352-34-1

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Remdesivir and Cyclosporine Synergistically Inhibit the Human Coronaviruses OC43 and SARS-CoV-2.

Hsing-Yu Hsu et al.

Frontiers in pharmacology, 12, 706901-706901 (2021-09-07)

Remdesivir, a prodrug targeting RNA-dependent-RNA-polymerase, and cyclosporine, a calcineurin inhibitor, individually exerted inhibitory activity against human coronavirus OC43 (HCoV-OC43) in HCT-8 and MRC-5 cells at EC50 values of 96 ± 34 ∼ 85 ± 23 nM and 2,920 ± 364 ∼

Single nucleotide polymorphism rs17849071 G/T in the PIK3CA gene is inversely associated with follicular thyroid cancer and PIK3CA amplification.

Jeffrey C Xing et al.

PloS one, 7(11), e49192-e49192 (2012-11-28)

The proto-oncogene PIK3CA has been well studied for its activating mutations and genomic amplifications but not single nucleotide polymorphism (SNP) in thyroid cancer. We investigated SNP rs17849071 (minor allele G and major allele T) in PIK3CA in thyroid tumors in

Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes.

M Loetscher et al.

The Journal of biological chemistry, 269(1), 232-237 (1994-01-07)

Several chemotactic agonists including interleukin-8 (IL-8) and related cytokines have been shown to activate and attract leukocytes via seven-transmembrane domain, GTP-binding protein-coupled receptors. A cDNA clone, LESTR, encoding a protein of 352 amino acids, corresponding to a novel receptor of

Off-the-Shelf Devices for Treatment of Thoracic Aortic Diseases: Midterm Follow-up of TEVAR With Chimneys or Physician-Made Fenestrations.

Lei Zhang et al.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 27(1), 132-142 (2019-12-04)

Purpose: To evaluate the midterm outcomes of thoracic endovascular aortic repair (TEVAR) using chimney grafts (ch-TEVAR) or thoracic stent-grafts with fenestrations made on the back table (f-TEVAR) to treat thoracic aortic dissection (TAD) and thoracic aortic aneurysm (TAA). Materials and

Treatment outcomes of multi drug resistant and rifampicin resistant Tuberculosis in Zimbabwe: A cohort analysis of patients initiated on treatment during 2010 to 2015.

Ronnie Matambo et al.

PloS one, 15(4), e0230848-e0230848 (2020-05-01)

Zimbabwe is one of the thirty countries globally with a high burden of multidrug-resistant tuberculosis (TB) or rifampicin-resistant TB (MDR/RR-TB). Since 2010, patients diagnosed with MDR/RR-TB are being treated with 20-24 months of standardized second-line drugs (SLDs). The profile, management

Evaluation of contrast injection site effectiveness: thoracic CT angiography in children with hand injection of IV contrast material.

Gary R Schooler et al.

AJR. American journal of roentgenology, 204(2), 423-427 (2015-01-24)

OBJECTIVE. The purpose of this study was to evaluate the effectiveness of various contrast injection sites when performing thoracic CT angiography (CTA) using hand injection of IV contrast material in infants and young children with a small IV catheter. MATERIALS

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.

Wendy De Roock et al.

The Lancet. Oncology, 11(8), 753-762 (2010-07-14)

Following the discovery that mutant KRAS is associated with resistance to anti-epidermal growth factor receptor (EGFR) antibodies, the tumours of patients with metastatic colorectal cancer are now profiled for seven KRAS mutations before receiving cetuximab or panitumumab. However, most patients

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