270989

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Practical aspects in gas chromatography-mass spectrometry for the analysis of pesticide residues in exotic fruits.

Julio César España Amórtegui et al.

Food chemistry, 182, 14-22 (2015-04-07)

The most relevant parameters of a multimode inlet were optimized to increase the injection volume up to 25 μL using solvent vent mode in order to improve the sensitivity of the gas chromatography-mass spectrometry system. Consequently, the implementation of a

Fructose- and glucose-conditioned preferences in FVB mice: strain differences in post-oral sugar appetition.

Anthony Sclafani et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 307(12), R1448-R1457 (2014-10-17)

Recent studies indicate that, unlike glucose, fructose has little or no post-oral preference conditioning actions in C57BL/6J (B6) mice. The present study determined whether this is also the case for FVB mice, which overconsume fructose relative to B6 mice. In

Preparation and biodistribution of 1-((2-methoxyphenyl) piperazine)ferrocenecarboxamide labeled with technetium-99m as a potential brain receptor imaging agent.

Nadia Malek Saied et al.

European journal of medicinal chemistry, 97, 280-288 (2015-05-21)

The goal of this study is to develop a novel brain receptor imaging agent. This study reports the synthesis, characterization and the biological evaluation of 1-((2-methoxyphenyl) piperazine)ferrocenecarboxamide labeled with technetium-99 m ((99m)Tc-MP). The (99m)Tc-MP was obtained quickly (radiolabelling time < 5 min), in 90%

Antineoplastic drug contamination in the urine of Canadian healthcare workers.

Chun-Yip Hon et al.

International archives of occupational and environmental health, 88(7), 933-941 (2015-01-30)

The purpose of this study was to quantify the urine concentration of non-metabolized cyclophosphamide (CP), a commonly administered antineoplastic drug, among potentially exposed Canadian healthcare workers and to identify factors associated with the drug concentration levels. Participants were asked to

Preparative separation and identification of novel subsidiary colors of the color additive D&C Red No. 33 (Acid Red 33) using spiral high-speed counter-current chromatography.

Adrian Weisz et al.

Journal of chromatography. A, 1380, 120-129 (2015-01-17)

Three low-level subsidiary color impurities (A, B, and C) often present in batches of the color additive D&C Red No. 33 (R33, Acid Red 33, Colour Index No. 17200) were separated from a portion of R33 by spiral high-speed counter-current

Antimicrobial activities of actinomycetes isolated from unexplored regions of Sundarbans mangrove ecosystem.

Sohan Sengupta et al.

BMC microbiology, 15, 170-170 (2015-08-22)

New broad spectrum antimicrobial agents are urgently needed to combat frequently emerging multi drug resistant pathogens. Actinomycetes, the most talented group of microorganisms isolated from unexplored regions of the world may be the ultimate solution to this problem. Thus the

Antibiofilm Activity of the Brown Alga Halidrys siliquosa against Clinically Relevant Human Pathogens.

Alessandro Busetti et al.

Marine drugs, 13(6), 3581-3605 (2015-06-10)

The marine brown alga Halidrys siliquosa is known to produce compounds with antifouling activity against several marine bacteria. The aim of this study was to evaluate the antimicrobial and antibiofilm activity of organic extracts obtained from the marine brown alga

Analysis of triterpenoids and phytosterols in vegetables by thin-layer chromatography coupled to tandem mass spectrometry.

Katerina Naumoska et al.

Journal of chromatography. A, 1381, 229-238 (2015-01-20)

Three TLC methods were used for an initial screening of some common plant triterpenoids and phytosterols in cuticular wax extracts of different vegetables (zucchini, eggplant, tomato, red pepper, mangold, spinach, lettuce, white-colored radicchio di Castelfranco, raddichio Leonardo, white cabbage, red

The glyoxylate shunt is essential for CO2-requiring oligotrophic growth of Rhodococcus erythropolis N9T-4.

Takanori Yano et al.

Applied microbiology and biotechnology, 99(13), 5627-5637 (2015-03-10)

Rhodococcus erythropolis N9T-4 shows extremely oligotrophic growth requiring atmospheric CO2 and forms its colonies on an inorganic basal medium (BM) without any additional carbon source. Screening of a random mutation library constructed by a unique genome deletion method that we

Investigating the influence of pH, temperature and agitation speed on yellow pigment production by Penicillium aculeatum ATCC 10409.

Majid Afshari et al.

Natural product research, 29(14), 1300-1306 (2015-01-09)

In this study, the combined effect of pH, temperature and agitation speed on yellow pigment production and mycelial growth of Penicillium aculeatum ATCC 10409 was investigated in whey media. Different pH levels (5, 6.5 and 8), temperatures (25, 30 and

Development of simplified HPLC methods for the detection of counterfeit antimalarials in resource-restraint environments.

