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Ana R Ribeiro et al.
Journal of chromatography. A, 1418, 140-149 (2015-10-04)
The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of 37 micropollutants including Priority Substances (Directive 2013/39/EU), substances of
Ottmar Golf et al.
Journal of the American Society for Mass Spectrometry, 26(1), 44-54 (2014-11-09)
Here we present a proof of concept cross-platform normalization approach to convert raw mass spectra acquired by distinct desorption ionization methods and/or instrumental setups to cross-platform normalized analyte profiles. The initial step of the workflow is database driven peak annotation
Iain M McIntyre et al.
Journal of analytical toxicology, 39(2), 152-155 (2014-12-18)
A 24-year-old man whose medical history was significant for alcohol abuse and depression was found unresponsive in bed. He had several prior suicide attempts with 'pills' and had also been hospitalized for an accidental overdose on a previous occasion. Autopsy
Ahmad Umar et al.
Dalton transactions (Cambridge, England : 2003), 44(48), 21081-21087 (2015-11-26)
Herein, we report the development of a simple and highly sensitive hydroquinone (HQ) chemical sensor based on an electrochemically activated iron-doped (Fe-doped) zinc oxide nanorod (ZnO NR) modified screen-printed electrode (SPE). The Fe-doped ZnO NRs were prepared using a hydrothermal
Binnian Wei et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 290-297 (2014-06-27)
Most sample preparation methods characteristically involve intensive and repetitive labor, which is inefficient when preparing large numbers of samples from population-scale studies. This study presents a robotic system designed to meet the sampling requirements for large population-scale studies. Using this
Kayla N Ellefsen et al.
Analytical and bioanalytical chemistry, 406(25), 6213-6223 (2014-08-19)
Breath has been investigated as an alternative matrix for detecting recent cocaine intake; however, there are no controlled cocaine administration studies that investigated the drug's disposition into breath. Breath was collected from 10 healthy adult cocaine users by asking them
Konstantin Chingin et al.
Analytical chemistry, 84(15), 6856-6862 (2012-07-12)
We introduce an online multiple-junction capillary isoelectric focusing fractionator (OMJ-CIEF) for separation of biological molecules in solution by pI. In OMJ-CIEF, the separation capillary is divided into seven equal sections joined with each other via tubular Nafion membrane insertions. Each
Huanchen Wang et al.
Biochemistry, 54(42), 6462-6474 (2015-10-01)
Iron-sulfur (Fe-S) clusters are widely distributed protein cofactors that are vital to cellular biochemistry and the maintenance of bioenergetic homeostasis, but to our knowledge, they have never been identified in any phosphatase. Here, we describe an iron-sulfur cluster in Asp1
Joanna H Clark et al.
Journal of the American Chemical Society, 133(4), 1016-1032 (2010-12-17)
Charge transfer between metal ions occupying distinct crystallographic sublattices in an ordered material is a strategy to confer visible light absorption on complex oxides to generate potentially catalytically active electron and hole charge carriers. CaCu3Ti4O12 has distinct octahedral Ti4+ and
Paula Paíga et al.
Journal of pharmaceutical and biomedical analysis, 106, 61-70 (2014-07-09)
An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass
Fang Zhang et al.
ChemSusChem, 8(6), 1043-1048 (2015-02-17)
A thermally regenerative ammonia battery (TRAB) is a new approach for converting low-grade thermal energy into electricity by using an ammonia electrolyte and copper electrodes. TRAB operation at 72 °C produced a power density of 236 ± 8 Wm(-2), with a
Ju-Young Kim et al.
Drug development and industrial pharmacy, 41(2), 292-299 (2013-11-21)
The purpose of the present study was to prepare desmopressin orally disintegrating microparticles (ODMs) using organic-aqueous crossover coating process which featured an organic sub-coating followed by an aqueous active coating. Sucrose beads and hydroxypropyl cellulose (HPC) were used as inert
Michael A Gardner et al.
Journal of analytical toxicology, 39(2), 118-125 (2014-12-11)
Fentanyl is a synthetic narcotic anesthetic ∼80-100 times more potent than morphine. Owing to the potential for its abuse, the drug may be included in a forensic toxicology work-up, which requires fast, precise and accurate measurements. Here, the stability of
Yunjia Yang et al.
Journal of agricultural and food chemistry, 62(46), 11130-11137 (2014-10-29)
This study aimed to develop a selective analytical method for the simultaneous determination of seven bisphenol analogues in beverage and canned food samples by using a new molecularly imprinted polymer (MIP) as a sorbent for solid-phase extraction (SPE). Liquid chromatography
A Farag et al.
Journal of dental research, 93(12), 1313-1319 (2014-10-02)
The periodontal ligament is the key tissue facilitating periodontal regeneration. This study aimed to fabricate decellularized human periodontal ligament cell sheets for subsequent periodontal tissue engineering applications. The decellularization protocol involved the transfer of intact human periodontal ligament cell sheets
Lisa Fischer et al.
