CN
Search Within
32307
应用筛选条件
关键词:'32307'
显示 1-30 共 38 条结果 关于 "32307" 范围 论文
Ana L Luna et al.
Toxicology letters, 214(3), 301-306 (2012-09-25)
Lead (Pb) alters the susceptibility to different pathogens suggesting that macrophage-mediated defense mechanisms, through activation of toll-like receptors (TLRs), may be affected by Pb. The aim of this study was to test whether activation of TLR4 is a targeted molecule
C-M Liu et al.
Free radical research, 47(3), 192-201 (2012-12-20)
Lead (Pb), a well-known environmental toxin, is one of the major hazards for human health. Quercetin (QE), a natural flavonoid, has been reported to have many benefits and medicinal properties. However, its protective effects against Pb-induced endoplasmic reticulum (ER) stress
Xiaochun Sun et al.
Molecular medicine reports, 6(4), 827-832 (2012-08-04)
Plumbum (Pb) is a heavy metal toxin that causes many pathophysiological effects in various systems of the human body. It has previously been reported that excessive lead trioxide causes hematopoietic system toxicity. Mesenchymal stem cells (MSCs), as cells with self-renewal
Hazardous Chemicals: Safety Management and Global Regulations, 244-244 (2013)
Yoshinori Ikenaka et al.
Environmental toxicology and chemistry, 31(10), 2300-2305 (2012-07-24)
The Republic of Zambia is rich in mineral resources, such as zinc (Zn) and lead (Pb), and mining is a key industry in Zambia. A previous study of Pb pollution in Kabwe, one of the main mining areas, found that
Yi-Ting Wang et al.
Toxicology, 305, 120-129 (2013-02-02)
Apurinic/apyrimidinic endonuclease 1 (APE1)/redox effector factor-1 is a multifunctional enzyme involved in DNA base excision repair and protein redox regulation. Previously, we have showed that lead acetate (Pb) elicits EGFR activation to initiate the SFK/PKCα/Ras/Raf-1/MKK1/2/ERK signaling cascade functioning against genotoxicity.
Norazah Ahmad et al.
The Malaysian journal of pathology, 34(1), 35-39 (2012-08-09)
Serotyping is not sufficient to differentiate between Salmonella species that cause paratyphoid fever from the strains that cause milder gastroenteritis as these organisms share the same serotype Salmonella Paratyphi B (S. Paratyphi B). Strains causing paratyphoid fever do not ferment
Jiangfei Chen et al.
Neurotoxicology and teratology, 34(6), 581-586 (2012-09-15)
Lead is a persistent metal and commonly present in our living environment. The present study was aimed to investigate lead-induced embryonic toxicity, behavioral responses, and adult learning/memory deficit in zebrafish. Lead acetate (PbAc) induced malformations such as uninflated swim bladder
Qinghua Jia et al.
Toxicology mechanisms and methods, 22(9), 705-710 (2012-08-17)
Lead-induced nephrotoxicity is a human health hazard problem. In this study, Human mesangial cells (HMCs) were treated with different concentration of lead acetate (5, 10, 20 μmol/l) in order to investigate the oxidative stress and apoptotic changes. It was revealed
Shu Guo et al.
Toxicology letters, 229(1), 150-157 (2014-06-25)
The demonstration of bystander effect, which means injured cells propagate damage to neighboring cells, in whole organisms has clear implication of the potential relevance of the non-targeted response to human health. Here we show that 10 μM lead acetate, the
Nilantika Paul et al.
Aquatic toxicology (Amsterdam, Netherlands), 152, 105-112 (2014-04-22)
Lead has no known role in the body that is physiologically relevant, and its harmful effects are myriad. Lead from the atmosphere and soil ends up in water bodies thus affecting the aquatic organisms. This situation has thus prompted numerous
Christina Sobin et al.
Toxicology letters, 220(1), 44-52 (2013-04-20)
The mechanisms by which early chronic lead (Pb) exposure alter brain development have not been identified. We examined neuroimmune system effects in C57BL/6J mice with Pb exposure, including levels that may be common among children in lower socioeconomic income environments.
Anne E Roberts et al.
Ecotoxicology and environmental safety, 102, 100-104 (2014-02-11)
The effect of lead accumulation on photopigment production, mineral nutrition, and Anabaena vegetative cell size and heterocyst formation in Azolla caroliniana was investigated. Plants were exposed to 0, 1, 5, 10, and 20 mg L(-1) lead acetate for ten days.
M Martínez-Pacheco et al.
Gene, 533(2), 508-514 (2013-10-02)
Metals are a threat to human health by increasing disease risk. Experimental data have linked altered miRNA expression with exposure to some metals. MiRNAs comprise a large family of non-coding single-stranded molecules that primarily function to negatively regulate gene expression
Guy A Perkins et al.
Molecular vision, 18, 3029-3048 (2013-01-05)
Postnatal lead exposure produces rod-selective and Bax-mediated apoptosis, decreased scotopic electroretinograms (ERGs), and scotopic and mesopic vision deficits in humans and/or experimental animals. Rod, but not cone, inner segment mitochondria were considered the primary site of action. However, photoreceptor synaptic
Epigenetic histone modification regulates developmental lead exposure induced hyperactivity in rats.
