284297

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Regulation of thyroid sodium-iodide symporter in different stages of goiter: Possible involvement of reactive oxygen species.

Lívia P L Matos et al.

Clinical and experimental pharmacology & physiology, 45(4), 326-334 (2017-11-08)

Na+ /I- symporter (NIS) transports iodide into thyrocytes, a fundamental step for thyroid hormone biosynthesis. Our aim was to evaluate NIS regulation in different status of goitrogenesis and its underlying mechanisms. Wistar rats were treated with methimazole (MMI) for 5

Elucidation of the absolute configuration of JNJ-27553292, a CCR2 receptor antagonist, by vibrational circular dichroism analysis of two precursors.

Tom Kuppens et al.

Chirality, 18(8), 609-620 (2006-05-23)

The absolute configurations of two precursors, that is, 1-(3',4'-dichlorophenyl)-propanol and 1-(3',4'-dichlorophenyl)-propanamine, of a potent 2-mercapto-imidazole CCR-2 receptor antagonist, JNJ-27553292, were determined using vibrational circular dichroism. As a consequence, the absolute configuration of the antagonist itself was also determined. The two

2-Mercaptoimidazole covalently bonded to a silica gel surface for the selective separation of mercury (II) from an aqueous solution.

Filho NLD and Gushikem Y.

Separation Science and Technology, 32(15), 2535-2545 (1997)

Rhenium(I) tricarbonyl complexes with poly(azolyl)borates generated in situ from an organometallic precursor containing the B-H...Re coordination motif.

Margarida Videira et al.

Inorganic chemistry, 48(9), 4251-4257 (2009-04-09)

Complex fac-[Re(kappa(3)-H(mu-H)(2)B(tim(Me)))(CO)(3)] (1) reacts with protic azoles, like 2-mercapto-1-methylimidazole (tim(Me)H), 2-mercaptobenzothiazole (bztH), or pyrazoles (pz*H), to afford fac-[Re(kappa(3)-H(mu-H)B(tim(Me))(2)(CO)(3)] (2), fac-[Re(kappa(3)-H(mu-H)B(tim(Me))(bzt))(CO)(3)] (3), fac-[Re(kappa(3)-H(mu-H)B(tim(Me))(pz))(CO)(3)] (4), fac-[Re(kappa(3)-HB(tim(Me))(pz)(2))(CO)(3)] (5), and fac-[Re(kappa(3)-H(mu-H)B(tim(Me))(3,5-Me(2)-4-EtOOCCH(2)pz))(CO)(3)] (6). Complexes 2-6 are stabilized by tridentate poly(azolyl)borates generated in situ, and their

Inhibitory effects of novel synthetic methimazole derivatives on mushroom tyrosinase and melanogenesis.

Chin-Feng Chan et al.

Bioorganic & medicinal chemistry, 22(9), 2809-2815 (2014-04-08)

In this study, we synthesized 4 methimazole (2-mercapto-1-methylimidazole, MMI) derivatives. The kinetics of inhibition on mushroom tyrosinase by methimazole and its derivatives were investigated. The results indicated that tert-butyl 3-methyl-2-sulfanylidene-2,3-dihydro-1H-imidazole-1-carboxylate (compound 3; 3), 2-mercaptoimidazole (MI; compound 1; 1) and MMI

Bis(mercaptoimidazolyl)(pyrazolyl)hydroborato complexes of zinc, cadmium, and cobalt: structural evidence for the enhanced tendency of zinc in biological systems to adopt tetrahedral M[S4] coordination.

C Kimblin et al.

Inorganic chemistry, 39(19), 4240-4243 (2001-02-24)

The bis(2-mercapto-1-methylimidazolyl)(pyrazolyl)hydroborato derivatives [pzBmMe]2Zn, [pzBmMe]2Co, and [pzBmMe]2Cd have been isolated and structurally characterized by X-ray diffraction. Despite their common [pzBmMe]2M composition, each of these complexes adopts a different structure. Thus, (i) the zinc complex exhibits a tetrahedral Zn[S4] structure in

2-Mercaptoimidazoles, a new class of potent CCR2 antagonists.

Guy Van Lomen et al.

Bioorganic & medicinal chemistry letters, 15(3), 497-500 (2005-02-26)

We describe the synthesis and SAR of a new class of CCR2 antagonists based on 2-mercaptoimidazole scaffold. The initial lead 1a was optimized to the 3,4-disubstituted analogues 1p-(S) and 1q-(S), which have IC(50) values in the MCP-1 induced Ca-flux below

Exploring the pH dependent SERS spectra of 2-mercaptoimidazole molecule adsorbed on silver nanocolloids in the light of Albrecht's "A" term and Herzberg-Teller charge transfer contribution.

Subhendu Chandra et al.

Journal of colloid and interface science, 399, 33-45 (2013-04-02)

The pH dependent surface-enhanced Raman scattering (SERS) spectra of biologically and industrially significant, 2-mercaptoimidazole (2-MI) molecule at 1.0×10(-10)M concentration have been investigated. The pH dependent SERS spectra are compared with the corresponding normal Raman spectra (NRS) of the molecule. The

Preconcentration and determination of mercury(II) at a chemically modified electrode containing 3-(2-thioimidazolyl)propyl silica gel.

Newton L Dias Filho et al.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 21(11), 1359-1363 (2005-12-02)

A mercury-sensitive chemically modified graphite paste electrode was constructed by incorporating modified silica gel into a conventional graphite paste electrode. The functional group attached to the (3-chloropropyl) silica gel surface was 2-mercaptoimidazole, giving a new product denoted by 3-(2-thioimidazolyl)propyl silica

Copper and cobalt complexes of carnosine and anserine: production of active oxygen species and its enhancement by 2-mercaptoimidazoles.

Z Hartman et al.

Chemico-biological interactions, 84(2), 153-168 (1992-09-28)

Phosphate buffer solutions of two dipeptides prevalent in striated muscle, L-carnosine (beta-alanyl-L-histidine) and L-anserine (beta-alanyl-L-1-methylhistidine), produce active oxygen species as measured by bleaching of N,N-dimethyl-4-nitrosoaniline (RNO). Activity is enhanced 5-14-fold in the presence of 2-mercaptoimidazoles such as ergothioneine, carbimazole (3-methyl-2-mercaptoimidazole-1-carboxylate)

Genesis of enhanced Raman bands in SERS spectra of 2-mercaptoimidazole: FTIR, Raman, DFT, and SERS.

Subhendu Chandra et al.

The journal of physical chemistry. A, 116(45), 10934-10947 (2012-10-25)

The surface enhanced Raman scattering (SERS) spectra of biologically and industrially significant, 2-mercaptoimidazole (2-MI) molecule have been investigated. The SERS spectra of the molecule at different concentrations of the adsorbate are compared with its Fourier transform infrared (FTIR) and normal

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