284432

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Phytanic acid and very long chain fatty acids in genetic peroxisomal disorders.

B Molzer et al.

Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 27(5), 309-314 (1989-05-01)

1. Phytanic acid, phytanyl-triacylglycerols, and very long chain fatty acids were analysed by gas chromatography or thin-layer chromatography in blood and tissues of patients with different genetic peroxisomal disorders (Refsum's disease, X-linked adrenoleukodystrophy, neonatal adrenoleukodystrophy, Zellweger syndrome). 2. We evaluated

Inhibition of cholesterol biosynthesis in cultured fibroblasts by D003, a mixture of very long chain saturated fatty acids.

R Menéndez et al.

Pharmacological research, 44(4), 299-304 (2001-10-11)

The present study was undertaken to investigate the effects of D003, a mixture of very long chain saturated fatty acids isolated and purified from sugar cane wax, on cholesterol biosynthesis in cultured fibroblasts. Cholesterol biosynthesis is regulated through feedback regulation

Lack of developmental toxicity of D-003: a mixture of long-chain fatty acids in rats.

M D Rodríguez et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 41(1), 89-93 (2002-11-28)

D-003 is a mixture of long-chain fatty acids isolated and purified from sugar cane wax, the major component of which is 1-octacosanoic acid and which possesses effective antiplatelet, antithrombotic and cholesterol-lowering effects. D-003 was suspended in 1% acacia gum solution

Partial phase behavior and micellar properties of tetrabutylammonium salts of fatty acids: unusual solubility in water and formation of unexpectedly small micelles.

Raoul Zana

Langmuir : the ACS journal of surfaces and colloids, 20(14), 5666-5668 (2006-02-08)

The tetrabutylammonium (TBA) salts of fatty acids, from dodecanoic acid (C12) to octacosanoic acid (C28), have been prepared by direct neutralization of the fatty acid by TBA hydroxide. Unexpectedly, all of these surfactants have been found to be soluble in

[Studies on chemical constituents of two plants from Costus].

Chun-feng Qiao et al.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 27(2), 123-125 (2003-05-31)

To study the chemical constituents of Costus speciosus and C. tonkinensis (Zingiberaceae) distributed in Yunnan province. Chromatography and spectral analyses were used to isolate the constituents and elucidate their structure. Six compounds were isolated from the rhizome of C. speciosus

[Studies on the chemical constituents of the petroleum ether portion of Nervilia fordii].

Han-shen Zhen et al.

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 33(5), 717-719 (2010-09-30)

To study the chemical constituents of the petroleum ether portion of Nervilia fordii. The constituents were separated and purified by using column chromatography with silica gel. These compounds were identified by their physical and spectral data. Six compounds were isolated

Stereoselective pH Responsive Peptide Dendrimers for siRNA Transfection.

Marc Heitz et al.

Bioconjugate chemistry, 30(8), 2165-2182 (2019-08-10)

Transfecting nucleic acids into cells is an essential procedure in biological research usually performed using nonviral transfection reagents. Unfortunately, most transfection reagents have polymeric or undisclosed structures and require nonstandard synthetic procedures. Herein we report peptide dendrimers accessible as pure

[Simple quantitative method of direct transesterification of higher fatty acid in biological samples].

V Z Lankin et al.

Voprosy meditsinskoi khimii, 17(3), 331-335 (1971-05-01)

Chemical constituents from aerial part of Curcuma wenyujin.

Zheng-Ming Tao et al.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 32(24), 2604-2606 (2008-03-15)

To investigate the chemical constituents from aerial part of Curcuma wenyujin. Compounds were isolated by repeated column chromatography on silica gel. Their structures were elucidated on the basis of spectral analysis and comparison with literature data. Six compounds were isolated

Effect of D-003 on a subconvulsive dose of kainic Acid in rats.

Daisy Carbajal et al.

Drugs in R&D, 5(6), 331-336 (2004-11-26)

Chemical constituents from the fruits of Hippophae rhamnoides.

Rui-Xia Zheng et al.

Natural product research, 23(15), 1451-1456 (2009-10-08)

Ten compounds were isolated from the fruits of Hippophae rhamnoides. On the basis of spectroscopic and chemical methods, the structures of these compounds were elucidated as hippophae cerebroside (1), oleanolic acid (2), ursolic acid (3), 19-alpha-hydroxyursolic acid (4), dulcioic acid

[Studies on the chemical constituents from Inula cappa (II)].

Qi-lei Guo et al.

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 30(1), 35-37 (2007-06-02)

To study the chemical constituents of the root of Inula cappa. The compounds were isolated and purified by recrystallization and chromatography with silica gel column and Sephadex LH-20 column. Their structures were identified by physico-chemical properties and spectral analysis. Seven

Inhibition of saturated very-long-chain fatty acid biosynthesis by mefluidide and perfluidone, selective inhibitors of 3-ketoacyl-CoA synthases.

Stefan Tresch et al.

Phytochemistry, 76, 162-171 (2012-01-31)

The trifluoromethanesulphonanilides mefluidide and perfluidone are used in agriculture as plant growth regulators and herbicides. Despite the fact that mefluidide and perfluidone have been investigated experimentally for decades, their mode of action is still unknown. In this study, we used

Preliminary evaluation of the cytotoxic and genotoxic potential of D-003: Mixture of very long chain fatty acids.

Rafael Gámez et al.

Teratogenesis, carcinogenesis, and mutagenesis, 22(3), 175-181 (2002-04-12)

D-003 is a mixture of very long chain aliphatic acids purified from sugar cane wax, wherein octacosanoic acid represents the major component. Previous experimental studies have shown that D-003 inhibits platelet aggregation in rodents. Also, its lowers total (TC) and

In vitro and in vivo study of octacosanol metabolism.

Roberto Menéndez et al.

Archives of medical research, 36(2), 113-119 (2005-04-26)

Policosanol is a mixture of very-long-chain aliphatic alcohols purified from sugar cane wax with cholesterol-lowering effects, whose main component is octacosanol. Scarce data about the metabolism of octacosanol and the other fatty alcohols composing policosanol have been published. Human fibroblasts

[Chemical constituents of Adenophora stricta Miq].

P Jiang et al.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 15(8), 486-487 (1990-08-01)

Four compounds were isolated from the roots of Adenophora stricta. On the basis of spectrometric analysis and physicochemical constants, they were identified as beta-sitosterol, beta-sitosterol-O-beta-D-glucopyranoside, taraxerone and octacasanoic acid respectively. Taraxerone and octacasanoic acid were isolated from the plants of

A new method for the determination of primary and secondary terrestrial and marine biomarkers in ice cores using liquid chromatography high-resolution mass spectrometry.

Amy C F King et al.

Talanta, 194, 233-242 (2019-01-06)

The majority of atmospheric compounds measured in ice cores are inorganic, while analysis of their organic counterparts is a less well developed field. In recent years, understanding of formation, transport pathways and preservation of these compounds in ice and snow

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