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Li-Yan Sun et al.
Biological trace element research, 150(1-3), 371-375 (2012-07-05)
It has been strongly suggested that two factors are involved in the development of Kaschin-Beck Disease (KBD), namely grains contamination with T-2 toxin and selenium deficiency. So our team undertook a survey about grains and drinking water in three rural
Hamide Z Senyuva et al.
Journal of AOAC International, 95(6), 1701-1708 (2013-03-05)
A comparison has been made of an LC/MS/MS method using direct analysis of acetonitrile extracts of feed and cereal samples and a method using acetonitrile extraction and subsequent immunoaffinity column (IAC) cleanup. Naturally contaminated samples containing one or more of
Jing Wu et al.
Toxicology letters, 232(3), 573-579 (2014-12-30)
T-2 toxin is a secondary metabolite produced by Fusarium genus and is a common contaminant in food and feedstuffs of cereal origin. In porcine granulosa cells(GC), T-2 toxin has been shown to inhibit the steroidogenesis; however, the mechanism has not
Lei Yang et al.
Biological trace element research, 190(2), 295-302 (2018-11-09)
The combination of excess mycotoxin exposure and selenium deficiency has been widely considered as a cause of Kashin-Beck disease (KBD). The present study aimed to investigate the expression profiles of selenium-related genes in human chondrocytes after exposure to T-2 toxin
Melinda Kovács et al.
Animal reproduction science, 137(3-4), 245-252 (2013-02-12)
T-2 toxin (T-2) was administered to adult Pannon White (n = 10/group) male rabbits for 65 days, first in a suspension by gavage (0.05, 0.1 or 0.2 mg/animal/day), and secondly mixed into the feed (0.33 and 0.66 mg/kg feed). In
Wayne E Steinmetz et al.
European journal of medicinal chemistry, 44(11), 4485-4489 (2009-07-10)
Trichothecene mycotoxins, toxic natural products of fungi from the family Hypocreaceae, are potent inhibitors of protein synthesis. The application of 3D QSAR to these toxins explored the structural basis for their biological activities. A CoMFA (Q(2)=0.619, R(2)=0.921) model was developed
D G Ndossi et al.
Toxicology letters, 214(3), 268-278 (2012-09-18)
Trichothecenes are a large family of chemically related mycotoxins. Deoxynivalenol (DON), T-2 and HT-2 toxins belong to this family and are produced by various species of Fusarium. The H295R steroidogenesis assay, regulation of steroidogenic gene expression and reporter gene assays
Elisabetta De Angelis et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 30(2), 345-355 (2012-11-20)
Deoxynivalenol, T-2 and HT-2 toxins are mycotoxins frequently occurring in cereals and cereal-based products along with their conjugated forms. In this paper, we provide insights into the fate of deoxynivalenol, T-2 and HT-2 toxins and their glucoside derivatives during bread
M Venkataramana et al.
Journal of food science and technology, 51(9), 1920-1928 (2014-09-06)
Fumonisins are one of the most agriculturally significant environmental toxins produced by Fusarium and Aspergillus species that grow on agricultural commodities in the field or during storage. Cereals contaminated with fumonisins causes serious loss to agricultural produce leads to health
Elin Verbrugghe et al.
Research in veterinary science, 93(3), 1139-1141 (2012-07-28)
The aim of the study was to investigate the effect of a modified glucomannan binder on the course of a Salmonella Typhimurium infection in pigs. Therefore, four pig diets were provided during 23 days: (1) free of mycotoxins, (2) containing
Arpad Czeh et al.
Journal of immunological methods, 384(1-2), 71-80 (2012-07-31)
Exposure to multiple mycotoxins through the food chain represents a major potential health hazard to both humans and livestock. They can cause a variety of severe acute as well as chronic diseases. Eliminating mycotoxins from various grain crops is a
A Osselaere et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 55, 150-155 (2013-01-15)
The effects of the mycotoxin T-2 on hepatic and intestinal drug-metabolizing enzymes (cytochrome P450) and drug transporter systems (MDR1 and MRP2) in poultry were investigated during this study. Broiler chickens received either uncontaminated feed, feed contaminated with 68μg/kg or 752μg/kg
Wayne E Steinmetz et al.
Journal of natural products, 71(4), 589-594 (2008-03-11)
A combination of NMR spectroscopy and molecular modeling has been employed to characterize the conformation and dynamics of the macrolide ring in verrucarin A and roridin A, two closely related toxins in the trichothecene mycotoxin family. Longitudinal carbon-13 relaxation times
T-2 toxin enhances catabolic activity of hypertrophic chondrocytes through ROS-NF-κB-HIF-2α pathway.
Juan Tian et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(7), 1106-1113 (2012-07-18)
T-2 toxin (T-2), one of the most important and toxic trichothecene mycotoxins, can cause many medical problems, such as diarrhea, nervous disorders, immunodepression and death, and is also believed as an etiological factor of Kashin-Beck disease, an endemic osteochondropathy prevailing
V Dohnal et al.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 56(4), 174-177 (2007-11-01)
The paper is focused on the occurrence and methods for the detection of T-2 toxin, one of the most toxic trichothecene Fusarium mycotoxin. Due to its physical-chemical properties and high toxicity, T-2 toxin is classified as a potential biological warfare
Veronica M T Lattanzio et al.
