247-361-2

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Hepatic transcriptome and proteome responses against diethyl maleate-induced glutathione depletion in the rat.

Shusuke Yamauchi et al.

Archives of toxicology, 85(9), 1045-1056 (2010-12-17)

Hepatic transcriptome and proteome responses against glutathione depletion were investigated by Affymetrix GeneChip Microarray and 2-dimensional gel electrophoresis (2D-DIGE), followed by MALDI-TOF-MS analysis and utilizing a glutathione-depleted rat model treated with diethyl maleate (DEM). Hepatic glutathione content decreased to 1.29 μmol/g

Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats.

Liu Liu et al.

American journal of physiology. Renal physiology, 301(6), F1195-F1201 (2011-08-26)

Renin expression in principal cells of collecting ducts (CD) is upregulated in angiotensin II (ANG II)-dependent hypertensive rats; however, it remains unclear whether increased CD-derived renin undergoes tubular secretion. Accordingly, urinary levels of renin (uRen), angiotensinogen (uAGT), and ANG II

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