320-60-5

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Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction.

Z Strakova et al.

The American journal of physiology, 272(5 Pt 1), E870-E876 (1997-05-01)

Occupancy of oxytocin receptor (OTR) binding sites in pregnant rat myometrial membranes with iodinated oxytocin antagonist (OTA), followed by detergent solubilization and size selection, showed that radioactivity eluted in two distinct peaks: one corresponding in size to the isolated receptor

SB 242084, a selective serotonin2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system.

V Di Matteo et al.

Neuropharmacology, 38(8), 1195-1205 (1999-08-26)

Electrophysiological techniques and in vivo microdialysis were used to investigate the effect of SB 242084, a potent and selective 5-HT2C receptor antagonist in the control of nigro-striatal and mesolimbic dopaminergic function. Thus, extracellular single unit recordings were performed from neurochemically-identified

A randomized, double-blind study to compare the efficacy and safety of two doses of mometasone furoate delivered via Breezhaler® or Twisthaler® in patients with asthma.

Roland Buhl et al.

Pulmonary pharmacology & therapeutics, 62, 101919-101919 (2020-05-11)

Mometasone furoate (MF) is the inhaled corticosteroid (ICS) component in the long-acting β2-agonist (LABA)/ICS fixed-dose combination of indacaterol/MF, delivered via Breezhaler®, in development for asthma. MF at low (80 μg) and high (320 μg) doses delivered via Breezhaler® is expected to be

Thymidylate synthase expression in colon carcinomas with microsatellite instability.

Frank A Sinicrope et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 12(9), 2738-2744 (2006-05-06)

Colon cancer cells with high-frequency microsatellite instability (MSI-H) display resistance to 5-fluorouracil (5-FU) that can be reversed by restoring DNA mismatch repair (MMR) proficiency. Given that thymidylate synthase (TS) is inhibited by 5-FU, we studied the relationship between MSI and

The nature of cancer and the mechanisms of its control: a review.

L C Strong

Cytobios, 28(111-112), 187-208 (1980-01-01)

Observations on the nature of spontaneous tumours of mammary gland origin in mice, published over a 60-year period in 320 papers, are reviewed. Data presented are (1) development of adequate experimental mice; (2) comparative studies on transplantable, chemically induced and

Comparison of fracture risk prediction among individuals with reduced and normal kidney function.

Kyla L Naylor et al.

Clinical journal of the American Society of Nephrology : CJASN, 10(4), 646-653 (2015-02-07)

The Fracture Risk Assessment Tool (FRAX) is widely used to predict the 10-year probability of fracture; however, the clinical utility of FRAX in CKD is unknown. This study assessed the predictive ability of FRAX in individuals with reduced kidney function

Assignment and ordering of twenty-three unique NotI-linking clones containing expressed genes including the guanosine 5'-monophosphate synthetase gene to human chromosome 3.

L Fedorova et al.

European journal of human genetics : EJHG, 5(2), 110-116 (1997-03-01)

Twenty-three unique NotI-linking clones, mainly isolated from the NRL1 library, were mapped and ordered by fluorescence in situ hybridization to human chromosome 3. All these clones were partially sequenced around the NotI sites and thus represent sequence-tagged sites. The EMBL

Colorectal cancer combination therapy using drug and gene co-delivered, targeted poly(ethylene glycol)-ε-poly(caprolactone) nanocarriers.

Zhiyu Wang et al.

Drug design, development and therapy, 12, 3171-3180 (2018-10-06)

Combination therapy is a promising strategy to treat cancer due to the synergistic effects. The drug and gene co-delivered systems attract more attention in the field of combination therapy. In the present research, poly(ethylene glycol)-ε-poly(caprolactone) block copolymer was used for

Protolichesterinic Acid, Isolated from the Lichen Cetraria islandica, Reduces LRRC8A Expression and Volume-Sensitive Release of Organic Osmolytes in Human Lung Epithelial Cancer Cells.

Unnur Arna Thorsteinsdottir et al.

Phytotherapy research : PTR, 30(1), 97-104 (2015-11-10)

We have tested the effect of protolichesterinic acid (PA) on the activity of the volume-sensitive release pathway for the organic osmolyte taurine (VSOAC) and the expression of the leucine-rich-repeat-channel 8A (LRRC8A) protein, which constitutes an essential VSOAC component. Exposing human

Limb remote ischemic preconditioning attenuates lung injury after pulmonary resection under propofol-remifentanil anesthesia: a randomized controlled study.

Cai Li et al.

