329045

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Synthesis, characterization, and molecular docking analysis of novel benzimidazole derivatives as cholinesterase inhibitors.

Yeong Keng Yoon et al.

Bioorganic chemistry, 49, 33-39 (2013-07-28)

Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structure were synthesized by a four-step reaction pathway starting from 4-fluoro-3-nitrobenzoic acid as the basic compound. The structure of the novel benzimidazoles was characterized and confirmed by

Synthesis and evaluation of antimycobacterial activity of new benzimidazole aminoesters.

Yeong Keng Yoon et al.

European journal of medicinal chemistry, 93, 614-624 (2014-07-06)

A total of 51 novel benzimidazoles were synthesized by a 4-step reaction starting from basic compound 4-fluoro-3-nitrobenzoic acid under relatively mild reaction conditions. The structure of the novel benzimidazoles was confirmed by mass spectra as well as (1)H NMR spectroscopic

Reagents for the preparation of chromophorically labeled polyethylene glycol-protein conjugates.

D L Ladd et al.

Analytical biochemistry, 210(2), 258-261 (1993-05-01)

We have developed a new class of reagents (2) for the covalent attachment of polyethylene glycol to proteins. These reagents (2) are the monomethoxypolyethylene glycol esters of 4-fluoro-3-nitrobenzoic acid. The reaction of 2 with lysine epsilon-amino groups produces a chromophore

Solid phase synthesis of functionalized biaryl ethers: versatile scaffolds for combinatorial chemistry.

J C Wijkmans et al.

Molecular diversity, 3(2), 117-120 (1997-01-01)

4-Fluoro-3-nitrobenzoic acid attached to a solid support was shown to react under mild conditions with a wide range of functionalized phenols to yield, after cleavage, the corresponding biaryl ethers in excellent purity. In a similar fashion, biaryl thioethers could be

Regioselective, unconventional Pictet-Spengler cyclization strategy toward the synthesis of benzimidazole-linked imidazoquinoxalines on a soluble polymer support.

Chih-Hau Chen et al.

Chemistry, an Asian journal, 6(6), 1557-1565 (2011-04-08)

A novel strategy for an unconventional Pictet-Spengler reaction has been developed for the regioselective cyclization of the imidazole ring system at the C2 position. The developed strategy was utilized to develop a diversity-oriented parallel synthesis for bis(heterocyclic) skeletal novel analogs

Combinatorial synthesis of biheterocyclic benzimidazoles by microwave irradiation.

Wen-Bing Yeh et al.

Combinatorial chemistry & high throughput screening, 7(3), 251-255 (2004-05-12)

Liquid phasel synthesis of biheterocyclic benzimidazoles by controlled microwave irradiation was investigated. Polymer immobilized o-phenylenediamines was synthesized under microwave irradiation. The resulting PEG bound diamines was N-acylated with 4-fluoro-3-nitrobenzoic acid selectively in primary aromatic amino moiety. Nucleophilic aromatic substitution of

Parallel solid-phase synthesis of trisubstituted triazinobenzimidazolediones.

Gérard Klein et al.

Journal of combinatorial chemistry, 4(4), 345-351 (2002-07-09)

An efficient method for the solid-phase synthesis of trisubstituted [1,3,5]triazino[1,2-a]benzimidazole-2,4(3H,10H)-diones from resin-bound amino acids is described. N-acylation of the primary amine of a resin-bound amino acid with 4-fluoro-3-nitrobenzoic acid, followed by displacement of the fluoro group and reduction of the

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