261-277-3

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Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists.

Irina D Pogozheva et al.

Biochemistry, 44(34), 11329-11341 (2005-08-24)

Specific interactions of human melanocortin-4 receptor (hMC4R) with its nonpeptide and peptide agonists were studied using alanine-scanning mutagenesis. The binding affinities and potencies of two synthetic, small-molecule agonists (THIQ, MB243) were strongly affected by substitutions in transmembrane alpha-helices (TM) 2

Acute and repeated vapor exposure toxicology of 3-(methylthio)propionaldehyde.

B Ballantyne et al.

Veterinary and human toxicology, 42(6), 330-336 (2000-12-09)

Because of its vapor pressure (0.6 torr at 20 C) there is a potential for vapor exposure to 3-(methylthio)propionaldehyde (3-MTP) vapor. Liquid 3-MTP may contain trace amounts of acrolein (up to 0.1%), and therefore acrolein vapor may also be present.

Effects of modified sham feeding on ghrelin levels in healthy human subjects.

Maura Arosio et al.

The Journal of clinical endocrinology and metabolism, 89(10), 5101-5104 (2004-10-09)

The mechanisms involved in the preprandial rise and postprandial fall of circulating ghrelin levels are as yet unknown. Many hormonal and metabolic responses to nutrient intake begin during the cephalic or preabsorptive phase and are mostly mediated by the autonomous

Impact of estrogen replacement therapy in a male with congenital aromatase deficiency caused by a novel mutation in the CYP19 gene.

Burkhard Lorenz Herrmann et al.

The Journal of clinical endocrinology and metabolism, 87(12), 5476-5484 (2002-12-06)

Recent reports of the impact of estrogen receptor alpha and aromatase deficiency have shed new light on the importance of estrogen for bone formation in man. We describe a novel mutation of the CYP19 gene in a 27-yr-old homozygous male

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