Man Luo et al.
Toxicology letters, 225(1), 78-85 (2013-12-03)
Lead (Pb) exposure was commonly considered as a high environmental risk factor for the development of attention-deficit/hyperactivity disorder (ADHD). However, the molecular basis of this pathological process still remains elusive. In light of the role of epigenetics in modulating the
Mohammed H Badawoud et al.
Neurosciences (Riyadh, Saudi Arabia), 18(1), 52-57 (2013-01-08)
To investigate the morphological changes in the peripheral motor system of the rat induced by exposure to lead. This study was conducted at the Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia from January 2011
Nabila Haddou et al.
Chemosphere, 107, 304-310 (2014-01-28)
The Gliding Arc Discharge (GAD) is an efficient non-thermal plasma technique able to degrade organic compounds dispersed in water at atmospheric pressure. The degradation of the organometallic lead acetate (PbAc) in aqueous solution was performed by two distinct plasmageneous processes:
M Nisanian et al.
Poultry science, 93(4), 891-897 (2014-04-08)
Heavy metals have been implicated for their ability to increase antibiotic resistance in bacteria collected from polluted waters, independent of antibiotic exposure. Specific-pathogen-free Leghorn chickens were therefore given Pb acetate in the drinking water to expose the enteric bacteria to
Gang Zheng et al.
Toxicology letters, 225(1), 110-118 (2013-12-10)
The blood-cerebrospinal fluid barrier (BCB) plays a key role in maintaining copper (Cu) homeostasis in the brain. Cumulative evidences indicate that lead (Pb) exposure alters cerebral Cu homeostasis, which may underlie the development of neurodegenerative diseases. This study investigated the
Tahere Farkhondeh et al.
Cardiovascular & hematological disorders drug targets, 13(1), 45-49 (2012-10-04)
This study was aimed to examine the effect of lead acetate on inflammatory biomarkers in blood of guinea pigs in comparison with sensitized animals. Thirty guinea pigs were randomly allocated into control (group C), sensitized (group S), and three Pb-exposed
Carbone L, et al.
Journal of Materials Chemistry, 16(40), 3952-3956 (2006)
A Rahman et al.
Acta biologica Hungarica, 63(4), 411-425 (2012-11-09)
Cognitive impairment is a common feature of both lead exposure and hyperphosphorylation of tau. We, therefore, investigated whether lead exposure would induce tau hyperphosphorylation. Wistar rat pups were exposed to 0.2% lead acetate via their dams' drinking water from postnatal
Yuan-Yuan Li et al.
Environmental toxicology, 27(8), 495-502 (2012-07-06)
It has been suggested that lead (Pb) exposure in early life may increase amyloid precursor protein (APP) expression and promote the pathogenesis of Alzheimer's disease in old age. The current study examined whether the DNA methylation patterns of APP gene
Fengwei Tian et al.
Biological trace element research, 150(1-3), 264-271 (2012-06-12)
Lead causes a broad range of adverse effects in humans and animals. The objective was to evaluate the potency of lactobacilli to bind lead in vitro and the protective effects of a selected Lactobacillus plantarum CCFM8661 against lead-induced toxicity in
Mohammad Hossein Boskabady et al.
Ecotoxicology and environmental safety, 86, 233-238 (2012-10-24)
The association between lead exposure and asthma is controversial. The effect of inhaled lead acetate on lung inflammation, tracheal responsiveness and immune components in guinea pigs after sensitization was examined in this study. Five groups of guinea pigs were randomly
I Baranowska-Bosiacka et al.
Toxicology, 303, 187-200 (2012-11-14)
The aim of this paper is to examine if pre- and neonatal exposure to lead (Pb) may intensify or inhibit apoptosis or necroptosis in the developing rat brain. Pregnant experimental females received 0.1% lead acetate (PbAc) in drinking water from
Asit Rai et al.
Toxicology mechanisms and methods, 23(2), 99-107 (2012-08-21)
Exposure to a mixture of As, Pb and Cd induces apoptosis and morphological alterations in the cortical astrocytes of rat brain. The levels of the glial fibrillary acidic protein (GFAP) undergo a reduction. The GFAP exists in several isoforms, viz.
J S Schneider et al.
Toxicology letters, 217(1), 75-81 (2012-12-19)
Developmental exposure to lead (Pb) has adverse effects on cognitive functioning and behavior that can persist into adulthood. Exposures that occur during fetal or early life periods may produce changes in brain related to physiological re-programming from an epigenetic influence
Sangeeta Chatterjee et al.
FEBS letters, 587(5), 474-480 (2013-01-30)
The human heme-regulated eIF2α kinase, also called the human heme-regulated inhibitor (hHRI) is significantly up-regulated particularly at the level of translation during stress. In this report we show that during lead-stress, the regulation of hHRI mRNA translation is mediated through
1/2