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K Ohmoto et al.
Hepato-gastroenterology, 46(26), 1249-1252 (1999-06-17)
In a patient with liver cirrhosis complicated by solitary gastric fundal varices and portosystemic encephalopathy, Balloon-occluded retrograde transvenous obliteration (B-RTO) of the varices was performed. The gastric varices were decreased in size 2 weeks after treatment and had not recurred
Raúl Pérez-Ortuño et al.
Analytical and bioanalytical chemistry, 407(28), 8463-8473 (2015-09-08)
A straightforward, high-throughput method was developed and fully validated for the simultaneous determination of the specific tobacco biomarkers nicotine and its main metabolite cotinine in a wide dynamic range and supporting the most common human biological matrices (urine, oral fluid
Kazunari Nohara et al.
Nutrition & metabolism, 12, 23-23 (2015-06-16)
Ammonia detoxification is essential for physiological well-being, and the urea cycle in liver plays a predominant role in ammonia disposal. Nobiletin (NOB), a natural dietary flavonoid, is known to exhibit various physiological efficacies. In the current study, we investigated a
Zhuo Li et al.
Biosensors & bioelectronics, 70, 246-253 (2015-04-02)
A magnetic and fluorescent nano-composite was prepared. It comprised of a core of Fe3O4 nanoparticles (NPs), a silica shell and satellitic Au nano-clusters (AuNCs) capped with bovine serum albumin (BSA). This nano-composite has many desirable properties, e.g. magnetism, red emission
Nikiwe Mhlanga et al.
International journal of biological macromolecules, 72, 1301-1307 (2014-12-03)
For decades, studies on drug-release kinetics have been an important topic in the field of drug delivery because they provide important insights into the mechanism of drug release from carriers. In this work, polylactide (PLA), doxorubicin (DOX), and metal oxide
P C Vieira et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(12), 2746-2752 (2013-06-22)
The objective of the work is to evaluate the performance of an innovative design of a trickling filter for small population sizes, which has been implemented for the post-treatment of sanitary effluent from a UASB (upflow anaerobic sludge blanket) reactor.
A J Cooper
Mental retardation and developmental disabilities research reviews, 7(4), 280-286 (2002-01-05)
Ammonia enters the brain by diffusion from the blood or cerebrospinal fluid, or is formed in situ from the metabolism of endogenous nitrogen-containing substances. Despite its central importance in nitrogen homeostasis, excess ammonia is toxic to the central nervous system
Janne Hakkarainen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(9), 3806-3816 (2015-05-29)
Hydroxysteroid (17β)-dehydrogenase type 1 (HSD17B1) catalyzes the conversion of low active 17-ketosteroids, androstenedione (A-dione) and estrone (E1) to highly active 17-hydroxysteroids, testosterone (T) and E2, respectively. In this study, the importance of HSD17B1 in ovarian estrogen production was determined using
Álvaro Alonso et al.
Bulletin of environmental contamination and toxicology, 92(5), 520-524 (2014-01-15)
Pollutants are an important factor that causes among others drift (i.e. downstream transport of aquatic organisms in the current) in aquatic invertebrates. However, drift response is taxon-specific, which necessitates the investigation of a wide variety of taxa. Additionally, no information
Ajit G Thomas et al.
PloS one, 10(8), e0127785-e0127785 (2015-08-08)
The cystine-glutamate antiporter (system xc-) is a Na+-independent amino acid transporter that exchanges extracellular cystine for intracellular glutamate. It is thought to play a critical role in cellular redox processes through regulation of intracellular glutathione synthesis via cystine uptake. In
Kazuki Takakura et al.
Anticancer research, 34(9), 4849-4855 (2014-09-10)
The therapeutic strategy against hepatocellular carcinoma (HCC) is determined by tumor stage and liver function. Improvements of stratification contribute to extending the survival of patients. However, stratification has been attributed little attention in animal models largely due to the lack
Mahmood M Alam et al.
Nature communications, 6, 7285-7285 (2015-07-08)
Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG. By employing chemical and genetic tools in combination with quantitative global
Tomas Fiedler et al.
Cancer biology & therapy, 16(7), 1047-1055 (2015-03-17)
Arginine auxotrophy constitutes a weak point of several tumors, among them glioblastoma multiforme (GBM). Hence, those tumors are supposed to be sensitive for arginine-depleting substances, such as arginine deiminase (ADI). Here we elucidated the sensitivity of patient-individual GBM cell lines
Zachary D Moye et al.
Applied and environmental microbiology, 80(16), 5053-5067 (2014-06-15)
Glucosamine and N-acetylglucosamine are among the most abundant sugars on the planet, and their introduction into the oral cavity via the diet and host secretions, and through bacterial biosynthesis, provides oral biofilm bacteria with a source of carbon, nitrogen, and
Alberto De Petris et al.
The journal of physical chemistry. B, 119(5), 1919-1929 (2015-01-13)
The iron(III) protoporphyrin IX complex with imidazole, a biologically relevant ligand, occupying an axial position, has been studied by infrared multiple photon dissociation (IRMPD) spectroscopy. The complex has been delivered in gas-phase by electrospray ionization (ESI), mass selected in an
Liquid chromatography-mass spectrometry analysis of five bisphosphonates in equine urine and plasma.
