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Ran Qin et al.
American journal of translational research, 11(3), 1460-1472 (2019-04-12)
Accumulating evidence suggests that oxidative stress plays an important role in the progression of osteoarthritis (OA), and pyrroloquinoline quinone (PQQ) is considered a strong antioxidant. However, it is unclear whether PQQ can prevent the progression of OA by inhibiting oxidative
Idoia Martín-de-Lucía et al.
Environmental pollution (Barking, Essex : 1987), 249, 581-588 (2019-04-02)
Hyperbranched polymers are nanomaterials belonging to the class of dendritic architectures with increasing applications in many diverse fields. We studied the toxicity of two hyperbranched polymers to the freshwater crustacean Daphnia magna. A hyperbranched hydroxyl-terminated polyester and a commercial hyperbranched
Ferdinando Carlo Sasso et al.
Acta diabetologica, 57(8), 947-958 (2020-03-05)
Excessive glucose serum concentration, endothelial dysfunction and microangiopathy are key features of diabetes mellitus, being both diagnostic parameters and pathogenetic mechanisms. Vascular endothelial growth factor (VEGF) is importantly implicated in the physiology and pathology of blood vessels, including diabetic vascular
Yanjuan Huang et al.
Journal of controlled release : official journal of the Controlled Release Society, 319, 119-134 (2019-12-29)
Current therapeutic strategies for the treatment of bone metastases are often limited by the lack of selectivity, severe systemic toxicity and suboptimal efficacy. Nanomedicine meditated chemo-photodynamic therapy provides a promising therapeutic opportunity for enhanced cancer therapy. Herein, we constructed an
Yue Gu et al.
Neural regeneration research, 13(10), 1842-1850 (2018-08-24)
The mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in the regulation of cell growth, proliferation, differentiation, transformation and death. Mitogen-activated protein kinase phosphatase 1 (MKP1) has an inhibitory effect on the p38MAPK and JNK pathways, but it
Hyesook Lee et al.
Molecular vision, 22, 1490-1502 (2017-01-05)
We previously have reported that chondrocyte-derived extracellular matrix (CDECM) suppresses the growth of pterygium in athymic nude mice. The aim of this study is to demonstrate the effect of CDECM on the pterygium epithelial cells and molecular signaling pathways in
Ying Chen et al.
Frontiers in pharmacology, 10, 1574-1574 (2020-02-06)
Oxidation injury to skin is one of the main reasons for skin aging. The aim of the present study was to explore the protective effect of squid ink polysaccharides and its mechanism of action against H2O2-induced dermal fibroblast damage. Our
Joo Young Lee et al.
Experimental and therapeutic medicine, 13(4), 1194-1202 (2017-04-18)
Persicarin is one of the major components of the
Lingmei Sun et al.
Journal of microbiology and biotechnology, 29(4), 538-547 (2019-04-04)
The aim of the present study was to evaluate the effects of two well-known natural antioxidants vitamin C (VC) and vitamin E (VE) on the antifungal activity of honokiol against Candida albicans. The broth microdilution method was employed to test
Fawad Ur Rehman et al.
Nanomedicine : nanotechnology, biology, and medicine, 14(8), 2619-2631 (2018-08-22)
Timely detection is crucial for successful treatment of cancer. The current study describes a new approach that involves utilization of the tumor cell environment for bioimaging with in-situ biosynthesized nanoscale gold and iron probes and subsequent dissemination of Au-Fe nanoclusters
Wataru Komatsu et al.
European journal of pharmacology, 833, 411-424 (2018-06-23)
Urolithin A, a gut microbial metabolite of ellagic acid, is reported to exert anti-inflammatory effects in vitro and in vivo. However, complete mechanisms underlying the regulation of inflammatory responses by urolithin A remain unclear. This study aimed to evaluate the
Fan Tang et al.
European journal of pharmacology, 820, 86-96 (2017-12-13)
Doxorubicin (Dox) is an effective anti-cancer agent but limited by its cardiotoxicity, thus the search for pharmacological agents for enhancing anti-cancer activities and protecting against cardiotoxicity has been a subject of great interest. We have previously reported the synergistic anti-cancer
Xiaolong Hou et al.
Life sciences, 130, 38-46 (2015-03-31)
Dihydromyricetin (DMY) is the most abundant ingredient in vine tea. Here, we investigated the cytoprotective effects and possible mechanisms of DMY on hydrogen peroxide (H2O2)-induced oxidative stress damage in human umbilical vein endothelial cells (HUVECs). The percentage of cell viability
Sun Ah Ham et al.
Journal of dermatological science, 76(1), 44-50 (2014-08-26)
Changes in skin connective tissues mediated by ultraviolet (UV) radiation have been suggested to cause the skin wrinkling normally associated with premature aging of the skin. Recent investigations have shown that peroxisome proliferator-activated receptor (PPAR) δ plays multiple biological roles
Xiang Han et al.
International journal of molecular medicine, 42(3), 1460-1472 (2018-05-31)
Acute lung injury (ALI) is an important cause of morbidity and mortality for critically ill patients, and linarin (LR) may be a potential treatment for ALI as it reportedly has antioxidant, anti‑inflammatory and apoptotic‑regulating activity. In the present study, the authors
Mayara Sandrielly Pereira Soares et al.
