296856

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A novel injectable thermoresponsive and cytocompatible gel of poly(N-isopropylacrylamide) with layered double hydroxides facilitates siRNA delivery into chondrocytes in 3D culture.

Hsiao-Yin Yang et al.

Acta biomaterialia, 23, 214-228 (2015-05-30)

Hybrid hydrogels composed of poly(N-isopropylacrylamide) (pNIPAAM) and layered double hydroxides (LDHs) are presented in this study as novel injectable and thermoresponsive materials for siRNA delivery, which could specifically target several negative regulators of tissue homeostasis in cartilaginous tissues. Effectiveness of

Eagleson M.

Concise Encyclopedia Chemistry, 325-325 (1994)

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.

Richard M Monaghan et al.

Nature cell biology, 17(6), 782-792 (2015-05-12)

The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing. Mitochondria communicate with nuclei through retrograde signalling pathways that modulate nuclear gene expression to maintain mitochondrial

Lipase catalysed synthesis of optically enriched alpha-haloamides.

A Azim et al.

Bioorganic & medicinal chemistry, 9(5), 1345-1348 (2001-05-30)

An efficient lipase catalysed synthesis of optically enriched alpha-halogenated amides with concomitant optical enrichment of the starting alpha-haloesters is described. Candida antarctica lipase (CAL) was found to be a better catalyst over porcine pancreatic lipase (PPL) and Candida cylindracea lipase

Novel (R)-oxynitrilase sources for the synthesis of (R)-cyanohydrins in diisopropyl ether.

Kiljunen E and Kanerva LT.

Tetrahedron Asymmetry, 8(8), 1225-1234 (1997)

Thiolsubtilisin acts as an acetyltransferase in organic solvents.

Dar Fu Tai et al.

FEBS letters, 517(1-3), 24-26 (2002-06-14)

The catalytic mechanism of arylamine N-acetyltransferase has been proposed to involve Cys-His-Asp as its catalytic triad. Thiolsubtilisin, a chemically modified enzyme that has a catalytic triad of Cys-His-Asp at the active site, mimics the catalysis of arylamine N-acetyltransferase, serotonin N-acetyltransferase

Metabolic study of androsta-1,4,6-triene-3,17-dione in horses using liquid chromatography/high resolution mass spectrometry.

Wai Him Kwok et al.

The Journal of steroid biochemistry and molecular biology, 152, 142-154 (2015-06-03)

Androsta-1,4,6-triene-3,17-dione (ATD) is an irreversible steroidal aromatase inhibitor and is marketed as a supplement. It has been reported to effectively reduce estrogen biosynthesis and significantly increase the levels of endogenous steroids such as dihydrotestosterone and testosterone in human. ATD abuses

Oxidative degradation of alternative gasoline oxygenates in aqueous solution by ultrasonic irradiation: mechanistic study.

Duk Kyung Kim et al.

The Science of the total environment, 430, 246-259 (2012-06-01)

Widespread pollution has been associated with gasoline oxygenates of branched ethers methyl tert-butyl ether (MTBE), di-isopropyl ether (DIPE), ethyl tert-butyl ether (ETBE), and tert-amyl ether (TAME) which enter groundwater. The contaminated plume develops rapidly and treatment for the removal/destruction of

Subchronic and developmental toxicity studies of vaporized diisopropyl ether in rats.

W Dalbey et al.

Journal of toxicology and environmental health, 49(1), 29-43 (1996-09-01)

Two inhalation studies were performed with a vaporized sample of commercial-grade diisopropyl ether (DIPE). In the subchronic study, Sprague-Dawley rats (14/sex) were exposed to 0 (both untreated and sham-exposed controls), 480, 3300, or 7100 ppm DIPE for 6 h/d, 5

Study of the water structure in poly(methyl methacrylate-block-2-hydroxyethyl methacrylate) and its relationship to platelet adhesion on the copolymer surface.

Akira Mochizuki et al.

Journal of biomaterials science. Polymer edition, 26(12), 750-765 (2015-05-30)

The water structure and platelet compatibility of poly(methyl methacrylate (MMA)-block-2-hydroxyethyl methacrylate (HEMA)) were investigated. The molecular weight (Mn) of the polyHEMA segment was kept constant (average: 9600), while the Mn of the polyMMA segment was varied from 1340 to 7390.

Characterization of a highly sensitive and selective novel trapping reagent, stable isotope labeled glutathione ethyl ester, for the detection of reactive metabolites.