Ludwig Hoellein et al.

Journal of pharmaceutical and biomedical analysis, 98, 434-445 (2014-07-13)

Regular quality control and post-marketing surveillance of pharmaceuticals has been a critical challenge for countries of the developing world ever since. Counterfeit and substandard medicines are widely distributed and the real extent of their prevalence still remains unknown. Compendial protocols

Detection and characterization of betamethasone metabolites in human urine by LC-MS/MS.

Xavier Matabosch et al.

Drug testing and analysis, 7(8), 663-672 (2014-12-30)

Glucocorticosteroids are prohibited in sports when administered by systemic routes and allowed using other administrations for therapeutic reasons. Therefore, markers to distinguish between routes of administration through the analysis of urine samples are needed in anti-doping control. As a first

Automated direct-immersion solid-phase microextraction using crosslinked polymeric ionic liquid sorbent coatings for the determination of water pollutants by gas chromatography.

María Cordero-Vaca et al.

Analytical and bioanalytical chemistry, 407(16), 4615-4627 (2015-05-01)

Four different crosslinked polymeric ionic liquid (PIL)-based sorbent coatings were evaluated in an automated direct-immersion solid-phase microextraction method (automated DI-SPME) in combination with gas chromatography (GC). The crosslinked PIL coatings were based on vinyl-alkylimidazolium- (ViCnIm-) or vinylbenzyl-alkylimidazolium- (ViBzCnIm-) IL monomers

Investigations into the decomposition of aminoacyl-substituted monosaccharide scaffolds from a drug discovery library.

Q Q He et al.

Organic & biomolecular chemistry, 13(13), 4070-4079 (2015-03-05)

This study investigated the unexpected decomposition and associated intermediates of compound 1, a specific member of a drug discovery library based on a monosaccharide scaffold. LC/MS and NMR spectroscopic analyses indicated that, under acidic conditions, 1 can be converted into

Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site.

Hannelore Rücker et al.

Organic & biomolecular chemistry, 13(10), 3040-3047 (2015-01-27)

Inflammatory signaling pathways orchestrate the cellular response to infection and injury. These pathways are known to be modulated by compounds that alkylate cysteinyl thiols. One class of phytochemicals with strong thiol alkylating activity is the chalcones. In this study we

Sugar composition of the pectic polysaccharides of charophytes, the closest algal relatives of land-plants: presence of 3-O-methyl-D-galactose residues.

Christina O'Rourke et al.

Annals of botany, 116(2), 225-236 (2015-06-27)

During evolution, plants have acquired and/or lost diverse sugar residues as cell-wall constituents. Of particular interest are primordial cell-wall features that existed, and in some cases abruptly changed, during the momentous step whereby land-plants arose from charophytic algal ancestors. Polysaccharides

Critical chromatography in ternary solvents.

Matthäus Mlynek et al.

Journal of chromatography. A, 1284, 112-117 (2013-03-08)

The behaviour of PMMA standards in mixtures composed of two binary critical eluents was investigated. It was found that combinations of two critical eluents do not result in a molar mass independent elution (critical conditions). When mixing two binary critical

Multivariate data analysis and metabolic profiling of artemisinin and related compounds in high yielding varieties of Artemisia annua field-grown in Madagascar.

John Suberu et al.

Journal of pharmaceutical and biomedical analysis, 117, 522-531 (2015-10-18)

An improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) protocol for rapid analysis of co-metabolites of A. annua in raw extracts was developed and extensively characterized. The new method was used to analyse metabolic profiles of 13 varieties of A. annua from

Enhancement of oral bioavailability of tripterine through lipid nanospheres: preparation, characterization, and absorption evaluation.

Xingwang Zhang et al.

Journal of pharmaceutical sciences, 103(6), 1711-1719 (2014-04-05)

Oral delivery of anticancer drugs remains challenging because of limited water-solubility and/or poor permeability. Here, we aimed to enhance the oral bioavailability of tripterine (TRI, a plant-derived anticancer compound) using lipid nanospheres (LNs) and to determine the mechanisms of oral

Rh2 (S-1,2-NTTL)4 : A novel Rh2 (S-PTTL)4 analog with lower ligand symmetry for asymmetric synthesis of chiral cyclopropylphosphonates.

Frady G Adly et al.

Chirality, 26(11), 764-774 (2014-07-22)

A new series of dirhodium(II) tetracarboxylate was derived from N-1,2-naphthaloyl-(S)-amino acid ligands. In terms of enantioselectivity, Rh2 (S-1,2-NTTL)4 () derived from N-1,2-naphthaloyl-(S)-tert-leucine, was the best-performing catalyst among the new series in the enantioselective synthesis of cyclopropylphosphonate derivatives (up to >99%

New polyhydroxylated sterols from Palythoa tuberculosa and their apoptotic activity in cancer cells.

