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Sarmah B Nayeem et al.
Molecular and cellular endocrinology, 405, 52-62 (2015-02-15)
Wnt signalling has important roles in decidualisation, implantation and placentation. We investigated the role of decidua-trophoblast communication and Wnt signalling in the placenta using a co-culture model. Expression of a wide range of Wnt-related genes was observed in both decidual
Yunjing Zhang et al.
British journal of pharmacology, 176(16), 2848-2863 (2019-05-12)
Ursodeoxycholic acid (UDCA) is the first-line treatment for primary biliary cholangitis, but its effects on the enterohepatic circulation of bile acid (BA) have been under-investigated. Therefore, we studied the influence of UDCA on BA enterohepatic circulation in vivo and the
Seiji Okada et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 44(2), 115-125 (2014-07-26)
Hematopoietic pre-B-cell leukemia transcription factor-interacting protein (HPIP) is a corepressor of pre-B-cell leukemia homeobox (PBX) 1 and is known to play a role in hematopoiesis. Recently, HPIP was demonstrated to promote breast cancer cell proliferation and hepatocellular carcinoma growth. Moreover
Hyowon Hong et al.
Biochemical and biophysical research communications, 461(1), 180-185 (2015-04-18)
The actin cytoskeleton has been implicated in the assembly of cilia, but roles of actin-dependent motor proteins in ciliogenesis remain unclear. Myosin heavy chain 10 (MYH10), one of the isoforms of non-muscle myosin II, is known to mediate centrosome reorientation
Sally E Trabucco et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(1), 113-122 (2014-07-11)
Approximately 50% of patients with diffuse large B-cell lymphoma (DLBCL) enter long-term remission after standard chemotherapy. Patients with DLBCL who do not respond to chemotherapy have few treatment options. There remains a critical need to identify effective and targeted therapeutics
Effects of fenofibrate on adiponectin expression in retinas of streptozotocin-induced diabetic rats.
Ying-Jung Hsu et al.
Journal of diabetes research, 2014, 540326-540326 (2014-12-20)
Adiponectin has been associated with increased risks of microvascular complications in diabetes; however, its role in the development of diabetic retinopathy (DR) is unknown. Fenofibrate is a lipid-lowering agent that has been shown to be capable of preventing DR progression.
Raghunath Chatterjee et al.
Epigenetics & chromatin, 7, 35-35 (2015-02-24)
Genome-wide DNA methylation at a single nucleotide resolution in different primary cells of the mammalian genome helps to determine the characteristics and functions of tissue-specific hypomethylated regions (TS-HMRs). We determined genome-wide cytosine methylation maps at 91X and 36X coverage of
Peng Cheng et al.
Molecular medicine reports, 12(3), 3257-3264 (2015-05-23)
The pathophysiological mechanisms of the irritable bowel syndrome (IBS), one of the most prevalent gastrointestinal disorders, are complex and have not been fully elucidated. The present study aimed to investigate the molecular and cellular mechanisms of tight junction (TJ) dysfunction
Xiaofang Jia et al.
Digestive diseases and sciences, 59(7), 1490-1501 (2014-01-23)
Our previous study indicated that hepatic bile acids (BAs) may have deposited and stimulated the pathogenesis of a high fat-cholesterol (HFC) diet-induced fibrotic steatohepatitis in stroke-prone spontaneously hypertensive 5/Dmcr rats, based on dysregulated BA homeostasis pathways. We aimed to further
J Hu et al.
Oncogene, 34(31), 4078-4088 (2014-10-28)
In glioblastoma (GBM), the EGF receptor (EGFR) and Src family kinases (SFKs) contribute to an aggressive phenotype. EGFR may be targeted therapeutically; however, resistance to EGFR-targeting drugs such as Erlotinib and Gefitinib develops quickly. In many GBMs, a truncated form
Ya-Ting Cheng et al.
International journal of cardiology, 201, 441-448 (2015-08-28)
Rho-associated kinase (ROCK) plays an important role in maintaining embryonic stem (ES) cell pluripotency. To determine whether ROCK is involved in ES cell differentiation into cardiac and hematopoietic lineages, we evaluated the effect of ROCK inhibitors, Y-27632 and fasudil on
N F LaRusso et al.
Gastroenterology, 72(1), 132-140 (1977-01-01)
The effect of deoxycholate ingestion, 750 mg per day, on bile acid kinetics, biliary bile acid composition, and biliary lipid secretion was studied in 7 healthy volunteers. Bile acid kinetics were measured by isotope dilution, and hourly outputs of bile
Antonella Napolitano et al.
PloS one, 9(7), e100778-e100778 (2014-07-06)
Metformin, a biguanide derivate, has pleiotropic effects beyond glucose reduction, including improvement of lipid profiles and lowering microvascular and macrovascular complications associated with type 2 diabetes mellitus (T2DM). These effects have been ascribed to adenosine monophosphate-activated protein kinase (AMPK) activation
Tomoaki Tadano et al.
Rinsho byori. The Japanese journal of clinical pathology, 54(2), 103-110 (2006-03-22)
Both radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) methods are utilized in the clinical laboratory to measure bile acids in human body fluids. For a more detailed analysis, we attempted simultaneous analysis of serum and feces bile acids using gas
Florence Teulé et al.
