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Malay K Das et al.
Acta poloniae pharmaceutica, 63(6), 535-541 (2007-04-19)
A transdermal dosage form of trazodone hydrochloride (TZN) may be useful in the treatment of moderate to severe depression in schizophrenic patients by providing prolonged duration of action. It will also improve patient compliance and bioavailability. Controlled input of TZN
Amnon C Sintov
International journal of pharmaceutics, 481(1-2), 97-103 (2015-02-07)
The objective of this study was to evaluate the transdermal delivery potential of a new curcumin-containing microemulsion system. Three series of experiments were carried out to comprehend the system characteristics: (a) examining the influence of water content on curcumin permeation
M S Pandey et al.
Indian journal of pharmaceutical sciences, 71(1), 87-90 (2010-02-24)
The purpose of this research is to formulate and evaluate the suitability of pluronic lecithin organogels containing flurbiprofen for topical application. Four formulations were developed using flurbiprofen, lecithin, Pluronic F127, isopropyl palmitate, water, sorbic acid and potassium sorbate were coded
Iatrogenic fenestration of a semicircular canal: a method of closure.
J R Cullen et al.
The Laryngoscope, 96(10), 1168-1169 (1986-10-01)
Contact allergy to benzyl alcohol and isopropyl palmitate, ingredients of topical corticosteroid.
S Lazzarini
Contact dermatitis, 8(5), 349-350 (1982-09-01)
Prapaporn Boonme et al.
AAPS PharmSciTech, 7(2), E45-E45 (2006-06-27)
This research was aimed to characterize microemulsion systems of isopropyl palmitate (IPP), water, and 2:1 Brij 97 and 1-butanol by different experimental techniques. A pseudoternary phase diagram was constructed using water titration method. At 45% wt/wt surfactant system, microemulsions containing
M El-Mahrab-Robert et al.
International journal of pharmaceutics, 348(1-2), 89-94 (2007-08-31)
In multiple emulsion systems, oily or aqueous transfers may occur between the dispersed droplets through the continuous phase. These transfers are controlled by both the surfactant system (micellar transport), and the partial solubility of one phase in another (molecular transport).
P Boonme et al.
Die Pharmazie, 61(11), 927-932 (2006-12-13)
The aim of this work was to determine the type and microstructure of microemulsion samples formed in IPP/water/AerosolOT:1-butanol (2:1) systems as a case study for the investigation of microemulsions. The concentration of the surfactant/cosurfactant mixture was kept constant while the
Ekapol Limpongsa et al.
AAPS PharmSciTech, 9(2), 464-470 (2008-04-24)
The objective was to investigate the suitable polymeric films for the development of diltiazem hydrochloride (diltiazem HCl) transdermal drug delivery systems. Hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC) were used as hydrophilic and hydrophobic film formers, respectively. Effects of HPMC/EC ratios
Rui Liang et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 29(1), 24-26 (2006-05-26)
To analyze the constituents of essential oil from the skin of water caltrop. Water steam distillation and GC-MS were used. 58 componds were separated respectively. 56 componds being identified which were 96. 5% of the totle essential oil. Diethyl phthalate
K Koike et al.
Journal of biotechnology, 80(2), 101-107 (2000-07-26)
A repeat-batch membrane bioreactor was constructed for the novel bioconversion of isopropyl hexadecanoate to isopropyl cis-6-hexadecenoate by a Rhodococcus mutant. The addition of glutamate, thiamine, and MgSO(4) was very effective in improving not only the rate and yield of the
Kinetically stable propofol emulsions with reduced free drug concentration for intravenous delivery.
Robert Damitz et al.
International journal of pharmaceutics, 486(1-2), 232-241 (2015-04-04)
Intravenous injections of propofol emulsions are accompanied by pain likely due to the interaction of the dissolved drug with endothelial cells of the vasculature. It is commonly hypothesized that reducing the aqueous phase concentration of propofol could reduce pain. To
Swati Pund et al.
International journal of pharmaceutics, 487(1-2), 148-156 (2015-04-15)
The present study is a mechanistic validation of 'proof of concept' of effective topical delivery of leflunomide (LFD) nanoemulgel for localized efficient treatment of psoriatic lesions as well as melanoma affected skin regions. Hyperproliferation of keratinocytes in psoriasis and symbiotic
K Koike et al.
Bioscience, biotechnology, and biochemistry, 64(2), 399-404 (2000-03-29)
Resting cells of a double mutant noted as KSM-MT66, derived from Rhodococcus sp. strain KSM-B-3 by UV irradiation, were found to cis-desaturate isopropyl hexadecanoate, yielding isopropyl cis-6-hexadecenoate. Addition of sodium glutamate (1.0%), Mg SO4 (2 mM), and thiamine (2 mM)
C Y Kee et al.