April S Y Wong et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 998-999, 1-7 (2015-07-06)
Bisphosphonates are used in the management of skeletal disorder in humans and horses, with tiludronic acid being the first licensed veterinary medicine in the treatment of lameness associated with degenerative joint disease. Bisphosphonates are prohibited in horseracing according to Article
Giles E D Oldroyd et al.
Current opinion in biotechnology, 26, 19-24 (2014-04-01)
The availability of nitrogen is one of the major limiting factors to crop growth. In the developed world, farmers use unsustainable levels of inorganic fertilisers to promote crop production. In contrast, in the developing world inorganic fertilisers are often not
Ana de Castro et al.
Journal of chromatography. A, 1374, 93-101 (2014-12-09)
Since the past few years, several synthetic cathinones and piperazines have been introduced into the drug market to substitute illegal stimulant drugs such as amphetamine and derivatives or cocaine due to their unregulated situation. These emerging drugs are not usually
Elin Möllerström et al.
Neurochemical research, 40(2), 336-352 (2014-09-25)
Brain tumors are heterogeneous with respect to genetic and histological properties of cells within the tumor tissue. To study subpopulations of cells, we developed a protocol for obtaining viable single cells from freshly isolated human brain tissue for single cell
Ying Cai et al.
Journal of chromatography. A, 1406, 40-47 (2015-07-01)
Fluorenyl functionalized superparamagnetic core/shell magnetic nanoparticles (MNPs, Fe3O4@SiO2@Flu) were prepared and characterized by transmission electron microscope, X-ray diffraction and infrared spectroscopy. The MNPs having an average diameter of 200nm were then used as solid-phase extraction sorbent for the determination of
Ka Yi Yung et al.
Analytica chimica acta, 884, 77-82 (2015-06-16)
We report a complementary metal oxide semiconductor integrated circuit (CMOS IC) with a buried double junction (BDJ) photodiode that (i) provides a real-time output signal that is related to the intensity ratio at two emission wavelengths and (ii) simultaneously eliminates
José R Verdú et al.
Scientific reports, 5, 13912-13912 (2015-09-10)
Ivermectin is a veterinary pharmaceutical generally used to control the ecto- and endoparasites of livestock, but its use has resulted in adverse effects on coprophilous insects, causing population decline and biodiversity loss. There is currently no information regarding the direct
Chongwen Wang et al.
Nanoscale, 7(44), 18694-18707 (2015-10-27)
Precise fabrication of subtle nanogaps amid individual nanoparticles or between adjacent ones to obtain the highest SERS enhancement is still a challenge. Here, we reported a novel approach for fabricating core-shell-satellite 3D magnetic microspheres (CSSM), that easily form a porous
István Ilisz et al.
Journal of chromatography. A, 1384, 67-75 (2015-02-11)
The enantiomers of four unusual, rather rigid isoxazoline-fused 2-aminocyclopentanecarboxylic acids were directly separated on a quinine- or a quinidine-based zwitterionic ion-exchanger as chiral selector. The effects of the mobile phase composition, the structures of the analytes and temperature on the
Ga-Hyun Kim et al.
Journal of biomaterials applications, 29(6), 854-866 (2014-08-08)
The aim of the present study was to investigate the effects of a composite nanofibrous matrix made of biopolymer blend polycaprolactone-gelatin (BP) and mesoporous bioactive glass nanoparticles (BGNs) on the odontogenic differentiation of human dental pulp cells (HDPCs). BGN-BP nanomatrices
Karel Horňák et al.
Journal of chromatography. A, 1365, 115-123 (2014-09-23)
The concentrations of free neutral carbohydrates and amino sugars were determined in freshwater samples of distinct matrix complexity, including meso-, eu- and dystrophic lakes and ponds, using high-performance ion-exclusion chromatography (HPIEC) coupled to mass spectrometry (MS). In contrast to other
Cytotoxic Activity of Highly Purified Silver Nanoparticles Sol Against Cells of Human Immune System.
Anna Barbasz et al.
Applied biochemistry and biotechnology, 176(3), 817-834 (2015-04-24)
The widespread use of silver nanoparticles (AgN) in the articles of common use justifies the need to investigate their effects on the human body. Nanosilver toxicity of highly purified, stable, and well-characterized Ag sol toward human immune cells at various
Robert Parker et al.
Molecular cancer therapeutics, 13(7), 1894-1906 (2014-05-16)
Activating mutations in the MAPK pathway are prevalent drivers of several cancers. The chief consequence of these mutations is a hyperactive ERK1/2 MAPK able to promote cell proliferation, producing a critical hallmark of metastatic disease. The biochemistry of the ERK
Rei-Ichi Ohno et al.
Journal of clinical biochemistry and nutrition, 57(1), 27-32 (2015-08-04)
The inhibition of advanced glycation end-products (AGEs) by daily meals is believed to become an effective prevention for lifestyle-related diseases. In the present study, the inhibitory effect of hot water extracts of mangosteen (Garcinia mangostana L.) pericarp (WEM) on the
Soon Huat Tiong et al.
Fitoterapia, 102, 182-188 (2015-02-11)
Vindogentianine, a new indole alkaloid together with six known alkaloids, vindoline, vindolidine, vindolicine, vindolinine, perivine and serpentine were isolated from leaf extract (DA) of Catharanthus roseus (L.) G. Don. Their structures were elucidated by spectroscopic methods; NMR, MS, UV and
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