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M P Do et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 342-350 (2014-05-17)
Novel in situ forming implants are presented showing a promising potential to overcome one of the major practical hurdles associated with local periodontitis treatment: limited adhesion to the surrounding tissue, resulting in accidental expulsion of at least parts of the
Laurie H L Sellings et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(15), 6295-6303 (2003-07-18)
Convergent evidence suggests that amphetamine (AMPH) exerts its rewarding and locomotor stimulating effects via release of dopamine in the nucleus accumbens. However, there is no consensus as to the relative contributions of core and medial shell subregions to these effects.
Saeed Shojaee et al.
Drug development and industrial pharmacy, 40(11), 1451-1458 (2013-08-22)
Polyethylene oxides (PEOs) are extensively used to control the release rate of drugs from matrices. Unfortunately, polyox polymers are prone to oxidation under high temperature and relative humidity. The aim of this study was to investigate the effect of sodium
S A Kim et al.
Journal of food protection, 78(12), 2233-2239 (2015-11-29)
This study investigated changes in the microbial composition of microbrewed beer during the manufacturing processes and identified potential microbial hazards, effective critical quality control points, and potential contamination routes. Comprehensive quantitative (aerobic plate count, lactic acid bacteria, fungi, acetic acid
Imola Plangár et al.
Ideggyogyaszati szemle, 66(11-12), 407-414 (2014-02-22)
The available scientific data indicate that the pathomechanism of Parkinson's disease (PD) involves the accumulation of endogenous and exogenous toxic substances. The disruption of the proper functioning of certain transporters in the blood-brain barrier and in the blood-cerebrospinal fluid barrier
Immediate type 1 hypersensitivity to apomorphine: a case report.
D Gutiérrez et al.
Journal of investigational allergology & clinical immunology, 21(4), 325-326 (2011-07-05)
Gisela Palma-Orozco et al.
Phytochemistry, 72(1), 82-88 (2010-11-23)
While a long shelf life for fruit products is highly desired, enzymatic browning is the main cause of quality loss in fruits and is therefore a main problem for the food industry. In this study polyphenol oxidase (PPO), the main
Eagleson M.
Concise Encyclopedia Chemistry, 337-337 (1994)
Juan García-Gavín et al.
Contact dermatitis, 67(5), 260-269 (2012-10-09)
Sulfites, preservatives and antioxidants used in the cosmetic, pharmaceutical and food industry are contact allergens whose relevance seems to be difficult to establish. To perform a retrospective study on patients patch tested with a sulfite. Materials and methods. Between 1990
Adriana B Pedale et al.
Anais da Academia Brasileira de Ciencias, 84(4), 1009-1014 (2012-09-20)
The sodium metabisulphite salt is usually used in shrimp culture to prevent black spot. Unfortunately the toxicological effect of this xenobiotic in decapod crabs is unknown. Thus, the present study aims to investigate the sodium metabisulphite LC(50) - 96 h
Wen-Bo Deng et al.
Endocrinology, 155(7), 2704-2717 (2014-05-07)
Thyroid dysfunction during human pregnancy is closely related to serious pregnancy outcome. However, the regulation and function of thyroid hormones during early pregnancy are largely unknown. We found that type II deiodinase, an enzyme converting T4 to activated T3, is
I U Nieves et al.
Bioresource technology, 102(13), 6959-6965 (2011-05-03)
Microaeration (injecting air into the headspace) improved the fermentation of hemicellulose hydrolysates obtained from the phosphoric acid pretreatment of sugarcane bagasse at 170°C for 10 min. In addition, with 10% slurries of phosphoric acid pretreated bagasse (180°C, 10 min), air
P Abate et al.
Behavioural brain research, 274, 194-204 (2014-08-26)
The endogenous opioid system is involved in ethanol reinforcement. Ethanol-induced changes in opioidergic transmission have been extensively studied in adult organisms. However, the impact of ethanol exposure at low or moderate doses during early ontogeny has been barely explored. We
Lubica Horvathova et al.
Journal of neuroimmunology, 278, 255-261 (2014-12-04)
The sympathetic nervous system regulates many immune functions and modulates the anti-tumor immune defense response, too. Therefore, we studied the effect of 6-hydroxydopamine induced sympathectomy on selected hematological parameters and inflammatory markers in rats with Yoshida AH130 ascites hepatoma. We
Sri Awalia Febriana et al.
Contact dermatitis, 67(5), 277-283 (2012-05-11)
Tannery workers are at considerable risk of developing occupational contact dermatitis. Occupational skin diseases in tannery workers in newly industrialized countries have been reported, but neither the prevalence of occupational allergic contact dermatitis nor the skin-sensitizing agents were specifically examined
Rahul Sonawane et al.
Expert opinion on drug delivery, 11(12), 1833-1847 (2014-08-01)
The primary aim of present work was to develop effective combination drug therapy for topical treatment of psoriasis. Betamethasone dipropionate and calcipotriol loaded solid lipid nanoparticles (CT-BD-SLNs) were prepared by hot melt high shear homogenization technique, which were then incorporated
Melinda A Engevik et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(6), G510-G524 (2015-01-02)
The majority of antibiotic-induced diarrhea is caused by Clostridium difficile (C. difficile). Hospitalizations for C. difficile infection (CDI) have tripled in the last decade, emphasizing the need to better understand how the organism colonizes the intestine and maintain infection. The
Ivana Mara da Costa Machado Matos Carvalho et al.
