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M Moubarak et al.
Physiological research, 64(4), 495-503 (2014-12-04)
Atrial natriuretic peptide antifibrotic properties are mainly described in cardiac myocytes or in induced cardiac myofibroblasts (Angiotensin II or TGF-beta induced differentiation). In the present work, we investigate the effects of ANP/NPRA/cGMP system in modulating rat cardiac fibroblasts function. Cardiac
Atsushi Nobuoka et al.
Gastroenterology, 127(2), 428-443 (2004-08-10)
Aberrant crypt foci, precursors of colonic adenoma, are frequently positive for glutathione-S-transferase P1-1. Because deoxycholic acid is an apoptosis-inducing xenobiotic in the colon, we examined the possibility that aberrant crypt foci, through the cytoprotecting function of glutathione-S-transferase P1-1, resist deoxycholic
E Passos et al.
Life sciences, 123, 51-60 (2014-12-24)
Pro-inflammatory mediators, glucocorticoids and transforming growth factor (TGF)-β are implicated in the pathogenesis of non-alcoholic steatohepatitis (NASH)-related insulin resistance. As physical activity is beneficial against NASH, we analyzed the voluntary physical activity (VPA) and endurance training (ET) (preventive and therapeutic
Meng-Ping Hsu et al.
Glia, 63(1), 132-141 (2014-08-12)
The interleukin (IL)-6/gp130 family of cytokines (e.g., IL-6, IL-11, leukemia inhibitory factor (LIF) and oncostatin M (OSM)) play important roles in the central nervous system (CNS) during neuroinflammation and neurodevelopment. However, little is known regarding the responses by astroglia and
N Yamaga et al.
Steroids, 48(5-6), 427-438 (1986-11-01)
Bile acids in serum, urine and dialysate of 8 patients with renal failure in chronic hemodialysis were analyzed by gas chromatography and gas chromatography-mass spectrometry. The following results were obtained: 1. Lithocholic acid, 3 beta-hydroxy-5-cholen-24-oic acid, deoxycholic acid, chenodeoxycholic acid
Reply: continuous infusion of amphotericin B deoxycholate for the treatment of life-threatening Candida infections.
Didier Dreyfuss et al.
American journal of respiratory and critical care medicine, 188(8), 1033-1034 (2013-10-17)
Zidong Donna Fu et al.
Toxicology and applied pharmacology, 273(3), 680-690 (2013-11-05)
Previous studies showed glucose and insulin signaling can regulate bile acid (BA) metabolism during fasting or feeding. However, limited knowledge is available on the effect of calorie restriction (CR), a well-known anti-aging intervention, on BA homeostasis. To address this, the
Claire Legendre et al.
Infection and immunity, 82(9), 3531-3541 (2014-06-11)
Gastroesophageal reflux (GER) frequently occurs in patients with respiratory disease and is particularly prevalent in patients with cystic fibrosis. GER is a condition in which the duodenogastric contents of the stomach leak into the esophagus, in many cases resulting in
Keshari M Thakali et al.
Pediatric research, 76(2), 202-210 (2014-05-14)
Maternal obesity is associated with unfavorable outcomes, which may be reflected in the as yet undiscovered gene expression profiles of the umbilical cord (UC). UCs from 12 lean (pregravid BMI < 24.9) and 10 overweight/obese (pregravid BMI ≥ 25) women
Christopher B Toomey et al.
Toxicological sciences : an official journal of the Society of Toxicology, 142(2), 339-349 (2014-09-23)
Susceptibility and resistance to systemic autoimmunity are genetically regulated. This is particularly true for murine mercury-induced autoimmunity (mHgIA) where DBA/2J mice are considered resistant to disease including polyclonal B cell activation, autoantibody responses, and immune complex deposits. To identify possible
Hyowon Hong et al.
Biochemical and biophysical research communications, 461(1), 180-185 (2015-04-18)
The actin cytoskeleton has been implicated in the assembly of cilia, but roles of actin-dependent motor proteins in ciliogenesis remain unclear. Myosin heavy chain 10 (MYH10), one of the isoforms of non-muscle myosin II, is known to mediate centrosome reorientation
Raghunath Chatterjee et al.
Epigenetics & chromatin, 7, 35-35 (2015-02-24)
Genome-wide DNA methylation at a single nucleotide resolution in different primary cells of the mammalian genome helps to determine the characteristics and functions of tissue-specific hypomethylated regions (TS-HMRs). We determined genome-wide cytosine methylation maps at 91X and 36X coverage of
Effects of fenofibrate on adiponectin expression in retinas of streptozotocin-induced diabetic rats.
Ying-Jung Hsu et al.
Journal of diabetes research, 2014, 540326-540326 (2014-12-20)
Adiponectin has been associated with increased risks of microvascular complications in diabetes; however, its role in the development of diabetic retinopathy (DR) is unknown. Fenofibrate is a lipid-lowering agent that has been shown to be capable of preventing DR progression.
Francesca Bugli et al.
Antimicrobial agents and chemotherapy, 57(3), 1275-1282 (2012-12-25)
Aspergillus fumigatus biofilms represent a problematic clinical entity, especially because of their recalcitrance to antifungal drugs, which poses a number of therapeutic implications for invasive aspergillosis, the most difficult-to-treat Aspergillus-related disease. While the antibiofilm activities of amphotericin B (AMB) deoxycholate
Yeng F Her et al.
