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34866
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Rachel Morrison et al.
Pharmaceutical research, 31(10), 2904-2917 (2014-05-06)
To design and synthesize chemoembolization particles for the delivery of Ophiobolin A (OphA), a promising fungal-derived chemotherapeutic, directly at the tumour location. To investigate cell death mechanism of OphA on a Rhabdomyosarcoma cancer (RD) cell line. Rhabdomyosarcoma is the most
James R Reed et al.
Biochemistry, 52(23), 4003-4013 (2013-05-17)
The goal of this study was to characterize the effects of CYP1A2·CYP2B4 complex formation on the rates and efficiency of toluene metabolism by comparing the results from simple reconstituted systems containing P450 reductase (CPR) and a single P450 to those
Salim Sioud et al.
Rapid communications in mass spectrometry : RCM, 28(22), 2389-2397 (2014-10-11)
The formation of ions during atmospheric pressure photoionization (APPI) mass spectrometry in the positive mode usually provides radical cations and/or protonated species. Intriguingly, during the analysis of some N-alkyl-substituted thieno[3,4-c]pyrrole-4,6-dione (TPD) derivatives synthesized in our laboratory, unusual [M-H](+) ion peaks
Banu Koz et al.
International journal of molecular sciences, 9(3), 383-393 (2009-03-28)
A new polyacetylene derivative with electroactive thiophene substituent, namely poly(2-methylbut-2-enyl thiophene-3-carboxylate) was synthesized and characterized. For this purpose, novel acetylene monomer was synthesized by the reaction of 3-thiophenecarboxylic acid with propargyl bromide and polymerized with a Rh catalyst to give
Reza Esfandiary et al.
Journal of pharmaceutical sciences, 104(2), 577-586 (2014-11-20)
Reversible self-association of protein therapeutics, the phenomenon of formation of native reversible oligomeric species as a result of noncovalent intermolecular interactions, can add additional manufacturing, stability, delivery, and safety complexities in biopharmaceutical development. Its early detection, characterization, and mitigation can
Marina Shalaeva et al.
Journal of medicinal chemistry, 56(12), 4870-4879 (2013-05-29)
This study demonstrates that ΔlogP(oct-tol) (difference between logP(octanol) and logP(toluene)) describes compounds propensity to form intramolecular hydrogen bonds (IMHB) and may be considered a privileged molecular descriptor for use in drug discovery and for prediction of IMHB in drug candidates.
Hoon Hur et al.
PloS one, 9(6), e98581-e98581 (2014-06-10)
The levels of organic acids representing metabolic pathway end products are important indicators of physiological status, and may be associated with metabolic changes in cancer. The aim of this study is to investigate the levels of organic acids in cancerous
Wararat Sriprapat et al.
Ecotoxicology and environmental safety, 102, 147-151 (2014-02-18)
Air borne uptake of toluene and ethylbenzene by twelve plant species was examined. Of the twelve plant species examined, the highest toluene removal was found in Sansevieria trifasciata, while the ethylbenzene removal from air was with Chlorophytum comosum. Toluene and
Leila Hejazi et al.
Rapid communications in mass spectrometry : RCM, 29(1), 91-99 (2014-12-03)
Mass spectrometric identification of compounds in chromatography can be obtained from molecular masses from soft ionization mass spectrometry techniques such as field ionization (FI) and fragmentation patterns from hard ionization techniques such as electron ionization (EI). Simultaneous detection by EI
Yuanhong Shan et al.
Journal of chromatography. A, 1375, 101-109 (2014-12-17)
To develop a novel hybrid monolithic column based on pentafluorobenzyl imidazolium bromide ionic liquid, a new ionic liquid monomer was synthesized from 1-vinylimidazole and pentafluorobenzyl bromide. By employing a facile one-step copolymerization of polyhedral-oligomeric-silsesquioxane-type (POSS) cross-linking agent and the home-made
Judith van Asperen et al.
Toxicology letters, 138(1-2), 51-62 (2003-02-01)
The toxicity of inhalatory exposure to organic solvents may not only be related to the total external dose, but also to the pattern of exposure. In this study physiologically based toxicokinetic (PBTK) modelling has been used to study the impact
Kwan Wee Tan et al.
ACS nano, 8(5), 4730-4739 (2014-04-02)
Structure control in solution-processed hybrid perovskites is crucial to design and fabricate highly efficient solar cells. Here, we utilize in situ grazing incidence wide-angle X-ray scattering and scanning electron microscopy to investigate the structural evolution and film morphologies of methylammonium
Arash Nikoubashman et al.
ACS nano, 8(8), 8015-8026 (2014-08-12)
We study thin films of homopolymers (PS) and monolayers of cylinder-forming diblock copolymers (PS–PHMA) under shear. To this end, we employed both experiments and computer simulations that correctly take into account hydrodynamic interactions and chain entanglements. Excellent quantitative agreement for
Naif H Alsharif et al.
Small (Weinheim an der Bergstrasse, Germany), 5(2), 221-228 (2008-12-06)
Nanocrystals of various inorganic materials are being considered for application in the life sciences as fluorescent labels and for such therapeutic applications as drug delivery or targeted cell destruction. The potential applications of the nanoparticles are critically compromised due to
Jin Young Lee et al.
Journal of chromatographic science, 52(10), 1239-1246 (2014-01-29)
Degradation products of V-type nerve agents are important markers of these toxic chemical warfare agents; hence their detection and identification are of high importance from verification point of view of Chemical Weapons Convention. The new analytical technique using quantitation-enhanced data-dependent
Julia E Vela-Ramirez et al.
