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Ana L Luna et al.
Toxicology letters, 214(3), 301-306 (2012-09-25)
Lead (Pb) alters the susceptibility to different pathogens suggesting that macrophage-mediated defense mechanisms, through activation of toll-like receptors (TLRs), may be affected by Pb. The aim of this study was to test whether activation of TLR4 is a targeted molecule
Yi-Ting Wang et al.
Toxicology, 305, 120-129 (2013-02-02)
Apurinic/apyrimidinic endonuclease 1 (APE1)/redox effector factor-1 is a multifunctional enzyme involved in DNA base excision repair and protein redox regulation. Previously, we have showed that lead acetate (Pb) elicits EGFR activation to initiate the SFK/PKCα/Ras/Raf-1/MKK1/2/ERK signaling cascade functioning against genotoxicity.
Norazah Ahmad et al.
The Malaysian journal of pathology, 34(1), 35-39 (2012-08-09)
Serotyping is not sufficient to differentiate between Salmonella species that cause paratyphoid fever from the strains that cause milder gastroenteritis as these organisms share the same serotype Salmonella Paratyphi B (S. Paratyphi B). Strains causing paratyphoid fever do not ferment
C-M Liu et al.
Free radical research, 47(3), 192-201 (2012-12-20)
Lead (Pb), a well-known environmental toxin, is one of the major hazards for human health. Quercetin (QE), a natural flavonoid, has been reported to have many benefits and medicinal properties. However, its protective effects against Pb-induced endoplasmic reticulum (ER) stress
Xiaochun Sun et al.
Molecular medicine reports, 6(4), 827-832 (2012-08-04)
Plumbum (Pb) is a heavy metal toxin that causes many pathophysiological effects in various systems of the human body. It has previously been reported that excessive lead trioxide causes hematopoietic system toxicity. Mesenchymal stem cells (MSCs), as cells with self-renewal
Jiangfei Chen et al.
Neurotoxicology and teratology, 34(6), 581-586 (2012-09-15)
Lead is a persistent metal and commonly present in our living environment. The present study was aimed to investigate lead-induced embryonic toxicity, behavioral responses, and adult learning/memory deficit in zebrafish. Lead acetate (PbAc) induced malformations such as uninflated swim bladder
Yoshinori Ikenaka et al.
Environmental toxicology and chemistry, 31(10), 2300-2305 (2012-07-24)
The Republic of Zambia is rich in mineral resources, such as zinc (Zn) and lead (Pb), and mining is a key industry in Zambia. A previous study of Pb pollution in Kabwe, one of the main mining areas, found that
Hazardous Chemicals: Safety Management and Global Regulations, 244-244 (2013)
Mohammed H Badawoud et al.
Neurosciences (Riyadh, Saudi Arabia), 18(1), 52-57 (2013-01-08)
To investigate the morphological changes in the peripheral motor system of the rat induced by exposure to lead. This study was conducted at the Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia from January 2011
Anne E Roberts et al.
Ecotoxicology and environmental safety, 102, 100-104 (2014-02-11)
The effect of lead accumulation on photopigment production, mineral nutrition, and Anabaena vegetative cell size and heterocyst formation in Azolla caroliniana was investigated. Plants were exposed to 0, 1, 5, 10, and 20 mg L(-1) lead acetate for ten days.
M Martínez-Pacheco et al.
Gene, 533(2), 508-514 (2013-10-02)
Metals are a threat to human health by increasing disease risk. Experimental data have linked altered miRNA expression with exposure to some metals. MiRNAs comprise a large family of non-coding single-stranded molecules that primarily function to negatively regulate gene expression
Qinghua Jia et al.
Toxicology mechanisms and methods, 22(9), 705-710 (2012-08-17)
Lead-induced nephrotoxicity is a human health hazard problem. In this study, Human mesangial cells (HMCs) were treated with different concentration of lead acetate (5, 10, 20 μmol/l) in order to investigate the oxidative stress and apoptotic changes. It was revealed
Nilantika Paul et al.
Aquatic toxicology (Amsterdam, Netherlands), 152, 105-112 (2014-04-22)
Lead has no known role in the body that is physiologically relevant, and its harmful effects are myriad. Lead from the atmosphere and soil ends up in water bodies thus affecting the aquatic organisms. This situation has thus prompted numerous
Guy A Perkins et al.
Molecular vision, 18, 3029-3048 (2013-01-05)
Postnatal lead exposure produces rod-selective and Bax-mediated apoptosis, decreased scotopic electroretinograms (ERGs), and scotopic and mesopic vision deficits in humans and/or experimental animals. Rod, but not cone, inner segment mitochondria were considered the primary site of action. However, photoreceptor synaptic
Epigenetic histone modification regulates developmental lead exposure induced hyperactivity in rats.
Man Luo et al.
Toxicology letters, 225(1), 78-85 (2013-12-03)
Lead (Pb) exposure was commonly considered as a high environmental risk factor for the development of attention-deficit/hyperactivity disorder (ADHD). However, the molecular basis of this pathological process still remains elusive. In light of the role of epigenetics in modulating the
Shu Guo et al.