Anesthesiology, 121(2), 249-259 (2014-04-20)

Remote ischemic preconditioning (RIPC) may confer the protection in critical organs. The authors hypothesized that limb RIPC would reduce lung injury in patients undergoing pulmonary resection. In a randomized, prospective, parallel, controlled trial, 216 patients undergoing elective thoracic pulmonary resection

Mutagenicity of UV-irradiated maltol in Salmonella typhimurium.

Mie Watanabe-Akanuma et al.

Mutagenesis, 22(1), 43-47 (2006-12-16)

We investigated the photomutagenicity of maltol (3-hydroxy-2-methyl-4H-pyran-4-one) in bacterial cells. Maltol has a caramel-butterscotch odour and is used as a food additive to impart flavour to bread and cakes. Unirradiated maltol was not mutagenic up to 5 mg/plate in the

The Gas7 gene encodes two protein isoforms differentially expressed within the brain.

E M Lazakovitch et al.

Genomics, 61(3), 298-306 (1999-11-24)

Gas7, a growth arrest-specific gene first isolated from serum-starved NIH3T3 cells, is expressed abundantly in the brain and is essential for the outgrowth of neurites from cultured cerebellar neurons. Here, we report the existence of a Gas7-related cDNA, designated Gas7-cb

Human bronchial fibroblasts express the 5-lipoxygenase pathway.

Anna J James et al.

Respiratory research, 7, 102-102 (2006-07-29)

Fibroblasts are implicated in sub-epithelial fibrosis in remodeled asthmatic airways and contribute to airway inflammation by releasing cytokines and other mediators. Fibroblast activity is influenced by members of the leukotriene family of bronchoconstrictor and inflammatory mediators, but it is not

Colorectal carcinomas and PTEN/MMAC1 gene mutations.

G Dicuonzo et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 7(12), 4049-4053 (2001-12-26)

PTEN/MMAC1/TEP1 is a tumor suppressor gene encoding a dual-specificity protein phosphatase with homology to the cytoskeleton proteins, chicken tensin and bovine auxilin. PTEN mutations have been described in several types of human cancer. Recently, mutations at an (A)(6) repeat of

Development of a rapid and sensitive high-performance liquid chromatographic method to determine CYP2D6 phenotype in human liver microsomes.

Bhaskar Rege et al.

Biomedical chromatography : BMC, 16(1), 31-40 (2002-01-30)

Dextromethorphan is a probe substrate to determine CYP2D6 phenotype. The conversion of dextromethorphan to dextrorphan by CYP2D6 accounts for approximately 60% of total metabolism. Most analytical methods utilize complicated labor- and time-intensive sample processing methods with several liquid-liquid extraction (LLE)

Effects of subchronic exposure to 2,6-dinitrotoluene in the northern bobwhite (Colinus virginianus).

Michael J Quinn et al.

Environmental toxicology and chemistry, 26(10), 2202-2207 (2007-09-18)

Explosives and their breakdown products are commonly found in soils at U.S. military installations. Many areas where these compounds are found represent useful habitat for ground-foraging birds. Because these birds likely are exposed to such compounds, we evaluated the oral

N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction.

Y Nishida et al.

Heart and vessels, 15(6), 268-273 (2002-01-05)

We examined whether pharmacological inhibition of glycogenolysis by N-methyl-1-deoxynojirimycin (MOR-14), a new compound which reduces the glycogenolytic rate by inhibiting the alpha-1,6-glucosidase activity of the glycogen-debranching enzyme, can protect the heart against postischemic left ventricular dysfunction. The hearts of male

Mechanism of early biphasic activation of poly(ADP-ribose) polymerase-1 in response to ultraviolet B radiation.

Momchil D Vodenicharov et al.

Journal of cell science, 118(Pt 3), 589-599 (2005-01-20)

The damage to DNA caused by ultraviolet B radiation (280-320 nm) contributes significantly to development of sunlight-induced skin cancers. The susceptibility of mice to ultraviolet B-induced skin carcinogenesis is increased by an inhibitor of the DNA damage-activated nuclear enzyme poly(ADP-ribose)

Elimination profiles of betamethasone after different administration routes: Evaluation of the reporting level and washout periods to ensure safe therapeutic administrations.

Sergi Coll et al.

Drug testing and analysis, 13(2), 348-359 (2020-09-20)

Betamethasone (BET) is prohibited in sports competitions when administered by systemic routes, and it is allowed by other routes for therapeutic purposes. In out-of-competition periods, there is no restriction of use. The present work aimed to assess the urinary excretion

The integrative analysis of microRNA and mRNA expression in Apis mellifera following maze-based visual pattern learning.

Qiu-Hong Qin et al.

Insect science, 21(5), 619-636 (2013-10-19)

The honeybee (Apis mellifera) is a social insect with strong sensory capacity and diverse behavioral repertoire and is recognized as a good model organism for studying the neurobiological basis of learning and memory. In this study, we analyzed the changes

The mechanism of atrial antiarrhythmic action of RSD1235.