The AAPS journal, 17(1), 256-267 (2014-11-26)
Carbohydrate functionalization of nanoparticles allows for targeting of C-type lectin receptors. This family of pattern recognition receptors expressed on innate immune cells, such as macrophages and dendritic cells, can be used to modulate immune responses. In this work, the in
Iris Grossman et al.
Journal of molecular biology, 425(22), 4366-4378 (2013-07-23)
Quiescin sulfhydryl oxidase 1 (QSOX1) is a catalyst of disulfide bond formation that undergoes regulated secretion from fibroblasts and is over-produced in adenocarcinomas and other cancers. We have recently shown that QSOX1 is required for incorporation of particular laminin isoforms
Simeon K Adesina et al.
Journal of pharmaceutical sciences, 103(8), 2546-2555 (2014-06-26)
The macromonomer method was used to prepare cross-linked, paclitaxel-loaded polylactide (PLA)-polyethylene glycol (stealth) nanoparticles using free-radical dispersion polymerization. The method can facilitate the attachment of other molecules to the nanoparticle surface to make it multifunctional. Proton nuclear magnetic resonance and
Songchen Xu et al.
Dalton transactions (Cambridge, England : 2003), 43(38), 14368-14376 (2014-06-19)
We report the synthesis of a new mixed oxazoline-carbene scorpionate ligand, bis(4,4-dimethyl-2-oxazolinyl)(1-mesitylimidazolyl)phenylborate (PhB(Ox(Me2))2Im(Mes)). Reactions of the protonated form PhB(Ox(Me2))2(Im(Mes)H) with dialkylzinc compounds provide four-coordinate zinc alkyl complexes, and X-ray diffraction studies of the {PhB(Ox(Me2))2Im(Mes)}ZnR (R = Me, Et) compounds show
[Advance on biological monitoring of occupational exposure to toluene].
Hong-xia Chen et al.
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 28(8), 613-615 (2010-12-04)
Fazel Mohammadi-Moghadam et al.
Journal of environmental and public health, 2013, 986083-986083 (2013-04-05)
The aim of this paper is to investigate the removal of toluene from gaseous solution through Glycyrrhiza glabra root (GGR) as a waste material. The batch adsorption experiments were conducted at various conditions including contact time, adsorbate concentration, humidity, and
Mike De Vrieze et al.
Analytical and bioanalytical chemistry, 406(25), 6179-6188 (2014-08-16)
Over the past decades, several in vitro methods have been tested for their ability to predict drug penetration across the blood-brain barrier. So far, in high-performance liquid chromatography, most attention has been paid to micellar liquid chromatography and immobilized artificial
Christian Bährle et al.
ChemSusChem, 7(7), 2022-2029 (2014-07-22)
Lignin pyrolysis is a promising method for the sustainable production of phenolic compounds from biomass. However, detailed knowledge about the radicals involved in this process and their influence on the molecular products is missing. Herein, we report on the pyrolysis
Cristina García-Simón et al.
Nature communications, 5, 5557-5557 (2014-11-27)
Since fullerenes are available in macroscopic quantities from fullerene soot, large efforts have been geared toward designing efficient strategies to obtain highly pure fullerenes, which can be subsequently applied in multiple research fields. Here we present a supramolecular nanocage synthesized
Ye Wang et al.
Investigative ophthalmology & visual science, 54(5), 3806-3814 (2013-05-11)
To investigate how Sirtuin (silent mating type information regulation 2 homolog) 1 (SIRT1) promotes high glucose-attenuated corneal epithelial wound healing. The effects of high glucose on SIRT1 expression were assessed in primary human corneal epithelial cells (CECs) in treatment of
Saet Buyl Lee et al.
Plant & cell physiology, 56(1), 48-60 (2014-10-13)
The aerial parts of all land plants are covered with hydrophobic cuticular wax layers that act as the first barrier against the environment. The MYB94 transcription factor gene is expressed in abundance in aerial organs and shows a higher expression
Daniel Matatagui et al.
Sensors (Basel, Switzerland), 14(7), 12658-12669 (2014-07-17)
The following paper examines a time-efficient method for detecting biological warfare agents (BWAs). The method is based on a system of a Love-wave immunosensor combined with a microfluidic chip which detects BWA samples in a dynamic mode. In this way
Chadin Kulsing et al.
Journal of chromatography. A, 1354, 85-91 (2014-06-18)
A new method has been developed for the preparation of molecular imprinted polymers as porous layers in open tubular (MIP-PLOT) capillary column formats for use in chiral separations by capillary liquid chromatography. The synthesis was based on 'in-capillary' ultraviolet (UV)
Daniel R Swale et al.
PloS one, 9(8), e103713-e103713 (2014-08-08)
Recent studies suggest that N, N-diethyl-meta-toluamide (DEET) is an acetylcholinesterase inhibitor and that this action may result in neurotoxicity and pose a risk to humans from its use as an insect repellent. We investigated the mode of action of DEET
Christelle Planche et al.
Journal of chromatography. A, 1392, 74-81 (2015-03-31)
This paper evaluates different multiresidue methods based on comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC×GC-TOF/MS) to analyze dioxin-related micropollutants in complex food matrices. In a first step, the column sets Rtx-PCB/BPX-50 and Rtx-Dioxin2/BPX-50 were compared in terms
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