Nature protocols, 4(3), 341-355 (2009-02-21)
The extreme strength and elasticity of spider silks originate from the modular nature of their repetitive proteins. To exploit such materials and mimic spider silks, comprehensive strategies to produce and spin recombinant fibrous proteins are necessary. This protocol describes silk
Ke Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1001, 27-34 (2015-08-09)
Many fishes are hypothesized to use bile acids (BAs) as chemical cues, yet quantification of BAs in biological samples and the required methods remain limited. Here, we present an UHPLC-MS/MS method for simultaneous, sensitive, and rapid quantification of 15 BAs
Amphotericin B in severe fungal infections: a critical reappraisal of the evidence.
Pedro Póvoa et al.
American journal of respiratory and critical care medicine, 188(8), 1032-1032 (2013-10-17)
Debashish Banerjee et al.
The Biochemical journal, 465(3), 423-431 (2014-11-12)
MUC1 is a transmembrane mucin highly expressed in the stomach. Although extensive research has uncovered many of its roles in cancer, knowledge about the functions of MUC1 in normal tissues is limited. In the present study, we showed that acetylsalicylic acid
Francesca Bugli et al.
Antimicrobial agents and chemotherapy, 57(3), 1275-1282 (2012-12-25)
Aspergillus fumigatus biofilms represent a problematic clinical entity, especially because of their recalcitrance to antifungal drugs, which poses a number of therapeutic implications for invasive aspergillosis, the most difficult-to-treat Aspergillus-related disease. While the antibiofilm activities of amphotericin B (AMB) deoxycholate
W T Beher et al.
Life sciences, 32(26), 2933-2937 (1983-06-27)
Daily excretion of fecal total bile acids and neutral steroids were compared in five controls and two patients with extremely low concentrations of plasma high density lipoprotein (3 to 11 mg/dl) and severe atherosclerosis. There was no significant difference in
E Nedivi et al.
The Journal of biological chemistry, 259(9), 5803-5808 (1984-05-10)
Agonist, but not antagonist, protects the beta-adrenergic receptor from inactivation during solubilization in deoxycholate. Protection is apparently due to locking of the agonist in the receptor, a high affinity interaction induced or stabilized by this detergent. The guanyl nucleotide-binding protein
Vincent P Ramirez et al.
Gene, 555(2), 430-437 (2014-12-03)
TNFα-induced protein 3-interacting protein 1 (TNIP1) represses signaling pathways initiated by specific nuclear and transmembrane receptors. This effect results in reduced activity of distinct transcription factors such as retinoic acid receptors (RAR), peroxisome-proliferator-activated receptors (PPAR), and NFκB. TNIP1-null and TNIP1-knockin
Ping-Sung Chiu et al.
Acta tropica, 140, 141-150 (2014-08-27)
Blood-brain barrier (BBB) disruption is associated with tight junction protein degradation, basal membrane disruption, and astrocyte damage. This study aims to investigate the role of matrix metalloproteinase (MMP)-9 in BBB disruption during Angiostrongylus cantonensis infection. We used mice infected with
Antonis Kourtidis et al.
Nature cell biology, 17(9), 1145-1157 (2015-08-25)
E-cadherin and p120 catenin (p120) are essential for epithelial homeostasis, but can also exert pro-tumorigenic activities. Here, we resolve this apparent paradox by identifying two spatially and functionally distinct junctional complexes in non-transformed polarized epithelial cells: one growth suppressing at
Jeffery L Smith et al.
Hepatology (Baltimore, Md.), 39(6), 1673-1682 (2004-06-09)
Focal biliary cirrhosis causes significant morbidity and mortality in cystic fibrosis (CF). Although the mechanisms of pathogenesis remain unclear, bile acids have been proposed as potential mediators of liver injury. This study examined bile acid composition in CF and assessed
Hiroaki Yazama et al.
International journal of clinical oncology, 20(3), 438-446 (2014-08-01)
We previously reported that dietary glucosylceramides show cancer-prevention activity in a mouse xenograft model of human head and neck cancer cells (SCCKN). However, the mechanism was unclear. Ceramides, metabolites of glucosylceramides, induce apoptotic cell death in various malignancies. Here, we
Jing Shan et al.
Journal of gastroenterology, 50(4), 414-423 (2014-08-19)
IL-33 is a new tissue-derived cytokine constitutively expressed in epithelial cells and plays a role in sensing damage caused by inflammatory diseases. The function of IL-33 in the esophageal mucosa has not been previously described. Accordingly, we examined the expression
Bin Gao et al.
International journal of molecular medicine, 36(5), 1282-1290 (2015-12-10)
The aim of the present study was to examine the apoptosis of the hepatocellular carcinoma cell line, HepG2, induced by treatment with folic acid-conjugated silica-coated gold nanorods (GNRs@SiO2-FA) in combination with radiotherapy, and to determine the involvement of apoptosis-related proteins.
Sean T Koester et al.
STAR protocols, 2(4), 100938-100938 (2021-11-23)
Gastrointestinal motility is regulated by a variety of environmental factors including gut microbes and metabolites. The ability to interrogate mouse models of gut motility has enabled elucidation of these relationships. Here we describe integration of the red carmine dye and
A Schmidt et al.
British journal of pharmacology, 153(6), 1311-1323 (2008-01-29)
Cystic fibrosis (CF) is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel. In the search for new CF therapies, small molecules have been identified that rescue the defective channel gating of CF mutants (termed CFTR
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