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Akira Kotani et al.
Journal of pharmaceutical and biomedical analysis, 97, 47-53 (2014-05-13)
The effects of hyperglycemia on the pharmacokinetics of valproic acid (VPA) were examined by time-concentration profiles of plasma VPA accompanied with blood glucose (BG) changing. In addition, time-concentration profiles of plasma free fatty acids (FFAs) were also obtained to examine
Takuya Kitamura et al.
The Biochemical journal, 465(1), 79-87 (2014-10-07)
Aldehyde dehydrogenases (ALDHs) catalyse the conversion of toxic aldehydes into non-toxic carboxylic acids. Of the 21 ALDHs in mice, it is the ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2 and ALDH3B3) that are responsible for the removal of lipid-derived aldehydes.
Liliana M R Silva et al.
Parasitology research, 114(1), 113-124 (2014-10-24)
Eimeria arloingi infections can cause severe haemorrhagic enteritis in young goat kids, thereby leading to high economic losses in goat industry worldwide. We aimed to isolate a new E. arloingi strain and establish a suitable in vitro culture system for
Jason Nardella et al.
Archives of biochemistry and biophysics, 579, 73-84 (2015-06-04)
The gypsy moth utilizes a pheromone, (7R,8S)-2-methyl-7,8-epoxyoctadecane, for mate location. The pheromone is detected by sensory hairs (sensilla) on the antennae of adult males. Sensilla contain the dendrites of olfactory neurons bathed in lymph, which contains pheromone binding proteins (PBPs).
Neslihan Ustündağ-Okur et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 204-215 (2014-08-12)
The objective of this study was to explore the potential of the nanostructured lipid carriers (NLCs) modified with chitosan oligosaccharide lactate (COL) for topical ocular application. Ofloxacin (OFX) loaded NLCs were prepared by microemulsion or high shear homogenization methods. For
Stephanie Phan et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 117-124 (2015-07-28)
Lipid-based formulations are gaining interest for use as drug delivery systems for poorly water-soluble drug compounds. During digestion, the lipolysis products self-assemble with endogenous surfactants in the gastrointestinal tract to form colloidal structures, enabling enhanced drug solubilisation. Although earlier studies
Zizwe A Chase et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(46), 16541-16546 (2015-09-26)
The state of Ni supported on HZSM-5 zeolite, silica, and sulfonated carbon was studied during aqueous-phase catalysis of phenol hydrodeoxygenation using in situ extended X-ray absorption fine structure spectroscopy. On sulfonated carbon and HZSM-5 supports, NiO and Ni(OH)2 were readily
Jin Han et al.
ACS nano, 9(3), 2805-2819 (2015-02-18)
Electrophysiological phenotype development and paracrine action of mesenchymal stem cells (MSCs) are the critical factors that determine the therapeutic efficacy of MSCs for myocardial infarction (MI). In such respect, coculture of MSCs with cardiac cells has windowed a platform for
UV-curable nanocomposite based on methacrylic-siloxane resin and surface-modified TiO2 nanocrystals.
Chiara Ingrosso et al.
ACS applied materials & interfaces, 7(28), 15494-15505 (2015-07-08)
A novel UV-light-curable nanocomposite material formed of a methacrylic-siloxane resin loaded with 1 wt % oleic acid and 3-(trimethoxysilyl)propyl methacrylate silane (OLEA/MEMO)-coated TiO2 nanorods (NRs) has been manufactured as a potential self-curing structural coating material for protection of monuments and
Song Ye et al.
Dalton transactions (Cambridge, England : 2003), 44(35), 15583-15590 (2015-08-06)
The pH value plays an important role in controlling the crystallization process and microstructure of the final products in the synthesis of nanocrystals with a solvothermal method. This work reported the effect of the mother solution pH value on the
Konstanze Steiner et al.
Toxicology and applied pharmacology, 280(3), 534-542 (2014-09-15)
Cyanobacterial blooms have an impact on the aquatic ecosystem due to the production of toxins (e.g. microcystins, MCs), which constrain fish health or even cause fish death. However the toxicokinetics of the most abundant toxin, microcystin-LR (MC-LR), are not yet
Bettina Mittendorfer et al.
Diabetes, 52(7), 1641-1648 (2003-06-28)
We evaluated the validity of using a single fatty acid tracer to assess total plasma long-chain free fatty acid (FFA) kinetics and the relationship between the rate of appearance (R(a)) of fatty acids in plasma and the fatty acid composition
Michael Chorny et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(6), 2198-2206 (2013-02-15)
Gene therapeutic strategies have shown promise in treating vascular disease. However, their translation into clinical use requires pharmaceutical carriers enabling effective, site-specific delivery as well as providing sustained transgene expression in blood vessels. While replication-deficient adenovirus (Ad) offers several important
Yuan Z Feng et al.
American journal of physiology. Cell physiology, 308(7), C548-C556 (2015-01-23)
Exercise improves insulin sensitivity and oxidative capacity in skeletal muscles. However, the effect of exercise on substrate oxidation is less clear in obese and type 2 diabetic subjects than in lean subjects. We investigated glucose and lipid metabolism and gene
Xuping Wang et al.
Biochemical and biophysical research communications, 460(2), 392-396 (2015-03-19)
More and more industrial chemistry reactions rely on green technologies. Enzymes are finding increasing use in diverse chemical processes. Epoxidized vegetable oils have recently found applications as plasticizers and additives for PVC production. We report here an unusual activity of
Ayman M Atta et al.
