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显示 1-18 共 18 条结果 关于 "307-30-2" 范围 论文
Anna Danielsson et al.
Biochemical and biophysical research communications, 342(4), 1183-1187 (2006-03-07)
Feedback control in insulin signaling involves serine phosphorylation of insulin receptor substrate-1 (IRS1). By analyzing the insulin-induced phosphorylation of IRS1 at serine 307, serine 312, and tyrosine in the same primary human adipocytes, we now report that negative feedback phosphorylation
M R McClung et al.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 24(1), 301-310 (2012-10-20)
Bone mineral density response to once weekly delayed-release formulation of risedronate, given before or following breakfast, was non-inferior to that seen with traditional immediate-release risedronate given daily before breakfast. Delayed-release risedronate is a convenient dosing regimen for oral bisphosphonate therapy
Shingo Nemoto et al.
American journal of physiology. Heart and circulatory physiology, 301(6), H2383-H2394 (2011-09-20)
In diabetic states, endothelial dysfunction is related to vascular complications. We hypothesized that insulin-induced relaxation and the associated proline-rich tyrosine kinase 2 (Pyk2)/Src/Akt pathway would be abnormal in aortas from the Goto-Kakizaki (GK) type 2 diabetic rat, which exhibits hyperglycemia/insulin
J Steinmetz et al.
Minerva anestesiologica, 78(3), 303-309 (2011-10-06)
The etiology of postoperative cognitive dysfunction (POCD) remains unclear but toxicity of anesthetic drugs and their metabolites could be important. We aimed to assess the possible association between POCD after propofol anesthesia and various phenotypes owing to polymorphisms in cytochrome
Amelia Marti et al.
Nutrition (Burbank, Los Angeles County, Calif.), 20(6), 498-501 (2004-05-29)
We conducted a case-control study to examine the association between the risk of obesity and the exon-8 insertion allele in the UCP2 gene. The case series included 157 subjects with a body mass index greater than 30 kg/m(2) (obesity) and
S Schmidt et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 13(7), 1807-1810 (1998-07-29)
Atrial natriuretic peptide is involved in blood pressure regulation via its vasodilating and natriuretic actions. Since diabetic nephropathy and hypertension are closely related, ANP is a reasonable candidate gene for diabetic nephropathy (DN). We genotyped 410 patients with type I
Silvana Aparecida Alves Corrêa et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 10(1), 51-58 (2009-03-17)
We evaluated the association between components of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type 1 (AT( 1))-receptor A1166C polymorphisms. Genotyping was performed
Jean-Philippe Theurillat et al.
International journal of cancer, 122(7), 1585-1591 (2007-11-29)
NY-BR-1 is a differentiation antigen and a potential target for cancer immunotherapy. Its mRNA expression is restricted to breast, testis, prostate and breast cancer by RT-PCR. In this study, we correlated NY-BR-1 protein and mRNA expression on tissue microarrays of
M P Kung et al.
The Journal of pharmacology and experimental therapeutics, 272(1), 429-437 (1995-01-01)
Binding characteristics of a radioiodinated serotonin-1A (5-HT1A) receptor antagonist, 4-(2'-methoxy-phenyl)-1-[2'-(n-2"-pyridinyl)-p- iodobenzamido]-ethyl-piperazine ([125I]p-MPPI) were evaluated using in vitro homogenate binding and autoradiographic techniques in rat brains. [125I]p-MPPI displayed a Kd value of 0.32 +/- 0.04 nM (in the presence of MgCl2)
Robert D Meade et al.
Acta physiologica (Oxford, England), 226(1), e13226-e13226 (2018-11-28)
Ageing and hypohydration independently attenuate heat dissipation during exercise; however, the interactive effects of these factors remain unclear. We assessed the hypothesis that ageing suppresses hypohydration-induced reductions in whole-body heat loss during exercise in the heat. On two occasions, eight
Xing Xian Yu et al.
American journal of physiology. Endocrinology and metabolism, 295(2), E436-E445 (2008-06-05)
To investigate the role of JNK1 in metabolism, male ob/ob and diet-induced obese mice were treated with a JNK1-specific antisense oligonucleotide (ASO) or control ASO at 25 mg/kg or saline twice/wk for 6 and 7 wk, respectively. JNK1 ASO reduced
J A Bourland et al.
Journal of analytical toxicology, 24(7), 489-495 (2000-10-24)
A total of 30 human head-hair samples were analyzed for cocaine (COC), cocaethylene (CE), benzoylecgonine (BE), methylecgonine (EME), and norcocaine (NCOC) using a sensitive positive ion chemical ionization gas chromatography-tandem mass spectrometry (GC-MS-MS) method. All 30 hair samples had been
Cristobal Girardi et al.
The Science of the total environment, 444, 32-42 (2012-12-25)
The persistence of chemicals is a key parameter for their environmental risk assessment. Extrapolating their biodegradability potential in aqueous systems to soil systems would improve the environmental impact assessment. This study compares the fate of (14/13)C-labelled 2,4-D (2,4-dichlorophenoxyacetic acid) and
M H Fernandez et al.
Immunology, 85(2), 176-183 (1995-06-01)
Viral variation has been proposed to play a role in the pathogenesis of human immunodeficiency virus type-1 (HIV-1) infection, and is an important consideration in vaccine design. During the course of an infection, isolates with sequence changes in CD8 T-cell
Erik Hanff et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 970, 44-52 (2014-09-23)
A specific, sensitive and fast LC-MS/MS method with positive electrospray ionization for the quantitative determination of nitrite in human plasma is reported. Added [(15)N]nitrite served as the internal standard (IS). Endogenous nitrite and IS were converted to their S-nitrosoglutathione (GSNO)
C B Sanjeevi et al.
Annals of the New York Academy of Sciences, 958, 317-320 (2002-05-22)
Insulin-dependent diabetes mellitus (IDDM) is positively associated with HLA-DQ8, DQ2, and DQ6 (B*0604) and negatively with DQ6 (B*0602). The mechanisms by which the DQ molecules control the development of IDDM is not known. DQ6 (B*0602) and DQ6 (B*0604) molecules share
Richard T Penson et al.
The Lancet. Oncology, 16(3), 301-311 (2015-02-02)
GOG 240 was a practice-changing randomised phase 3 trial that concluded that chemotherapy plus bevacizumab for advanced cervical cancer significantly improves overall and progression-free survival, and the proportion of patients achieving an overall objective response, compared with chemotherapy alone. In
Zhiyuan Fang et al.
Journal of dairy science, 105(8), 6895-6908 (2022-07-16)
Endoplasmic reticulum (ER) stress can be induced by various stimuli and triggers the unfolded protein response to activate intracellular signaling pathways that are mediated by 3 ER-resident sensors: inositol requiring protein-1α (IRE1α), PKR-like ER kinase (PERK), and activating transcription factor-6
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