27920

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Single Molecule Enzymology (2011)

Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis.

Sameh S M Soliman et al.

Nature microbiology, 6(3), 313-326 (2021-01-20)

Fungi of the order Mucorales cause mucormycosis, a lethal infection with an incompletely understood pathogenesis. We demonstrate that Mucorales fungi produce a toxin, which plays a central role in virulence. Polyclonal antibodies against this toxin inhibit its ability to damage

Flanking Regions Determine the Structure of the Poly-Glutamine in Huntingtin through Mechanisms Common among Glutamine-Rich Human Proteins.

Annika Urbanek et al.

Structure (London, England : 1993), 28(7), 733-746 (2020-05-14)

The causative agent of Huntington's disease, the poly-Q homo-repeat in the N-terminal region of huntingtin (httex1), is flanked by a 17-residue-long fragment (N17) and a proline-rich region (PRR), which promote and inhibit the aggregation propensity of the protein, respectively, by

A reconstituted cell-free assay for the evaluation of the intrinsic activity of purified human ribosomes

Penzo M, et al.

Nature Protocols, 11(7), 1309-1309 (2016)

Internal friction controls active ciliary oscillations near the instability threshold.

Debasmita Mondal et al.

Science advances, 6(33), eabb0503-eabb0503 (2020-08-28)

Ciliary oscillations driven by molecular motors cause fluid motion at micron scale. Stable oscillations require a substantial source of dissipation to balance the energy input of motors. Conventionally, it stems from external fluid. We show, in contrast, that external fluid

Determination of total creatine kinase activity in blood serum using an amperometric biosensor based on glucose oxidase and hexokinase.

I S Kucherenko et al.

Talanta, 144, 604-611 (2015-10-11)

Creatine kinase (CK: adenosine-5-triphosphate-creatine phosphotransferase) is an important enzyme of muscle cells; the presence of a large amount of the enzyme in blood serum is a biomarker of muscular injuries, such as acute myocardial infarction. This work describes a bi-enzyme

Variability in the Munc13-1 content of excitatory release sites.

Maria Rita Karlocai et al.

eLife, 10 (2021-04-28)

The molecular mechanisms underlying the diversity of cortical glutamatergic synapses are still incompletely understood. Here, we tested the hypothesis that presynaptic active zones (AZs) are constructed from molecularly uniform, independent release sites (RSs), the number of which scales linearly with

W. Gerhardt et al.

Methods of Enzymatic Analysis, 3, 510-510 (1983)

A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.

Noemi Holderith et al.

Cell reports, 32(4), 107968-107968 (2020-07-30)

Elucidating the molecular mechanisms underlying the functional diversity of synapses requires a high-resolution, sensitive, diffusion-free, quantitative localization method that allows the determination of many proteins in functionally characterized individual synapses. Array tomography permits the quantitative analysis of single synapses but

Reconstitution of the cell cycle-regulated Golgi disassembly and reassembly in a cell-free system

Tang D, et al.

Nature Protocols, 5(4), 758-758 (2010)

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