Toxicology letters, 229(1), 150-157 (2014-06-25)
The demonstration of bystander effect, which means injured cells propagate damage to neighboring cells, in whole organisms has clear implication of the potential relevance of the non-targeted response to human health. Here we show that 10 μM lead acetate, the
Christina Sobin et al.
Toxicology letters, 220(1), 44-52 (2013-04-20)
The mechanisms by which early chronic lead (Pb) exposure alter brain development have not been identified. We examined neuroimmune system effects in C57BL/6J mice with Pb exposure, including levels that may be common among children in lower socioeconomic income environments.
Gagan Flora et al.
Biological trace element research, 152(1), 31-40 (2013-01-08)
Chronic lead exposure is associated with several health disorders in humans and animals. Lead exposure leads to the generation of reactive oxygen species and depletes body antioxidant enzymes causing damage to various macromolecules and ultimately cell death. Curcumin has been
J S Schneider et al.
Toxicology letters, 217(1), 75-81 (2012-12-19)
Developmental exposure to lead (Pb) has adverse effects on cognitive functioning and behavior that can persist into adulthood. Exposures that occur during fetal or early life periods may produce changes in brain related to physiological re-programming from an epigenetic influence
I Baranowska-Bosiacka et al.
Toxicology, 303, 187-200 (2012-11-14)
The aim of this paper is to examine if pre- and neonatal exposure to lead (Pb) may intensify or inhibit apoptosis or necroptosis in the developing rat brain. Pregnant experimental females received 0.1% lead acetate (PbAc) in drinking water from
Yuan-Yuan Li et al.
Environmental toxicology, 27(8), 495-502 (2012-07-06)
It has been suggested that lead (Pb) exposure in early life may increase amyloid precursor protein (APP) expression and promote the pathogenesis of Alzheimer's disease in old age. The current study examined whether the DNA methylation patterns of APP gene
Fengwei Tian et al.
Biological trace element research, 150(1-3), 264-271 (2012-06-12)
Lead causes a broad range of adverse effects in humans and animals. The objective was to evaluate the potency of lactobacilli to bind lead in vitro and the protective effects of a selected Lactobacillus plantarum CCFM8661 against lead-induced toxicity in
Mohammad Hossein Boskabady et al.
Ecotoxicology and environmental safety, 86, 233-238 (2012-10-24)
The association between lead exposure and asthma is controversial. The effect of inhaled lead acetate on lung inflammation, tracheal responsiveness and immune components in guinea pigs after sensitization was examined in this study. Five groups of guinea pigs were randomly
Sangeeta Chatterjee et al.
FEBS letters, 587(5), 474-480 (2013-01-30)
The human heme-regulated eIF2α kinase, also called the human heme-regulated inhibitor (hHRI) is significantly up-regulated particularly at the level of translation during stress. In this report we show that during lead-stress, the regulation of hHRI mRNA translation is mediated through
Gang Zheng et al.
Toxicology letters, 225(1), 110-118 (2013-12-10)
The blood-cerebrospinal fluid barrier (BCB) plays a key role in maintaining copper (Cu) homeostasis in the brain. Cumulative evidences indicate that lead (Pb) exposure alters cerebral Cu homeostasis, which may underlie the development of neurodegenerative diseases. This study investigated the
Jane V Knichal et al.
Chemical communications (Cambridge, England), 50(92), 14436-14439 (2014-10-11)
5-Ethynyl-1,3-benzenedicarboxylic acid (H2ebdc) reacted with lead(II) acetate trihydrate yields a 1D ladder network, [Pb(ebdc)(MeOH)]2·H2O (1). Removing crystals of 1 from the mother liquor results in a facile single crystal to single crystal transition, yielding 2D [Pb(ebdc)] net (2) with a
Asit Rai et al.
Toxicology mechanisms and methods, 23(2), 99-107 (2012-08-21)
Exposure to a mixture of As, Pb and Cd induces apoptosis and morphological alterations in the cortical astrocytes of rat brain. The levels of the glial fibrillary acidic protein (GFAP) undergo a reduction. The GFAP exists in several isoforms, viz.
Samuel Greani et al.
Comptes rendus biologies, 335(10-11), 657-667 (2012-12-04)
The ultrastructural organization of the female reproductive system of Metadena depressa, digenean intestinal parasite of Sparidae (Dentex dentex), was investigated by electron microscopy. The vitellogenesis is divided into four stages: stage I, vitellocytes have a cytoplasm mainly filled with ribosomes
Anke Visan et al.
Neurotoxicology, 33(5), 1135-1146 (2012-06-27)
Mouse embryonic stem cells (mESCs) represent an attractive cellular system for in vitro studies in developmental biology as well as toxicology because of their potential to differentiate into all fetal cell lineages. The present study aims to establish an in
Somayeh Hosseinzadeh et al.
Pharmaceutical biology, 51(2), 240-245 (2012-11-09)
For many years it has been known that lead is life-threatening, not only as an air pollutant but also because of it has been associated with several conditions including neurodegenerative disease. Curcumin (the principal curcuminoid found in turmeric) has demonstrated
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