David Fedida et al.

Journal of cardiovascular electrophysiology, 16(11), 1227-1238 (2005-11-24)

RSD1235 is a novel drug recently shown to convert AF rapidly and safely in patients.(1) Its mechanism of action has been investigated in a rat model of ischemic arrhythmia, along with changes in action potential (AP) morphology in isolated rat

Genetic variation that predicts platinum sensitivity reveals the role of miR-193b* in chemotherapeutic susceptibility.

Dana Ziliak et al.

Molecular cancer therapeutics, 11(9), 2054-2061 (2012-07-04)

Platinum agents are the backbone of cancer chemotherapy. Recently, we identified and replicated the role of a single nucleotide polymorphism (SNP, rs1649942) in predicting platinum sensitivity both in vitro and in vivo. Using the CEU samples from the International HapMap

Zero kinetic energy photoelectron spectroscopy of tryptamine and the dissociation pathway of the singly hydrated cation cluster.

Quanli Gu et al.

The Journal of chemical physics, 137(10), 104312-104312 (2012-09-18)

The relative ionization energies of tryptamine conformations are determined by zero kinetic energy photoelectron spectroscopy and photoionization efficiency measurements. The relative cationic conformational stabilities are compared to the published results for the neutral molecule. In the cation, the interaction strength

Phenotypic expression of Bardet-Biedl syndrome in patients homozygous for the common M390R mutation in the BBS1 gene.

Kyle F Cox et al.

Vision research, 75, 77-87 (2012-09-04)

To characterize the phenotype of Bardet-Biedl syndrome (BBS) patients homozygous for the BBS1 M390R mutation. Three patients [PT1, F, 27 years old (yo) at last examination, 14-year follow-up (F/U) PT2, F, 15-yo PT3, M, 15-yo, both 1-year F/U] underwent eye

Thiopurine S-methyltransferase pharmacogenetics in a large-scale healthy Italian-Caucasian population: differences in enzyme activity.

Loredana Serpe et al.

Pharmacogenomics, 10(11), 1753-1765 (2009-11-07)

To investigate the influence of genotype, age and gender on the thiopurine S-methyltransferase (TPMT) phenotype in healthy Italian-Caucasian subjects. The study investigated the TPMT genotype and the TPMT phenotype of 943 healthy Italian-Caucasian subjects of different age and gender (age

Potentiating effect of dietary vitamin A on photocarcinogenesis in hairless mice.

S Mikkelsen et al.

Carcinogenesis, 19(4), 663-666 (1998-05-26)

Vitamin A and its derivatives (retinoids) exert modulatory effects on epithelial differentiation and are used therapeutically against skin cancers, but the role of dietary vitamin A in ultraviolet (UV)-induced carcinogenesis is far from clear. To study this process, 220 hairless

Structural polymorphism of oligomeric adiponectin visualized by electron microscopy.

Mazdak Radjainia et al.

Journal of molecular biology, 381(2), 419-430 (2008-07-11)

Adiponectin, a macromolecular complex similar to the members of the C1q and other collagenous homologues, elicits diverse biological functions, including anti-diabetes, anti-atherosclerosis, anti-inflammation and anti-tumor activities, which have been directly linked to the high molecular weight (HMW) oligomeric structures formed

Sorption of biocides, triazine and phenylurea herbicides, and UV-filters onto secondary sludge.

Arne Wick et al.

Water research, 45(12), 3638-3652 (2011-05-17)

The sludge-water distribution of a total of 41 organic micropollutants (9 phenylurea herbicides, 11 triazines, 16 biocides and 5 UV-filters) was investigated in laboratory batch experiments with fresh secondary sludge taken from a municipal WWTP. Sorption kinetics as well as

Determination of benzimidazolic fungicides in fruits and vegetables by supramolecular solvent-based microextraction/liquid chromatography/fluorescence detection.

Antonia Moral et al.

Analytica chimica acta, 650(2), 207-213 (2009-09-02)

A supramolecular solvent consisting of vesicles, made up of equimolecular amounts of decanoic acid (DeA) and tetrabutylammonium decanoate (Bu4NDe), dispersed in a continuous aqueous phase, is proposed for the extraction of benzimidazolic fungicides (BFs) from fruits and vegetables. Carbendazim (CB)

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

H E Hohmeier et al.

Diabetes, 49(3), 424-430 (2000-06-27)

The biochemical mechanisms involved in regulation of insulin secretion are not completely understood. The rat INS-1 cell line has been used to gain insight in this area because it secretes insulin in response to glucose concentrations in the physiological range.

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