Chemosphere, 82(7), 1056-1061 (2010-11-09)
Sodium metabisulfite is used in marine shrimp harvesting to prevent the occurrence of black spots. Shrimps are soaked in a sodium metabisulfite solution in ice, which is disposed of in sewages that run into marine canals, creating an environmental hazard.
Ceren Kencebay et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 52, 129-136 (2012-11-22)
We aimed at investigating the effects of sulfite-induced lipid peroxidation and apoptosis mediated by secretory phospholipase A2 (sPLA2) on somatosensory evoked potentials (SEP) alterations in rats. Thirty male albino Wistar rats were randomized into three experimental groups as follows; control
Bidyadhar Mandal et al.
Materials science & engineering. C, Materials for biological applications, 44, 132-143 (2014-10-05)
Interpenetrating network (IPN) type hydrogels of a biopolymer and a synthetic polymer were prepared from chitosan and crosslink copolymer of acrylic acid, sodium acrylate and hydroxyethyl methacrylate. Acrylic acid, sodium acrylate, hydroxyethyl methacrylate and N'N'-methylenebisacrylamide (MBA) monomers were free radically
Zhenhua Yang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(9), 3114-3119 (2012-06-26)
Sodium metabisulfite (SMB) is most commonly used as a food additives, however few study was performed on the vasodilator effect of SMB. In the present paper, the vasodilator effects of SMB and roles of Ca(2+) and K(+) channels as well
Elena Pérez et al.
International journal of pharmaceutics, 470(1-2), 107-119 (2014-05-13)
Environmentally sensitive hydrogels have gained considerable attention in recent years as one of the most promising drug delivery systems. In the present study, two new formulations of pH and temperature stimuli-responsive nanogels (NGs) based on poly-N-isopropylacrylamide (NIPA), N-hydroxyethyl acrylamide (HEAA)
Jeffrey N Hemenway et al.
Journal of pharmaceutical sciences, 101(9), 3305-3318 (2012-05-23)
A 2,4-dinitrophenylhydrazine (DNPH) precolumn derivatization high-performance liquid chromatography-ultraviolet detection (HPLC-UV) method was developed to quantify levels of formaldehyde and acetaldehyde in polyethylene glycol (PEG) solutions. Formic acid and acetic acid were quantified by HPLC-UV. Samples of neat and aqueous PEG
Patrizia Marchetti et al.
Scientific reports, 5, 17353-17353 (2015-12-03)
Thin film composite membranes were prepared through a facile single-step wire-wound rod coating procedure in which internally crosslinked poly(styrene-co-butadiene) polymer nanoparticles self-assembled to form a thin film on a hydrophilic ultrafiltration support. This nanoparticle film provided a defect-free separation layer
Microextraction by packed sorbent (MEPS) to analyze catecholamines in innovative biological samples.
Maria Addolorata Saracino et al.
Journal of pharmaceutical and biomedical analysis, 104, 122-129 (2014-12-17)
A new microextraction by packed sorbent (MEPS) procedure coupled to a high-performance liquid chromatographic method has been developed for quantitation of catecholamines (i.e. norepinephrine, epinephrine and dopamine) in innovative biological samples, namely dried plasma and urine spots. Analyses were carried
Maria A Vlasova et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 96-102 (2014-06-26)
Intravenously administered nanocarriers are widely studied to improve the delivery of various therapeutic agents. However, recent in vivo studies have demonstrated that intravenously administered nanocarriers that do not contain any drug may affect cardiovascular function. Here we provide an example
Johanne Louise Neiiendam et al.
Journal of neurochemistry, 91(4), 920-935 (2004-11-05)
The Neural Cell Adhesion Molecule (NCAM) plays a crucial role in development of the central nervous system regulating cell migration, differentiation and synaptogenesis. NCAM mediates cell-cell adhesion through homophilic NCAM binding, subsequently resulting in activation of the fibroblast growth factor
Zhiliang Cheng et al.
Langmuir : the ACS journal of surfaces and colloids, 24(15), 8169-8173 (2008-06-24)
The ability of chelated Gd to serve as an effective magnetic resonance (MR) contrast agent largely depends on fast exchange rates between the Gd-bound water molecules and the surrounding bulk water. Because water diffuses slowly across lipid bilayers, liposomes with
Jiafu Feng et al.
Drug development and industrial pharmacy, 38(3), 264-270 (2011-08-05)
The objective of this paper is to calculate the shelf life of ascorbic acid solution under given conditions by using a mathematical model. An antioxidant, sodium metabisulfite, was added to the ascorbic acid solution. The kinetic parameters of the degradation
Ivana M C M M Carvalho et al.
Mutation research, 720(1-2), 58-61 (2010-12-28)
Sodium metabisulfite (SMB, Na(2)S(2)O(5)) is widely used in the food and pharmaceutical industries, because of its ability to inhibit proliferation of microorganisms and its antioxidant properties. We have evaluated the genotoxic effects of SMB on different tissues of the mouse
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