34857

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Biobased polymers: synthesis of graft copolymers and comb polymers using lactic acid macromonomer and properties of the product polymers.

Kiyoaki Ishimoto et al.

Biomacromolecules, 13(11), 3757-3768 (2012-09-19)

For developing broader application of biobased polymers, graft copolymers and comb polymers having poly(lactic acid) (PLA) side chains have been synthesized by using a macromonomer technique. PLA macromonomers (MMm) having a methacryloyl polymerizable group with different PLA chain length with

[Peculiarities of extraction of 6-mercaptopurine and azathioprine from aqueous saline solutions].

Ia I Korenman et al.

Sudebno-meditsinskaia ekspertiza, 55(6), 38-41 (2013-02-15)

The results of extraction of 6-mercaptopurine and azathioprine from aqueous saline solutions with organic solvents of different chemical nature and their mixtures are presented. Synergism between the distribution coefficients was demonstrated during the extraction of the above compounds with 1,4-dioxane

Toward prediction of alkane/water partition coefficients.

Anita Toulmin et al.

Journal of medicinal chemistry, 51(13), 3720-3730 (2008-06-19)

Partition coefficients were measured for 47 compounds in the hexadecane/water ( P hxd) and 1-octanol/water ( P oct) systems. Some types of hydrogen bond acceptor presented by these compounds to the partitioning systems are not well represented in the literature

Monolithic cryopolymers with embedded nanoparticles. I. Capillary liquid chromatography of proteins using neutral embedded nanoparticles.

R Dario Arrua et al.

Journal of chromatography. A, 1273, 26-33 (2013-01-01)

Rigid monolithic cryostructures were prepared in capillary format at sub-zero temperatures and used successfully in the separation of proteins by hydrophobic interaction chromatography (HIC). The polymerization mixture consisted of poly(ethyleneglycol) diacrylate (PEGDA) M(n)∼258 as the single monomer, a mixture of

Natural low-molecular mass organic compounds with oxidase activity as organocatalysts.

Tatsuya Nishiyama et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(48), 17152-17157 (2014-11-21)

Organocatalysts, low-molecular mass organic compounds composed of nonmetallic elements, are often used in organic synthesis, but there have been no reports of organocatalysts of biological origin that function in vivo. Here, we report that actinorhodin (ACT), a natural product derived

Unraveling the interplay of backbone rigidity and electron rich side-chains on electron transfer in peptides: the realization of tunable molecular wires.

John R Horsley et al.

Journal of the American Chemical Society, 136(35), 12479-12488 (2014-08-15)

Electrochemical studies are reported on a series of peptides constrained into either a 310-helix (1-6) or β-strand (7-9) conformation, with variable numbers of electron rich alkene containing side chains. Peptides (1 and 2) and (7 and 8) are further constrained

Isoniazid conjugated poly(lactide-co-glycolide): long-term controlled drug release and tissue regeneration for bone tuberculosis therapy.

Da Huang et al.

Biomaterials, 52, 417-425 (2015-03-31)

Bone tuberculosis (TB) is one of the most common extrapulmonary TB. Effective integration of chemotherapy and bone regeneration is an optimal solution for bone TB therapy. Herein, we produce a composite scaffold drug delivery system fabricated with an isoniazid conjugated

Enhanced decomposition of 1,4-dioxane in water by ozonation under alkaline condition.

Gui-Peng Tian et al.

Water science and technology : a journal of the International Association on Water Pollution Research, 70(12), 1934-1940 (2014-12-19)

1,4-Dioxane is a probable human carcinogenic and refractory substance that is widely detected in aquatic environments. Traditional wastewater treatment processes, including activated sludge, cannot remove 1,4-dioxane. Removing 1,4-dioxane with a reaction kinetic constant of 0.32 L/(mol·s) by using ozone, a

Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity.

Rodrigo Abonia et al.

European journal of medicinal chemistry, 57, 29-40 (2012-10-10)

Novel quinoline-2-one based chalcones were synthesized from a Claisen-Schmidt condensation by using the couple KOH/1,4-dioxane as reaction medium. A relatively stable aldol was isolated and identified as the intermediate species in the formation of the target chalcones. Nine of the

Analysis of the polymorph changes of a drug candidate.

P Láng et al.

Journal of pharmaceutical and biomedical analysis, 102, 229-235 (2014-10-12)

The effects of solvents, temperature and humidity on the stability of a former drug candidate obtained from Sanofi (Hungary) were examined by a slurry equilibration method, variable temperature and humidity X-ray powder diffractometry (VT/VH-XRPD) and differential scanning calorimetry (DSC). The

Enhanced cellular uptake and gene silencing activity of siRNA molecules mediated by chitosan-derivative nanocomplexes.