Toshikazu Yamaoka et al.

Journal of pharmacological and toxicological methods, 76, 83-95 (2015-09-01)

Glutathione (GSH) trapping assays are widely used to predict the post-marketing risk for idiosyncratic drug reactions (IDRs) in the pharmaceutical industry. Although several GSH derivatives have been introduced as trapping reagents for reactive intermediates, more sensitive and selective reagents are

Single stage synthesis of diisopropyl ether-an alternative octane enhancer for lead-free petrol.

Heese FP, et al.

Catalysis Today, 49(1), 327-335 (1999)

Mass Spectrometry in Pharmacokinetic Studies of a Synthetic Compound for Spinal Cord Injury Treatment.

María Sánchez-Sierra et al.

BioMed research international, 2015, 169234-169234 (2015-06-20)

The studies of drugs that could constitute a palliative to spinal cord injury (SCI) are a continuous and increasing demand in biomedicine field from developed societies. Recently we described the chemical synthesis and antiglioma activity of synthetic glycosides. A synthetic

Effect of solvents on the thermal isomerization of 1 alpha-hydroxyprevitamin D3 diacetate to 1 alpha-hydroxyvitamin D3 diacetate.

T Sato et al.

Journal of nutritional science and vitaminology, 36(4), 299-309 (1990-08-01)

The thermal conversion of 1 alpha-hydroxyprevitamin D3 (1 alpha-OH-previtamin D3) diacetate to 1 alpha-hydroxyvitamin D3 (1 alpha-OH-vitamin D3) diacetate was investigated in five solvents. The fraction of 1 alpha-OH-vitamin D3 diacetate was calculated from the HPLC peak areas (UV detection)

Analytical procedure for the determination of the new antitumour drug N-benzoylstaurosporine and three potential metabolites in human plasma by reversed-phase high-performance liquid chromatography.

R van Gijn et al.

Journal of chromatography. B, Biomedical applications, 667(2), 269-276 (1995-05-19)

The staurosporine derivative, N-benzoylstaurosporine (CGP 41 251; I), is a protein kinase C inhibitor that has been selected for phase I clinical evaluation in cancer patients. We have developed a selective and sensitive assay of the drug and three potential

A probe on the intermolecular forces in diisopropyl ether-n-butyric acid mixture by dielectric, FTIR studies and quantum chemical calculations.

G Arivazhagan et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 105, 102-108 (2013-01-09)

The results of FTIR spectral measurement on equimolar diisopropyl ether-butyric acid binary mixture and quantum chemical calculations on the complex molecule have been presented. Dielectric studies have been carried out on the binary mixture over the entire composition range and

Study of fuel oxygenates solubility in aqueous media as a function of temperature and tert-butyl alcohol concentration.

R Gonzalez-Olmos et al.

Chemosphere, 71(11), 2098-2105 (2008-02-27)

Methyl tert-butyl ether (MTBE) is the most widely used oxygenate in gasoline blending and has become one of the world's most widespread groundwater and surface water pollutants. Alternative oxygenates to MTBE, namely ethyl tert-butyl ether (ETBE), tert-amyl ether (TAME) and

Attractors in Sequence Space: Peptide Morphing by Directed Simulated Evolution.

Jan A Hiss et al.

Molecular informatics, 34(11-12), 709-714 (2016-01-19)

Synthesis and characterization of copolyanhydrides of carbohydrate-based galactaric acid and adipic acid.

Tuomas Mehtiö et al.

Carbohydrate research, 402, 102-110 (2014-12-17)

A series of copolyanhydrides, consisting of 2,3,4,5-tetra-O-acetylgalactaric acid (AGA) and adipic acid (AA) as monomer units, was polymerized. Synthesis of AGA monomer consisted of two steps. First, O-acetylation of galactaric acid secondary hydroxyl groups was performed using acetic anhydride as

Bis(1,2-dithiosquarato)nickelates(II) - Synthesis, Structure, EPR and Thermal Behavior.

Peter Strauch et al.

Acta chimica Slovenica, 62(2), 288-296 (2015-06-19)

1,2-Dithiosquaratonickelates are available by direct synthesis from metal salts with dipotassium-1,2-dithiosquarate and the appropriate counter cations. The synthesis and characterization, including mass spectrometry, of a series 1,2-dithiosquaratonickelates(II), [Ni(dtsq)2]2-, with several "onium" cations is reported and the X-ray structures of two

Delipidation of a hepadnavirus: Viral inactivation and vaccine development.