Abdulrahman M Elbagory et al.

Steroids, 101, 110-115 (2015-06-23)

The chemical study on the total extract of the zoanthid Palythoa tuberculosa, collected from the Red Sea, resulted in the isolation of seven polyhydroxylated sterols (1-7), six of which, palysterols A-F (2-7), are new. Their chemical structures were elucidated on

Detection and characterization of triamcinolone acetonide metabolites in human urine by liquid chromatography/tandem mass spectrometry after intramuscular administration.

Xavier Matabosch et al.

Rapid communications in mass spectrometry : RCM, 28(16), 1829-1839 (2015-01-07)

Glucocorticosteroids are prohibited in sports when used by systemic administrations (e.g. intramuscular, IM), whereas they are allowed using other ways of administration. Strategies to discriminate between administrations routes have to be developed by doping control laboratories. For this reason, the

Rapid and sensitive multiresidue analysis of pesticides in tobacco using low pressure and traditional gas chromatography tandem mass spectrometry.

Zareen S Khan et al.

Journal of chromatography. A, 1418, 228-232 (2015-10-04)

Public exposure to pesticide residues through the main/side-stream smoke of tobacco (Nicotiana tabacum L.) is an international concern. This article reports optimization and validation of large-scale multiresidue analysis methods involving low pressure and traditional gas chromatography tandem mass spectrometry in

Aspects of surface scanning by direct analysis in real time mass spectrometry employing plasma glow visualization.

Elena S Chernetsova et al.

Rapid communications in mass spectrometry : RCM, 29(13), 1242-1252 (2015-09-24)

Visual monitoring of the Direct Analysis in Real Time (DART) gas impact region during sampling was demonstrated via its metastable plasma glow. It is known that adding neon into helium for DART leads to plasma glow, but this effect has

Concentrations of Contaminants with Regulatory Limits in Samples of Clam (Chamelea gallina) Collected along the Abruzzi Region Coast in Central Italy.

Pierina Visciano et al.

Journal of food protection, 78(9), 1719-1728 (2015-09-01)

Concentrations of pollutants with regulatory limits were determined in specimens of Chamelea gallina, a species of clam collected along the Abruzzi coastal region of the central Adriatic Sea. Nine sampling sites were selected to evaluate the distribution of contaminants in

Development and application of a non-targeted extraction method for the analysis of migrating compounds from plastic baby bottles by GC-MS.

Matthias Onghena et al.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 31(12), 2090-2102 (2014-11-20)

In 2011, the European Union prohibited the production of polycarbonate (PC) baby bottles due to the toxic effects of the PC monomer bisphenol-A. Therefore, baby bottles made of alternative materials, e.g. polypropylene (PP) or polyethersulphone (PES), are currently marketed. The

Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin Pill following oral administration to mice.

Huimei Huang et al.

Journal of ethnopharmacology, 161, 175-185 (2014-09-10)

Shexiang Baoxin Pill (SBP) is a well-known composite formula of traditional Chinese medicine (TCM), widely used to treat cardiovascular diseases such as angina pectoris and myocardial infarction. Bufadienolides are major active compounds of Venenum Bufonis, which is one of the

Formulation development and evaluation of the anti-malaria properties of sustained release artesunate-loaded solid lipid microparticles based on phytolipids.

E E Chinaeke et al.

Drug delivery, 22(5), 652-665 (2014-02-01)

CONTEXTS: Artemisinins and its derivatives are considered the basis in the treatment of Plasmodium falciparum malaria due to their high potency and rapid action. However, they have short half life, low solubility, and poor oral bioavailability, hence the need to

Fabrication of doxorubicin-loaded ellipsoid micelle based on diblock copolymer with a linkage of enzyme-cleavable peptide.

Haitao Huang et al.

Colloids and surfaces. B, Biointerfaces, 133, 362-369 (2015-07-06)

In this study, a novel micellar drug carrier was fabricated from an amphiphilic diblock copolymer containing poly (ethylene glycol) monomethyl ether (mPEG) and stearic moiety (C18) with a linkage of valine-citrulline (VC), which can be cleaved by cathepsin B (CB)

Propylthiouracil quantification in human plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry: application in a bioequivalence study.

Gustavo D Mendes et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 969, 19-28 (2014-08-26)

A rapid, sensitive and specific method for quantifying propylthiouracil in human plasma using methylthiouracil as the internal standard (IS) is described. The analyte and the IS were extracted from plasma by liquid-liquid extraction using an organic solvent (ethyl acetate). The

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