Journal of mass spectrometry : JMS, 47(4), 466-475 (2012-06-13)
The presence of glucoside derivatives of T-2 and HT-2 toxins (type A trichothecene mycotoxins) in naturally contaminated wheat and oats is reported for the first time. The use of advanced high-resolution mass spectrometry based on Orbitrap technology allowed to obtain
Susan P McCormick et al.
Applied and environmental microbiology, 78(24), 8694-8702 (2012-10-09)
Trichothecenes are sesquiterpenoid toxins produced by Fusarium species. Since these mycotoxins are very stable, there is interest in microbial transformations that can remove toxins from contaminated grain or cereal products. Twenty-three yeast species assigned to the Trichomonascus clade (Saccharomycotina, Ascomycota)
Ann Osselaere et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 51, 350-355 (2012-10-27)
Mycotoxins lead to economic losses in animal production. A way to counteract mycotoxicosis is the use of detoxifiers. The European Food Safety Authority stated that the efficacy of detoxifiers should be investigated based on toxicokinetic studies. Little information is available
M C Ferreras et al.
Journal of comparative pathology, 148(2-3), 236-242 (2012-07-24)
A flock of approximately 1,000 sheep were exposed intermittently to food contaminated with T-2 toxin (T-2), a potent type-A trichothecene mycotoxin produced primarily by Fusarium sporotrichioides and Fusarium poae. In the acute stage of the intoxication, affected sheep developed anorexia
Guyue Cheng et al.
PloS one, 9(9), e106769-e106769 (2014-09-04)
T-2 toxin, one of the type A trichothecenes, presents a potential hazard to human and animal health. Our previous work demonstrated that porcine cytochrome P450 3A29 (CYP3A29) played an important role in the hydroxylation of T-2 toxin. To identify amino
H J van der Fels-Klerx et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(11), 1716-1726 (2012-05-26)
Most recent information on the occurrence of Fusarium Head Blight species and related mycotoxins in wheat grown in the Netherlands dates from 2001. This aim of this study was to investigate the incidence and levels of Fusarium Head Blight species
Loredana Annunziata et al.
Analytical and bioanalytical chemistry, 409(21), 5143-5155 (2017-06-25)
A fast, easy, and cheap method for the simultaneous determination and quantification of aflatoxins (B1, B2, G1, G2), T-2 and HT-2 toxins, and fumonisins (B1, B2) in cereal-derived products was developed. This method involved a quick, easy, cheap, effective, rugged
Marijana Sokolović et al.
Arhiv za higijenu rada i toksikologiju, 59(1), 43-52 (2008-04-15)
T-2 toxin is the most toxic type A trichothecene mycotoxin. It is the secondary metabolite of the Fusarium fungi, and is common in grain and animal feed. Toxic effects have been shown both in experimental animals and in livestock. It
Joline Goossens et al.
BMC veterinary research, 8, 245-245 (2012-12-19)
The gastrointestinal tract is the first target for the potentially harmful effects of mycotoxins after intake of mycotoxin contaminated food or feed. With deoxynivalenol (DON), T-2 toxin (T-2), fumonisin B1 (FB1) and zearalenone (ZEA) being important Fusarium toxins in the
Agha Waqar Yunus et al.
Mycotoxin research, 29(1), 23-27 (2013-01-04)
The present investigations were conducted to test the effects of T-2 toxin on electrophysiological variables of jejunal epithelium of chicken. Jejunal segments of broilers were monitored in Ussing chambers in the presence of T-2 toxin at the levels of 0 (negative
Metabolism and pharmacokinetics of T-2 toxin and related trichothecenes.
B Yagen et al.
Drug metabolism reviews, 25(3), 281-323 (1993-01-01)
Jafar Salimian et al.
Immunopharmacology and immunotoxicology, 36(4), 275-281 (2014-06-24)
Abstract Context: T-2 toxin, a potent mycotoxin, has serious effects on immune system. Here, the effects of a sublethal dose of this toxin on T lymphocyte sub-population levels and the potential protective effects from treatment with selenium or vitamin E
Vlastimil Dohnal et al.
Current drug metabolism, 9(1), 77-82 (2008-01-29)
Among the naturally-occurring trichothecenes found in food and feed, T-2 toxin is the most potent and toxic mycotoxin. After ingestion of T-2 toxin into the organism, it is processed and eliminated. Some metabolites of this trichothecene are equally toxic or
Suchitra Ngampongsa et al.
Toxicology mechanisms and methods, 22(9), 662-673 (2012-08-03)
This study was conducted to clarify and reevaluate the cardiac and autonomic nervous effects of T-2 toxin, which had been previously examined by several acute experiments, in unrestrained and conscious rats implanted with telemetric transmitters. Two groups of rats were
H J Van Der Fels-Klerx et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(10), 1581-1592 (2012-06-29)
This study aimed to investigate mycotoxin contamination of cereal grain commodities for feed and food production in North Western Europe during the last two decades, including trends over time and co-occurrence between toxins, and to assess possible effects of climate
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