Molecules (Basel, Switzerland), 20(1), 1244-1261 (2015-01-17)
This work presents a new method to prepare poly(sodium acrylate) magnetite composite nanoparticles. Core/shell type magnetite nanocomposites were synthesized using sodium acrylate as monomer and N,N-methylenebisacrylamide (MBA) as crosslinker. Microemulsion polymerization was used for constructing core/shell structures with magnetite nanoparticles
J R Kumar et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 168, 28-38 (2014-12-06)
Three isoenzymes of phospholipase A2 (PLA2), VRV-PL-IIIc, VRV-PL-VII, and VRV-PL-IX were isolated from Daboia russelii snake venom. The venom, upon gel filtration on Sephadex G-75 column, resolved into six peaks (DRG75 I-VI). The VRV-PL-IIIc was purified by subjecting DRG75II to
E Zamora-Rojas et al.
Meat science, 95(3), 503-511 (2013-06-25)
A handheld micro-electro-mechanical system (MEMS) based spectrometer working in the near infrared region (NIR) (1600-2400nm) was evaluated for in-situ and non-destructive prediction of main fatty acids in Iberian pig (IP) carcasses. 110 IP carcasses were measured. Performance of the instrument
Konstantin N Belosludtsev et al.
Biochimica et biophysica acta, 1838(10), 2600-2606 (2014-07-06)
In the present work, we examine and compare the effects of saturated (palmitic) and unsaturated (oleic) fatty acids in relation to their ability to cause the Ca(2+)-dependent membrane permeabilization. The results obtained can be summarized as follows. (1) Oleic acid
Kamla Pathak et al.
Clinical pharmacokinetics, 54(4), 325-357 (2015-02-11)
The delivery of drugs through the oral route is regarded as most optimal to achieve desired therapeutic effects and patient compliance. However, poor pharmacokinetic profiles of oral drug candidates remains an area of concern, and approaches to enhance their bioavailability
Ekta Lachmandas et al.
PloS one, 10(2), e0117941-e0117941 (2015-02-11)
Type 2 diabetes mellitus is an established risk factor for tuberculosis but the underlying mechanisms are largely unknown. We examined the effects of hyperglycaemia, a hallmark of diabetes, on the cytokine response to and macrophage infection with Mycobacterium tuberculosis. Increasing
Yi Tong et al.
Scientific reports, 5, 16761-16761 (2015-11-17)
The advent of flexible optoelectronic devices has accelerated the development of semiconducting polymeric materials. We seek to replace conventional expensive semiconducting photodetector materials with our cost-effective composite system. We demonstrate in this work the successful fabrication of a photoconductive composite
G Hoffmann et al.
Clinical chemistry, 35(4), 587-595 (1989-04-01)
This new method for qualitative and quantitative determination of organic acids, aldehydes, and ketones in biological samples is effective for use with urine, plasma, and amniotic fluid, and it requires no deproteinization. Isolation by batch-wise liquid partition chromatography on silicic
Marija Stojanović et al.
Biotechnology and applied biochemistry, 62(4), 458-466 (2014-09-17)
Fatty acid (FA) ascorbyl esters are recently emerging food, cosmetic, and pharmaceutical additives, which can be prepared in an eco-friendly way by using lipases as catalysts. Because they are amphiphilic molecules, which possess high free radical scavenging capacity, they can
Eunjae Jung et al.
International journal of pharmaceutics, 487(1-2), 49-55 (2015-04-12)
The aim of this study was to develop drug-in adhesive (DIA) patch formulations for the transdermal delivery of fluoxetine (FX). The DIA patch formulations containing FX were prepared and optimized with various pressure sensitive adhesives, drug contents and enhancers. Among
Suzanne M Caliph et al.
The Journal of pharmacy and pharmacology, 66(10), 1377-1387 (2014-05-14)
To assess the role of intestinal lymphatic transport in the oral bioavailability and brain deposition of a highly lipophilic, centrally acting drug candidate (Org 49209) in comparison to cholesterol, a close structural analogue. The intestinal lymphatic transport of Org 49209
Robin P da Silva et al.
Biochimica et biophysica acta, 1841(11), 1639-1646 (2014-09-11)
Non-alcoholic fatty liver disease encompasses a wide spectrum of liver damage including steatosis, non-alcoholic steatohepatitis, fibrosis and cirrhosis. We have previously reported that creatine supplementation prevents hepatic steatosis and lipid peroxidation in rats fed a high-fat diet. In this study
Lin Han et al.
Dalton transactions (Cambridge, England : 2003), 43(31), 11981-11987 (2014-06-28)
Phase transfer techniques possess remarkable advantages for the synthesis of inorganic nanomaterials. In contrast to the abundant reports on the preparation of noble metal nanoparticles using phase transfer, the number of semiconductor nanocrystals syntheses based on phase transfer techniques is
Jing Tang et al.
Nanoscale, 7(35), 14752-14759 (2015-08-20)
Red upconversion luminescence (UCL) is selectively enhanced by about 7 times via Fe(3+) codoping into a NaYF4:Yb,Er nanocrystalline lattice. The maximum red-to-green ratio (R/G) as well as the overall integrated UCL intensity features at an Fe(3+) content of 20 mol%.
Karen Kleberg et al.
The Journal of physiology, 593(8), 2097-2109 (2015-02-03)
Sensing of dietary triacylglycerol in the proximal small intestine results in physiological, hormonal and behavioural responses. However, the exact physiological pathways linking intestinal fat sensing to food intake and the activation of brain circuits remain to be identified. In this
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