International journal of legal medicine, 129(2), 279-287 (2014-10-12)
Insurance agencies might request laboratories to differentiate whether a deceased has been a smoker or not to decide about refunding of his nonsmoker rate. In this context, the question on a solid proof of tobacco alkaloids and major metabolites in
Sandrine Aros-Calt et al.
Journal of proteome research, 14(11), 4863-4875 (2015-10-27)
Staphylococcus aureus can cause a variety of severe disease patterns and can readily acquire antibiotic resistance; however, the mechanisms by which this commensal becomes a pathogen or develops antibiotic resistance are still poorly understood. Here we asked whether metabolomics can
Levi B Wood et al.
Scientific reports, 5, 16622-16622 (2015-11-14)
Alzheimer's disease (AD) therapeutics based on the amyloid hypothesis have shown minimal efficacy in patients, suggesting that the activity of amyloid beta (Aβ) represents only one aspect of AD pathogenesis. Since neuroinflammation is thought to play an important role in
Blanca Estela Jaramillo-Loranca et al.
Synapse (New York, N.Y.), 69(4), 213-225 (2015-02-17)
Sigma (σ) receptors have generated a great deal of interest due to their possible role in psychosis, neuroprotection, and various other behaviors including addictive processes. Sigma receptors have been located in brain areas involved in motor functions, including the dopaminergic
Caroline Strasinger et al.
Journal of pharmaceutical sciences, 103(6), 1829-1838 (2014-05-03)
Oral dosage forms and traditional transdermal patches are inadequate for complex clonidine therapy dosing schemes, because of the variable dose/flux requirement for the treatment of opioid withdrawal symptoms. The purpose of this study was to evaluate the in vitro transdermal
Sena Caglar et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 25-32 (2015-03-10)
On-line solid-phase extraction (SPE) is becoming an increasingly widespread technique in the clean-up of complex matrices such as body fluids, prior to chromatographic analysis. The use of small SPE columns instead of disposable SPE cartridges allows multiple injections and complete
Michael J Boundy et al.
Journal of chromatography. A, 1387, 1-12 (2015-02-24)
Routine regulatory monitoring of paralytic shellfish toxins (PST) commonly employs oxidative derivitisation and complex liquid chromatography fluorescence detection methods (LC-FL). The pre-column oxidation LC-FL method is currently implemented in New Zealand and the United Kingdom. When using this method positive
Yothin Teethaisong et al.
Journal of biomedical science, 21, 90-90 (2014-09-12)
Ampicillin-resistant S. aureus (ARSA) now poses a serious problem for hospitalized patients, and their care providers. Plant-derived antibacterial that can reverse the resistance to well-tried agents which have lost their original effectiveness are the research objectives of far reaching importance.
Neelesh Kumar Mehra et al.
Molecular pharmaceutics, 12(2), 630-643 (2014-12-18)
Our main aim in the present investigation was to assess and compare the in vitro and in vivo cancer targeting propensity of doxorubicin (DOX) loaded folic acid (FA) and estrone (ES) anchored PEGylated multiwalled carbon nanotubes (MWCNTs) employing tumor bearing
Michael Boppré et al.
Phytochemical analysis : PCA, 26(3), 215-225 (2015-02-04)
The freshwater aquatic plant Gymnocoronis spilanthoides (Senegal tea plant, jazmín del bañado, Falscher Wasserfreund) is an invasive plant in many countries. Behavioural observations of pyrrolizidine alkaloid-pharmacophagous butterflies suggested the presence of pyrrolizidine alkaloids in the plant. To determine whether the
Saroj Kumar Das et al.
BMC neuroscience, 16, 2-2 (2015-04-17)
Although there have been several reports on social isolation induced mood alterations, the independent contribution of monotonous environment in mediating mood alterations has been less studied. In view of the above, the present study is aimed at investigating the relative
Marzieh Enteshari Najafabadi et al.
Journal of pharmaceutical and biomedical analysis, 107, 244-250 (2015-01-28)
Magnetic nanoparticles (MNPs) conjugated with aptamer was developed for the selective extraction of adenosine in urine samples followed by electrospray ionization-ion mobility spectrometry (ESI-IMS). The ion mobility spectrum of adenosine showed two peaks at low concentrations and two more peaks
J C Naviaux et al.
Translational psychiatry, 4, e400-e400 (2014-06-18)
Autism spectrum disorders (ASDs) now affect 1-2% of the children born in the United States. Hundreds of genetic, metabolic and environmental factors are known to increase the risk of ASD. Similar factors are known to influence the risk of schizophrenia
Camilla Benevides Freitas et al.
Talanta, 147, 335-341 (2015-11-26)
This report describes the development of an analytical methodology on microchip electrophoresis (ME) devices coupled with capacitively coupled contactless conductivity detection (C(4)D) to monitor inorganic anions in environmental samples. The buffer composition as well as detection operating parameters were optimized
Sébastien Sart et al.
Tissue engineering. Part A, 20(1-2), 54-66 (2013-07-16)
Embryonic stem cells (ESCs) emerge as a promising tool for tissue engineering and regenerative medicines due to their extensive self-renewal ability and the capacity to give rise to cells from all three-germ layers. ESCs also secrete a large amount of
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