Artificial cells, blood substitutes, and immobilization biotechnology, 27(5-6), 393-398 (1999-12-14)
The objective of this research was to study the kinetics of synthesis of a commercially important ester - Isopropyl Palmitate (IPP) using immobilized lipase (Lipozyme IM). It was studied in a packed bed differential reactor. In order to establish the
Varaporn Buraphacheep Junyaprasert et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 10(3), 288-298 (2007-08-31)
To characterize the physicochemical properties of drug-loaded oil-in-water (o/w) and water-in-oil (w/o) Brij 97-based microemulsions in comparison to their blank counterparts and to investigate the influence of microemulsion type on in vitro skin permeation of model hydrophobic drugs and their
Amnon C Sintov et al.
International journal of pharmaceutics, 471(1-2), 516-524 (2014-05-29)
The aim of this study was to explore the transdermal delivery potential of a new caffeine-containing microemulsion system. The skin permeability of caffeine (CAF) was measured in vitro using skin excised from three different animal species: rat, rabbit and pig.
Ruggero Angelico et al.
Langmuir : the ACS journal of surfaces and colloids, 21(1), 140-148 (2004-12-29)
The microstructure of organogels formed upon the addition of tiny amounts of water to a solution of lecithin in fatty acid esters (viz. isopropylpalmitate and ethyloleate) was investigated by means of molecular self-diffusion measurements. In both systems lecithin and water
Fabian Klar et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 71(1), 124-129 (2008-08-08)
Previous studies described several dry powder coating procedures. Most of these techniques used polymer powders and plasticizers for attaining film formation. Thermo analytical methods showed that some of the used plasticizers did not reduce the glass transition temperature of the
Anuj Shukla et al.
Journal of pharmaceutical sciences, 92(4), 730-738 (2003-03-28)
Dynamic light scattering (DLS) was used to study the droplet size and the droplet interaction of o/w microemulsions (MEs) consisting of oils, a blend of a high and a low hydrophilic-lipophilic balance (HLB) surfactant, and a hydrophilic phase (propylene glycol/water).
N Pfammatter et al.
Biochemical and biophysical research communications, 161(3), 1244-1251 (1989-06-30)
Baker yeast cells are solubilized in organic solvents by the use of surfactants and small amounts of water. Data are reported for three different systems, Tween/Isopropylpalmitat, Asolectin/IPP, Asolectin/Hexadecane. The viability (life-capability) can remain as high as 80% for 10 Days
Honglei Xi et al.
International journal of pharmaceutics, 436(1-2), 857-861 (2012-07-17)
The aim of this work was to investigate the effect of the stability of hydrogen-bonded ion pairs with organic amines on transdermal penetration of teriflunomide (TEF). Five organic amines, diethylamine (DEtA), triethylamine (TEtA), diethanolamine (DEA), triethanolamine (TEA), and N-(2'-hydroxyethanol)-piperdine (NP)
G Häring et al.
Biochemical and biophysical research communications, 127(3), 911-915 (1985-03-29)
A reverse micellar system containing Tween 85 and water in isopropylpalmitate was developed which permitted the solubilization of bacteria in the form of homogenous organic solutions. The presence of the bacteria in solution was demonstrated by light microscopy. Immediately after
Solomon T Garner et al.
Pharmaceutical development and technology, 12(2), 169-174 (2007-05-19)
Transdermal permeation of N-acetyl-D-glucosamine (NAG), a metabolite of glucosamine was examined. Glucosamine salts are nutraceuticals used in the oral treatment of osteoarthritis. Sparse information is available regarding glucosamine and NAG transdermal or percutaneous transport and absorption. Permeability of NAG in
Hong Guo et al.
Biological & pharmaceutical bulletin, 29(11), 2324-2326 (2006-11-02)
The model penetrants oxaprozin, nimesulide, gliclazide, and ribavirin, because of their different lipophilicities, were selected to assess the enhancing activity of pre-treatment solutions consisting of isopropyl palmitate (IP) in ethanol (5%, 10%, 15%and 20%, w/w, respectively) across excised rat skin
Varaporn Buraphacheep Junyaprasert et al.
Drug delivery, 15(5), 323-330 (2008-09-03)
The skin permeation enhancement of many kinds of drugs and cosmetic substances by microemulsions has been widely known; however, the correlations between microemulsion microstructures and the efficiency of skin permeation are not fully elucidated. Therefore, the aim of our study
Rodrigo Molina Martins et al.
Journal of microencapsulation, 31(7), 644-653 (2014-04-29)
Solid-lipid microparticles loaded with high amounts of the sunscreen UV filter benzophenone-3 were prepared by spray congealing with the objective of decreasing its skin penetration and evaluate whether the sunscreen's photoprotection were impaired by the microencapsulation process. The microparticles were
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