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Lucija Tomljenovic et al.
Journal of inorganic biochemistry, 105(11), 1489-1499 (2011-11-22)
Autism spectrum disorders (ASD) are serious multisystem developmental disorders and an urgent global public health concern. Dysfunctional immunity and impaired brain function are core deficits in ASD. Aluminum (Al), the most commonly used vaccine adjuvant, is a demonstrated neurotoxin and
Alexey V Krasavin et al.
Nano letters, 11(6), 2231-2235 (2011-05-06)
We experimentally demonstrate suppressed absorption and stimulated emission of surface plasmon polaritons (SPP) leading to all-plasmonic modulation of an SPP signal propagating at the interface between a metal and a gain medium; these observations are supported by the developed theory.
Lorena E Brown
Vaccine, 28(50), 8043-8045 (2010-09-21)
Current seasonal influenza vaccines aim to induce high-titred virus-neutralizing antibody to the viral hemagglutinin (HA), which is the best form of protection against infection, but these vaccines can be poorly efficacious in the elderly and other target groups that rely
Shahram Shahabi et al.
Iranian journal of allergy, asthma, and immunology, 13(5), 307-316 (2014-08-26)
We have previously shown the adjuvant activity of propranolol (PRP) (a beta-adrenergic receptor antagonist) using a vaccine model for Salmonella typhimurium. In this study PRP was used as an adjuvant in combination with Plasmodium berghei (P. berghei) whole blood stage
Jun Lü et al.
Plant cell reports, 31(1), 49-56 (2011-08-25)
Phosphorus (P) is an essential nutrient for plant growth and development, but is generally unavailable and inaccessible in soil, since applied P is mostly fixed to aluminium (Al) and ferrum (Fe) in acidic soils and to calcium (Ca) in alkaline
Solmaz Adamaref et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 70(8), 1412-1418 (2014-10-30)
Disk membranes generated from high-purity natural clinoptilolite mineral rock have shown promising water desalination and de-oiling performance. In order to scale up production of these types of membranes for industrial wastewater treatment applications, a coating strategy was devised. A composite
Chellapandian Kannan et al.
Journal of hazardous materials, 244-245, 10-20 (2012-12-19)
Dye pollution in aquatic nature produce serious environmental effects. In this investigation, mesoporous aluminophosphate molecular sieve synthesized and applied for the removal of hazardous dyes Malachite green (MG) and Methylene blue (MB). In the synthesis of mesoporous aluminophosphate (AlPO(4)) molecular
Alasdair Bamford et al.
AIDS (London, England), 28(14), 2033-2043 (2014-09-16)
Children with perinatally acquired HIV (paHIV) remain at an increased risk of pneumococcal infection despite highly active antiretroviral therapy (HAART). Beyond infancy, responses to pneumococcal conjugate vaccine (PCV) remain under-investigated. There are currently no published data on serological response to
Sompong Sapsutthipas et al.
PLoS neglected tropical diseases, 9(3), e0003609-e0003609 (2015-03-17)
Snake envenomation has been estimated to affect 1.8 million people annually with about 94,000 deaths mostly in poor tropical countries. Specific antivenoms are the only rational and effective therapy for these cases. Efforts are being made to produce effective, affordable
Shahram Shahabi et al.
Immunological investigations, 43(7), 653-666 (2014-07-16)
We previously showed that the mixture of naltrexone (NLT), a general opioid antagonist, and alum, acts as an effective adjuvant in enhancing vaccine-induced T helper 1 (TH1) humoral immune responses against Toxoplasma gondii. Here, we tested the efficacy of the
Qingling Liu et al.
ChemSusChem, 4(1), 91-97 (2011-01-13)
The pressure-swing adsorption method for carbon dioxide capture would ideally be facilitated by adsorbents with a high capacity and a high selectivity for CO₂. Several aluminophosphates with 8-ring window apertures (AlPO₄-17, AlPO₄-18, AlPO₄-53, and AlPO₄-25) were synthesized by hydrothermal crystallization
Yun-Zhou Yu et al.
Biologicals : journal of the International Association of Biological Standardization, 38(6), 658-663 (2010-09-02)
DNA vaccines against botulinum neurotoxin (BoNTs) induce protective humoral immune responses in mouse model, but when compared with conventional vaccines such as toxoid and protein vaccines, DNA vaccines often induce lower antibody level and protective efficacy and are still necessary
Gregory M Glenn et al.
Vaccine, 31(3), 524-532 (2012-11-17)
We performed a Phase 1 randomized, observer-blinded, placebo-controlled trial to evaluate the safety and immunogenicity of a recombinant respiratory syncytial virus (RSV) fusion (F) protein nanoparticle vaccine. Six formulations with (5, 15, 30 and 60 μg) and without (30 and
Isabel Leroux-Roels et al.
Vaccine, 33(4), 577-584 (2013-11-02)
The protection elicited by polysaccharide pneumococcal vaccines against community-acquired pneumonia in older adults remains debatable. Alternative vaccine targets include well-conserved pneumococcal protein antigens, such as pneumococcal histidine triad protein D (PhtD). To evaluate humoral and cellular immune responses and safety/reactogenicity
Shibo Jiang et al.
Expert review of vaccines, 11(12), 1405-1413 (2012-12-21)
A subunit vaccine, RBD-S, is under development to prevent severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV), which is classified by the US NIH as a category C pathogen. This vaccine is comprised of a recombinant receptor-binding domain
Eun Ju Jeong et al.