PloS one, 10(5), e0127471-e0127471 (2015-05-20)
Familial paraganglioma (PGL) is a rare neuroendocrine cancer associated with defects in the genes encoding the subunits of succinate dehydrogenase (SDH), a tricarboxylic acid (TCA) cycle enzyme. For unknown reasons, a higher prevalence of PGL has been reported for humans
Su Jin Chung et al.
Life sciences, 108(2), 88-93 (2014-06-01)
Phosphatidylcholine with deoxycholic acid (PC/DA) is widely used to reduce localized fat deposits with mild adverse effects. We previously demonstrated that PC induces lipolysis with mild PMN infiltration, while DA induces adipose tissue damage. Therefore, the aim of this study
Eun Sun Jang et al.
Journal of cancer research and clinical oncology, 140(1), 133-144 (2013-11-28)
The hydrophobic bile acid, deoxycholic acid (DC), can induce apoptosis in hepatocytes. The roles of DC and its transporter are not yet established in hepatocellular carcinoma (HCC) cells. We investigated DC-induced alterations in HCC cell growth, with a particular focus
Sook Hee Ku et al.
Archives of pharmacal research, 38(7), 1317-1324 (2015-01-07)
The activation of receptor for advanced glycation end products (RAGE) signaling is mainly associated with myocardial ischemia/reperfusion injury. Thus the blockade of RAGE-ligands axis can be considered as a potential therapeutic strategy to protect myocardial infarction after ischemia/reperfusion injury. Herein
Mohamed M M Abdel-Latif et al.
European journal of cancer (Oxford, England : 1990), 51(4), 464-472 (2015-01-19)
Nuclear factor-kappaB (NF-κB) regulates the expression of a large number of genes involved in the immune and inflammatory response. NF-κB is constitutively activated in oesophageal tumour tissues and induced in oesophageal cells by bile and acid. The aim of the
Claudia M Cremers et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(16), E1610-E1619 (2014-04-08)
Commensal and pathogenic bacteria must deal with many different stress conditions to survive in and colonize the human gastrointestinal tract. One major challenge that bacteria encounter in the gut is the high concentration of bile salts, which not only aid
Kirsten Holthusen et al.
Journal of virology, 89(14), 7277-7290 (2015-05-08)
Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) induces constitutive signaling in EBV-infected cells to ensure the survival of the latently infected cells. LMP1 is localized to lipid raft domains to induce signaling. In the present study, a genome-wide
Lingmin Yuan et al.
Biochemical pharmacology, 95(1), 58-70 (2015-03-17)
Most human UDP-glucuronosyltransferase (UGT; EC 2.4.1.17) genes contain non-synonymous single nucleotide polymorphisms (nsSNPs) which cause amino acid substitutions. Allelic variants caused by nsSNPs may exhibit absent or reduced enzyme activity. UGT2B7 is one of the most important UGTs that glucuronidates
Chrisovalantis Papadopoulos et al.
PLoS genetics, 11(4), e1005149-e1005149 (2015-04-16)
Mutations in SPAST, encoding spastin, are the most common cause of autosomal dominant hereditary spastic paraplegia (HSP). HSP is characterized by weakness and spasticity of the lower limbs, owing to progressive retrograde degeneration of the long corticospinal axons. Spastin is
Limin Zhang et al.
Environmental health perspectives, 123(7), 679-688 (2015-03-15)
Alteration of the gut microbiota through diet and environmental contaminants may disturb physiological homeostasis, leading to various diseases including obesity and type 2 diabetes. Because most exposure to environmentally persistent organic pollutants (POPs) occurs through the diet, the host gastrointestinal
Sarmah B Nayeem et al.
Molecular and cellular endocrinology, 405, 52-62 (2015-02-15)
Wnt signalling has important roles in decidualisation, implantation and placentation. We investigated the role of decidua-trophoblast communication and Wnt signalling in the placenta using a co-culture model. Expression of a wide range of Wnt-related genes was observed in both decidual
Guillaume Duret et al.
The Journal of biological chemistry, 281(29), 19899-19905 (2006-05-04)
OmpT and OmpU are general diffusion porins of the human intestinal pathogen Vibrio cholerae. The sole presence of OmpT in the outer membrane sensitizes cells to the bile component deoxycholic acid, and the repression of OmpT in the intestine may
Shaquria P Adderley et al.
Microcirculation (New York, N.Y. : 1994), 22(4), 237-248 (2015-01-15)
The mechanisms by which histamine increases microvascular permeability remain poorly understood. We tested the hypothesis that H1 receptor activation disrupts the endothelial barrier and investigated potential downstream signals. We used confluent EC monolayers, assessing TER as an index of barrier
Maria C Estiú et al.
British journal of clinical pharmacology, 79(2), 316-329 (2014-08-08)
Intrahepatic cholestasis of pregnancy (ICP) is characterized by pruritus and elevated bile acid concentrations in maternal serum. This is accompanied by an enhanced risk of intra-uterine and perinatal complications. High concentrations of sulphated progesterone metabolites (PMS) have been suggested to
Catia L Amaral et al.
Journal of nutrigenetics and nutrigenomics, 7(4-6), 314-326 (2015-05-30)
To investigate the global changes in DNA methylation and methylation of the promoter region of the peroxisome proliferator-activated receptor gamma transcript variant 2 (Pparg2) gene resulting from a high-fat diet (HFD) and/or fish oil supplementation. Fish oil, rich in omega-3
Polina A Kameneva et al.
Toxins, 7(10), 3947-3959 (2015-10-02)
For the first time the presence of dinophysistoxin-1 (DTX-1) in a culture of Prorocentrum foraminosum was revealed in cells and in the culture medium. The clone was isolated from coastal waters of the Sea of Japan and identified by molecular
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