Diana Guzman-Villanueva et al.

International journal of pharmaceutics, 473(1-2), 579-590 (2014-07-27)

The RNA interference (RNAi) constitutes a conservative mechanism in eukaryotic cells that induces silencing of target genes. In mammalians, the RNAi is triggered by siRNA (small interfering RNA) molecules. Due to its potential in silencing specific genes, the siRNA has

Ultrasonic studies of intermolecular interactions in binary mixtures of 4-methoxy benzoin with various solvents: Excess molar functions of ultrasonic parameters at different concentrations and in different solvents.

B Thanuja et al.

Ultrasonics sonochemistry, 19(6), 1213-1220 (2012-04-14)

Density (ρ), ultrasonic velocity (U), for the binary mixtures of 4-methoxy benzoin (4MB) with ethanol, chloroform, acetonitrile, benzene, and di-oxane were measured at 298K. The solute-solvent interactions and the effect of the polarity of the solvent on the type of

Bone regeneration in a massive rat femur defect through endochondral ossification achieved with chondrogenically differentiated MSCs in a degradable scaffold.

Noriko Harada et al.

Biomaterials, 35(27), 7800-7810 (2014-06-24)

Mesenchymal stem cells (MSCs) are multipotent cells capable of proliferating and differentiating into several lineages. In regenerative medicine, their potential as a resource for tissue-replacement therapy is receiving much attention. However, transplanting MSCs to repair larger bone defects in animal

Reliable quantitation of β-hydroxyethoxyacetic acid in human urine by an isotope-dilution GC-MS procedure.

Elisabeth Eckert et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 935, 80-84 (2013-08-21)

An analytical method for the determination of β-hydroxyethoxyacetic acid (HEAA), the main urinary metabolite of 1,4-dioxane was developed and validated. The presented method involves liquid-liquid extraction of HEAA from the urine samples, followed by silylation and subsequent analytical separation and

Synthesis of 2-arylamino substituted 5,6-dihydropyrido[2,3-d]pyrimidine-7(8H)-ones from arylguanidines.

Iñaki Galve et al.

Molecular diversity, 16(4), 639-649 (2012-10-12)

A practical protocol was developed for the synthesis of 2-arylamino substituted 4-amino-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-ones from α,β-unsaturated esters, malononitrile, and an aryl substituted guanidine via the corresponding 3-aryl-3,4,5,6- tetrahydropyrido[2,3-d]pyrimidin-7(8H)-ones. Such compounds are formed upon treatment of 2-methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles with an aryl substituted guanidine in

Direct functionalization of tetrahydrofuran and 1,4-dioxane: nickel-catalyzed oxidative C(sp3)-H arylation.

Dong Liu et al.

Angewandte Chemie (International ed. in English), 52(16), 4453-4456 (2013-03-21)

Nitroanilines as quenchers of pyrene fluorescence.

Carlos E Agudelo-Morales et al.

Chemphyschem : a European journal of chemical physics and physical chemistry, 13(18), 4195-4201 (2012-10-24)

The quenching of pyrene and 1-methylpyrene fluorescence by nitroanilines (NAs), such as 2-, 3-, and 4-nitroaniline (2-NA, 3-NA, and 4-NA, respectively), 4-methyl-3-nitroaniline (4-M-3-NA), 2-methyl-4-nitroaniline (2-M-4-NA), and 4-methyl-3,5-dinitroaniline (4-M-3,5-DNA), are studied in toluene and 1,4-dioxane. Steady-state fluorescence data show the higher

Self-curable benzoxazine functional polybutadienes synthesized by click chemistry.

Kukut M, et al.

Designed Monomers and Polymers, 12(2), 167-176 (2009)

Selective Solid-Phase Extraction of Zinc(II) from Environmental Water Samples Using Ion Imprinted Activated Carbon.

Elham Moniri et al.

Journal of AOAC International, 98(1), 206-212 (2015-04-11)

A simple ion imprinted amino-functionalized sorbent was synthesized by coupling activated carbon with iminodiacetic acid, a functional compound for metal chelating, through cyanoric chloride spacer. The resulting sorbent has been characterized using FTIR spectroscopy, elemental analysis, and thermogravimetric analysis and

Health evaluation of 1,4-dioxane.

C T DeRosa et al.

Toxicology and industrial health, 12(1), 1-43 (1996-01-01)

A new ELISA for quantification of brassinosteroids in plants.

Andrey G Pradko et al.