Archives of pharmacal research, 35(9), 1621-1628 (2012-10-12)
Two types of radioiodinated plasma driven antigens, heat-inactivated (¹²⁵I-h-HBsAg) and formalin-inactivated HBsAg (¹²⁵I-f-HBsAg) were investigated for the effect of immunoadjuvant, aluminium phosphate (AP) on pharmacokinetics, organ distribution and humoral immunity of differently inactivated hepatitis B surface antigens (HBsAg) in rats.
Ruth Pepper et al.
BMC nephrology, 12, 55-55 (2011-10-14)
Aluminium (Al) toxicity was frequent in the 1980s in patients ingesting Al containing phosphate binders (Alucaps) whilst having HD using water potentially contaminated with Al. The aim of this study was to determine the risk of Al toxicity in HD
Daniel Holme et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 61 Suppl 5, S563-S569 (2015-11-11)
A group A meningococcal conjugate vaccine, PsA-TT, was licensed in 2010 and was previously studied in a phase 2 clinical trial to evaluate its safety and immunogenicity in African children 12-23 months of age. Subjects received either PsA-TT; meningococcal group
Ting Wang et al.
Colloids and surfaces. B, Biointerfaces, 126, 520-530 (2015-01-24)
To develop an effective, convenient and stable mucosal vaccine against hepatitis B virus (HBV), the mannose-PEG-cholesterol/lipid A-liposomes (MLLs) loaded with HBsAg were prepared by the procedure of emulsification-lyophilization and, subsequently, filled into the microholes of microneedle array reverse molds and
Phosphorus recovery as AlPO4 from beneficially reused aluminium sludge arising from water treatment.
X H Zhao et al.
Environmental technology, 34(1-4), 263-268 (2013-03-28)
The purpose of this study was to develop an efficient and, possibly, a practically operated methodology to recover phosphorus (P) from P-saturated dewatered aluminium sludge cakes (DASC) after the DASC have been beneficially reused as constructed wetlands substrate for P-rich
Belma Ljutic et al.
Vaccine, 30(19), 2981-2988 (2012-03-03)
We investigated the immunogenicity, stability and adsorption properties of an experimental pneumococcal vaccine composed of three protein vaccine antigens; Pneumococcal histidine triad protein D, (PhtD), Pneumococcal choline-binding protein A (PcpA) and genetically detoxified pneumolysin D1 (PlyD1) formulated with aluminum salt
Fikru Tafesse et al.
Talanta, 83(5), 1491-1495 (2011-01-18)
A highly selective and sensitive phosphate sensor has been fabricated by constructing a crystal disk consisting of variable mixtures of aluminium powder (Al), aluminium phosphate (AlPO(4)) and powdered copper (Cu). The membrane sensor exhibits linear potential response in the concentration
G Berthon et al.
Journal of the American College of Nutrition, 11(3), 340-348 (1992-06-01)
Initially characterized in uremic patients undergoing hemodialysis, toxic effects due to high aluminum (Al) body loads were subsequently observed in a number of conditions, in particular following ingestion of Al-containing antacids. Among compounds of this class, aluminum phosphate (AlPO4) was
Ai-Hsiang Chou et al.
PloS one, 7(4), e34834-e34834 (2012-04-25)
Enterovirus 71 (EV71) has caused several epidemics of hand, foot and mouth diseases (HFMD) in Asia and now is being recognized as an important neurotropic virus. Effective medications and prophylactic vaccine against EV71 infection are urgently needed. Based on the
Vidyashankara Iyer et al.
Journal of pharmaceutical sciences, 101(9), 3078-3090 (2012-04-28)
The preformulation of a trivalent recombinant protein-based vaccine candidate for protection against Streptococcus pneumoniae is described both in the presence and in the absence of aluminum salt adjuvants. The biophysical properties of the three protein-based antigens, fragments of pneumococcal surface
Olatomirin O Kolade et al.
Journal of pharmaceutical sciences, 104(2), 378-387 (2014-09-02)
Adjuvant-containing drug products can be exposed to high levels of interfacial shear during manufacture. This may affect the integrity of the adjuvant, alter its interaction with the drug substance or change the physical characteristics of the drug product. In this
H M El Sahly et al.
Clinical and vaccine immunology : CVI, 17(10), 1552-1559 (2010-08-13)
Erythrocyte binding antigen region II (EBA-175) is a conserved antigen of Plasmodium falciparum that is involved in binding of the parasite to the host's erythrocytes. We evaluated the safety and immunogenicity of a recombinant EBA-175 vaccine with aluminum phosphate adjuvant
Hsin-Wei Chen et al.
Archives of virology, 158(7), 1523-1531 (2013-03-05)
We have previously demonstrated that vaccination with a subunit dengue vaccine containing a consensus envelope domain III with aluminum phosphate elicits neutralizing antibodies against all four serotypes of dengue virus in mice. In this study, we evaluated the immunogenicity of
Unified internal architecture and surface barriers for molecular diffusion of microporous crystalline aluminophosphates.
Lukasz Karwacki et al.
Angewandte Chemie (International ed. in English), 49(38), 6790-6794 (2010-08-18)
Umut Gazi et al.
The Journal of biological chemistry, 286(10), 7822-7829 (2011-01-06)
The mannose receptor (MR) is an endocytic type I membrane molecule with a broad ligand specificity that is involved in both hemostasis and pathogen recognition. Membrane-anchored MR is cleaved by a metalloproteinase into functional soluble MR (sMR) composed of the
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