B E Cham et al.

Journal of virological methods, 137(1), 160-163 (2006-07-01)

Many viruses including HIV, hepatitis C and hepatitis B, have an outer lipid envelope which maintains inserted viral peptides in the "correct" functional conformation and orientation. Disruption of the lipid envelope by most solvents destroys infectivity and often results in

Smart morpholine-functional statistical copolymers synthesized by nitroxide mediated polymerization

Lessard BH, et al.

Polymer, 53(25), 5649-5656 (2012)

Activation of enzymes in organic media at low water activity by polyols and saccharides.

P Adlercreutz

Biochimica et biophysica acta, 1163(2), 144-148 (1993-05-13)

Horse liver alcohol dehydrogenase and alpha-chymotrypsin were deposited on a porous support material, Celite. After equilibration at a well-defined water activity, the catalytic activity was measured with diisopropyl ether as reaction medium. The effects of the presence of polyols and

Mapping B-cell epitopes for the peroxidoxin of Leishmania (Viannia) braziliensis and its potential for the clinical diagnosis of tegumentary and visceral leishmaniasis.

Daniel Menezes-Souza et al.

PloS one, 9(6), e99216-e99216 (2014-06-13)

The search toward the establishment of novel serological tests for the diagnosis of leishmaniasis and proper differential diagnosis may represent one alternative to the invasive parasitological methods currently used to identify infected individuals. In the present work, we investigated the

A kinetic model for enzyme interfacial activity and stability: pa-hydroxynitrile lyase at the diisopropyl ether/water interface.

Luis G Cascão Pereira et al.

Biotechnology and bioengineering, 78(6), 595-605 (2002-05-07)

A kinetic framework is developed to describe enzyme activity and stability in two-phase liquid-liquid systems. In particular, the model is applied to the enzymatic production of benzaldehyde from mandelonitrile by Prunus amygdalus hydroxynitrile lyase (pa-Hnl) adsorbed at the diisopropyl ether

Quantitative determination of CGP 53,437, a new HIV protease inhibitor, in plasma by high-performance liquid chromatography and fluorescence detection.

G Flesch et al.

Journal of chromatography. B, Biomedical applications, 657(1), 155-161 (1994-07-01)

A specific and sensitive liquid chromatographic assay for CGP 53,437 (I), a potent HIV protease inhibitor, is described. The method is based on a deproteinization step, followed by a liquid-liquid extraction with diisopropyl ether. Then a deprotection step of the

A spectrophotometric micromethod for determining erythrocyte protoporphyrin-IX in whole blood or erythrocytes.

Guenther Kufner et al.

Clinical chemistry and laboratory medicine, 43(2), 183-191 (2005-04-22)

An increased concentration of erythrocyte protoporphyrin-IX in whole blood or erythrocytes is a valuable diagnostic indicator for acquired porphyrias, e.g., iron deficiency anemia and lead poisoning, and for inherited porphyrias. We developed a spectrophotometric micromethod for determining erythrocyte protoporphyrin-IX. In

Pharmacokinetics and pharmacodynamics of 3,3'-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes.

Tien-Yuan Wu et al.

Journal of pharmacokinetics and pharmacodynamics, 42(4), 401-408 (2015-07-04)

3,3'-Diindolylmethane (DIM) has been investigated as a potential anti-cancer chemopreventive agent in many preclinical and clinical studies. In this study, we sought to characterize the pharmacokinetics of DIM and to build a pharmacokinetic (PK) and pharmacodynamic (PD) model of the

Enhancing crystalline properties of a cardiovascular active pharmaceutical ingredient using a process analytical technology based crystallization feedback control strategy.

Ali N Saleemi et al.

International journal of pharmaceutics, 430(1-2), 56-64 (2012-03-28)

Pharmaceutical regulatory bodies require minimal presence of solvent in an active pharmaceutical ingredient (API) after crystallization. From a processing point of view bigger crystals with minimal agglomeration and uniform size distribution are preferred to avoid solvent inclusion and for improved

Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane.

Soile Ae Pakkanen et al.

Veterinary anaesthesia and analgesia, 42(5), 527-536 (2014-12-23)

To investigate MK-467 as part of premedication in horses anaesthetized with isoflurane. Experimental, crossover study with a 14 day wash-out period. Seven healthy horses. The horses received either detomidine (20 μg kg(-1) IV) and butorphanol (20 μg kg(-1) IV) alone (DET) or with MK-467 (200 μg kg(-1)

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