345-24-4

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Candidate gene linkage analysis indicates genetic heterogeneity in Marfan syndrome.

L V S Teixeira et al.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 44(8), 793-800 (2011-07-27)

Marfan syndrome (MFS) is an autosomal dominant disease of the connective tissue that affects the ocular, skeletal and cardiovascular systems, with a wide clinical variability. Although mutations in the FBN1 gene have been recognized as the cause of the disease

Morphine enhances microglial migration through modulation of P2X4 receptor signaling.

Ryan J Horvath et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(4), 998-1005 (2009-01-30)

Opioids, although fundamental to the treatment of pain, are limited in efficacy by side effects including tolerance and hyperalgesia. Using an in vitro culture system, we report that morphine increased microglial migration via a novel interaction between mu-opioid and P2X(4)

Lipid Nanocarrier-Mediated Drug Delivery System to Enhance the Oral Bioavailability of Rifabutin.

Pradip Nirbhavane et al.

AAPS PharmSciTech, 18(3), 829-837 (2016-06-29)

Rifabutin (RFB) is prescribed for the treatment of tuberculosis infections as well as Mycobacterium avium complex (MAC) infection in immunocompromised individuals and HIV patients. With a view to develop a sustained release oral solid lipid nanoformulation (SLN), RFB was encapsulated

Radiation Dosimetry Study of [(89)Zr]rituximab Tracer for Clinical Translation of B cell NHL Imaging using Positron Emission Tomography.

Arutselvan Natarajan et al.

Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(4), 539-547 (2014-12-17)

We evaluated the dosimetry of [(89)Zr]rituximab, an anti-CD20 immunoPET tracer to image B cell non-Hodgkin's lymphoma (NHL) using a humanized transgenic mouse model that expresses human CD20 transgenic mice (huCD20TM). Rituximab was conjugated to desferrioxamine (Df) for radiolabeling of Zirconium-89.

Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression.

João V Esteves et al.

Frontiers in endocrinology, 9, 536-536 (2018-09-28)

The reduced expression of solute carrier family 2, facilitated glucose transporter member 4 (GLUT4) and hexokinase-2 (HK2) in skeletal muscle participates in insulin resistance of diabetes mellitus (DM). MicroRNAs (miRNAs) have emerged as important modulators of mRNA/protein expression, but their

Estrogen replacement suppresses function of thrombin stimulated platelets by inhibiting Ca(2+) influx and raising cyclic adenosine monophosphate.

Yukiko Nakano et al.

Cardiovascular research, 53(3), 634-641 (2002-02-28)

Estrogen replacement therapy (ERT) in postmenopausal women reduces the risk of cardiovascular diseases. Beneficial changes in lipid profiles account for only one part, thereby raising the question of other estrogen induced benefit that may be lost at menopause. The purpose

Blockage of oncostatin M-induced LDL receptor gene transcription by a dominant-negative mutant of C/EBPbeta.

Yue Zhou et al.

The Biochemical journal, 397(1), 101-108 (2006-03-28)

OM (oncostatin M) activates the human LDLR [LDL (low-density lipoprotein) receptor] gene transcription in HepG2 cells through the SIRE (sterol-independent regulatory element) of LDLR promoter. The SIRE sequence consists of a C/EBP (CCAAT/enhancer-binding protein)-binding site and a CRE (cAMP-response element).

Telbivudine or lamivudine use in late pregnancy safely reduces perinatal transmission of hepatitis B virus in real-life practice.

Hua Zhang et al.

Hepatology (Baltimore, Md.), 60(2), 468-476 (2014-09-05)

Little observational data exist describing telbivudine (LdT) or lamivudine (LAM) use in late pregnancy for preventing hepatitis B mother-to-child transmission (MTCT) in real-world settings. During the period of January 2009 to March 2011, we enrolled hepatitis B e antigen-positive mothers

Both the cytosols and detergent extracts of breast cancer tissues are suited to evaluate the prognostic impact of the urokinase-type plasminogen activator and its inhibitor, plasminogen activator inhibitor type 1.

F Jänicke et al.

Cancer research, 54(10), 2527-2530 (1994-05-15)

The serine protease urokinase-type plasminogen activator (uPA) plays a key role in tumor-associated proteolysis in malignant solid tumors. Proteolytic activity of uPA is controlled by its naturally occurring plasminogen activator inhibitor type 1. As an initial observation, a correlation of

[Effect of gene silencing of integrin β1 on the proliferation and secretory function of airway smooth muscle in asthmatic mice].

Chen Qiu et al.

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 33(11), 811-816 (2011-01-08)

to investigate the effect of gene silencing of integrin β1 on the proliferation and secretory function of airway smooth muscle cells (ASMC) in asthmatic mice. integrin β1 gene was silenced by using RNAi technology in the fifth generation ASMC of

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