Metabolic brain disease, 32(5), 1693-1703 (2017-07-06)
High plasma levels of methionine (Met) and its metabolites such as methionine sulfoxide (MetO) may occur in several genetic abnormalities. Patients with hypermethioninemia can present neurological dysfunction; however, the neurotoxicity mechanisms induced by these amino acids remain unknown. The aim
Zhigang Zhang et al.
Food & function, 11(10), 9252-9262 (2020-10-14)
Ongoing groundwater arsenic contamination throughout China was first recognized in the 1960s. Groundwater arsenic contamination is a high risk for human and animal health worldwide. Apart from drinking water, diet is the second pathway for arsenic to enter the human
Xinhao Zhao et al.
Cell death & disease, 11(5), 379-379 (2020-05-20)
Inappropriate neutrophil infiltration and subsequent neutrophil extracellular trap (NET) formation have been confirmed to be involved in chronic inflammatory conditions. Fatty liver disease is an increasingly severe health problem worldwide and currently considered the most common cause of chronic liver
Huihui Ke et al.
International journal of biological macromolecules, 133, 1063-1071 (2019-04-30)
Palmitic acid (PA) is known to induce lipotoxicity, a metabolic syndrome as a result of lipid accumulation in multiple cell lines. Bioactive phytochemicals derived from vegetables and fruits have gained increasing attention owing to their potential on suppressing the detrimental
Yan-Ling Qiu et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 106, 192-199 (2018-06-30)
Aucubin (Ai), a natural compound isolated from plants, including Aucuba japonica and Eucommia ulmoides, shows significant anti-inflammatory and anti-oxidative bioactivities. Here, we attempted to explore the protect effects of Ai on LPS-induced acute lung injury (ALI). Our results indicated that
Yun Qian et al.
Small (Weinheim an der Bergstrasse, Germany), 16(32), e2000796-e2000796 (2020-07-08)
Piezoelectric materials can produce electrical power from the mechanical stimulation and thus, they may accelerate electroactive tissue healing as a promising treatment for traumatic peripheral nerve injuries. In this study, a piezoelectric zinc oxide nanogenerator scaffold is manufactured by 3D
Yanjie Li et al.
Die Pharmazie, 69(8), 610-614 (2014-08-28)
Beyond lipid-lowering effect, statins, the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase competitively inhibitors, have recently attracted wide concern on their anticarcinogenic properties in various cancer cells. However, the molecular mechanisms by which statins inhibit cancer cell proliferation remain unclear. In this
Yuan Liu et al.
Nature communications, 9(1), 4429-4429 (2018-10-26)
It is well known that high-risk human papilloma virus (HR-HPV) infection is strongly associated with cervical cancer and E7 was identified as one of the key initiators in HPV-mediated carcinogenesis. Here we show that lactate dehydrogenase A (LDHA) preferably locates
Katre Juganson et al.
Environmental pollution (Barking, Essex : 1987), 225, 481-489 (2017-03-21)
Silver nanoparticles (AgNPs) are highly toxic to aquatic organisms, however, there is no consensus whether the toxicity is caused solely by released Ag-ions or also by reactive oxygen species (ROS). Here, the effects of protein-coated AgNPs (14.6 nm, Collargol) were studied
Sebastian Friedrich Petry et al.
PloS one, 12(5), e0176267-e0176267 (2017-05-26)
The onset and progression of diabetes mellitus type 2 is highly contingent on the amount of functional beta-cell mass. An underlying cause of beta-cell decay in diabetes is oxidative stress, which markedly affects the insulin producing pancreatic cells due to
Lixiao Zhou et al.
Chemosphere, 241, 125075-125075 (2019-11-07)
Carbon black nanoparticle (CBNP) is a core constituent of air pollutants like fine particulate matter (PM2.5) as well as a common manufactural material. It was proved to pose adverse effects on lung function and even provoke pulmonary fibrosis. However, the
Marijke C C Sachweh et al.
Oncotarget, 6(18), 16488-16506 (2015-06-02)
Malignant melanoma is the most dangerous type of skin cancer. Although recent progress in treatment has been achieved, lack of response, drug resistance and relapse remain major problems. The tumor suppressor p53 is rarely mutated in melanoma, yet it is
Wageh Sobhy Darwish et al.
Environmental science and pollution research international, 26(15), 15443-15457 (2019-04-04)
Cadmium (Cd) is an environmental pollutant that can get entry into human body via ingestion of contaminated foods causing multiple organ damage. This study aimed at monitoring Cd residues in 20 foodstuffs of animal origin that are commonly consumed in
Daniel Tonial Thomaz et al.
Neurochemical research, 45(9), 2217-2229 (2020-07-16)
Stroke is a major cause of disability and death worldwide. Oxygen and glucose deprivation (OGD) in brain tissue preparations can reproduce several pathological features induced by stroke providing a valuable ex vivo protocol for studying the mechanism of action of
Xianpu Zhang et al.
Molecular medicine reports, 18(1), 855-863 (2018-05-31)
Treatment with doxorubicin (DOX), which is an effective anticancer agent, is limited by cardiotoxicity. CUE domain‑containing 2 (CUEDC2) serves a role in numerous cellular processes. The present study aimed to elucidate the potential function of CUEDC2 in DOX‑induced cardiotoxicity. Cell
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