283-60-3

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Discordant expression and variable numbers of neighboring GGA- and GAA-rich triplet repeats in the 3' untranslated regions of two groups of messenger RNAs encoded by the rat polymeric immunoglobulin receptor gene.

K S Koch et al.

Nucleic acids research, 23(7), 1098-1112 (1995-04-11)

An unusual S1-nuclease sensitive microsatellite (STMS) has been found in the single copy, rat polymeric immunoglobulin receptor gene (PIGR) terminal exon. In Fisher rats, elements within or beyond the STMS are expressed variably in the 3' untranslated regions (3'UTRs) of

A novel carbonyl reductase from Pichia stipitis for the production of ethyl (S)-4-chloro-3-hydroxybutanoate.

Qi Ye et al.

Biotechnology letters, 31(4), 537-542 (2009-01-07)

An NADPH-dependent carbonyl reductase (PsCR) gene from Pichia stipitis was cloned. It contains an open reading frame of 849 bp encoding 283 amino acids whose sequence had less than 60% identity to known reductases that produce ethyl (S)-4-chloro-3-hydroxybutanoates (S-CHBE). When

Efficient nuclear export of p65-IkappaBalpha complexes requires 14-3-3 proteins.

Cristina Aguilera et al.

Journal of cell science, 119(Pt 17), 3695-3704 (2006-08-26)

IkappaB are responsible for maintaining p65 in the cytoplasm under non-stimulating conditions and promoting the active export of p65 from the nucleus following NFkappaB activation to terminate the signal. We now show that 14-3-3 proteins regulate the NFkappaB signaling pathway

CYP2C9 genotype vs. metabolic phenotype for individual drug dosing--a correlation analysis using flurbiprofen as probe drug.

Silvia Vogl et al.

PloS one, 10(3), e0120403-e0120403 (2015-03-17)

Currently, genotyping of patients for polymorphic enzymes responsible for metabolic elimination is considered a possibility to adjust drug dose levels. For a patient to profit from this procedure, the interindividual differences in drug metabolism within one genotype should be smaller

Aromatase transgenic upregulation modulates basal cardiac performance and the response to ischemic stress in male mice.

James R Bell et al.

American journal of physiology. Heart and circulatory physiology, 306(9), H1265-H1274 (2014-03-13)

Estrogen in females is conventionally considered a cardioprotective influence, but a role for estrogen in male cardioprotection has yet to be defined. Estrogen biosynthesis from testosterone is regulated by aromatase. Aromatase has recently been shown to be expressed in the

Phosphorylation of the leucocyte NADPH oxidase subunit p47(phox) by casein kinase 2: conformation-dependent phosphorylation and modulation of oxidase activity.

H S Park et al.

The Biochemical journal, 358(Pt 3), 783-790 (2001-09-06)

The leucocyte NADPH oxidase of neutrophils is a membrane-bound enzyme that catalyses the reduction of oxygen to O(-)(2) at the expense of NADPH. The enzyme is dormant in resting neutrophils but becomes active when the cells are exposed to the

Homozygous c.14576G>A variant of RNF213 predicts early-onset and severe form of moyamoya disease.

S Miyatake et al.

Neurology, 78(11), 803-810 (2012-03-02)

RNF213 was recently reported as a susceptibility gene for moyamoya disease (MMD). Our aim was to clarify the correlation between the RNF213 genotype and MMD phenotype. The entire coding region of the RNF213 gene was sequenced in 204 patients with

Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat.

C Li et al.

Proceedings of the National Academy of Sciences of the United States of America, 88(17), 7739-7743 (1991-09-01)

Human immunodeficiency virus (HIV) gene expression is regulated by both general transcription factors and factors induced by activation of T lymphocytes such as NF-kappa B and the nuclear factor of activated T cells (NFAT). Within the HIV long terminal repeat

Foveal cone density shows a rapid postnatal maturation in the marmoset monkey.

Alan D Springer et al.

Visual neuroscience, 28(6), 473-484 (2011-12-24)

The spatial and temporal pattern of cone packing during marmoset foveal development was explored to understand the variables involved in creating a high acuity area. Retinal ages were between fetal day (Fd) 125 and 6 years. Cone density was determined

The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injury.

Neel R Sodha et al.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 33(5), 906-913 (2008-03-04)

Ischemia-reperfusion (I/R) injury, often encountered clinically, results in myocardial apoptosis and necrosis. Hydrogen sulfide (H(2)S) is produced endogenously in response to ischemia and thought to be cardioprotective, although its mechanism of action is not fully known. This study investigates cardioprotection

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