333-18-6

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SCA15 due to large ITPR1 deletions in a cohort of 333 white families with dominant ataxia.

Cecilia Marelli et al.

Archives of neurology, 68(5), 637-643 (2011-05-11)

Deletions in ITPR1, coding for the inositol-triphosphate receptor type 1, have been recently identified in spinocerebellar ataxia type 15 (SCA15). To determine the frequency and the phenotypical spectrum of SCA15. Taqman polymerase chain reaction (258 index cases) or single-nucleotide polymorphism

Early-onset Crohn disease is associated with male sex and a polymorphism in the IL-6 promoter.

Keren Sagiv-Friedgut et al.

Journal of pediatric gastroenterology and nutrition, 50(1), 22-26 (2009-11-26)

Pediatric onset of Crohn disease (CD) is characterized by male sex predominance while adult-onset disease demonstrates female sex predominance. It has been postulated that this phenomenon may be genetically determined or due to an effect of estrogen on age of

Neurological impairment in fetal mouse brain by drinking water disinfectant byproducts.

Ahmed E Ahmed et al.

Neurotoxicology, 26(4), 633-640 (2005-08-23)

Developmental exposure to environmental chemicals may have detrimental effects on embryonic brains that could play a major role in the etio-pathology of fetal and adult neurological diseases. The exact mechanism by which prenatal exposures to environmental agents, such as drinking

Effects of age and sex on aquaporin-4 autoimmunity.

Amy M L Quek et al.

Archives of neurology, 69(8), 1039-1043 (2012-04-18)

To determine the sex and age distribution of aquaporin-4 (AQP4) autoimmunity using data derived from clinical service laboratory testing of 56,464 patient samples. Observational analysis. Mayo Clinic Neuroimmunology Laboratory. Between October 1, 2005, and January 4, 2011, 56,464 patients were

Identification of inadequate maternal progesterone concentrations in nulliparous dairy heifers and treatment with human chorionic gonadotrophin.

S G King et al.

The Veterinary record, 173(18), 450-450 (2013-10-17)

Plasma progesterone concentrations were estimated for 381 nulliparous dairy heifers from eight farms on days 4-6 after insemination. Heifers were synchronised using two treatments of prostaglandin F2α (PGF2α) 11 days apart. Alternate heifers were treated with 1500 IU human chorionic

Hyperinsulinemia and impaired leptin-adiponectin ratio associate with endothelial nitric oxide synthase polymorphisms in subjects with in-stent restenosis.

Elena Galluccio et al.

American journal of physiology. Endocrinology and metabolism, 294(5), E978-E986 (2008-03-20)

Little is known about the association of endothelial nitric oxide synthase (NOS3) gene polymorphisms and the presence of insulin resistance and the early evolution of atherosclerosis in nondiabetic subjects with cardiovascular disease (CAD) and stent implantation. The present study was

Delivering the Thinking Healthy Programme for perinatal depression through peers: an individually randomised controlled trial in India.

Daniela C Fuhr et al.

The lancet. Psychiatry, 6(2), 115-127 (2019-01-29)

The Thinking Healthy Programme (THP) is a psychological intervention recommended for the treatment of perinatal depression. However, efforts to integrate the intervention at scale into the routines of community health workers who delivered the THP when it was first evaluated

Blood pressure of endothelin-3 null (-/-) knockout mice and endothelin A receptor null (-/-) knockout mice under anaesthesia.

Tomoyuki Kuwaki et al.

Clinical science (London, England : 1979), 103 Suppl 48, 48S-52S (2002-08-24)

Blood pressure (BP) and heart rate (HR) in endothelin-3 (ET-3) null (-/-) knockout mice and ET(A) receptor (-/-) mice were measured using the servo null pressure measuring technique under halothane anaesthesia. In infant ET-3 (-/-) mice (2-3 weeks old), mean

Structural studies on the PH domains of Db1, Sos1, IRS-1, and beta ARK1 and their differential binding to G beta gamma subunits.

D Mahadevan et al.

Biochemistry, 34(28), 9111-9117 (1995-07-18)

Pleckstrin homology (PH) domains are approximately 110 amino acid residues in length and are structurally conserved in a number of intracellular signaling proteins. A role for these domains has been postulated for beta ARK, which binds to G beta gamma

Effects of high-intensity training on prostate cancer-induced cardiac atrophy.

Dryden R Baumfalk et al.

American journal of translational research, 13(1), 197-209 (2021-02-03)

Recent evidence suggests prostate cancer independent of treatment has atrophic effects on whole heart and left ventricular (LV) masses, associated with reduced endurance exercise capacity. In a pre-clinical model, we tested the hypothesis that high-intensity training could prevent cardiac atrophy

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