reports, the respiratory syncytial virus (RSV) was identified as an oncolytic virus in cancer cells (e.g., lung and prostate cancer). However, the effects of RSV in hepatocellular carcinoma (HCC) cells have not yet been investigated. Here, we observed
Sheue-Er Wang et al.
Clinical interventions in aging, 10, 1825-1837 (2015-11-27)
Neurodegeneration is characterized by progressive neurological deficits due to selective neuronal loss in the nervous system. Huntington's disease (HD) is an incurable neurodegenerative disorder. Neurodegeneration in HD patients shows aging-dependent pattern. Our previous study has suggested that a herbal formula
Esther Roselló-Lletí et al.
PloS one, 9(11), e112971-e112971 (2014-11-15)
Dilated cardiomyopathy (DCM) is a public health problem with no available curative treatment, and mitochondrial dysfunction plays a critical role in its development. The present study is the first to analyze the mitochondrial proteome in cardiac tissue of patients with
Ian Brown et al.
Shock (Augusta, Ga.), 43(1), 92-98 (2014-09-23)
Sepsis is a complex medical condition characterized by a systemic inflammatory response in the setting of infection. We hypothesized that combining antibiotics plus an immunosuppressant would protect against the morbidity and mortality of polymicrobial sepsis in mice better than would
Shahid Ullah et al.
Analytical chemistry, 87(22), 11553-11560 (2015-10-28)
An analytical method based on high-performance liquid chromatography coupled to quadrupole tandem mass spectrometry was developed for the quantitative determination of four phosphatidylcholines (PCs) in human exhaled breath particles. Analytes were conveniently collected on an electrostatic polymer filter and extracted
Tae Hwan Kim et al.
Journal of chromatographic science, 53(7), 1100-1106 (2014-12-20)
Chloroacetamide (CAA) is a preservative used in various cosmetic, personal care and household products. Due to the hazard potential for allergic reaction and reproductive toxicity, CAA is being considered a high priority for screening assessment and toxicological re-evaluation. This study
Sruthi Purushothaman et al.
Journal of proteomics, 112, 113-124 (2014-09-03)
The extensive arm regeneration of brittle stars following amputation is becoming increasingly recognized as a model system for understanding cellular differentiation and regeneration in a whole animal context. In this study we have used the emerging brittle star model Amphiura
Hasan Imam et al.
Pakistan journal of biological sciences : PJBS, 16(23), 1796-1800 (2014-02-11)
Previously it was reported elsewhere that Lawsonia inermis have anti-inflammatory and analgesic effect in experimental animals. The in vitro porcine alpha amylase inhibitory effect was investigated of this plant methanolic extracts and consequently hypoglycemic effect by quantitatively determining the maltose
Boyan Gao et al.
Journal of agricultural and food chemistry, 62(32), 8075-8084 (2014-07-23)
Ultraperformance liquid chromatography mass spectrometry (UPLC-MS), flow injection mass spectrometry (FIMS), and headspace gas chromatography (headspace-GC) combined with multivariate data analysis techniques were examined and compared in differentiating organically grown oregano from that grown conventionally. It is the first time
Ratchanee Kongkachuichai et al.
Food chemistry, 173, 838-846 (2014-12-04)
Evidence from epidemiological studies has strongly suggested that diets rich in fruits and vegetables play a vital role in disease prevention. The aim of this study was to determine nutrient and antioxidant content for 15 varieties of indigenous vegetables and
Zheng Guan et al.
Phytochemical analysis : PCA, 25(6), 508-513 (2014-04-17)
Perilla frutescens (L.) Britt., an essential traditional Asian crop and Chinese medicine, potentially exerts anti-oxidation effects through its phenolic compounds. These compounds have already been reported in perilla seed, however, little is reported in Perilla pomace, the primary waste during
Jianshe Ma et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 963, 24-28 (2014-06-13)
Solasodine is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. A simple and selective liquid chromatography mass spectrometry method for determination of solasodine in rat plasma was developed and validated over the range of 3-1,000
Nehal Ibrahim et al.
International journal of pharmaceutics, 495(2), 671-679 (2015-09-19)
More than 40 years after its discovery, artemisinin has become the most promising antimalarial agent. However, no intravenous formulation is available due to its poor aqueous solubility. Here, we report the preparation, characterization, and in vitro and in vivo biological
Mohamed R Berber et al.
Scientific reports, 5, 16711-16711 (2015-11-26)
Driven by the demand for the commercialization of fuel cell (FC) technology, we describe the design and fabrication of a highly durable FC electrocatalyst based on double-polymer-coated carbon nanotubes for use in polymer electrolyte membrane fuel cells. The fabricated electrocatalyst
Zhiqian Liu et al.
Journal of dairy science, 98(12), 8473-8485 (2015-10-20)
The n-3 long-chain polyunsaturated fatty acids (LC-PUFA) are low-abundance components in milk fat, but have great potential in promoting human health. A comprehensive survey on triacylglycerol (TAG) molecular species in milk that contain at least one type of n-3 LC-PUFA
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