Steroids, 97, 78-86 (2014-09-10)

Starting from (22R,23R)-2α,3α,22,23,26-pentahydroxy-5α-cholestan-6-one 26-hemisuccinate, conjugates of 28-norcastasterone with horse radish peroxidase and bovine serum albumin were prepared. The latter conjugate was injected into rabbits; produced polyclonal antibodies were used to quantitate 6-keto-brassinosteroids. The newly developed analytical system was used in

Synthesis and characterization of poly[N-isopropylacrylamide-co-1-(N,N-bis-carboxymethyl)amino-3-allylglycerol] grafted to magnetic nano-particles for the extraction and determination of fluvoxamine in biological and pharmaceutical samples.

Homayon Ahmad Panahi et al.

Journal of chromatography. A, 1345, 37-42 (2014-05-02)

In this research, a novel method is reported for the surface grafting of N-isopropylacrylamide as a thermosensitive agent and 1-(N,N-bis-carboxymethyl)amino-3-allylglycerol with an affinity toward fluvoxamine onto magnetic nano-particles modified by 3-mercaptopropyltrimethoxysilane. The grafted nano-particles were characterized by Fourier transform infrared

Probing hyperconjugation experimentally with the conformational deuterium isotope effect.

Kyle T Greenway et al.

The Journal of organic chemistry, 77(20), 9221-9226 (2012-10-03)

Hyperconjugation underlies many chemical phenomena of fundamental and practical importance. Owing to a great deal of interest in the anomeric effect, anomeric-like hyperconjugative effects have been thoroughly investigated in oxygen-containing systems. However, such interactions in the second- and third-row chalcogens

Rapid screening of oleuropein from olive leaves using matrix solid-phase dispersion and high-performance liquid chromatography.

Marzieh Rashidipour et al.

Journal of AOAC International, 97(4), 1109-1113 (2014-08-26)

Matrix solid-phase dispersion (MSPD) methodology as a quick and easy extraction method has been developed to extract oleuropein from Olea europaea leaves. This method has been compared with conventional maceration and Soxhlet extraction (SOXE) methods. Variables affecting MSPD, such as

A convenient ultrasound-promoted synthesis of some new thiazole derivatives bearing a coumarin nucleus and their cytotoxic activity.

Sobhi M Gomha et al.

Molecules (Basel, Switzerland), 17(8), 9335-9347 (2012-08-07)

Successful implementation of ultrasound irradiation for the rapid synthesis of a novel series of 3-[1-(4-substituted-5-(aryldiazenyl)thiazol-2-yl)hydrazono)ethyl]-2H-chromen-2-ones 5a-h, via reactions of 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene) thiosemicarbazide (2) and the hydrazonoyl halides 3(4), was demonstrated. Also, a new series of 5-arylidene-2-(2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)hydrazinyl)thiazol-4(5H)-ones 10a-d were synthesized from reaction

Development of surrogate correlation models to predict trace organic contaminant oxidation and microbial inactivation during ozonation.

Daniel Gerrity et al.

Water research, 46(19), 6257-6272 (2012-10-16)

The performance of ozonation in wastewater depends on water quality and the ability to form hydroxyl radicals (·OH) to meet disinfection or contaminant transformation objectives. Since there are no on-line methods to assess ozone and ·OH exposure in wastewater, many

Effect of acid-catalyzed formation rates of benzimidazole-linked polymers on porosity and selective CO2 capture from gas mixtures.

Suha Altarawneh et al.

Environmental science & technology, 49(7), 4715-4723 (2015-03-03)

Benzimidazole-linked polymers (BILPs) are emerging candidates for gas storage and separation applications; however, their current synthetic methods offer limited control over textural properties which are vital for their multifaceted use. In this study, we investigate the impact of acid-catalyzed formation

Structure-retention behaviour of biologically active fused 1,2,4-triazinones--correlation with in silico molecular properties.

Małgorzata Sztanke et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 68, 114-126 (2014-12-22)

The chromatographic behaviour and significant lipophilicity/hydrophobicity indices (log k(w), S, φ(0)) are presented for 21 biologically active fused 1,2,4-triazinones based on the linear relationship: log k = log k(w)-Sφ established for the retention on LC-18 HPLC column, using as mobile

Reconstruction of hepatic stellate cell-incorporated liver capillary structures in small hepatocyte tri-culture using microporous membranes.

Junichi Kasuya et al.

Journal of tissue engineering and regenerative medicine, 9(3), 247-256 (2012-10-23)

In liver sinusoids, hepatic stellate cells (HSCs) locate the outer surface of microvessels to form a functional unit with endothelia and hepatocytes. To reconstruct functional liver tissue in vitro, formation of the HSC-incorporated sinusoidal structure is essential. We previously demonstrated

1,4-Dioxane.

IARC monographs on the evaluation of carcinogenic risks to humans, 71 Pt 2, 589-602 (1999-09-07)

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